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Therapeutic Applications of RNAi
by Cristina M. Rondinone John F. Reidhaar-OlsonThe phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
Therapeutic Endoscopy in the Gastrointestinal Tract
by Georg Kähler Martin Götz Norbert SenningerIn the second edition of the book, the diversity of established and modern endoscopic therapeutic interventions is systematically, comprehensively, and practically presented by experts in visceral surgery and gastroenterology. Numerous endoscopic images and schematic drawings illustrate the descriptions of therapeutic procedures. For each endoscopic procedure, the following is described: Indications Personnel, instrumental, and technical requirements Implementation Results Limitations, complications, and their management All contributions have been updated; a new chapter on hygiene measures has been added. Practical tips and references to alternative approaches appeal to both the young specialist and the experienced endoscopist, as well as endoscopy professionals from other fields.
Therapeutic Farms
by Sana LoueThis book serves as a reference for social workers, psychologists, counselors, and other mental health professionals who utilize therapeutic farm therapy with their children or adult clients. The Brief is also valuable for policy makers at state mental health agencies and legislators, who must decide how to best utilize limited funding for mental health care. Chapters focus on the development of the therapeutic farm approach, various models of therapeutic farms in the U. S. and Europe, and case studies of specific therapeutic farms.
Therapeutic Landscape Design: Methods, Design Strategies And New Scientific Approaches (Springerbriefs In Applied Sciences And Technology Series)
by Stefano Capolongo Andrea Rebecchi Monica BottaThrough an approach strongly oriented to socio-health contexts and healthcare facilities, with multidisciplinary contributions on the methodological and technical aspects, or legislative issues, the book provides tools and design strategies to plan and realize therapeutic places and healing gardens for care, rehabilitation, interaction, and social inclusion. It addresses all the technical and medical professionals - like Architects, Urban Planners, Agronomist, Sociologists, Epidemiologists, Public Health experts, Policy Makers, etc. - wishing to explore the link between built environment, well-being, and health, referring in particular to the direct relationship between places and therapy.
Therapeutic Medicinal Plants in Traditional Persian Medicine (Exploring Medicinal Plants)
by Roja Rahimi Roodabeh BahramsoltaniTraditional Persian Medicine (TPM) is one of the oldest medical doctrines, globally known due to pioneering physicians and scientists. The greatest source of natural medicines in TPM originates from medicinal plants. Therapeutic Medicinal Plants in Traditional Persian Medicine provides a background on the history of TPM, as well as an introduction to 40 of the most popular medicinal plants used in TPM. It is a practical guide for readers interested in medicinal plants used in the prevention, management, and treatment of different diseases.Features: Includes both traditional therapeutic applications and modern evidence/ uses Makes a comparison between preclinical and clinical studies Provides information on major chemical constituents, therapeutic uses, adverse reactions, and safety for each plant species A volume in the “Exploring Medicinal Plants” series, this book is a valuable resource for researchers, students, academicians, and scientists dealing witth medicinal plants, as well as for those interested in the fields of pharmacognosy, naturopathy, phytotherapy, and traditional medicines.
Therapeutic Nanomaterials
by Mustafa O. Guler Ayse B. TekinayAddressing a cutting-edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology. - Addresses the increasing demand for nanomedicine in a cutting-edge, multidisciplinary field- Introduces concepts, strategies, and requirements of developing materials- Discusses hot topics in drug delivery, such as neural regeneration, cartilage regeneration, bone tissue regeneration, dental regeneration, biomedical imaging, tissue adhesives and biosensors- Includes a chapter about nanotoxicology to help readers further understand the biocompatability of nanomaterials
Therapeutic Proteins: Methods and Protocols (Methods in Molecular Biology #2720)
by Millicent O. Sullivan Bryce Chackerian Wilfred ChenThis volume covers the latest key aspects of therapeutic protein applications. Chapters in this book cover topics such as the discovery, production, and conjugation of protein-proteins with discussions on the direction of future development and advancements; ways to use these engineering proteins for therapeutic and vaccine applications; and the use of modified protein nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Therapeutic Proteins: Methods and Protocols is a valuable resource for any researcher who are interested in learning more about the field of therapeutic proteins.
