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Development of Implantable Electronics as Novel Approaches to Obstructive Sleep Apnea (Springer Theses)
by Jungmin SeoThis book addresses novel methods to treat a very popular disease, obstructive sleep apnea, based on a knowledge of an electrical engineering. Two approaches are given in the book using an upper-airway stimulation based on the pathogenesis of an obstructive sleep apnea. Implantable electronics are devised to control the tongue and the soft palate considering that they are the major pharyngeal muscles contributing to the apnea. First, for tongue control, a cuff electrode was designed and fabricated to stimulate the hypoglossal nerve, which innervates to the tongue muscle. Rare-earth magnets were embedded in the cuff for easy and repeatable installation of the electrode. For soft palate control, a palatal implant system was firstly developed to contract the soft palate muscle by applying electrical stimuli. Comprised of an implant, an intra-oral device, and an external controller, the palatal implant system is fully powered and controlled by means of wireless communication. The approaches were demonstrated in both in vitro and in vivo assessments, in collaboration with department of Otorhinolaryngology, Seoul National University Bundang Hospital.
Development of In-Tether Carbon Chiral Center-Induced Helical Peptide: Methodology and Applications (Springer Theses)
by Kuan HuThis book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
Development of Infrared Techniques for Practical Defect Identification in Bonded Joints
by Rachael C. WaughMaximizing reader insights into the use of thermography, specifically pulsed and pulse phase thermography (PT and PPT), for the identification of kissing defects in adhesive bonds, this thesis focuses on the application of PT and PPT for the identification of a range of defect types in a variety of materials to establish the effect of material properties on identification of defects. Featuring analysis of a numerical model developed to simulate the thermal evolution created during a PT or PPT experiment, after validation through a series of case studies, this model is then used as a predictive tool to relate defect detectability to the thermal property contrast between defect and bulk materials. Demonstrating a means of producing realistic kissing defects in bonded joints where insufficient thermal property contrast exists defects have a limited effect on heat propagation through a component and therefore are not detected using PT or PPT, this thesis discusses the addition of a small load to bonds containing kissing defects which was found to open the defects sufficiently to enable their detection. A low cost infrared detector, Flir Tau320, is compared to the research based photon detector, Flir SC5000, and is shown to be suitable for application in PT, thus enabling a significantly lower cost tool to be developed.
Development of Medical Garments and Apparel for the Elderly and the Disabled (Textile Progress Ser.)
by Ng Sau-FunAlthough the main theme of this book is products for the elderly and the disabled, it also contains major sections on medical garments, which include personal protective equipment (PPE), hip protectors (HP), pressure garments (PG), compression stockings (CS), wet dressings, products for wound dressing, adult incontinence products, sanitary napkins, disposable diapers, vital signs monitoring garments, motion aware clothing, wearable sensors and smart diapers and so on. The development of apparel for the elderly and the disabled is a challenge for the healthcare and clothing industries. The developed apparel products are not only based on various design, fashion and comfort concepts but also considered in terms of particular medical problems, restorative care functions, and appropriate solutions for healthcare purposes.
Development of Medications for the Treatment of Opiate and Cocaine Addictions: Issues for the Government and Private Sector
by Committee to Study Medication Development Research at the National Institute on Drug AbusePharmacotherapy, as a means of treating drug addiction in combination with other treatment modalities, has received too little attention from the research community, the pharmaceutical industry, public health officials, and the federal government. Medications to combat drug addiction could have an enormous impact on the medical consequences and socioeconomic problems associated with drug abuse, both for drug-dependent individuals and for American society as a whole. This book examines the current environment for and obstacles to the development of anti-addiction medications, specifically those for treating opiate and cocaine addictions, and proposes incentives for the pharmaceutical industry that would help overcome those obstacles and accelerate the development of anti-addiction medications.
Development of Navigation Technology for Flight Safety (Springer Aerospace Technology)
by Sauta O.I. Shatrakov Y.G. Bestugin A.R. Baburov S.V. Galyamov A.M.This book highlights practical solutions for flight safety improvement techniques, which are currently the focus of the International Civil Aviation Organization (ICAO). It has become clear that, in order to rapidly and significantly improve flight safety, the integrated use of new aeronautical technologies is called for. Considering the size of the aviation fleet, its constant growth and the long service lives of aircraft, new technologies should be adapted both to cutting-edge air navigation systems and to those that have been used for over a decade. Concretely, the book discusses methodological approaches to the construction of ground and on-board avionics that make it possible to achieve improved flight safety using innovative new methods. The proposed approaches are illustrated with real-world examples of e.g. satellite-based navigation systems and enhanced ground proximity warning systems. The book is written for professionals involved in the development of avionics systems, as well as students, researchers and experts in the field of radiolocation, radio navigation and air traffic control, the book will support the development and modeling of radio technical complexes, as well as the analysis of complex radio technical systems.
