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Radiation Protection in Medical Physics
by Yves Lemoigne Alessandra CanerThis book introduces the fundamental aspects of Radiation Protection in Medical Physics and covers three main themes: General Radiation Protection Principles; Radiobiology Principles; Radiation Protection in Hospital Medical Physics. Each of these topics is developed by analysing the underlying physics principles and their implementation, quality and safety aspects, clinical performance and recent advances in the field. Some issues specific to the individual techniques are also treated, e.g. calculation of patient dose as well as that of workers in hospital, optimisation of equipment used, shielding design of radiation facilities, radiation in oncology such as use of brachytherapy in gynecology or interventional procedures. All topics are presented with didactical language and style, making this book an appropriate reference for students and professionals seeking a comprehensive introduction to the field as well as a reliable overview of the most recent developments.
Understanding Gene Therapy
by Prof Nick LemoineThis title explains what gene therapy is, how genes are delivered and how they are targeted. It discusses recent gene therapy trials, future applications and considers the ethical and safety issues surrounding gene therapy. Understanding Gene Therapy is a
LYMPH & LONGEVITY: The Untapped Secret to Health
by Dr Gerald M LemoleThe lymphatic system has been one of the most misunderstood systems in our bodies. Until now.Cardiothoracic surgeon Dr. Gerald M. Lemole explains why a healthy lymphatic flow aids our bodies in reducing toxins that contribute to disease and injury. In ten short chapters, Dr. Lemole demystifies the lymphatic system, describes how powerful it is and shows how to maintain a healthy lymph system to combat specific diseases and health problems - from heart disease to cognitive function to weight management.Featuring sidebars with charts and graphs that illustrate basic principles, Lymph & Longevity also includes menus, recipes and information on supplements, as well as basic yoga and meditation guides.Illuminating, informative, and practical this essential guide is timelier now than ever as we continue to work to protect ourselves and our communities against COVID-19 and other viruses.
Happy
by Alex LemonHis freshman year of college, Alex Lemon was supposed to be the star catcher on the Macalester College baseball team. He was the boy getting every girl, the hard-partying kid everyone called Happy. In the spring of 1997, he had his first stroke. For two years Lemon coped with his deteriorating health by sinking deeper into alcohol and drug abuse. His charming and carefree exterior masked his self-destructive and sometimes cruel behavior as he endured two more brain bleeds and a crippling depression. After undergoing brain surgery, he is nursed back to health by his free-spirited artist mother, who once again teaches him to stand on his own. Alive with unexpected humor and sensuality, Happy is a hypnotic self-portrait of a young man confronting the wreckage of his own body; it is also the deeply moving story of a mother's redemptive and healing powers. Alex Lemon's Technicolor sentences pop and sing as he writes about survival--of the body and of the human spirit.
The Perpetual Now: A Story of Amnesia, Memory, and Love
by Michael D. LemonickIn the aftermath of a shattering illness, Lonni Sue Johnson lives in a "perpetual now," where she has almost no memories of the past and a nearly complete inability to form new ones. The Perpetual Now is the moving story of this exceptional woman, and the groundbreaking revelations about memory, learning, and consciousness her unique case has uncovered. Lonni Sue Johnson was a renowned artist who regularly produced covers for The New Yorker, a gifted musician, a skilled amateur pilot, and a joyful presence to all who knew her. But in late 2007, she contracted encephalitis. The disease burned through her hippocampus like wildfire, leaving her severely amnesic, living in a present that rarely progresses beyond ten to fifteen minutes. Remarkably, she still retains much of the intellect and artistic skills from her previous life, but it's not at all clear how closely her consciousness resembles yours or mine. As such, Lonni Sue's story has become part of a much larger scientific narrative—one that is currently challenging traditional wisdom about how human memory and awareness are stored in the brain. In this probing, compassionate, and illuminating book, award-winning science journalist Michael D. Lemonick uses the unique drama of Lonni Sue Johnson's day-to-day life to give us a nuanced and intimate understanding of the science that lies at the very heart of human nature.
The Marathon of the Messenger: A History of Messenger RNA Vaccines
by Jérôme Lemonnier Nicolas LemonnierThe Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI).
