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Toxicological Risk Assessment for Beginners
by José A. Torres Sol BobstThis book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.
Toxicological Risk Assessment of Chemicals: A Practical Guide
by Elsa Nielsen Grete Ostergaard John Christian LarsenUnlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Toxicological Risks of Selected Flame-Retardant Chemicals
by National Research CouncilIn its fiscal 1999 appropriations report, Congress directed the US Consumer Product Safety Commission to arrange for an independent study by the National Research Council to conduct toxicological assessments for flame-retardant (FR) chemicals that are likely to be used on furniture upholstery. This report evaluates the toxicological, epidemiological, and exposure data on 16 specified FR chemicals and characterizes risks to human health from exposure to furniture upholstery treated with such chemicals. Introductory chapters discuss the study purposes, assessment process, and methodology. An appendix presents information on the durability and permanence of flame-retardancy in fabrics. The volume is not indexed. Annotation c. Book News, Inc. , Portland, OR (booknews. com)
Toxicology Biological Monitoring of Metals in Humans
by Bonnie L. CarsonAs one of many tasks of an analytical chemistry program sponsored by the office of Pesticides and Toxic Substances, Field Studies Branch, U.S. Environmental Protection Agency (EPA) (EPA Prime Contract No. 68-02-3938), Midwest Research Institute (MRI) prepared these summaries of the mammalian toxicology of 52 individual elements (metals and metalloids) and the lanthanides (rare earth elements). MRI is assisting the EPA in developing protocols for the monitoring of selected metals and organic compounds in the blood of the general U.S. population. The monitoring will enable evaluation of changes in the blood levels over time and any trends associated with instituted control measures. This review will help EPA select the metals to be included in the monitoring effort based on toxicity, relative exposure, and the ability of blood measurements to reflect exposure.
Toxicology of Amphibian Tadpoles
by Juliane Silberschmidt Freitas Eduardo Alves de AlmeidaAnuran amphibians are among the animal groups with the highest rate of population decline on the planet. Among the factors driving this decline are environmental pollutants, whose negative effects on larvae and tadpoles are still relatively little studied. This is the first book devoted entirely to studying the effects of environmental pollutants on amphibian tadpoles. Throughout its 14 chapters, various aspects of the toxic effects of different classes of environmental contaminants are explored, such as the toxicokinetics of toxic compounds in tadpoles and their health effects, which may result in negative consequences at populations level.
Toxicology of Essential and Xenobiotic Metals
by Michael Aschner João Batista Teixeira da Rocha Pablo Andrei NogaraThis book explores how metals like cadmium, mercury, lead, aluminium, manganese, and chromium can harm our health, whether through short-term or long-term exposure. It covers symptoms ranging from immediate nausea to long-term issues like Parkinson's and Alzheimer's diseases. Understanding how these metals interact with our bodies is crucial for identifying their harmful effects. The book, divided into 11 chapters, provides straightforward explanations about how these metals affect our health, making it useful for anyone interested in understanding how metals can impact the environment as well as human and animal health.
Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems
by Marc A. WilliamsToxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems An indispensable compendium detailing the toxicology of nanoparticles with a focus on mechanisms, emerging issues, and new approaches Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems provides authoritative information on the toxicology of ultrafine and nanoparticulate matter that contaminate terrestrial or aquatic environments and present unique challenges in applied public health and toxicological research. Detailed chapters by a panel of world-renowned experts examine the complementary and dynamic interdependence of aquatic, terrestrial, and human systems and the toxicological impacts on exposure to engineered and manufactured nanoparticles and nanomaterials. Organized into four sections, the book opens with a thorough overview of the field, including known challenges and the necessity for current research activity. The second section describes terrestrial and aquatic systems and the ecotoxicological impact of nanomaterials, followed by critical analysis of the many human health effects of nanomaterials. The book concludes with an in-depth discussion of current gaps in knowledge, future directions, new approach methodologies, alternatives to animal models, and the emerging environmental threat from nanoplastics. Presenting case exemplars of the ecotoxicological impact of nanoparticles in aquatic and terrestrial systems, this important resource: Presents in-depth coverage of ecosafety, environmental behavior, fate and transport, interactive effects with other contaminants, and current challenges in soil nano-ecotoxicology Addresses rising concerns regarding air pollution and neurological disorders, and the roles played by the gastrointestinal system, the mucosal microbiome, and the immunotoxicology and vasculotoxicity of metal-based nanoparticles Provides detailed coverage of nanomaterial health effects from both animal and in vitro models, including the gut microbiome, innate immunity, neurological and cardiovascular impacts, mechanisms of action, and hazard characterization Analyzes key topics in ecological nanotoxicology such as environmental micro- and nano-plastic pollution and applied risk assessment Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems is essential reading for toxicologists, applied biologists, ecotoxicologists, research scientists, medical professionals, regulators, and advanced students in fields such as public health, environmental ecotoxicology and medicine, immunotoxicology, neurotoxicology, cardiovascular and systems biology, hazard identification, and risk assessment.
