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Breakthrough: The Greatest Pitched Battle in America’s History
by Franklin M. Davis Jr“This battle,” Hitler said, “is to decide whether we shall live or die.”Skilfully, secretly, he assembled three German armies—24 divisions, 250,000 men, 970 tanks and 1900 pieces of artillery.Taking advantage of the harsh winter, he picked a place where the Allied forces were water-thin—four American divisions and one armored cavalry regiment—and unleashed a devastating attack to annihilate the outnumbered defenders.Thus started the greatest pitched battle ever fought by the United States in its history—the engagement that destroyed forever the myth of the vaunted superiority of the German soldier.
The Breakthrough
by Jan Eckel Samuel MoynBetween the 1960s and the 1980s, the human rights movement achieved unprecedented global prominence. Amnesty International attained striking visibility with its Campaign Against Torture; Soviet dissidents attracted a worldwide audience for their heroism in facing down a totalitarian state; the Helsinki Accords were signed, incorporating a "third basket" of human rights principles; and the Carter administration formally gave the United States a human rights policy.The Breakthrough is the first collection to examine this decisive era as a whole, tracing key developments in both Western and non-Western engagement with human rights and placing new emphasis on the role of human rights in the international history of the past century. Bringing together original essays from some of the field's leading scholars, this volume not only explores the transnational histories of international and nongovernmental human rights organizations but also analyzes the complex interplay between gender, sociology, and ideology in the making of human rights politics at the local level. Detailed case studies illuminate how a number of local movements--from the 1975 World Congress of Women in East Berlin to anti-apartheid activism in Britain, to protests in Latin America--affected international human rights discourse in the era as well as the ways these moments continue to influence current understanding of human rights history and advocacy. The global south--an area not usually treated as a scene of human rights politics--is also spotlighted in groundbreaking chapters on Biafran, South American, and Indonesian developments. In recovering the remarkable presence of global human rights talk and practice in the 1970s, The Breakthrough brings this pivotal decade to the forefront of contemporary scholarly debate.Contributors: Carl J. Bon Tempo, Gunter Dehnert, Celia Donert, Lasse Heerten, Patrick William Kelly, Benjamin Nathans, Ned Richardson-Little, Daniel Sargent, Brad Simpson, Lynsay Skiba, Simon Stevens.
Breakthrough
by Michael Fullan Mr Peter Hill Carmel CrévolaRedesign classroom instruction to transform learning for both students and teachers! Breakthrough presents a revolutionary new approach to educational reform, breaking away from the conventional paradigm to help educators create powerful, focused instruction that raises and sustains performance levels in the classroom. Based on three core components—personalization, precision, and professional learning—these breakthrough concepts turn reform into precise, data-driven classroom instruction personalized to every student. Unique elements of the Breakthrough framework include: Improvement by design Assessment for learning Critical learning instructional paths Mapping instructional paths Smart use of data to drive instruction Locking in ongoing improvement
Breakthrough!: 100 Astronomical Images That Changed the World
by Robert Gendler R. Jay GabanyThis unique volume by two renowned astrophotographers unveils the science and history behind 100 of the most significant astronomical images of all time. The authors have carefully selected their list of images from across time and technology to bring to the reader the most relevant photographic images spanning all eras of modern astronomical history. Based on scientific evidence today we have a basic notion of how Earth and the universe came to be. The road to this knowledge was paved with 175 years of astronomical images acquired by the coupling of two revolutionary technologies - the camera and telescope. With ingenuity and determination humankind would quickly embrace these technologies to tell the story of the cosmos and unravel its mysteries. This book presents in pictures and words a photographic chronology of our aspiration to understand the universe. From the first fledgling attempts to photograph the Moon, planets, and stars to the marvels of orbiting observatories that record the cosmos at energies beyond the range of human vision, astronomers have always relied on images to "break through" to the next level of understanding. A subset of these breakthrough images has profound significance in documenting some of the greatest milestones in modern astronomy.
Breakthrough: Autobiographical Accounts of the Education of Some Socially Disadvantaged Children (Routledge Library Editions: Education)
by Ronald GoldmanSocial mobility, educational priority areas and equality of opportunity are topics discussed as much today as when this book was first published over 30 years ago. This book is written by people of varying ages and professions who have broken through from poor social beginnings, deprived backgrounds and many disadvantages into a high level of professional achievement. Starting in working class or slum environments in areas such as Sheffield, Wales, Manchester, Leeds, Huddersfield, London, Glasgow and Birmingham they describe their struggles and the ways in which they attempted to over-come their earlier deprivations. The descriptions in this volume are illustrations of potential which is present in the most unpromising beginnings.