Development of New Catalytic Performance of Nanoporous Metals for Organic Reactions
by Mei YanIn this thesis, the focus is on the study of new catalytic properties of unsupported nanoporous metals in heterogeneous organic reactions under liquid-phase conditions. The author was the first to fabricate nanoporous copper with tunable nanoporosity and apply it for organic reactions. The catalyst can be reused up to ten times without loss of catalytic activity. In addition, the author developed the highly selective semihydrogenation of alkynes using nanoporous gold as a catalyst for the first time, affording Z-alkenes in 100% selectivity, which cannot be realized by traditional catalysts. All of the results described here will help readers to develop new catalytic performance of nanoporous metals for organic reactions.
Development of Novel Bioelectrochemical Membrane Separation Technologies for Wastewater Treatment and Resource Recovery (Springer Theses)
by Yunkun WangThe most commonly used biological wastewater treatment technologies still have serious technical-economical and sustainability-related limitations, due to their high energy requirements, poor effluent quality, and lack of energy and resource recovery processes. In this thesis, novel electrochemical membrane bioreactors (EMBRs), which take advantage of membrane separation and bioelectrochemical techniques, are developed for wastewater treatment and the simultaneous recovery of energy and resources. Above all, this innovative system holds great promise for the efficient wastewater treatment and energy recovery. It can potentially recover net energy from wastewater while at the same time harvesting high-quality effluent. The book also provides a proof-of-concept study showing that electrochemical control might offer a promising in-situ means of suppressing membrane fouling. Lastly, by integrating electrodialysis into EMBRs, phosphate separation and recovery are achieved. Hence, these new EMBR techniques provide viable alternatives for sustainable wastewater treatment and resource recovery.
Development of Procedures and Technical Manuals for the Marine and Offshore Industries (Synthesis Lectures on Ocean Systems Engineering)
by Alexander Arnfinn Olsen Fidaa KarkoriThis book is devoted to the development of procedures and technical manuals for the marine and offshore industries, providing a comprehensive guide to creating clear, effective instructional materials. At the heart of this book is the matter of safety and environmental considerations, ensuring that all documentation aligns with current practices, policies, and regulatory requirements. The chapters cover topics such as the role of instructional materials, writing techniques, the use of graphics, and the processes for verifying, validating, approving, certifying, and implementing these materials. The authors present an expert analysis of how well-written administrative, regulatory, operating, emergency, maintenance, and routine duty procedures can enhance productivity and reduce accidents. Readers will also discover practical insights into managing instructional materials within safety programs. This book is essential for engineers and professionals tasked with developing technical manuals and texts in safety-critical industries. It serves as a valuable reference for academics and students in industrial design and engineering, as well as a textbook for students of marine architecture. Offshore installation managers and senior safety management professionals will find this guide indispensable for ensuring consistency and quality control in their operations.
Development of Redox Mediators for High-Energy-Density and High-Efficiency Lithium-Oxygen Batteries (Springer Theses)
by Youngmin KoThis thesis addresses the introduction of redox mediator into lithium-oxygen batteries to improve their electrochemical performance especially in terms of practical energy density and round-trip efficiency. In chapter 1, basic electrochemistry regarding lithium-oxygen batteries and redox mediators are introduced. In chapter 2 to 4, comprehensive researches including the discovery of a new redox mediator inspired by biological system, the investigation on kinetic property of redox mediator, and the prevention of shuttle phenomenon are introduced, followed by chapter 5 summarizing the contents. This thesis is targeted to students and researchers interested in electrochemistry and energy storage systems.
Development of Smart Context-Aware Services for Cargo Transportation: An Operational Management Approach (International Series in Operations Research & Management Science #330)
by Dalė Dzemydienė Aurelija Burinskienė Kristina Čižiūnienė Arūnas MiliauskasWith a focus on cargo transportation, this book addresses the development of approaches intended to secure an infrastructure of smart services to support the adaptive implementation of online multi-modal freight transport management processes. It discusses the development of multi-criteria decision-making components and their integration into the multi-layered computer-based information management of intelligent systems. Through detailed descriptions of various components of intelligent transport management systems, the book demonstrates how to develop the services needed in the right place and at the right time, and how to properly adapt to user needs, making necessary interventions to ensure the safety of the transportation process. Further, it describes the main ways to increase the autonomy and efficiency of user-vehicle interaction and shows how Information and Communications Technology (ICT) structural support for current and past situations in AI-based systems can help to anticipate future developments in freight transportation.
