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Cytokine and Chemokine Networks in Cancer
by Manzoor Ahmad MirCytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
Rasch Meta-Metres of Growth for Some Intelligence and Attainment Tests
by David Andrich Ida Marais Sonia SapplThis book adapts Rasch’s approach for quantifying growth on physiological variables, where growth decelerates, to intellectual variables. To apply this approach, it is necessary to construct measurements in a constant unit over the relevant range of the variable. With such measurements, the book illustrates the approach to quantifying growth on six intellectual variables - two intelligences tests and two each of tests of proficiencies in reading comprehension and mathematics. The book discusses how it is not immediately obvious that deceleration on a quantitative scale should also hold for the growth in intellectual variables. It goes on to show that this is indeed the case with all six tests analysed and considers some implications of this feature for understanding intellectual development, in particular the centrality of the growth trajectory set in early life.
Moving Beyond Grades to Purposeful Learning: Lessons from Singaporean Research (Studies in Singapore Education: Research, Innovation & Practice #5)
by David Wei Loong HungThis book explores future directions in Singaporean education as it moves beyond its historically formative goals of survival, efficiency and performance, and its emphasis on grades and formal credentialing. It examines the future of education via the 4Life framework, a four-form model for purposeful learning centered around social-emotional regulation and the well-being of the individual learner: Life-long learning, the learning that occurs over a learner's lifespan; Life-deep learning, a deep understanding of learned content and adaptive expertise; Life-wide learning, learning in multiple contexts besides the school environment; and Life-wise learning, learning which focuses on the learner's values, morals, character and historical empathy. This book also illustrates how purposeful learning serves to equip learners with the knowledge, skills, dispositions and competencies they need to thrive as adaptive workers in the economy of the future.
Understanding Disability: Interdisciplinary Critical Approaches
by Ranu Uniyal Fatima RizviThis edited volume brings together contributions on disability studies organized around two themes: literary and sociological aspects. The contributors include academics, disability activists, and researchers from within and outside the Indian periphery. While the book strengthens the disability discourse and contributes to building academic scholarship on this subject, it also promotes disability activism by giving space to both direct practitioners and persons with disabilities. The chapters discuss various analytical and literary aspects of the marginalization experienced by the disabled community and bring forth new and elaborate perspectives. It draws connections across multiple identities and includes personal narratives across nations, cultures and societies. It is an excellent research resource on disability studies in India for scholars and students in the area of humanities, education, law, sociology and social work, while at the same time also addressing the global context.
Human Microbiome in Health, Disease, and Therapy
by Pallaval Veera BramhachariThis book illustrates the role of the human microbiome in health and diseases. It discusses the association of an imbalanced human microbiome with different human diseases, including inflammatory, metabolic conditions, neurological, cardiovascular, and respiratory diseases. The book further reviews the association between intestinal microbiota and immune defense systems. The book provides evolving knowledge of the development, complexity, and functionality of the healthy gut microbiota and covers interventions that modulate and stabilize the gut microbiota. Further, it introduces the human microbiome as a reservoir of AMR genes, the current knowledge on the resistome, and the recent and upcoming advances in molecular diagnostic approaches to unravel this reservoir. Toward the end, the book reviews the advances in understanding the human urinary microbiome and its potential role in urinary tract infection. The chapter also presents the dynamics of the skin microbiome and the association of microbiota with skin disorders and therapeutic interventions. This book is an invaluable read for health professionals, medical students, microbiologists, and scientific research communities who are eager to update themselves with recent trends in microbiome research.
Neuroleadership: Creative Leadership with a Focus on the Brain
by James Teboul Philippe DamierThis book illustrates, through a number of examples from different domains, how to put in place a disciplined process to develop a creative leadership approach. Today's managers seem to have all the tools at their disposal, leadership training, seminars and executive coaching, to exercise effective leadership, but most continue to take the easy path of raw authority, neglecting the interwoven texture of leadership and followership. The classic models of leadership fail routinely because leaders find it hard to develop an effective way of motivating their followers and do not realize how far they are conditioned by the limitations and biases hardwired in their brains. Just like sports professionals who need a good understanding of their body, leaders need to practice and explore the capabilities of their brains. With some knowledge in the latest discoveries in Neurosciences and mastery of their cognitive predispositions, leaders can draw on a range of resources to engage all parties in learning and collaborating towards common goals and create a culture based on cooperation and innovation. Ideal for organizations or associations, private or public companies, this book offers practical advice on neuroleadership through examples of successful transformation including a case study at Netflix.
