- Table View
- List View
Neurotoxicity of Aluminum
by Qiao NiuThis book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid beta—the pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment.The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.
Neurotrophic Factors
by Stephen D SkaperNervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. Among these environmental cues, neurotrophic factors are secreted proteins that promote neurite outgrowth, neuronal cell differentiation and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides. Neurotrophic Factors: Methods and Protocols presents a selection of protocols and procedures which make use of cellular, tissue, and whole animal models which can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. Chapters cover a wide-range of topics such as dealing with the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia co-culture models, and cell-based assays for the evaluation of neuroprotective molecules, as well as assays which can be applied to the study of agents with neuroregenerative potential. Protocols describing viral- and nanoparticle-based delivery methods to neural cells are also presented, following by chapters dealing with organotypic slice culture protocols. Lastly, several chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurotrophic Factors: Methods and Protocols seeks to serve both professionals and novices alike with its well-honed methodologies in an effort to further our knowledge of what has been described as the last frontier of science.
Neurowissenschaften: Ein Grundlegendes Lehrbuch Für Biologie, Medizin Und Psychologie
by Monika Niehaus-Osterloh Andreas Held Andreas K. Engel Michael A. Paradiso Barry W. Connors Mark F. BearDer perfekte Einstieg in die Neurowissenschaften – ideal zum Verstehen und LernenSeit vielen Jahren zählt diese didaktisch durchdachte, verständlich geschriebene und hervorragend illustrierte Einführung international zu den führenden Lehrbüchern im Bereich der Neurowissenschaften. Das moderne Grundlagenwerk richtet sich an Studierende der Biologie, der Medizin und der Psychologie gleichermaßen. Die wieder von Andreas Engel herausgegebene deutsche Ausgabe ist an die hiesige Studiensituation angepasst und stellenweise erweitert. Der Bogen spannt sich von der Anatomie des Gehirns bis zur Sinnesphysiologie, von der Entwicklungsbiologie bis zum Verhalten, von den Störungen des Nervensystems bis zur Kognitionswissenschaft, von den molekularen Mechanismen bis zu den neuen bildgebenden Verfahren. Ein eigenständiger „Bildatlas der menschlichen Neuroanatomie“ erlaubt dem Lernenden, seine Kenntnisse der Hirnstrukturen zu überprüfen und zu erweitern. Jedes Kapitel endet mit Verständnisfragen und Übungsaufgaben sowie einer Zusammenstellung wichtiger weiterführender Literatur. In spannenden Exkursen berichten renommierte Wissenschaftler, wie sie zu ihren entscheidenden Entdeckungen kamen. So führt das Buch den Leser von den Grundlagen zu den aktuellen Forschungsthemen des Faches.In der durchgehend aktualisierten 4. Auflage sind unter anderem neue Forschungsergebnisse zu Optogenetik, Konnektomik, tiefer Hirnstimulation, molekularer Medizin und Neuroökonomie eingearbeitet worden. Zahlreiche neue oder aktualisierte Abbildungen veranschaulichen in bewährter Manier die im Text beschriebenen Prozesse, Strukturen und Methoden. Wer Neurowissenschaften in ihrer ganzen Bandbreite verstehen will, ist mit "dem Bear" bestens bedient. Den drei Verfassern des Buches gelingt, womit Lehrbuchautoren im deutschsprachigen Raum sich nach wie vor schwer tun: anschaulich und spannend den Leser vom Einstieg in die Grundlagen bis an die vorderste Front der Forschung mitzunehmen und ohne überflüssigen Ballast wissenschaftliche Erkenntnis mehr erzählend als erklärend zu vermitteln … Ein didaktisches Meisterwerk ist nun topaktuell auch in deutscher Sprache neu aufgelegt verfügbar. Aus dem Vorwort von Prof. Andreas K. Engel, Universitätsklinikum Hamburg-Eppendorf
Never Box with a Kangaroo #11
by Nancy Krulik Sebastien BraunSparky goes down under!When Sparky chomps on his magic bone, this time it kabooms him to Kangaroo Island, Australia! There he discovers a fox terrier puppy named Mick who's lost his family. But Sparky has a plan--he'll help Mick find a new family! They ask everyone they come across: bats, penguins, kangaroos, even bees! But will anyone give Mick a home?
