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In Search of the Good: A Life in Bioethics (Basic Bioethics)
by Daniel CallahanOne of the founding fathers of bioethics describes the development of the field and his thinking on some of the crucial issues of our time. Daniel Callahan helped invent the field of bioethics more than forty years ago when he decided to use his training in philosophy to grapple with ethical problems in biology and medicine. Disenchanted with academic philosophy because of its analytical bent and distance from the concerns of real life, Callahan found the ethical issues raised by the rapid medical advances of the 1960s—which included the birth control pill, heart transplants, and new capacities to keep very sick people alive—to be philosophical questions with immediate real-world relevance. In this memoir, Callahan describes his part in the founding of bioethics and traces his thinking on critical issues including embryonic stem cell research, market-driven health care, and medical rationing. He identifies the major challenges facing bioethics today and ruminates on its future.Callahan writes about founding the Hastings Center—the first bioethics research institution—with the author and psychiatrist Willard Gaylin in 1969, and recounts the challenges of running a think tank while keeping up a prolific flow of influential books and articles. Editor of the famous liberal Catholic magazine Commonweal in the 1960s, Callahan describes his now-secular approach to issues of illness and mortality. He questions the idea of endless medical “progress” and interventionist end-of-life care that seems to blur the boundary between living and dying. It is the role of bioethics, he argues, to be a loyal dissenter in the onward march of medical progress. The most important challenge for bioethics now is to help rethink the very goals of medicine.
In Search of the Missing: Working with Search and Rescue Dogs
by Mick Mccarthy Patricia AhernMick McCarthy has experienced first-hand the dangers, thrills, tragedies, and triumphs of search and rescue operations, which he has carried out on flood-swollen rivers, raging seas, through woodland, bog land, and on treacherous mountains, often in the dead of night. This book narrates the captivating story of his dogs, his life, and his adventures in the field, in search of missing persons.
In Search of the Next Memory
by Giovanni Campardo Roberto GastaldiThis book provides students and practicing chip designers an easy-to-follow yet thorough, introductory treatment of the most promising emerging memories under development in the industry. Focusing on the chip designer rather than the end user, this book offers expanded, up-to-date coverage of emerging memories circuit design. After an introduction on the old solid-state memories and the fundamental limitations soon to be encountered, the working principle and main technology issues of each of the considered technologies (PCRAM, MRAM, FeRAM, ReRAM) are reviewed and a range of topics related to design is explored: the array organization, decoding, sensing and writing circuitry, data path design, redundancy and error correction, I/O interfaces, power requirements are reviewed comparing the approach followed and the constraints for each of the technologies considered. Additionally some considerations are entertained about how emerging memories can find a place in the new memory paradigm required by future electronic systems. This book is an up-to-date and comprehensive introduction for students in courses on memory circuit design or advanced digital courses in VLSI or CMOS circuit design. It also serves as an essential, one-stop resource for academics, researchers and practicing engineers.
In Search of the Perfect Peach: Why flavour holds the answer to fixing our food system
by Franco FubiniWITH A FOREWORD FROM TIM SPECTOR, author of The Diet Myth, Spoon-Fed and Food for Life ‘This book is a passionate rallying call for a change of mindset…’ Mail on Sunday "A pioneering approach."—Anna Jones, cook and bestselling author of Easy Wins "By valuing and reclaiming flavour, Franco argues that we can transform the system and also enrich our relationship with food. Essential reading."—Dan Saladino, journalist, broadcaster and author of Eating to Extinction Let flavour guide our food choices – and lead us to a better food future. In Search of the Perfect Peach shows us how this simple desire can bring about a healthier, tastier and brighter future for our food, the people who produce it and the soil it grows in. That first bite of a perfectly ripe peach can be truly transformative – a joyful moment that will stay with you forever. For Franco Fubini, founder and CEO of Natoora, this encounter also leads him to realise that flavour is not simply a fleeting, visceral experience but a window into the farmer, a connection to our natural environment and a taste test for our food system. What makes a great-tasting tomato? Why is scarring on a greengage a good sign? Does ‘eating local’ narrow our priorities to the exclusion of others? In Search of the Perfect Peach follows Franco as he navigates the food system in pursuit of this elusive element. As he takes us from Sicily’s citrus groves to the streets of Mexico City, he shows how we have allowed the wider industry to compromise on more than just flavour. Franco’s search for the Greta peach culminates in his own clarity and conviction: by looking to flavour, we can unpick the industrialisation of our food production, restore nutrition and seasonal diversity to our plates and the craft of growing back to our landscapes. And, above all, we can find that perfect peach every summer. "This exciting and important book now brings Natoora and all its ingredients not just to restaurants like ours but … to everyone’s home."—Ruth Rogers, chef and co-founder of The River Cafe "An incredible read for those who love food and care about its future. In Search of the Perfect Peach is both a love story and technical guide."—Kyle Connaughton, chef and owner of SingleThread Farm, Restaurant and Inn