System of Human Activity Systems: A Novel Way to Visualize Invisible Risks (Translational Systems Sciences #37)
by Takafumi NakamuraThis book has unique features that set it apart from conventional books on the prevention of system failures in that it provides a method that views human activities from a meta-methodological perspective based upon an inter-disciplinary understanding of human activities. With these characteristics, the book also proposes a common methodological basis to apply to various problems surrounding society today such as an aging social infrastructure; the safety of food, medicine, and public transportation; and the creation of sustainable electricity and cybersecurity. Furthermore, since the failure of human activities is expressed in a three-dimensional space and the topological metrics are implemented, the failure trajectories can be quantitatively monitored in time series to take effective preventive measures. Considering the implementation of the topological metrics, the causes of each failure are classified into two dimensions of the degree of coupling between system elements and the interaction between the target system and the external environment. Owing to the nature of the introduction of topological metrics, all individual and diverse systems can share general topological metrics. Consequently, understanding various failures over cross-industries is possible with the use of common meta-systemic language and mutual learning between different industries, and the solution of social problems can be effectively achieved. A system of system failures (SOSF) proposed and confirmed the effectiveness of this meta-methodology for information and communication technologies (ICT) systems and the SOSF is extended to human activity systems (SOHAS: system of human activity systems) as a whole. Therefore, the SOHAS becomes an academic foundation for theoretical research on meta-methodology, and it has an impact on practitioners to prevent system failures by accumulating knowledge of failures and learning from other industries.
A Poetics of Minds and Madness: Fiction, Cognition and Interpretation
by XINRAN YANGThis monograph aims to explore the mind-narrative nexus by conducting a cognitive narratological study on the mad minds in fictional narratives. Set on the interface of narrative and cognitive science (cognitive linguistics, cognitive psychology and cognitive neuropsychology), it adopts an indirect empirical approach to the fictional representation of madness. The American writer Ken Kesey’s novel One Flew Over the Cuckoo’s Nest is chosen as the primary text of investigation, whereas due consideration is also given to other madness narratives when necessary. This book not only demonstrates the value of reading and rereading literary classics in the modern era, but also sheds light on the studies of cognitive narratology, cognitive poetics, madness narratives and literature in general.
Analysis of Categorical Data from Historical Perspectives: Essays in Honour of Shizuhiko Nishisato (Behaviormetrics: Quantitative Approaches to Human Behavior #17)
by Eric J. Beh Rosaria Lombardo Jose G. ClavelThis collection of essays is in honor of Shizuhiko Nishisato on his 88th birthday and consists of invited contributions only. The book contains essays on the analysis of categorical data, which includes quantification theory, cluster analysis, and other areas of multidimensional data analysis, covering more than half a century of research by the 41 interdisciplinary and international researchers who are contributors. Thus, it offers the wisdom and experience of work past and present and attracts a new generation of researchers to this field. Central to this wisdom and experience is that of Prof. Nishisato, who has spent much of the past 60 years mentoring and providing leadership in the research of quantification theory, especially that of “dual scaling”. The book includes contributions by leading researchers who have worked alongside Prof. Nishisato, published with him, been mentored by him, or whose work has been influenced by the research he has undertaken over his illustrious career. This book inspires researchers young and old as it highlights the significant contributions, past and present, that Prof. Nishisato has made in his field.
Applying the Science of Learning to Education: An Insight into the Mechanisms that Shape Learning
by Wei Loong David Hung Azilawati Jamaludin Aishah Abdul RahmanThis book provides an overview of the various 'Science of Learning' (SoL) research projects led by researchers at the National Institute of Education, Nanyang Technological University, Singapore, and international research collaborators. It presents the goals and rationale behind the Science of Learning in Education (SoLE) initiative and examines a spectrum of topics relevant to bolstering our understanding of the science underlying learning. The Science of Learning (SoL) is an advancing field, with proponents extolling its potential impact on educational practice. This book investigates the possible correlations or causal relationships between brain functioning and development, physiology, environment factors, and their impact on learning. It promotes an interdisciplinary approach to understanding biological to behavioural mechanisms of learning that are oriented toward optimizing and maximizing every learner’s potential.