Never Cry Wolf: Penguin Modern Classics Edition (Hrw Library)
by Farley MowatThe bestselling nature classic that stands as a hallmark of conservation writing and forever changed the way we look at wolves In 1948, Farley Mowat landed in the far north of Manitoba, Canada, a young biologist sent to investigate the region's dwindling population of caribou. Many people thought that the caribous' conspicuous decline had been caused by the tundra's most notorious predator: the wolf. Alone among the howling canine packs, Mowat expected to find the bloodthirsty beasts of popular conception. Instead, over the course of a summer spent observing the powerful animals, Mowat discovered an animal species with a remarkable capacity for loyalty, virtue, and playfulness. Praised for its humor and engrossing narrative, Never Cry Wolf describes a group of wolves whose interactions and behaviors seem strikingly similar to our own. Mowat humanizes these animals that have long been demonized, turning the widespread narrative of the "savage wolf" on its head and inspiring many governments to enact protective legislation for the North's most mysterious creature.
Never Enough Cowboy (Creedence Horse Rescue #4)
by Jennie Marts"A swoon-worthy, must-read romance."?SARA RICHARDSON, National bestselling authorFans of Carolyn Brown, Maisey Yates, and Jennifer Ryan will fall head over cowboy boots for this second-chance romance from USA Today bestseller Jennie Marts.Single mom Jillian Bennett barely has a moment to herself between raising her ten-year old son, volunteering at the horse rescue ranch, and working her new job as head librarian of Creedence, Colorado. She doesn't have time for romance either, even though she and the cute deputy, Ethan Rayburn, have been doing a lot of flirting the last few weeks. But when he also forms a bond with her son, Milo, Jillian falls hard, and Ethan soon realizes he would do anything for the feisty librarian who's won his heart."Full of hope, humor, and undeniable swoon."?A.J. PINE, USA Today bestselling author, for How to Cowboy"Funny, complicated, and irresistible."?JODI THOMAS, New York Times bestselling author, for Caught Up in a Cowboy"Deliciously steamy but still sweet."?JOANNE KENNEDY for Wish Upon a Cowboy
Never Forget Eleanor
by Jason JuneThis poignant story from New York Times bestselling author Jason June and #1 New York Times bestselling illustrator Loren Long reminds us of the life-changing power of words and the ways we remember the ones we love who've been affected by Alzheimer's or dementia. Perfect for fans of Drawn Together and The Rough Patch. Elijah loves spending time with his grandma Eleanor. She knows all the best words to answer tricky crossword puzzles and to tell the most beautiful stories to her family and friends.Everyone calls her “Never Forget Eleanor” because she remembers every word she reads and person she meets. Lately though, Elijah has started to notice Grandma Eleanor forgetting little things.So when Grandma Eleanor doesn’t show up for her Saturday story session, Elijah will need to find a way to use her favorite words and become the storyteller himself to bring her home.
Never Home Alone: From Microbes to Millipedes, Camel Crickets, and Honeybees, the Natural History of Where We Live
by Rob DunnA natural history of the wilderness in our homes, from the microbes in our showers to the crickets in our basements <P><P>Even when the floors are sparkling clean and the house seems silent, our domestic domain is wild beyond imagination. In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone. <P><P>Yet, as we obsess over sterilizing our homes and separating our spaces from nature, we are unwittingly cultivating an entirely new playground for evolution. These changes are reshaping the organisms that live with us--prompting some to become more dangerous, while undermining those species that benefit our bodies or help us keep more threatening organisms at bay. <P><P>No one who reads this engrossing, revelatory book will look at their homes in the same way again.