In Search of the Zeppelin War: The Archaeology of the First Blitz
by Neil Faulkner Nadia DurraniThis is the story of the first Blitz and the first Battle of Britain, featuring a full account of the first Zeppelin crash site excavation and also covering airfields, gun sites, searchlights, and radio listening posts. The book features contemporary accounts and archive photographs alongside the reports and photographs from the excavations, including Hunstanton, Monkhams, Chingford and North Weald Basset, the Lea Valley, Potters Bar and Theberton. Written in collaboration between academic archaeologists and aviation enthusiasts/metal detectorists, this fascinating project has also been the subject of a BBC2 Timewatch documentary.
In Silico Approach for Sustainable Agriculture
by Manoj Kumar Devendra K. Choudhary Ram Prasad Vivek KumarThis book explores the role of in silico deployment in connection with modulation techniques for improving sustainability and competitiveness in the agri-food sector; pharmacokinetics and molecular docking studies of plant-derived natural compounds; and their potential anti-neurodegenerative activity. It also investigates biochemical pathways for bacterial metabolite synthesis, fungal diversity and plant-fungi interaction in plant diseases, methods for predicting disease-resistant candidate genes in plants, and genes-to-metabolites and metabolites-to-genes approaches for predicting biosynthetic pathways in microbes for natural product discovery. The respective chapters elaborate on the use of in situ methods to study biochemical pathways for bacterial metabolite synthesis; tools for plant metabolites in defence; plant secondary metabolites in defence; plant growth metabolites; characterisation of plant metabolites; and identification of plant derived metabolites in the context of plant defence. The book offers an unprecedented resource, highlighting state-of-the-art research work that will greatly benefit researchers and students alike, not only in the field of agriculture but also in many disciplines in the life sciences and plant sciences.
In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future
by Brian S. HilbushLearn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies. In this fascinating book, you'll discover: An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.
In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications
by Claudio N. CavasottoIn Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita
In Situ Bioremediation of Perchlorate in Groundwater
by C. Herb Ward Hans F. StrooThis volume presents a critical analysis and timely synthesis of the past decade of intensive research, development, and demonstrations on the in situ bioremediation of perchlorate in groundwater. The intended audiences include the decision makers, practicing engineers and hydrogeologists who will select, design, and operate these remedial systems, as well as researchers seeking to improve the current state-of-the-art. Our hope is that this volume will serve as a useful resource to assist remediation professionals in applying and developing the technology as effectively as possible. An overview of the current state-of-understanding of perchlorate remediation is followed by a discussion of basic principles of microbial and abiotic processes, and of the engineering and implementation issues underlying the technologies described. Characterization of both anthropogenic and natural sources of perchlorate, including isotopic analysis to distinguish between differing sources, precedes discussions of the advantages, performance, and relative costs of applying a range of remedial technologies. Active, semi-passive, and passive in situ bioremediation are fully described and compared with emphasis on field application. Cost information for each technology, using case studies and analyses of several template sites, covers capital costs, as well as costs for laboratory testing, pilot-scale demonstration, design, system operation, monitoring and maintenance during operations, and demolition and restoration after remediation. In addition, analogous cost data are presented for pump-and-treat systems for each template site to illustrate the potential cost savings associated with the use of alternative approaches. Emerging technologies such as monitored natural attenuation, phytoremediation, and vadose zone bioremediation are described, and field demonstrations are used to illustrate the current stage of maturity and the potential applicability of these approaches for specific situations.Each chapter in this volume has been thoroughly reviewed for technical content by one or more experts in each subject area covered.