Chinese People’s Time Use and Their Quality of Life: Research Report of Chinese Time Use Survey
by Fenglian Du Wenbin Wang Xiaoyuan DongThis book analyzes how Chinese people use their time, including how busy Chinese seek a healthy work-life balance, how some children win from the outset in terms of education, and how people pursue quality of life outside of or after work. General readers will get a vivid and detailed impression of the way Chinese people spend their time, while researchers will find a wealth of phenomena and data for analysis from both economic and social perspectives. The research presented here was conducted in the context of the Chinese Time Use Survey (CTUS), a nationwide initiative launched by Inner Mongolia University in 2017. The CTUS covers 29 Chinese provinces, and the database contains the time use information of 30,591 people aged 3 years and over from 12,471 households. The survey collects information at three main levels: personal, family and community.
Positive Psychology and Positive Education in Asia: Understanding and Fostering Well-Being in Schools (Positive Education)
by Ronnel B. King Imelda Santos Caleon Allan B. I. BernardoThis book explores students’ and teachers’ well-being from positive psychology and education perspectives and showcases interventions that optimize well-being in the school context. The book also covers crucial positive psychology and education topics/themes including character strengths, gratitude, growth mindset, grit, resilience, positive emotions, and well-being among others. The chapters include reviews and empirical research based on diverse methodologies, such as correlational, experimental, quasi-experimental, intervention, longitudinal, and qualitative approaches from six different Asian sociocultural contexts—Singapore, Hong Kong, Mainland China, Israel, Macau, and Philippines. All the chapters, provide practical pointers for teachers and educators who aim to nurture well-being in schools.
New Research and Possibilities in Wellbeing Education
by Mathew A. White Faye McCallum Christopher BoyleThis book examines a variety of issues related to wellbeing education and cross-cultural education, curriculum and pedagogy, education policy and systems, teacher education and professional development of educators, educational administration, management and leadership, and inclusive education. Stimulated, in part, by the launch of positive psychology, wellbeing education has grown worldwide. Various theories of wellbeing have been adopted in education, coining the term 'wellbeing education', defined in this book as how school leaders and teachers plan to implement evidence-informed wellbeing interventions to promote wellbeing and academic goals. This book investigates a series of questions related to wellbeing education, and how evidence-informed wellbeing approaches are integrated into learning, teaching, and education.
Die Psychologie des Phubbing: Ursachen und Auswirkungen der Smartphone-Nutzung in Gesprächssituationen
by Yeslam Al-SaggafDieses Buch konzentriert sich auf die Auswirkungen von Phubbing durch Eltern auf ihre Kinder, Partner auf ihre Partner, Chefs auf ihre Angestellten, Freunde auf ihre Freunde und Familienmitglieder auf andere Familienmitglieder. Nach einer Zusammenfassung der Erkenntnisse aus der veröffentlichten Forschung über die spezifischen Auswirkungen auf diese phubbenden Personen in wichtigen Beziehungen werden die psychologischen Prädiktoren für Phubbing (die Auslöser) dargelegt, gefolgt von einer umfassenderen Darstellung der psychologischen Auswirkungen von Phubbing-Verhalten. Das letzte Kapitel befasst sich mit der Rolle sozialer Normen bei der Erklärung von Phubbing über die individuellen Prädiktoren hinaus, die das Verhalten auslösen, und versucht, eine Verbindung zwischen Phubbing und sozialer Theorie herzustellen.
Urogenital Trauma: A Practical Guide
by Said Abdallah AL-MamariThis book is written in a unique style that immediately catches the reader's interest and takes him on an enjoyable and fruitful journey from the kidneys to the male genital organs. Throughout the chapters, the researchers, the practitioners, and the junior doctors under urological training are offered a rare opportunity to rapidly refresh their knowledge with updated information starting from the mythical and historical conception of the involved organ, its embryology and anatomy, and progressing to the epidemiology, etiology, anatomopathology, mechanism, treatment and prognosis of its trauma.It aims to provide the reader with the most complete and practical information possible and includes an abundant and well-selected illustration to help the learning process. A special section on male genital self-mutilations is added at the end of the book as the icing on the cake, treating this phenomenon systematically with a harmonious marriage between mythology, history, and a comprehensive literature review and management strategies. This manual has been reviewed and recommended by an internationally renowned expert in urogenital trauma and reconstructive surgery and is a very useful vade mecum for every Practitioner or resident in Urology.