Toxicology of Nanoparticles: Insights from Drosophila
by Namita Agrawal Prasanna ShahThis book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications.Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
Toxikologie für Einsteiger
by Holger Barth Katharina Ernst Panagiotis PapatheodorouIn diesem kurzen Lehrbuch werden grundlegende wissenschaftliche und klinische Aspekte der Toxikologie dargestellt und ihre wichtigsten Inhalte, Ziele und Aufgaben beschrieben. Das Buch richtet sich an Studierende biowissenschaftlicher und chemischer Bachelor- und Masterstudiengänge, die Toxikologie als medizinisches Wahlfach belegen. Zu Beginn werden wichtige toxikologische Fachbegriffe definiert, um den Einstieg zu erleichtern. Es wird beschrieben was ein „Gift“ ausmacht und wie Giftstoffe in den menschlichen Körper gelangen können. Akute Vergiftungen, ihre Ursachen und die wichtigsten Maßnahmen für ihre Therapie werden im Einzelnen vorgestellt. Der Großteil des Lehrbuches beschreibt die Wirkung ausgewählter, medizinisch relevanter Giftstoffe aus Natur und Umwelt, häuslicher Umgebung und dem Arbeitsplatz wie Toxine aus Tieren, Pflanzen, Pilzen und Bakterien, Giftgase, Stäube, Metalle, Pestizide, Lösungsmittel und Alkohol. Am Ende werden die grundlegenden Prinzipien der chemischen Kanzerogenese zusammengefasst und die krebsauslösende Wirkung einiger toxikologisch wichtiger Substanzen exemplarisch vorgestellt sowie rechtliche Grundlagen im Umgang mit Giftstoffen zusammengefasst.
Toxikologie für alle: Wann ist ein Stoff gefährlich?
by Helmut Greim Heidrun GreimWas man über Giftstoffe, deren Wirkung und Bewertung wissen muss: Zwei erfahrene Toxikologen erklären allgemeinverständlich, wann ein Stoff zum Schadstoff wird. Der Schwerpunkt liegt dabei auf den allgemeinen Grundlagen einer toxikologischen Untersuchung und Bewertung von Schadstoffen, sowie den daraus abgleiteten Handlungsempfehlungen. Anhand bekannter Beispiele aus den letzten Jahren, u. a. des Unkrautvernichters Glyphosat oder des Insektizids Fipronil, die beide in Nahrungsmitteln nachgewiesen wurden, wird erläutert, wie konkrete Gesundheitsgefährdungen anhand toxikologischer Daten und Verfahren ermittelt und welche Maßnahmen zum Schutz der Gesundheit daraus abgeleitet werden. Die Anwendung der toxikologischen Verfahren für die Bewertung von Gesundheitsrisiken wird anhand von Beispielen aus dem Alltag anschaulich dargestellt, von Lebensmitteln über Kosmetika bis hin zu Arzneimitteln und Alltagsprodukten. Ein kompakter, aber fundierter Einstieg in ein wichtiges und oft kontrovers diskutiertes Thema - für alle, die Toxine und deren Wirkungen auf Mensch und Umwelt verstehen wollen.