In Situ Chemical Oxidation for Groundwater Remediation
by Robert L. Siegrist Michelle Crimi Thomas J. SimpkinThis volume provides comprehensive up-to-date descriptions of the principles and practices of in situ chemical oxidation (ISCO) for groundwater remediation based on a decade of intensive research, development, and demonstrations, and lessons learned from commercial field applications.
In Situ Monitoring of Fiber-Reinforced Composites
by Markus G. R. Sause". . . a comprehensive and well written book, which. . . will be useful reading for both researchers entering the field and experienced specialists looking for new ideas. . . . a valuable and long-lasting contribution to experimental mechanics. " - Stepan Lomov, KU Leuven This expert volume, an enhanced Habilitation thesis by the head of the Materials Testing Research Group at the University of Augsburg, provides detailed coverage of a range of inspection methods for insitu characterization of fiber-reinforced composites. The failure behavior of fiber reinforced composites is a complex evolution of microscopic damage phenomena. Beyond the use of classical testing methods, the ability to monitor the progression of damage insitu offers new ways to interpret the materials failure modes. Methods covered include digital image correlation, acoustic emission, electromagnetic emission, computed tomography, thermography, shearography, and promising method combinations. For each method, the discussion includes operational principles and practical applications for quality control as well as thoughtful assessment of the method's strengths and weakness so that the reader is equipped to decide which method or methods are most appropriate in a given situation. The book includes extensive appendices covering common experimental parameters influencing comparability of acoustic emission measurements; materials properties for modeling; and an overview of terms and abbreviations.
In Situ Remediation Engineering
by Suthan S. Suthersan Fred C. PayneIn Situ Remediation Engineering provides a comprehensive guide to the design and implementation of reactive zone methods for treatment of all major classes of groundwater contamination. It teaches the fundamentals that underlie development of cost-effective reactive zone strategies, guides the selection of cost-effective remedial strategies and provides environmental engineers and scientists with tools to achieve optimal deployment of source area, reactive barrier, and site-wide treatments. It offers extensive coverage of remedial system operation, discussing reagent injection strategies, interpretation of process monitoring results for biological and chemical reactive zone systems, and impacts of treatment processes on aquifer hydraulic characteristics.
In Situ Remediation of Chlorinated Solvent Plumes
by C. Herb Ward Hans F. StrooThis volume provides a review of the past 10 to 15 years of intensive research, development and demonstrations on the in situ remediation of dissolved chlorinated solvents. The intended audience includes the decision makers and practicing engineers and hydrogeologists who will select, design and operate these remedial systems, as well as researchers seeking to improve the current state-of-the-art. Our hope is that this volume will serve as a useful resource to assist remediation professionals in applying and developing the technology as effectively as possible.
In Situ Testing Methods in Geotechnical Engineering
by Alan J. LuteneggerIn Situ Testing Methods in Geotechnical Engineering covers the field of applied geotechnical engineering related to the use of in situ testing of soils to determine soil properties and parameters for geotechnical design. It provides an overview of the practical aspects of the most routine and common test methods, as well as test methods that engineers may wish to include on specific projects. It is suited for a graduate-level course on field testing of soils and will also aid practicing engineers. Test procedures for determining in situ lateral stress, strength, and stiffness properties of soils are examined, as is the determination of stress history and rate of consolidation. Readers will be introduced to various approaches to geotechnical design of shallow and deep foundations using in situ tests. Importantly, the text discusses the potential advantages and disadvantages of using in situ tests.
In Situ Testing in Geomechanics: The Main Tests
by Fernando SchnaidThis book outlines the practice and theory of the five key tests used in site characterisation by Geomechanical and Environmental Engineers. These tests are: Standard Penetration Tests, Cone Penetration Tests, Vane Test, Pressuremeter Tests, Dilatometer Tests. This book is aimed at practising engineers although its practical angle will also appeal to Civil Engineering students in their 3rd and 4th years.