Development of Solar Cells: Theory and Experiment (Challenges and Advances in Computational Chemistry and Physics #32)
by Jerzy Leszczynski Supratik Kar Juganta K. RoyThis book presents a comprehensive overview of the fundamental concept, design, working protocols, and diverse photo-chemicals aspects of different solar cell systems with promising prospects, using computational and experimental techniques. It presents and demonstrates the art of designing and developing various solar cell systems through practical examples. Compared to most existing books in the market, which usually analyze existing solar cell approaches this volume provides a more comprehensive view on the field. Thus, it offers an in-depth discussion of the basic concepts of solar cell design and their development, leading to higher power conversion efficiencies. The book will appeal to readers who are interested in both fundamental and application-oriented research while it will also be an excellent tool for graduates, researchers, and professionals working in the field of photovoltaics and solar cell systems.
Development of Sustainable Thermal Insulators from Waste Materials: A Circular Economy Approach (Materials Horizons: From Nature to Nanomaterials)
by Sarika Verma A. K. Srivastava Mohd. Akram KhanThis book focuses on the major global waste management issues and development of thermal insulating materials by utilizing these wastes. It helps address various global issues like sustainable environment, waste to wealth, waste to resource material, advanced multifunctional material, skill development and employment generation. The book highlights the potentiality and the applicability of various wastes, such as municipal solid waste, agricultural waste, industrial waste, construction waste, textile waste, waste polystyrene, geopolymer, leather rubber waste, other miscellaneous waste to be considered as a resource and its availability and conversion technologies from waste to wealth as thermal insulating materials. It also discusses recent trends, for processing the waste to wealth as a thermally insulating material. This book is a useful guide to researchers and professionals working in the areas of energy storage, sustainable civil engineering, material science and others allied fields.
Development of Transport by Telematics: 19th International Conference on Transport System Telematics, TST 2019, Jaworze, Poland, February 27 – March 2, 2019, Selected Papers (Communications in Computer and Information Science #1049)
by Jerzy MikulskiThis book constitutes selected papers from the 19th International Conference on Transport Systems Telematics, TST 2019, held in Jaworze, near Bielsko-Biala, Poland, in March 2019. The 31 full papers presented in this volume were carefully reviewed and selected from 104 submissions. They were organized in topical sections named: telematics in rail transport; telematics in road transport; telematics in marine transport; telematics in air transport; and general about telematics.
Development of a Cyber Physical System for Fire Safety
by Rosalie Faith Wills André MarshallThis SpringerBrief presents cutting-edge research on an important aspect of smart firefighting which will improve performance, safety, prediction, and resilience. It demonstrates the viability of real-time decision support for smart firefighting and provides validation data for continued cyber-physical system (CPS) development by using a smart networked fire test bed consisting of a multi-story instrumented building, a variety of fire and non-fire networked sensors, and a computational framework anchored by a Building Information Modeling (BIM) representation of the building. The author conducted well-controlled full-scale fire experiments and represents them in the three-dimensional BIM, allowing for visualization of critical static and dynamic building and fire information. The CPS test bed produces clear evidence about the opportunities for fire safety created by the communication between sensors, BIM, and fire. When applied to fire protection, CPS fuses the emerging sensor and computing technologies with building control systems, firefighting equipment, and apparatus. This SpringerBrief reveals some of the key ways CPS makes firefighting safer and more efficient.
Development of a Decision Support System for Groundwater Pollution Assessment
by N. KukuricThis book discusses the development of the decision support system for groundwater pollution assessment, one of the first integrated information systems in the field of hydrogeology, reflecting the purpose of knowledge encapsulation in the field of groundwater quality management.
Development of a Remote Laboratory for Engineering Education (Technology Guides)
by Ning Wang Xuemin Chen Qianlong Lan Gangbing Song Hamid ParsaeiThe field of information technology continues to advance at a brisk pace, including the use of Remote Laboratory (RL) systems in education and research. To address the needs of remote laboratory development for such purposes, the authors present a new state-of-the-art unified framework for RL system development. Included are solutions to commonly encountered RL implementation issues such as third-party plugin, traversing firewalls, cross platform running, and scalability, etc. Additionally, the book introduces a new application architecture of remote lab for mobile-optimized RL application development for Mobile Learning (M-Learning). It also shows how to design and organize the remote experiments at different universities and make available a framework source code. The book is intended to serve as a complete guide for remote lab system design and implementation for an audience comprised of researchers, practitioners and students to enable them to rapidly and flexibly implement RL systems for a range of fields.