Therapeutic and Diagnostic Nanomaterials
by Devasena TThis brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Ecofriendly methods which are ideal for the synthesis of medicinally valued nanoparticles are explained and the characteristic features of these particles projected. The role of these particles in the therapeutic field, and the induced biological changes in some diseases are discussed. The main focus is on inflammation, oxidative stress and cellular membrane integrity alterations. The effect of nanoparticles on these changes produced by various agents are highlighted using in vitro and in vivo models. The mechanism of nanoparticles in ameliorating the biological changes is supported by relevant images and data. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.
Therapeutic and Nutritional Uses of Algae
by Leonel PereiraAlgae have been used since ancient times as food, fodder, fertilizer and as source of medicine. Nowadays seaweeds represent an unlimited source of the raw materials used in pharmaceutical, food industries, medicine and cosmetics. They are nutritionally valuable as fresh or dried vegetables, or as ingredients in a wide variety of prepared foods. In particular, seaweeds contain significant quantities of protein, lipids, minerals and vitamins. There is limited information about the role of algae and algal metabolites in medicine. Only a few taxa have been studied for their use in medicine. Many traditional cultures report curative powers from selected alga, in particular tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. Nonetheless, at present, only a few genera and species of algae are involved in aspects of medicine and therapy. Beneficial uses of algae or algal products include those that may mimic specific manifestations of human diseases, production of antibiotic compounds, or improvement of human nutrition in obstetrics, dental research, thallassotherapy, and forensic medicine.
Therapeutische Endoskopie im Gastrointestinaltrakt
by Georg Kähler Martin Götz Norbert SenningerAuch in der 2. Auflage des Buches ist die Vielfalt der etablierten und modernen endoskopisch-therapeutischen Interventionen von Experten aus Viszeralchirurgie und Gastroenterologie systematisch, umfassend und praxisnah dargestellt. Zahlreiche endoskopische Bilder und Schemazeichnungen illustrieren die Beschreibungen der Therapieverfahren.Zu jedem endoskopischen Verfahren sind beschrieben:- Indikationen- personelle, instrumentelle und technische Voraussetzungen- Durchführung- Ergebnisse- Limitationen, Komplikationen und deren Management.Alle Beiträge wurden aktualisiert; neu hinzugekommen ist ein eigenes Kapitel über Hygienemaßnahmen. Praktische Tipps und Hinweise auf alternative Vorgehensweisen sprechen den jungen Facharzt ebenso an wie den erfahrenen Endoskopiker und Endoskopie-Fachkräfte aus anderen Berufsgruppen.
Therapy Tech: The Digital Transformation of Mental Healthcare
by Emma Bedor HilandA pointed look at the state of tech-based mental healthcare and what we must do to change it Proponents of technology trumpet it as the solution to the massive increase in the mental distress that confronts our nation. They herald the arrival of algorithms, intelligent chatbots, smartphone applications, telemental healthcare services, and more—but are these technological fixes really as good as they seem? In Therapy Tech, Emma Bedor Hiland presents the first comprehensive study of how technology has transformed mental healthcare, showing that this revolution can&’t deliver what it promises.Far from providing a solution, technological mental healthcare perpetuates preexisting disparities while relying on the same failed focus on personal responsibility that has let us down before. Through vivid, in-depth case studies, Therapy Tech reveals these problems, covering issues including psychosurveillance on websites like Facebook and 7 Cups of Tea, shortcomings of popular AI &“doctors on demand&” like Woebot, Wysa, and Joy, and even how therapists are being conscripted into the gig economy.Featuring a vital coda that brings Therapy Tech up to date for the COVID era, this book is the first to give readers a large-scale analysis of mental health technologies and the cultural changes they have enabled. Both a sobering dissection of the current state of mental health and a necessary warning of where things are headed, Therapy Tech makes an important assertion about how to help those in need of mental health services today.