Cultural and Social Influences on Consumer Behavior: Uncertainty Avoidance, Rituals, and External Threats (Management for Professionals)
by Xuehua WangThis book explores how cultural and social influences affect consumer decision making with a focus on uncertainty avoidance, rituals, and external threats. Indeed, uncertainty avoidance can exert significant influence on consumer behavior. For example, consumers in a culture with high uncertainty avoidance may show less positive attitudes towards new products than those in a culture with low uncertainty avoidance. Prior cultural research has mainly focused on how individualism/collectivism or power distance belief influences consumer attitudes and behaviors at an individual level, while seldom does research investigate the effect of uncertainty avoidance on consumption. This book examines how uncertainty avoidance affects superstitious consumption as well as its underlying mechanism and boundary condition. Rituals, as a component of culture, can affect consumer behaviors. However, few studies have shedded light on how repeating rituals can affect consumers’ willingness to use the products involved in the ritual. Consumer behavior is complex. Consumers are surrounded with various external threats such as health, economic, and informational threats, while prior research has primarily focused on health threats. Beyond this, inter-client conflicts, as a special type of social threat, can also affect consumption experience. In all, this book aims to examine how uncertainty avoidance, rituals and external threats influence consumer attitudes and behaviors. In this book, new research models would be developed. This book enriches our understanding on how cultural and social influences affect consumer decision making and provides insights for both researchers and practitioners in marketing.
Artificial Intelligence and Machine Learning in Healthcare
by Dharmendra Kumar Yadav Anamika GulatiThis book is about the use of artificial intelligence (AI) and machine learning in healthcare. AI and related technologies are increasingly prevalent in business and society and are beginning to be applied to healthcare. These technologies have the potential to transform many aspects of patient care, as well as administrative processes within provider, payer, and pharmaceutical organizations. There are already a number of research studies suggesting that AI can perform as well as or better than humans at key healthcare tasks, such as diagnosing disease. Today, algorithms are already outperforming radiologists at spotting malignant tumors and guiding researchers in how to construct cohorts for costly clinical trials. However, for a variety of reasons, the authors believe that it will be many years before AI replaces humans for broad medical process domains. Through this book, the authors describe both the potential that AI offers to automate aspects of care and some of the barriers to rapid implementation of AI in healthcare.
Computational Methods in Psychiatry
by Gopi Battineni Mamta Mittal Nalini ChintalapudiThis book presents a particular area of interest in computing psychiatry with the modelling of mood and anxiety disorders. It highlights various methods for building these models. Clinical applications are prevalent due to the growth and interaction of these multiple approaches. Besides, it outlines some original predictive and computational modelling ideas for enhancing psychological treatment interventions. Computational psychiatry combines multiple levels and types of computation with different data types to improve mental illness understanding, prediction, and treatment.
Leaderful Classroom Pedagogy Through an Interdisciplinary Lens: Merging Theory with Practice
by Soyhan Egitim Yu UmemiyaThis book focuses on the impact of teachers’ leadership identity on their pedagogical and class management choices and proposes a new pedagogical framework, leaderful classroom practices which emerged through collective, concurrent, collaborative, and compassionate interactions between the teacher and students. The interdisciplinary aspect of the book appeals to a wide range of readers from different disciplines and gives readers the opportunity to take a moment and reflect on their leadership identity, recognize the limitations of their practices, and adopt a leaderful pedagogy in their respective disciplines. Establishing an open, democratic, and participatory learning environment for all learners is a major leadership responsibility of teachers, and this book demonstrates how to accomplish this mission both in theory and practice.
Hyperbaric Oxygen Therapy: Principles and Applications
by Manoj Gupta Indumathi SomasundaramThis book covers the hyperbaric oxygen therapy (HBOT) in current recommended indications, emphasizing the mechanisms involved in the benefits of supplemental oxygen under high pressure. The physiological changes associated with high pressure and hyperoxic conditions are discussed in initial chapters, along with their physical basis governed by the laws of gas followed by the functioning of hyperbaric chambers and the safety precautions needed in operating them. Utilization of HBOT in indications such as wound healing, severe anemia, and burn injuries is thoroughly explained, along with the recommended protocol for HBOT administration. The final chapters present the contraindications of HBOT and its promising effects on aging and regeneration.This book is helpful to HBOT practitioners in understanding its underlying mechanism and major applications.