Never Look a Polar Bear in the Eye: A Family Field Trip to the Arctic's Edge in Search of Adventure, Truth, and Mini-Marshmallows
by Zac Unger"I like to go out for walks, but it's a little awkward to push the baby stroller and carry a shotgun at the same time."--housewife from Churchill, Manitoba Yes, welcome to Churchill, Manitoba. Year-round human population: 943. Yet despite the isolation and the searing cold here at the arctic's edge, visitors from around the globe flock to the town every fall, driven by a single purpose: to see polar bears in the wild.Churchill is "The Polar Bear Capital of the World," and for one unforgettable "bear season," Zac Unger, his wife, and his three children moved from Oakland, California, to make it their temporary home. But they soon discovered that it's really the polar bears who are at home in Churchill, roaming past the coffee shop on the main drag, peering into garbage cans, languorously scratching their backs against fence posts and front doorways. Where kids in other towns receive admonitions about talking to strangers, Churchill schoolchildren get "Let's All Be Bear Aware" booklets to bring home. (Lesson number 8: Never explore bad-smelling areas.)Zac Unger takes readers on a spirited and often wildly funny journey to a place as unique as it is remote, a place where natives, tourists, scientists, conservationists, and the most ferocious predators on the planet converge. In the process he becomes embroiled in the controversy surrounding "polar bear science"--and finds out that some of what we've been led to believe about the bears' imminent extinction may not be quite the case. But mostly what he learns is about human behavior in extreme situations . . . and also why you should never even think of looking a polar bear in the eye.
Never Race a Runaway Pumpkin (Roscoe Riley Rules #7)
by Katherine ApplegateRoscoe is determined to guess the weight of a giant pumpkin in order to win books for his school library and candy for himself, but is overwhelmed by superstitions, especially about a certain black kitten.
Never Say Die: A Kentucky Colt, the Epsom Derby, and the Rise of the Modern Thoroughbred Industry
by James C. NicholsonA history of the American horse that won Britain’s greatest race and changed the Thoroughbred racing world.A quarter of a million people braved miserable conditions at Epsom Downs on June 2, 1954, to see the 175th running of the prestigious Derby Stakes. Queen Elizabeth II and Sir Winston Churchill were in attendance, along with thousands of Britons who were all convinced of the unfailing superiority of English bloodstock and eager to see a British colt take the victory. They were shocked when a Kentucky-born chestnut named Never Say Die galloped to a two-length triumph at odds of 33–1, winning Britain’s greatest race and beginning an important shift in the world of Thoroughbred racing.Never Say Die traces the history of this extraordinary colt, beginning with his foaling in Lexington, Kentucky, as well as the stories of the influential individuals brought together by the horse and his victory?from the heir to the Singer sewing machine fortune to the Aga Khan. Most fascinating is the tale of Mona Best of Liverpool, England, whose well-placed bet on the long-shot Derby contender allowed her to open the Casbah Coffee Club. There, her son met musicians John Lennon, Paul McCartney, and George Harrison, later joining their band.Featuring a foreword by the original drummer for the Beatles, Pete Best, this remarkable book reveals how an underdog’s surprise victory played a part in the formation of the most successful and influential rock band in history and made the Bluegrass region of Kentucky the center of the international Thoroughbred industry.Praise for Never Say Die“Nicholson has done a very fine job of placing the unique role of Never Say Die in perspective within the specific confines of Thoroughbred racing history, while at the same time explaining how this horse was touched by a vivid array of characters in other social and historical contexts. Who would have imagined that a racehorse would link such diverse institutions as the Singer sewing machine company, the Epsom Derby, and the Beatles?” —Edward L. Bowen, author of The Lucky Thirteen“As a reader, I was left with a clear understanding of how the breeding industry has gone global, and importantly, how it will always follow the money. Racing enthusiasts will enjoy how the author sews together this unusual patchwork of characters into a narrative.” —John Eisenberg, author of The Great Match Race: When North Met South in America’s First Sports Spectacle“[E]nlightening and entertaining. . .Nicholson’s tale of close connections and global links is a yarn worth following.” —Wall Street Journal
Never Smile at a Monkey: And 17 Other Important Things to Remember
by Steve JenkinsWhen it comes to wild animals, everyone knows that there are certain things that one should not do. In this fascinating picture book, readers find out what they should "never" do if they encounter one of these surprisingly dangerous animals.
Never Take a Bear to School
by Mark SperringA delightfully funny story that will reassure every child anxious about starting a new school or nursery.Bears are clumsy. They don't sit still. They're much, much bigger than teachers - and they eat SUCH a lot of lunch! Yes, taking a bear to school is a BAD idea. But will this little boy find the courage to face the first day of school alone?With so much to do, like painting, dressing up, storytime, and making new friends, he just might! And Bear? He'll always be waiting at the end of the day, with a great big hug!