Toxins and Contaminants in Indian Food Products
by Salvatore Parisi Ramesh Kumar SharmaThis book discusses the complex of problems of contaminants in foods with the example of Indian food products. The presence and analytical detection of detrimental substances such as pesticides, mycotoxins and other biologically-produced toxins, food chemicals and additives with natural or industrial origin are treated. Furthermore, the book addresses the production and the commercial exploitation of native botanical ingredients, and the question if such ingredients should be regarded as foods or drugs. In the modern highly industrialized world, the interest in organic food production raises. The book sheds light on chemical aspects of organic farming practices in India. Readers will also find information on pesticides and other detrimental chemicals detection in Indian farming. In an outlook, the author reviews the resulting problems, such as how and why this can lead to border rejections during export, in particular to the European Union.
Toxins and Other Harmful Compounds in Foods (Chemical & Functional Properties of Food Components)
by A. Witczak Zdzislaw SikorskiToxins and Other Harmful Compounds in Foods provides information on the contents, distribution, chemical properties, and biological activity of toxins and other harmful compounds in foods that are natural components of the raw materials, accumulated due to microbial actions and environmental pollution, or are generated due to processing. This book shows how different factors related to the production of raw materials, as well as to storage and processing conditions, affect the presence and concentration of toxins and other harmful compounds in foods. It shows how various regulations, as well as unit operations and processes used in food production, may eliminate different toxins or generate new ones. The real health hazards for the consumers resulting from the presence of toxic/harmful compounds in aliments are discussed, and various national and international regulations obligatory in agriculture and industry aimed at increasing food safety are presented. Methods of analysis used for detection and determination of undesirable compounds are also discussed, making it possible to understand the effect of storage and processing parameters, as well as systems of quality assurance, on food safety and to select optimum procedures for analytical control.
Toxins in Food
by Waldemar M. Dąbrowski Zdzisław E. SikorskiWhile systems such as GMP and HACCP assure a high standard of food quality, foodborne poisonings still pose a serious hazard to the consumer's health. The lack of knowledge among some producers and consumers regarding the risks and benefits related to food makes it imperative to provide updated information in order to improve food safety.To
Toyota Kaizen Methods: Six Steps to Improvement
by Art Smalley Isao KatoToyota Kaizen Methods: Six Steps to Improvement focuses on the skills and techniques practiced inside Toyota Motor Corporation during the past decades. This workbook focuses on the actual training course concepts and methods used by Toyota to develop employee skill level, a core element of Toyota‘s success. It is not a book about holding Western-st
Toyota Methods and Operating Models: Achieve Business Success with the Toyota Way
by Stefano Cortiglioni Leonardo Salcerini Danilo VergaToyota Methods and Operating Models presents a case study of a small, traditional Italian manufacturer in the Toyota Industries Corporation Group, which began an important process of transformation until it became a successful, modern and advanced international business: Toyota Material Handling. Toyota management made internal changes and developed the commercial networks, successfully applying the Toyota Production System (TPS, or Lean Production) as well as the values of the Toyota Way. Author Stefano Cortiglioni led the transformation project, which took four years. Toyota Methods and Operating Models presents the continuing success story. The authors analyze the Toyota methods and operating models that can be directly applied to your business in order to reach excellence in operations and industry 4.0. It provides tangible advice on how to grow a business and achieve commercial success, with superior processes and logistics networks, as well as the development of an advanced and highly successful supply chain.
Toyota Production System: An Integrated Approach to Just-In-Time, 4th Edition
by Yasuhiro MondenA bestseller for almost three decades, Toyota Production System: An Integrated Approach to Just-In-Time supplies in-depth coverage of Toyota's production practices, including theoretical underpinnings and methods for implementation. Exploring the latest developments in the Toyota Production System (TPS) framework at Toyota, this new edition updates
Toys and Sustainability (Environmental Footprints and Eco-design of Products and Processes)
by Subramanian Senthilkannan MuthuThis book presents five interesting chapters dealing with the sustainability of toys. The concept of sustainability has reached all industrial sectors these days and being practiced in almost all the sectors. One of the main sectors where sustainability has to be embedded to the core is the toy sector. Needless to enumerate the importance of sustainability in this sector especially when it comes to usage of chemicals and so on. There are various elements associated with the sustainability of toys and there is a dearth of published literature on this subject.