Disorder-Specific Psychodrama Therapy in Theory and Practice (Psychodrama in Counselling, Coaching and Education #4)
by Reinhard T. KrügerThe open access book explains the practical approach in psychodrama with the help of multidisciplinary theories of self-development, mentalization, play, and psychosomatic resonance. These theories help to structure the therapeutic experiences of Moreno and other psychodramatists and to compare them with experiences and theories of other psychotherapy methods. Against this background, the author develops models of a disorder-specific psychodrama therapy for people with personality disorders, borderline organization, trauma disorders, anxiety disorders, obsessive-compulsive disorders, depression, grief reactions, suicidal crises, masochism, psychoses, addiction disorders, eating disorders, and behavioral addictions. The therapy models convey a deep understanding of these disorders and sometimes open up new ways of treatment. They can be used both in individual and in group therapy. The methods are explained with the help of more than 120 case examples. The theoretical explanation makes the psychodramatic action methods accessible and applicable to therapists from other schools of therapy as well as in counseling and coaching. This makes the practical work therapeutically more effective and creative.This is an open access book.
Advances of Multisensory Integration in the Brain (Advances in Experimental Medicine and Biology #1437)
by Yong Gu Adam ZaidelThis book presents the latest research on multisensory brain function. Namely, the mechanisms by which the brain processes and integrates information from multiple sensory modalities. Its contents cover a broad range of topics, including optimal integration, cross-modal interactions, calibration, and causal inference – with an emphasis on their neuronal underpinnings. By bringing together efforts from different laboratories around the world we aim to collaboratively shed light on these fundamental brain processes, that underlie perception, cognition, and behavior in a complex multisensory world, and to spur innovation of brain-inspired technologies
Occupational Health Safety Factors and Their Impact on the Mental Health of Workers (New Perspectives in Behavioral & Health Sciences)
by Suchismita Satapathy Arturo Realyvásquez Vargas Meghana MishraThis book is about occupational health and safety in the workplace. Work-related productivity has been decreasing in most of the labor-intensive sectors on account of the fatigue and discomfort in workplaces, which is the most significant factor for consideration at all levels. Moreover, improper workplace design leads to most of the occupational accidents as well as injuries in production sites. This book explores discomfort in working environments and its impact on mental health in varying workplaces. It then offers some innovative solutions to provide comfort, safety, and sustainability in workplaces to reduce mental workload.
Selbstmord in Bangladesch: Epidemiologie, Risikofaktoren und Prävention
by S. M. Yasir Arafat Murad M. KhanDieses Buch befasst sich umfassend mit suizidalem Verhalten in Bangladesch. Es basiert auf vorhandenen Erkenntnissen und Fachwissen und behandelt im Speziellen die Bereiche Epidemiologie, Quellen für Qualitätsdaten, lokale Kultur, forensische und rechtliche Aspekte, Gesundheit und psychische Versorgung, Medien und Suizid, Krisenmanagementsystem, Suizidprävention und den Stand der Erkenntnisse im Land. Dieses Buch ist das erste seiner Art, das sich mit verschiedenen Aspekten der Suizidalität in Bangladesch befasst.
Self-Determination Theory and Socioemotional Learning
by Betsy NgThis book approaches the field of socioemotional learning from the perspective of self-determination theory (SDT). The volume examines socioemotional learning (SEL) in schools, higher educational institutions, and workplaces. It is a timely work in its comprehensive presentation of a means of understanding motivation for one’s own work, the motivation of others, stress tolerance, team-working, conflict resolution, as well as dealing with critical situations. Socioemotional learning relates to competencies in a combination of behaviors, cognitions, and emotions that are essential for all individuals’ success, including educational and employment settings. This book presents the most comprehensive discussion of SDT perspectives on socioemotional learning in various domains, ranging from formal to informal settings. This book is an essential resource for social scientists, educators, and researchers working in education, organizational psychology, and family sociology.