Never Tease a Weasel
by Jean Conder SouleReading this book together is an excellent and fun way to learn about teasing. " You can knit a kitten mittens And perhaps that cat would purr. You could fit a fox with socks That exactly matched his fur. ... But never tease a weasel; This is very good advice. A weasel will not like it And teasing isn't nice!" This file should make an excellent embossed braille copy.
Never Turn Your Back on an Angus Cow
by David Fisher Dr Jan PolThe star of The Incredible Dr. Pol shares his amusing, and often poignant, tales from his four decades as a vet in rural Michigan. Dr. Jan Pol is not your typical veterinarian. Born and raised the Netherlands on a dairy farm, he is the star of Nat Geo Wild's hit show The Incredible Dr. Pol and has been treating animals in rural Michigan since the 1970s. Dr. Pol's more than 20,000 patients have ranged from white mice to 2600-pound horses and everything in between. From the time he was twelve years old and helped deliver a litter of piglets on his family's farm to the incredible moments captured on his hit TV show, Dr. Pol has amassed a wealth of stories of what it's like caring for this menagerie of animals. He shares his own story of growing up surrounded by animals, training to be a vet in the Netherlands, and moving to Michigan to open his first practice in a pre fab house. He has established himself as an empathetic yet no-nonsense vet who isn't afraid to make the difficult decisions in order to do what's best for his patients--and their hard-working owners. A sick pet can bring heartache, but a sick cow or horse could threaten the very livelihood of a farmer whose modest profits are dependent on healthy livestock.Reminiscent of the classic books of James Herriot, Never Turn Your Back on an Angus Cow is a charming, fascinating, and funny memoir that will delight animal lovers everywhere.
Never Turn Your Back on an Angus Cow
by Dr Jan Pol David FisherThe star of The Incredible Dr. Pol shares his amusing, and often poignant, tales from his four decades as a vet in rural Michigan. Dr. Jan Pol is not your typical veterinarian. Born and raised the in Netherlands on a dairy farm, he is the star of Nat Geo Wild's hit show The Incredible Dr. Pol and has been treating animals in rural Michigan since the 1970s. Dr. Pol's more than 20,000 patients have ranged from white mice to 2600-pound horses and everything in between. From the time he was twelve years old and helped deliver a litter of piglets on his family's farm to the incredible moments captured on his hit TV show, Dr. Pol has amassed a wealth of stories of what it's like caring for this menagerie of animals. He shares his own story of growing up surrounded by animals, training to be a vet in the Netherlands, and moving to Michigan to open his first practice in a pre fab house. He has established himself as an empathetic yet no-nonsense vet who isn't afraid to make the difficult decisions in order to do what's best for his patients--and their hard-working owners. A sick pet can bring heartache, but a sick cow or horse could threaten the very livelihood of a farmer whose modest profits are dependent on healthy livestock. Reminiscent of the classic books of James Herriot, Never Turn Your Back on an Angus Cow is a charming, fascinating, and funny memoir that will delight animal lovers everywhere.
Neversink
by Barry Wolverton Sam NielsonAlong the Arctic Circle lies a small island called Neversink, whose jagged cliffs and ice-gouged rocks are home to a colony of odd-looking seabirds called auks, including one Lockley J. Puffin. With their oceanfront views and plentiful supply of fish, the auks have few concerns--few, save for Lockley's two best friends, Egbert and Ruby, a know-it-all walrus and a sharp-tongued hummingbird. But all of this is about to change. Rozbell, the newly crowned king of the Owl Parliament, is dealing with a famine on the mainland of Tytonia--and he has long had his scheming eyes on the small colony to the north. Now Neversink's independence hangs in the balance. An insurgence of owls will inevitably destroy life as the auks know it--unless Lockley can do something about it. Barry Wolverton's debut is an epic tale of some very un-epic birds, a fast-paced and funny story of survival, friendship, and fish.
Neverwoof
by Gabe JensenIn retro pantone style, a hilarious picture book about a dog who never barks. But what will he do when a burglar threatens his home?
The New Adventures of Curious George
by Margret ReyThis collection includes eight full-length stories including Curious George Goes to a Chocolate Factory, Curious George and the Puppies, Curious George Makes Pancakes, Curious George Feeds the Animals, Curious George Goes to a Movie, Curious George and the Hot Air Balloon, Curious George in the Snow, and Curious George’s Dream.