Development of a Self-Sufficient, Wireless Sensor Node Using the Outer FML Layer as an Antenna (Mechanics and Adaptronics)
by Sarah BornemannThis book presents an investigation on integrating wireless sensor nodes including their antennas into fiber metal laminates (FMLs) for the purpose of enabling wireless, material-integrated structural health monitoring. Within the scope of this work, a digital sensor node is presented, which can be fully integrated into a conductive host material. A stainless steel antenna supplies the system with sufficient power to provide the functions required for its intended use. This system enables the wireless readout of sensor data for the detection of damage in FMLs. The application focuses on aerospace components, for the detection of damage in the inner material layers, which are not or only hardly detectable by optical inspection methods. Guided ultrasonic waves in the form of Lamb waves are used for this. The flexible electronics are inserted into the layers of the target material, while the associated antenna is cut into the outer metal layer. This turns the outer metal layer, which would prevent wireless communication from inside the laminate, into an advantage, as the need for an additional, external antenna is eliminated. Two fundamentally different principles can be used as the sensor element. Piezoelectric sensors were already used extensively in structural health monitoring using ultrasound and recently developed piezoresistive sensors, which are designed to be very small, making them highly suitable for material integration. Both types of sensors can be read out with the presented system so that the most appropriate approach can be chosen depending on the application. The suitability of the wireless sensor system for its intended purpose is verified by material-integrated measurements. At the end of this work, it is shown that the raw data of the measurements reproducibly provide a sufficient resolution of the sensor signal to manually identify changes caused by applied reversible, artificial pseudo-defects from reference measurements without any damage. The intended audience of this book are people from the field which are familiar with the basic concepts of electrical engineering or similar regions, embedded system enthusiasts and all readers who like to follow the process of a complete wireless electronic system design from requirements analysis to final material-integrated measurement demonstrations.
Development of a Sub-glacial Radio Telescope for the Detection of GZK Neutrinos
by Thomas MeuresThe goal of the project presented in this book is to detect neutrinos created by resonant interactions of ultrahigh energy cosmic rays on the CMB photon field filling the Universe. In this pioneering first analysis, the author puts forward much of the analysis framework, including calibrations of the electronic hardware and antenna geometry, as well as the development of algorithms for event reconstruction and data reduction. While only two of the 37 stations planned for the Askaryan Radio Array were used in this assessment of 10 months of data, the analysis was able to exclude neutrino fluxes above 10 PeV with a limit not far from the best current limit set by the IceCube detector, a result which establishes the radio detection technique as the path forward to achieving the massive volumes needed to detect these ultrahigh energy neutrinos.
Development of an Efficient Modelling Approach to Support Economically and Socially Acceptable Flood Risk Reduction in Coastal Cities: Can Tho City, Mekong Delta, Vietnam (IHE Delft PhD Thesis Series)
by Hieu Quang NgoFlooding is one of the most frequently occurring and damaging natural disasters worldwide. Quantitative flood risk management (FRM) in the modern context demands statistically robust approaches (e.g. probabilistic) due to the need to deal with complex uncertainties. However, probabilistic estimates often involve ensemble 2D model runs resulting in large computational costs.Additionally, modern FRM necessitates the involvement of a broad range of stakeholders via co-design sessions. This makes it necessary for the flood models, at least at a simplified level, to be understood by and accessible to non-specialists. This study was undertaken to develop a flood modelling system that can provide rapid and sufficiently accurate estimates of flood risk within a methodology that is accessible to a wider range of stakeholders for a coastal city – Can Tho city, Mekong Delta, Vietnam. A web-based hydraulic tool, Inform, was developed based on a simplified 1D model for the entire Mekong Delta, flood hazard and damage maps, and estimated flood damages for the urban centre of Can Tho city (Ninh Kieu district), containing the must-have features of a co-design tool (e.g. inbuilt input library, flexible options, easy to use, quick results, user-friendly interface). Inform provides rapid flood risk assessments with quantitative information (e.g. flood levels, flood hazard and damage maps, estimated damages) required for co-designing efforts aimed at flood risk reduction for Ninh Kieu district in the future.