Toys!: Amazing Stories Behind Some Great Inventions
by Don WulffsonDescribes the creation of a variety of toys and games, from seesaws to Silly Putty and toy soldiers to Trivial Pursuit. <P><P>[This text is listed as an example that meets Common Core Standards in English language arts in grades 4-5 at http://www.corestandards.org.]
Trace Elemental Analysis of Metals: Methods and Techniques
by Thomas R. DulskiThis work details minor, trace and ultratrace methods; addresses the essential stages that precede measurement; and highlights the measurement systems most likey to be used by the pragmatic analyst. It features key material on inclusion and phase isolation. The book is designed to provide useful maps and signposts for metals analysts who must verify that stringent trace level compositional specifications have been met.
Trace Elements in Abiotic and Biotic Environments
by Alina Kabata-Pendias Barbara SztekeThis book helps readers understand the fundamental principles and phenomena that control the transfer of trace elements. It describes the occurrence and behavior of trace elements in rocks, soil, water, air, and plants, and also discusses the anthropogenic impact to the environment. In addition, the book covers the presence of trace elements in feeds, as either contaminants or as nutritional or zootechnical additives, and their transfer across the food chain to humans. All trace elements are covered-from aluminum to zirconium-as well as rare-earth elements (actinides and lanthanides).
Trace Elements in Coal and Coal Combustion Residues (Advances In Trace Substances Research Ser. #5)
by Robert F. Keefer Kenneth S. SajwanTrace Elements in Coal and Coal Combustion Residues focuses on trace metal chemistry of coal and coal combustion residues. Special emphasis is placed on management of coal combustion residues in electric power plants and the influence of coal and associated residues on soils, plants, water, and animals. Topics covered include a brief summary of research sponsored by Electric Power Research Institute, environmental pollution from coal combustion plants in low-rainfall regions, accumulation of trace elements in freshwater mussels near a power plant, testing to evaluate fossil fuel wastes by chemicals and isotopes, transport of metals from coal piles and ash impoundments, leachability and toxicity of metals in fly ash, and plant absorption of chemicals from ash. The book will be a useful reference for environmental and reclamation consultants, environmental engineers, toxicologists, environmental regulatory personnel, officials with electric power utilities and water treatment plants, and soil scientists.
Trace Elements in Soil: Bioavailability, Flux, and Transfer
by M. B. Kirkham I. K. IskandarHistorically, research on the methods and amounts of trace element application to agriculture soils for correcting plant deficiencies has received major attention. More recently, due to industrial development and past disposal activities, trace elements are considered to be important environmental contaminants that affect all components in the atmo
Trace Elements in Soils and Plants
by Alina Kabata-PendiasStill the Gold Standard Resource on Trace Elements and Metals in SoilsThis highly anticipated fourth edition of the bestselling Trace Elements in Soils and Plants reflects the explosion of research during the past decade regarding the presence and actions of trace elements in the soil-plant environment. The book provides information on the biogeoch
Trace Elements in Waterlogged Soils and Sediments (Advances in Trace Elements in the Environment #3)
by Michael Paller Anna Sophia KnoxMany wetlands around the world act as sinks for pollutants, in particular for trace elements. In comparison to terrestrial environments, wetlands are still far less studied. A collaborative effort among world experts, this book brings the current knowledge concerning trace elements in temporary waterlogged soils and sediments together. It discusses factors controlling the dynamics and release kinetics of trace elements and their underlying biogeochemical processes. It also discusses current technologies for remediating sites contaminated with trace metals, and the role of bioavailability in risk assessment and regulatory decision making. This book is intended for professionals around the world in disciplines related to contaminant bioavailability in aquatic organisms, contaminant fate and transport, remediation technologies, and risk assessment of aquatic and wetland ecosystems.
Trace Elements in the Environment: Biogeochemistry, Biotechnology, and Bioremediation
by M.N.V. Prasad Ravi Naidu Kenneth S. SajwanNew analytical techniques have enhanced current understanding of the behavior of trace and ultratrace elements in the biogeochemical cycling, chemical speciation, bioavailability, bioaccumulation, and as applied to the phytoremediation of contaminated soils. Addressing worldwide regulatory, scientific, and environmental issues, Trace Elements in th