There Is Life After the Nobel Prize
by Eric KandelOne day in 1996, the neuroscientist Eric R. Kandel took a call from his program officer at the National Institute of Mental Health, who informed him that he had been awarded a key grant. Also, the officer said, he and his colleagues thought Kandel would win the Nobel Prize. “I hope not soon,” Kandel’s wife, Denise, said when she heard this. Sociologists had found that Nobel Prize winners often did not contribute much more to science, she explained.In this book, Kandel recounts his remarkable career since receiving the Nobel in 2000—or his experience of proving to his wife that he was not yet “completely dead intellectually.” He takes readers through his lab’s scientific advances, including research into how long-term memory is stored in the brain, the nature of age-related memory loss, and the neuroscience of drug addiction and schizophrenia. Kandel relates how the Nobel Prize gave him the opportunity to reach a far larger audience, which in turn allowed him to discover and pursue new directions. He describes his efforts to promote public understanding of science and to put brain science and art into conversation with each other. Kandel also discusses his return to Austria, which he had fled as a child, and observes Austria’s coming to terms with the Nazi period. Showcasing Kandel’s accomplishments, erudition, and wit, There Is Life After the Nobel Prize is a candid account of the working life of an acclaimed scientist.
There Was An Old Astronaut Who Swallowed the Moon! (There Was an Old Lady)
by Lucille ColandroScholastic's bestselling OLD LADY becomes an astronaut in this adventure full of hilarious laughs and fun facts about space -- perfect for the 50th anniversary of the moon landing!There was an old astronaut who swallowed the moon. I don't know why she swallowed the moon. It happened at noon.Scholastic's bestselling OLD LADY returns in this adventure series with a nonfiction twist that will make you laugh AND learn! In this spin-off, the OLD LADY turns into an OLD ASTRONAUT who travels through space, swallowing a moon... along with a star, a planet, a comet, a meteor, a rocket, and a satellite... Why? Well, it went down just right, that bright satellite! Two new characters lead the reader through this hilarious adventure while exchanging some awesome facts about outer space for a light take on nonfiction that's perfect for this age. With expanded back matter about the solar system and a search-and-find game at the end, this OLD ASTRONAUT definitely shoots for the stars!
There's No Such Thing as an IT Project: A Handbook for Intentional Business Change
by Bob Lewis Dave KaiserLearn how to stop pouring vast sums of money into technology projects that don't have a lasting impact by closing the communication gap between IT and leadership.Too many businesses miss opportunity after opportunity to design, plan, and achieve intentional business change. Why? Because they charter projects focused on delivering software products: IT projects. But as this groundbreaking book points out, there's no such thing as an IT project—or at least there shouldn't be. It's always about intentional business change, or what's the point?It's time to stop providing simplistic, one-dimensional, all-you-gotta-do panaceas. When the only constant in business is change, truly useful IT has to help you change instead of build solutions that are obsolete even before they are completed. IT consultant Bob Lewis, author of the bestselling Bare Bones Project Management, has joined forces with seasoned CIO Dave Kaiser to give you the tools you need. It's a multidimensional, relentlessly practical guide. Condensed to handbook length and seasoned with Lewis's trademark sardonic humor, it's an enjoyable and digestible read as well.Lewis and Kaiser take you step by step through the process of building a collaboration between IT and the rest of the business that really works. Insisting on intentional business change takes patience, communication, and courage, but it has a huge payoff. More to the point, insist on anything else and every penny you spend will be a wasted dime and a waste of time.