Development of an Environmental Impact Assessment and Decision Support System for Seawater Desalination Plants
by Sabine LattemanSeawater desalination is a coastal-based industry. The growing number of desalination plants worldwide and the increasing size of single facilities emphasises the need for greener desalination technologies and more sustainable desalination projects. A comprehensive evaluation of potential environmental impacts of desalination plants, this book emphasizes discusses strategies for impact mitigation. The author proposes a best-available technology concept for seawater desalination technologies in combination with a methodological approach for the environmental impact assessment (EIA) of desalination projects. It outlines the scope of EIA studies, including environmental monitoring and toxicity and hydrodynamic modeling studies. The book also explores the usefulness of multi-criteria analysis as a decision support tool for EIAs and then uses them to compare different intake and pretreatment options for seawater reverse osmosis plants.
Development of an Environmental and Economic Assessment Tool (Enveco Tool) for Fire Events
by Brian Meacham Francine Amon Jonatan Gehandler Selim Stahl Mai TomidaThis book investigates the feasibility of developing a tool that enables fire departments to estimate the value of their services to a community in terms of environmental and financial impact. This book provides a summary of this effort, which resulted in development of a prototype tool for fire department use. The impact of fire on a community is usually measured in terms of the number of fires, human casualties, and property damage. There are, however, more subtle impacts of fire that are not so easily estimated but contribute to the measure of overall performance of the fire service in protecting a community. While environmental and economic impact assessment methodologies exist as separate systems, they generally require a high level of knowledge that is outside the scope of most fire departments. A relatively simple methodology for estimating the environmental and economic impact of fires helps communities understand the degree to which fire department activities can benefit a community s environmental and economic well-being. The scope and approach for this prototype tool is explained, including risk assessment, cost benefit analysis, life cycle assessment, integration and implementation, and sensitivity and uncertainty analysis. It includes multiple case studies and offers statistical support for future expansion of the tool. Fire service professionals will find this a useful new approach to presenting value in a community, as well as a method for examining their own financial and environmental plans. "
Development of an Ultrasonic Sensing Technique to Measure Lubricant Viscosity in Engine Journal Bearing In-Situ
by Michele SchirruThis thesis presents a novel ultrasonic instrument for non-invasive and in-situ characterization of journal bearing lubricant viscosity. In particular, the application to journal bearings is described by non-invasively measuring the viscosity and localized power losses throughout operation. This ultrasonic viscometer is based on the reflection of polarized shear waves from a thin resonating coating layer to increase the measurement sensitivity, in comparison to conventional ultrasonic methods. This instrument allows for a full engine oil viscoelastic characterization in-situ. The book investigates the effects of temperature, pressure and shear rate, and describes in detail the ultrasonic setup and method. Further, it demonstrates that the same technique can be applied similarly to monitor the lubrication of other engine components. As such, it offers a unique instrument that can drive the research of oil formulations to improve engine performance and fulfill the requirements of international fuel economy regulations.
Development with Identity: Community, Culture, and Sustainability in the Andes
by Robert E. RhoadesThroughout Latin America, indigenous peoples are demanding that development must address local priorities, including ethnic identity. Simultaneously, sustainability scientists need to conduct place-based research on the interaction between environment and society that will have global relevance. This book reports on a 6 year interdisciplinary research project on natural resource management in Cotacachi, Ecuador, where scientists and indigenous groups learned to seek common ground. The book discusses how local people and the environment have engaged each other over time to create contemporary Andean landscapes. It also explores human-environment interaction in relation to biodiversity, soils and water, and equitable development. This book will be of significant interest to sociologists, anthropologists, economists and sustainability scientists researching environment and agriculture in rural communities.
Development, Social Change and Environmental Sustainability: Proceedings of the International Conference on Contemporary Sociology and Educational Transformation (ICCSET 2020), Malang, Indonesia, 23 September 2020
by SumarmiNowadays, the concept of SDGs (Sustainable Development Goals) is starting to replace the concept of MDGs (Millennium Developmental Goals). It is a global goal adopted by all United Nations member states. It emphasizes the idea that the development of every country can only be achieved by balancing other factors such as social, economic, and environmental sustainability. It is already clear how sustainable development works with environmental ethics and management. However, there are still issues regarding the sustainable development and human well-being. Sustainable development should focus on finding a way for society to meet their present needs for the long term without sacrificing the ability of future generations to meet their needs. This international seminar provides research results and literature regarding the topic of sustainable development concept, the dynamics of sustainable development and social change, and environmental sustainability. The international seminar, entitled 1st International Conference on Contemporary Sociology and Educational Transformation, listed speakers from several countries providing an overview on human and environmental resilience. This book contains a selection of papers presented at the conference.