Neurosecretion: Secretory Mechanisms (Masterclass in Neuroendocrinology #8)
by José R. Lemos Govindan DayanithiHow do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted.While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley
Atlas of Surgical Pathology Grossing (Atlas of Anatomic Pathology)
by Monica B. Lemos Ekene OkoyeThis book is a unique surgical pathology grossing atlas, comprised of a collection of photos of various anatomic specimens frequently encountered in routine and frozen surgical pathology practice, including various organ systems. The photos in this atlas have been collected over many years of practicing surgical pathology in one of the largest medical centers in the world, and include emphasis on important anatomic landmarks and explanations on how to properly orient, section and sample anatomic specimens. The use of actual gross images allows readers to more readily apply the grossing tips to actual specimens that they encounter at the grossing bench. Each chapter is arranged by organ system and includes essential tips for grossing each specimen and sample dictations with all the essential elements that must be addressed for proper assessment of each organ specimen.Written by expert pathologists, Atlas of Surgical Pathology Grossing is an excellent resource for pathologists, medical and pathology assistant students, residents, both in surgery and pathology, and pathology assistants.
Não É Só Sangue: Uma Conversa Sobre o Ciclo Menstrual
by Patrícia LemosO ciclo menstrual é reflexo da sua saúde. Aprenda o que o seu corpo lhe está a querer dizer. Além das questões menstruais, o livro ajudará as mulheres a compreender o importante conceito de literacia de corpo: que se traduz na capacidade de interpretarmos os sinais que o corpo nos dá e capacitar-nos no sentido de nos permitir tornarmo-nos uma autoridade nos nossos próprios assuntos. Porque é que precisa de um livro sobre ciclo menstrual? O mais provável é que seja diferente do que aquilo que lhe contaram. Para algumas pessoas, a menstruação é a chatice que aparece de quando em vez; para outras, não incomoda assim tanto. Mas para todas as pessoas que menstruam: o ciclo menstrual é informação. Patrícia Lemos, educadora para a saúde menstrual e fertilidade, ajuda-nos a compreender o nosso ciclo menstrual e a olhá-lo como um indicador de saúde, sempre — e não apenas quando se pensa em ter bebés. Neste livro, descobrirá que:· No ciclo menstrual, o mais importante é invisível aos olhos. · Ovular faz-nos falta, mesmo quando não queremos engravidar. · A expressão do período (cor, consistência, cheiro, duração) fornece pistas sobre a nossa saúde.· Num pico de fertilidade, as probabilidades de conceção são de cerca de 20% a 25% a cada ciclo. · A TPM tem tratamento, e não é suposto existir. · A síndrome dos ovários poliquísticos é uma condição crónica, não se cura com a pílula e não se diagnostica apenas com uma ecografia.· A endometriose é uma condição de saúde séria e estrogénio-dependente. · Infertilidade e subfertilidade são coisas distintas.
Advances for Prosthetic Technology: From Historical Perspective to Current Status to Future Application
by Robert LemoyneThis book focuses on the advances in transtibial prosthetic technology and targets research in the evolution of the powered prosthesis such as the BiOM, which was derived from considerable research and development at the Massachusetts Institute of Technology. The concept of the book spans the historical evolution of prosthetic applications from passive to new and futuristic robotic prosthetic technologies. The author describes the reasons for amputation, surgical procedures, and an historical perspective of the prosthesis for the lower limb. He also addresses the phases and sub-phases of gait and compensatory mechanisms arising for a transtibial prosthesis and links the compensatory mechanisms to long-term morbidities. The general technologies for gait analysis central to prosthetic design and the inherent biomechanics foundations for analysis are also explored. The book reports on recent-past to current-term applications with passive elastic prostheses. The core of the book deals with futuristic robotic prostheses including their function and major subsystems, such as actuator technology, state machine control, and machine learning applications. Finally, the envisioned future trends in the prosthetic technology space are presented.
Particulate Matter
by Felicia Luna LemusIn concise and distilled prose, Lemus presents a collection of still lifes, landscapes, and portraits of a challenging year that threatened all she loved most. "There are only a few words per page in Particulate Matter, but that
Immune Homeostasis
by Michael J. Lenardo Andrew L. SnowMany questions remain unresolved as researchers continue to characterize and define the nature of normal immune homeostasis and determine how these processes are dysregulated in immunodeficiency, as well as in autoimmune and lymphoproliferative disorders. Immune Homeostasis: Methods and Protocols focuses on experimental techniques for measuring and analyzing immune cell dynamics, with a particular emphasis on examining lymphocyte programmed cell death in different contexts. With contributions by leading experts in the field, the collection examines detailed protocols for studying various pathways of apoptosis and necrosis in different types of hematopoietic cells, both in vitro and in vivo, methods for studying the maintenance of lymphocyte populations in the steady-state or following infectious challenges in both mice and humans, and technical insights into state-of-the-art genomics tools, among other topics. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Valuable and easy to use, Immune Homeostasis: Methods and Protocols serves as an important toolkit for basic and clinical scientists interested in examining various aspects of immune homeostasis in both normal and disease-related contexts in order to further study the dynamic processes that contribute to homeostasis of the immune system.