In Situ Tests in Geotechnical Engineering
by Jacques MonnetThis book deals with in-situ tests that are performed in geotechnics to identify and characterize the soil. These measurements are then used to size the Civil Engineering works This book is intended for engineers, students and geotechnical researchers. It provides useful information for use and optimal use of in-situ tests to achieve a better book adaptation of civil engineering on the ground
In Situ Transmission Electron Microscopy Studies of Carbon Nanotube Nucleation Mechanism and Carbon Nanotube-Clamped Metal Atomic Chains
by Dai-Ming TangUsing an in situ transmission electron microscopy (TEM) approach to investigate the growth mechanism of carbon nanotubes (CNTs) as well as the fabrication and properties of CNT-clamped metal atomic chains (MACs) is the focus of the research summarized in this thesis. The application of an in situ TEM approach in the above-mentioned research provides not only real-time observation but also monitored machining and structural evolvement at the atomic level. In this thesis, the author introduces a CNT tubular nano furnace that can be operated under TEM for investigation of the CNT nucleation mechanism. By studying the nucleation process of CNTs in the presence of various catalysts, including iron-based metallic catalysts and silicon oxide-based non-metallic catalysts, the physical states of the catalysts as well as the nucleation and growth process of CNTs are revealed. Based on the understanding of the nucleation mechanism, the author proposes a hetero-epitaxial growth strategy of CNTs from boron nitride, which provides a new route for the controllable growth of CNTs. In addition, the author presents an electron beam-assisted nanomachining technique and the fabrication of a CNT-clamped MAC prototype device based on this technique. The formation process of CNT-clamped Fe atomic chains (ACs) can be monitored with atomic resolution. The demonstrated quantized conductance and uninfluenced half-metallic properties of Fe ACs indicate that CNTs can be promising nanoscale electrodes or interconnectors for the linking and assembly of nano and subnano structures.
In Situ Treatment Technology
by Evan K. Nyer Peter L. Palmer Eric P. Carman Gary Boettcher James M. Bedessem Frank Lenzo Tom L. Crossman Gregory J. Rorech Donald F. KiddCompletely revised and updated, the second edition of the bestselling In Situ Treatment Technology adds three new chapters to provide the reader with an even more comprehensive reference source on remediation. This authoritative book goes beyond discussion of individual in situ technologies by providing an understanding of the geologic foun
In Sync: The Emergence of Function in Minds, Groups and Societies (Understanding Complex Systems)
by Ryszard Praszkier Robin R. Vallacher Agnieszka Rychwalska Andrzej K. Nowak Michal ZochowskiThis book introduces the reader to the concept of functional synchronization and how it operates on very different levels in psychological and social systems – from the emergence of thought to the formation of social relations and the structure of societies. For years, psychologists have investigated phenomena such as self-concept, social judgment, social relations, group dynamics, and cooperation and conflict, but have discussed these phenomena seoarately.This book shows how synchronization provides a foundational approach to these otherwise distinct and diverse psychological processes.This work shows that there is a basic tendency with many processes to become coordinated and progressively integrated into increasingly larger units through well-defined processes. For these larger units, new and largely adaptive functions emerge. Although synchronization affords progressive integration of system elements to enable correspondingly higher-order functions, the trajectory of synchronization is often characterized by periods of assembly and disassembly of system elements. This occurs when a task is completed and synchronization is no longer essential so that the elements once again operate in an independent fashion. It is argued that the disassembly-resynchronization scenario occurs at all levels of psychological and social reality. The implications of this approach for important issues in interpersonal relations and societal processes are discussed.
In The Blink Of An Eye
by Pat MiltonOne man's battle to get his life back after locked-in stroke left him totally paralysed.Peter Coghlan is an ordinary bloke whose life is transformed, for the second time, after a knock to the head. So begins an extraordinary story of recovery. Peter takes the reader on a journey that will appeal to those who can relate to Peter's circumstances as well as those wanting to understand what it means to be 'Locked-in', what it takes to break free and how to build a new life. A story told in two parts, it is (at times) uncomfortable, drawing the reader into a reality where what happens is not in his control; but Peter's easy dialogue, honesty and irrepressible humour make that journey very well worth taking with him. Be prepared to laugh, cringe and cry. His story offers some answers, but also raises many questions about the obstacles to overcome and what 'success' can look and feel like, as well as shining a light on how society can view people with disabilities. Despite many setbacks and difficulties, at the heart of this story is an acknowledgement of the sacrifices he and others made, with a deep appreciation of the love, care and professionalism shown by those helping him along the way to becoming Peter Coghlan - reborn.