New Age Herbals: Resource, Quality And Pharmacognosy
by Brahma Singh K. V. PeterImportance of herbs (medicinal plants) can hardly be overemphasized. They are exploited for manyfold applications, ranging from phytopharmaceuticals, to nutraceuticals, to cosmetics and many others. Keeping in view the richness of herbs and their vast potential, this book collates the most up-to-date knowledge of important herbs and herbals. The book also gives an overview of some issues causing hindrance in the promotion of herbals. This book attempts to compile the rich experience of experts working on various herbs. New age single plant species, having multiple medicinal traits worth exploiting i.e. Hippophae rhamnoides (seabuckthorn), and Morinda citrifolia (noni) also find place as full chapters in the book.
The New Agrarianism: Land, Culture, and the Community of Life
by Eric T. FreyfogleThe engaging writings gathered in this new book explore an important but little-publicized movement in American culture -- the marked resurgence of agrarian practices and values in rural areas, suburbs, and even cities. It is a movement that in widely varied ways is attempting to strengthen society's roots in the land while bringing greater health to families, neighborhoods, and communities. The New Agrarianism vividly displays the movement's breadth and vigor, with selections by such award-winning writers as Wendell Berry, William Kittredge, Stephanie Mills, David Orr, Scott Russell Sanders, and Donald Worster. As editor Eric Freyfogle observes in his introduction, agrarianism is properly conceived in broad terms, as reaching beyond food production to include a wide constellation of ideals, loyalties, sentiments, and hopes. It is a temperament and a moral orientation as well as a suite of diverse economic practices -- all based on the insistent truth that people everywhere are part of the land community, as dependent as other life on its fertility and just as shaped by its mysteries and possibilities. The writings included here have been chosen for their engaging narratives as well as their depiction of the New Agrarianism's broad scope. Many of the selections illustrate agrarian practitioners in action, while other selections offer pointed critiques of contemporary American culture and its market-driven, resource-depleting competitiveness. Together, they reveal what Freyfogle identifies as the heart and soul of the New Agrarianism: its yearning to regain society's connections to the land and its quest to help craft a more land-based and enduring set of shared values. The New Agrarianism offers a compelling vision of this hopeful new way of living. It is an essential book for social critics, community activists, organic gardeners, conservationists, and all those seeking to forge sustaining ties with the entire community of life.
The New Art of Photographing Nature: An Updated Guide to Composing Stunning Images of Animals, Nature, and Landscapes
by Art Wolfe Martha HillA new spin on the classic guide to composing stunning images of nature and wildlife What is the difference between a good picture and a great one? In this fully revised edition of the classic bestseller The Art of Photographing Nature, master photographer Art Wolfe and former Audubon photo editor Martha Hill team up to explain the art of composing images of enduring beauty. Against a backdrop of more than 250 photographs of nature, wildlife, and landscapes, they share insights and advice about what works and what doesn't, and how small changes can take an image from ordinary to extraordinary. Throughout, all-new tips from digital imaging expert Tim Grey show readers how to make the most of digital technology, whether by choosing the right color space, understanding sensor size, or removing distracting elements in post-processing. The result is an invaluable collection of expert advice updated for the modern age.
New Aspects of Axonal Structure and Function
by Joachim Lübke Dirk FeldmeyerAxons are neuronal output elements and are responsible for the transfer and processing of signals from one neuron to another, even over very large distances. For a given neuronal cell type, axons are unique and display very heterogeneous patterns with respect to shape, length and target structure. Axons are the usually long process of a nerve fiber that generally conducts impulses away from the body of the nerve cell. This book is intended to summarize recent findings covering morphological, physiological, developmental, computational and pathophysiological aspects of axons. It attempts to cover new findings concerning axonal structure and functions together with their implications for signal transduction, processes implicated in the formation of axonal arbors and the transport of subcellular elements to their targets, and finally how a dysfunction in one or several of these steps could lead to axonal degeneration and ultimately to neurodegenerative diseases.
A New Beginning (Magic Puppy #1)
by Andrew Farley Angela Swan Sue BentleyLily loves working at Greengates Riding Stables, but she can't help feeling sad that she doesn't have her own pony. Or even her own pet. But when Storm, a golden retriever with sparkling midnight-blue eyes, magically appears, she can't believe it. A wonderful adventure awaits them.