Biomedical Technology: Modeling, Experiments And Simulation (Lecture Notes in Applied and Computational Mechanics #74)
by Thomas Lenarz Peter WriggersDuring the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types of implants and related topics.
Biomedical Technology: Modeling, Experiments and Simulation (Lecture Notes in Applied and Computational Mechanics #84)
by Thomas Lenarz Peter WriggersDuring the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types of implants and related topics.
The Encultured Brain: An Introduction to Neuroanthropology
by Daniel H. Lende Greg DowneyBasic concepts and case studies from an emerging field that investigates human capacities and pathologies at the intersection of brain and culture. The brain and the nervous system are our most cultural organs. Our nervous system is especially immature at birth, our brain disproportionately small in relation to its adult size and open to cultural sculpting at multiple levels. Recognizing this, the new field of neuroanthropology places the brain at the center of discussions about human nature and culture. Anthropology offers brain science more robust accounts of enculturation to explain observable difference in brain function; neuroscience offers anthropology evidence of neuroplasticity's role in social and cultural dynamics. This book provides a foundational text for neuroanthropology, offering basic concepts and case studies at the intersection of brain and culture.After an overview of the field and background information on recent research in biology, a series of case studies demonstrate neuroanthropology in practice. Contributors first focus on capabilities and skills—including memory in medical practice, skill acquisition in martial arts, and the role of humor in coping with breast cancer treatment and recovery—then report on problems and pathologies that range from post-traumatic stress disorder among veterans to smoking as a part of college social life.Contributors Mauro C. Balieiro, Kathryn Bouskill, Rachel S. Brezis, Benjamin Campbell, Greg Downey, José Ernesto dos Santos, William W. Dressler, Erin P. Finley, Agustín Fuentes, M. Cameron Hay, Daniel H. Lende, Katherine C. MacKinnon, Katja Pettinen, Peter G. Stromberg
The Encultured Brain
by Daniel H. Lende Greg DowneyThe brain and the nervous system are our most cultural organs. Our nervous system is especially immature at birth, our brain disproportionately small in relation to its adult size and open to cultural sculpting at multiple levels. Recognizing this, the new field of neuroanthropology places the brain at the center of discussions about human nature and culture. Anthropology offers brain science more robust accounts of enculturation to explain observable difference in brain function; neuroscience offers anthropology evidence of neuroplasticity's role in social and cultural dynamics. This book provides a foundational text for neuroanthropology, offering basic concepts and case studies at the intersection of brain and culture. After an overview of the field and background information on recent research in biology, a series of case studies demonstrate neuroanthropology in practice. Contributors first focus on capabilities and skills--including memory in medical practice, skill acquisition in martial arts, and the role of humor in coping with breast cancer treatment and recovery--then report on problems and pathologies that range from post-traumatic stress disorder among veterans to smoking as a part of college social life.
Shape-Memory Polymers
by Andreas LendleinTable of Contents -Shape-Memory Polymers and Shape-Changing Polymers By M. Behl, J. Zotzmann, and A. Lendlein -Shape-Memory Polymer Composites By Samy A. Madbouly and Andreas Lendlein -Characterization Methods for Shape-Memory Polymers By W. Wagermaier, K. Kratz, M. Heuchel, and A. Lendlein -Shape-Memory Polymers for Biomedical Applications By Christopher M. Yakacki and Ken Gall -Controlled Drug Release from Biodegradable Shape-Memory Polymers By ChristianWischke, Axel T. Neffe, and Andreas Lendlein
Anabolic Steroids: And Other Performance-enhancing Drugs
by Patrick LenehanAnabolic steroids have traditionally been controversial in the sporting arena. Today, research indicates a dramatic increase in the use of anabolic steroids and other performance-enhancing drugs outside of competitive sports. With evidence of widespread steroid abuse among the general population, health professionals are citing the emergence of an
The Heart of the Brain: The Hypothalamus and Its Hormones (The\mit Press Ser.)
by Gareth LengHow hormonal signals in one small structure of the brain—the hypothalamus—govern our physiology and behavior.As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain—the hypothalamus—influences what we do, how we love, and who we are.The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
Computational Neuroendocrinology
by Gareth Leng Duncan J. MacgregorA key aim of this cutting edge volume is to encourage interaction between researchers in neuroendocrinology and mathematical and computer modellers of biological systems, by showing the usefulness of this approach in analysing neuroendocrine systems, and in better understanding of the important disorders that result from their dysfunction. Computational modelling works through simulations, and providing readers with supporting video clips so that they can see the simulations discussed within the text will be a particularly important feature of this book.