Thermal Analysis of Materials (Materials Engineering)
by Robert SpeyerDiscussing the design and optimum use of thermal analysis instrumentation for materials' property measurement, this work details how the instruments work, what they measure, potential pitfalls and the fitting of experimental results to theoretical models. It presents a tutorial on writing computer programs for data manipulation, advanced thermoanal
Thermal Analysis of Pharmaceuticals
by Duncan Q. M. CraigAs a result of the Process Analytical Technologies (PAT) initiative launched by the U.S. Food and Drug Administration (FDA), analytical development is receiving more attention within the pharmaceutical industry. Illustrating the importance of analytical methodologies, Thermal Analysis of Pharmaceuticals presents reliable and versatile charac
Thermal Analysis of Polymeric Materials: Methods and Developments
by Krzysztof Pielichowski Kinga PielichowskaAn all-in-one reference work covering the essential principles and techniques on thermal behavior and response of polymeric materials This book delivers a detailed understanding of the thermal behavior of polymeric materials evaluated by thermal analysis methods. It covers the most widely applied principles which are used in method development to substantiate what happens upon heating of polymers. It also reviews the key application areas of polymers in materials science. Edited by two experts in the field, the book covers a wide range of specific topics within the aforementioned categories of discussion, such as: Crucial thermal phenomena - glass transition, crystallization behavior and curing kinetics Polymeric materials that have gained considerable interest over the last decade The latest advancements in techniques related to the field, such as modulated temperature DSC and fast scanning calorimetry The recent advances in hyphenated techniques and their applications Polymer chemists, chemical engineers, materials scientists, and process engineers can use this comprehensive reference work to gain clarity on the topics discussed within and learn how to harness them in practical applications across a wide range of disciplines.
Thermal Analysis of Power Electronic Devices Used in Renewable Energy Systems
by Alhussein Albarbar Canras BatunluThis book analyzes the thermal characteristics of power electronic devices (PEDs) with a focus on those used in wind and solar energy systems. The authors focus on the devices used in such applications, for example boost converters and inverters under different operating conditions. The book explains in detail finite element modeling techniques, setting up measuring systems, data analysis, and PEDs' lifetime calculations. It is appropriate reading for graduate students and researchers who focus on the design and reliability of power electronic devices.
Thermal Barrier Coatings: Failure Theory and Evaluation Technology
by Li Yang Yichun Zhou Wang ZhuThis book highlights the failure theories and evaluation techniques of thermal barrier coatings, covering the thermal-mechanical–chemical coupling theories, performance and damage characterization techniques, and related evaluations. Thermal barrier coatings are the key thermal protection materials for high-temperature components in advanced aeroengines. Coating spallation is a major technical bottleneck faced by researchers. The extremely complex microstructure, diverse service environments, and failure behaviors bring challenges to the spallation analysis in terms of the selective use of mechanical theories, experimental methods, and testing platforms. In the book, the authors provide a systematic summary of the latest research and technological advances and present their insights and findings in the past couple of decades. This book is not only suitable for researchers and engineers in thermal barrier coatings and related fields but also a good reference for upper-undergraduate and postgraduate students of materials science and mechanics majors.
Thermal Behavior of Photovoltaic Devices
by Olivier Dupré Rodolphe Vaillon Martin A. GreenThis book provides a comprehensive introduction to the thermal issues in photovoltaics. It also offers an extensive overview of the physics involved and insights into possible thermal optimizations of the different photovoltaic device technologies. In general, temperature negatively affects the efficiency of photovoltaic devices. The first chapter describes the temperature-induced losses in photovoltaic devices and reviews the strategies to overcome them. The second chapter introduces the concept of temperature coefficient, the underlying physics and some guidelines for reducing their negative impacts. Subsequent chapters offer a comprehensive and general thermal model of photovoltaic devices, and review how current and emerging technologies, mainly solar cells but also thermophotovoltaic devices, can benefit from thermal optimizations. Throughout the book, the authors argue that the energy yield of photovoltaic devices can be optimized by taking their thermal behavior and operating conditions into consideration in their design.
Thermal Cameras in Science Education (Innovations in Science Education and Technology #26)
by Jesper Haglund Fredrik Jeppsson Konrad J. SchönbornThis book presents a collection of educational research and developmental efforts on the rapidly emerging use of infrared cameras and thermal imaging in science education. It provides an overview of infrared cameras in science education to date, and of the physics and technology of infrared imaging and thermography. It discusses different areas of application of infrared cameras in physics, chemistry and biology education, as well as empirical research on students’ interaction with the technology. It ends with conclusions drawn from the contributions as a whole and a formulation of forward-looking comments.