In The Blink of An Eye: Winner of the Theakstons Crime Novel of the Year and the CWA New Blood Dagger
by Jo CallaghanTHE SUNDAY TIMES bestseller, as seen on BBC 2's BETWEEN THE COVERS A WATERSTONES THRILLER BOOK OF THE MONTH *WINNER* OF THE THEAKSTON OLD PECULIER CRIME NOVEL OF THE YEAR 2024 *WINNER* OF THE CRIME WRITERS' ASSOCIATION ILP JOHN CREASEY (NEW BLOOD) DAGGER 2024 AND NOMINATED FOR TWO OTHER MAJOR AWARDS Capital Crime Book of the Year 2023 Crimefest Specsavers Best Debut Crime Novel &‘I devoured this in one sitting&’ Rob Rinder, as featured on BBC 2&’s Between the Covers&‘Terrifyingly timely and provocative' Val McDermid'The most original crime novel you'll read this year' Clare Mackintosh In the UK, someone is reported missing every 90 seconds. Just gone. Vanished. In the blink of an eye. DCS Kat Frank knows all about loss. A widowed single mother, Kat is a cop who trusts her instincts. Picked to lead a pilot programme that has her paired with AIDE (Artificially Intelligent Detective Entity) Lock, Kat's instincts come up against Lock's logic. But when the two missing person's cold cases they are reviewing suddenly become active, Lock is the only one who can help Kat when the case gets personal. AI versus human experience. Logic versus instinct. With lives on the line can the pair work together before someone else becomes another statistic? In the Blink of an Eye is a dazzling debut from an exciting new voice and asks us what we think it means to be human. 'Just brilliant!' Lisa Jewell 'Has to be a strong contender for crime debut of the year - sharp, perceptive writing and a brilliant new take on the detective duo' T. M. Logan'Everything you could hope for in a thriller: heartbreaking, intelligent, deftly plotted and so original' Fiona Cummins'Jo Callaghan makes her entry into the crowded police procedural genre with a fresh take on the buddy-buddy cop trope . . . Provocative and compelling' Vaseem Khan 'The kind of fresh and fearless debut I just adore. Wildly original, heartfelt, funny, and properly thrilling. Take a bow, Jo Callaghan' Chris Whitaker
In The Company Of Men: A Woman At The Citadel
by Mary Jane Ross Nancy Mace"Leaning forward until I could feel his breath on the back of my neck he began to rack me in an insidious, threatening manner. 'We all hate you. When are you going to leave? We hate you, do you hear me?'...On and on the voice went, and for the first time since I had come to the school, I was afraid, afraid and disgusted."<P> When Nancy Mace entered The Citadel, the United States government had just recently overturned the ruling that women were not allowed to enter the "Core of Cadets." Having grown up in a military family, Nancy was not unfamiliar with the harsh realities of military life. Her father, a brigadier general, had graduated from The Citadel and her older sister was a military graduate, but it would be Nancy's journey alone. And as many a knob has found out, life inside the dazzling white ramparts of this famous fortress is far from pleasant. Upon entering those grand gates, Nancy Mace soon found out that she wasn't just fighting the tradition of the corps, but the culture and city that surrounded it. Steeped in tradition and lore, the grand bastion known as El Cid is considered one of the South's most infamous and controversial institutions. Built in 1842, it has turned out a unique brand of Southern man -- and now woman. This is the true first-person account of a young woman's battle to be a part of the long gray line.
In Vitro Neuronal Networks: From Culturing Methods to Neuro-Technological Applications (Advances in Neurobiology #22)
by Monica Frega Michela Chiappalone Valentina PasqualeThis book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
In Vivo Optical Imaging of Brain Function
by Ron D. FrostigThese are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques a
In Vivo Self-Assembly Nanotechnology for Biomedical Applications
by Hao Wang Li-Li LiThis book reviews and discusses the development of self-assembled nanomaterials applied in biomedical fields. Based on self-assembled nanomaterial constructions, it highlights the mechanisms of the stimuli-response-induced assembly/disassembly and transformation. Moreover, it examines healthcare-related diseases, the applications of nanomaterials and therapy/detection strategies, providing readers with both a deeper understanding of the subject and inspirations for future research. The book is primarily intended for researchers and graduate students in the fields of material sciences and chemistry who wish to learn about the principles, methods, mechanisms and biomedical applications of self-assembled nanomaterials.