Achieving High Quality Care
by Gillian Leng Val Moore Sasha AbrahamDrawing on the experience of the National Institute for Health and Care Excellence (NICE), Achieving High Quality Care is a practical guide on how to recognise and implement high quality evidence and guidance.This new title provides an overview of the evidence behind successful initiatives designed to change practice and improve the quality of health care. It provides an overall picture of change management, from understanding the barriers to change to how these barriers can best be overcome. It presents a concise summary of the evidence for change, plus examples of specific initiatives drawn from experience of putting NICE guidance into practice.The book includes a wide range of examples of positive change - plus key practical points highlighted throughout the text - to help readers achieve improvements in patient care. Finally, it shows how to measure change, assess improvement to agreed standards and to manage the ongoing process of change towards improving health care.Achieving High Quality Care is a helpful guide for busy health care professionals wanting to improve services and patient care. It is relevant to everyone involved in the organisation and provision of quality health care, including clinicians and health care managers, who are trying to lead change and improve care through implementing evidence-based guidance.
The Washington Manual of Cardio-Oncology: A Practical Guide for Improved Cancer Survivorship
by Daniel J Lenihan Kathleen Zhang Joshua MitchellWritten by experts in cardiovascular disease, hematology, and oncology, The Washington Manual® of Cardio-Oncology: A Practical Guide for Improved Cancer Survivorship is a clinically relevant, easy-to-use primer on the detection, management, and improved cardiovascular-based patient outcomes in adults undergoing treatment for cancer or who have previously survived cancer therapy. Edited by Drs. Daniel J. Lenihan, Joshua D. Mitchell, and Kathleen W. Zhang, this concise yet comprehensive manual provides high-yield information that reflects today’s advances in risk stratification, early diagnosis, and treatment of cardiovascular disease—all in an easy-access, concisely bulleted format for on-the-go reference.
Creating Community Health: Interventions for Sustainable Healthcare
by Simon LennaneThis important book explores how community-based interventions can bridge the gap between health services and the voluntary sector to create more sustainable, healthy communities. Moving beyond a technologically driven, medicalised approach to healthcare, the book shows how social prescribing can provide a direct pathway to improving community health, embracing connection and challenging inequality. Written by a practicing GP, and illustrated through practical guidance, it demonstrates how this can offer a cost-effective, preventative means to improving health outcomes, enabling communities to be more resilient when confronting major issues such as climate change or pandemics. Building to a case study of how these methods were used in one town, Ross-on-Wye, the book will be invaluable reading for those working in healthcare, public health, local authorities, and the voluntary sector, as well as students and researchers interested in these areas.
The Heavens Are All Blue: A memoir of two doctors, a marriage and a life of love before loss
by Dr Finbar Lennon Dr Kathleen McGarryWhen Dr Kate McGarry was diagnosed with an advanced cancer of unknown origin she resolved to write a book to chart her experience: as a woman coming to terms with such devastating news and what this meant to her as a wife and a mother but also, crucially, how she experienced cancer and its treatment as a doctor, who had become a patient. As Kate adjusted to living with cancer and underwent treatment, she enlisted the help of her husband, fellow doctor, Finbar to help her write the book but then she sadly passed away on the 5 January 2018. With no writing experience, and wrestling with his own heartache, Finbar set about finishing their story. The result is a touchingly beautiful memoir about love, grief and togetherness.'A loving memoir of time spent both together and apart ... [Kate's] personal legacy, as a mother, a wife and the life and soul of the party, is recorded beautifully in this moving memoir' Sunday Business Post
The Heavens Are All Blue: A memoir of two doctors, a marriage and a life of love before loss
by Dr Finbar Lennon Dr Kathleen McGarryWhen Dr Kate McGarry was diagnosed with an advanced cancer of unknown origin she resolved to write a book to chart her experience: as a woman coming to terms with such devastating news and what this meant to her as a wife and a mother but also, crucially, how she experienced cancer and its treatment as a doctor, who had become a patient. As Kate adjusted to living with cancer and underwent treatment, she enlisted the help of her husband, fellow doctor, Finbar to help her write the book but then she sadly passed away on the 5 January 2018. With no writing experience, and wrestling with his own heartache, Finbar set about finishing their story. The result is a touchingly beautiful memoir about love, grief and togetherness.'A loving memoir of time spent both together and apart ... [Kate's] personal legacy, as a mother, a wife and the life and soul of the party, is recorded beautifully in this moving memoir' Sunday Business Post