Thermal Characteristics and Convection in Nanofluids (Lecture Notes in Mechanical Engineering)
by Aditya Kumar Sudhakar SubudhiThis book covers synthesis, characterization, stability, heat transfer and applications of nanofluids. It includes different types of nanofluids, their preparation methods as well as its effects on the stability and thermophysical properties of nanofluids. It provides a discussion on the mechanism behind the change in the thermal properties of nanofluids and heat transfer behaviour. It presents the latest information and discussion on the preparation and advanced characterization of nanofluids. It also consists of stability analysis of nanofluids and discussion on why it is essential for the industrial application. The book provides a discussion on thermal boundary layer properties in convection. Future directions for heat transfer applications to make the production and application of nanofluids at industrial level are also discussed.
Thermal Claddings for Engineering Applications
by Jasbir Singh Lalit Thakur Hitesh VasudevThe text presents advances in the field of thermal claddings for protection against erosion, corrosion, and wear in hydraulic turbines, automobiles, agricultural equipment, power plant, chemical industries, and jet engines. It further discusses different cladding techniques such as electron beam, oxyfuel, arc welding processes, and microwave hybrid heating. It explains the mechanism for failure of materials and cladding and emphasizes the protection mechanism.This book: Discusses the design and simulation of thermal claddings and the use of algorithms to predict the process parameters and performance of developed clads using artificial intelligence and machine learning Presents the tribological behaviour of novel wear-resistant thermal claddings for the components used in construction, mining, drilling, and hydropower plant Showcases high-temperature oxidation, corrosion, and erosion-resistant thermal claddings for power plants, the automotive sector, and jet engines Highlights the application of the thermal cladding process in remelting the existing surface to enhance the surface properties Examines post-heat treatment procedures on thermal claddings for improving the microstructure and tribological properties The text is primarily written for senior undergraduate, graduate students, and academic researchers in the fields of mechanical engineering, manufacturing engineering, industrial engineering, and production engineering.
Thermal Comfort Assessment of Buildings
by Salvatore CarlucciA number of metrics for assessing human thermal response to climatic conditions have been proposed in scientific literature over the last decades. They aim at describing human thermal perception of the thermal environment to which an individual or a group of people is exposed. More recently, a new type of "discomfort index" has been proposed for describing, in a synthetic way, long-term phenomena. Starting from a systematic review of a number of long-term global discomfort indices, they are then contrasted and compared on a reference case study in order to identify their similarities and differences and strengths and weaknesses. Based on this analysis, a new short-term local discomfort index is proposed for the American Adaptive comfort model. Finally, a new and reliable long-term general discomfort index is presented. It is delivered in three versions and each of them is suitable to be respectively coupled with the Fanger, the European Adaptive and the American Adaptive comfort models.
Thermal Comfort Perception: A Questionnaire Approach Focusing on Children (Springerbriefs In Applied Sciences And Technology Ser.)
by Kristian FabbriThis book offers a comprehensive exploration of children's understanding and experiences of thermal comfort. The book provides a methodology for evaluating comfort that takes into account the unique perspectives of children. The first part of the book provides an overview of the history of thermal comfort, the human body and environmental parameters, and common thermal comfort indexes. It also offers guidelines for creating questionnaires that accurately assess children's perceptions of indoor thermal comfort. The book then delves into children's understanding of the concepts of comfort and energy, as well as the factors that influence their perception of these concepts. It addresses the psychological and pedagogical aspects of thermal comfort judgment, as well as the architectural and environmental characteristics that contribute to children's perceptions of comfort. First published as Indoor Thermal Comfort Perception, this updated edition also includes new sections on architecture and sensitivity, exploring the impact of classroom spaces on learning, and outdoor education and thermal comfort outdoors, based on qualitative research. These additions provide valuable insights for future studies on these topics. While physical parameter measurements and comfort indexes are useful in thermal comfort, the book emphasizes the importance of ergonomic assessments in the form of questionnaires, which offer unique insights into children's experiences. The book fills a critical gap in understanding children's perceptions of thermal comfort and is essential reading for HVAC engineers, architects, environmental psychologists, and researchers in the medical and cognitive fields.