The Breakthrough: Immunotherapy and the Race to Cure Cancer
by Charles GraeberCharles Graeber, New York Times bestselling author of The Good Nurse, details the astonishing scientific discovery of the code to unleashing the human immune system to fight -- and possibly even cure -- cancer, featuring interviews with 2018 Nobel Prize in Medicine award-winners James P. Allison and Tasuku Honjo.For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold?As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment," a revolutionary discovery in our understanding of cancer and how to beat it.In THE BREAKTHROUGH, Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step-harnessing the wealth of new information to create modern and more effective patient therapies-is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease.Groundbreaking, riveting, and expertly told, THE BREAKTHROUGH is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
Breakthrough: A Story of Hope, Resilience and Mental Health Recovery
by Ahmed Hankir“An honest, engaging and most of all, hopeful book.”―Adam Kay, BAFTA-winning, multi-million-bestselling author, TV writer and performer. "Warm, funny and devastatingly honest. An incredibly insightful story full of hope and resilience." ―Dr Amir Khan, Sunday Times bestselling author and Resident Doctor for ITV's Lorraine and Good Morning Britain "An inspiring rebuke to the nihilism which prevails in society about persons living with mental illness due to myths, misinformation and stigma...Professor Hankir's personal journey bursts with courage, resilience and hope." ―Vikram Patel, Paul Farmer Professor and Chair of Global Health and Social Medicine, Harvard Medical School, USA Explore mental health, wellness, and illness in this engaging and insightful discussion from a practicing psychiatrist who himself lives with a mental health condition In Breakthrough: A Story of Hope, Resilience and Mental Health Recovery, World Health Organization Award Winning psychiatrist, former psychiatric patient and mental health advocate Dr. Ahmed Hankir delivers a unique and powerful insight into mental health and wellness, mental illness, mental health treatment, and the culture surrounding mental health by tracing his own personal recovery journey from impoverished and shunned psychiatric patient, to becoming an NHS Consultant psychiatrist. In the book you’ll explore many of the issues currently dominating the discussion of mental health and illness, including the impacts of poverty, unemployment, the cost of living crisis, homelessness, addictions, the use of medication to treat mental illness, the widespread prevalence of stigma, discrimination and racism in mental health and much more. You’ll also find: Comprehensive discussions about how to overcome shame and stigma to seek help if you’re suffering from a mental illness. Explorations of how mental health practitioners and family members of people living with mental health conditions can themselves remain healthy as they care for others. Examinations of why mental health related stigma remains so stubbornly common in our societies and what we can do to combat it. Breakthrough is a resource of hope and a companion for people suffering in silence who feel isolated and disconnected from society. It will also be of interest to mental health practitioners, including psychiatrists, psychologists, social workers, counsellors, addictions specialists, carers and clients. The take home messages are clear: living with a mental health condition is nothing to be ashamed about and, with the right support, recovery is a reality for the many and not the few.
The Breakthrough: Politics and Race in the Age of Obama
by Gwen IfillVeteran journalist Ifill surveys the American political landscape, shedding new light on the impact of Barack Obama's stunning presidential campaign and introducing the emerging young African-American politician's forging a bold new path to political power.
Breakthrough
by Paul Kurnit Steve LanceConsider some big ideas that have become business and cultural phenomena: how Starbucks transformed a declining coffee market by combining an experience destination with a premium product. Or how the established notion that "dolls are for girls" was shattered by a toy line called G. I. Joe. Most people mistakenly think breakthrough ideas are a matter of divine inspiration and luck. This book reveals a step-by-step methodology individuals and organizations can use to develop, create, and nurture the kinds of new products and services that capture the public's imagination. Loaded with examples - and packed with straightforward explanations of the processes that can lead to breakout hits - this book shows readers how to create an idea methodology, encourage free-thinking, keep good ideas, and bring revolutionary, revenue-generating new concepts to market.
Breakthrough: Katalin Karikó and the mRNA Vaccine
by Stephanie Sammartino McPhersonA thorough and accessible biography of Dr. Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose hard work pioneering mRNA research led to the COVID-19 vaccines. Her monumental contribution to global health care has rightfully placed Karikó as one of the most important scientists in history. She has won awards, given speeches, and appeared in magazines and television programs. But she wasn’t always famous—in fact, it took decades for anyone to recognize the importance of her research into RNA and the potential of mRNA to help cells fight off disease. Beginning with her birth in a small village in rural Hungary, Breakthrough tells the story of how a young girl interested in the wildlife around her became an internationally celebrated hero. Exuberant, devoted to her family, and hard-working, Karikó persevered in the face of challenges and obstacles that would have discouraged many of her peers. Her achievements remind us that if we believe in ourselves, no matter the setbacks we encounter, we can succeed.
Breakthrough!: Canada's Greatest Inventions and Innovations
by John MeladyFrom the jetliner and the snowmobile to the pacemaker and the BlackBerry, Canadians have long been at the forefront of innovation and invention. Canadians are behind a variety of cutting-edge products, life-saving medicines, innovative machines, and fascinating ideas. Although our inventions have typically been created with little fanfare, financing, or expectation of return, they have often gone on to play important roles in day-to-day life. Our "greatest invention" is probably insulin, which millions of people depend on for life and health. But the light bulb, the Canadarm, and the BlackBerry certainly vie for that honour as well. Some of our inventions are small: the paint roller, the Robertson screwdriver, and the crash position indicator – the forerunner of the black box on planes. Others are larger: the jetliner, the snow-blower, and the snowmobile. Some, such as Standard Time, are really just complex ideas while others, such as the pacemaker, are triumphs of complex technology. Put simply, Canadians are supremely innovative!
Breakthrough!: How Three People Saved "Blue Babies" and Changed Medicine Forever
by Jim MurphyIn 1944 a groundbreaking operation repaired the congenital heart defect known as blue baby syndrome. The operation's success brought the surgeon Alfred Blalock international fame and paved the way for open-heart surgery. But the technique had been painstakingly developed by Vivien Thomas, Blalock's African American lab assistant, who stood behind Blalock in the operating room to give him step-by-step instructions. The stories of this medical and social breakthrough and the lives of Thomas, Blalock, and their colleague Dr. Helen Taussig are intertwined in this compelling nonfiction narrative.
Breakthrough: A Sure-Fire Guide to Realizing Your Potential, Pushing Through Limitations, and Achieving Things You Didn't Know Were Possible
by David NurseDeliver innovative results like clockwork with this repeatable formula for creativity-on-demand Have you ever sat down at your desk with an impossible deadline or an insurmountable obstacle staring you directly in the face and an expectation that you’ll come up with a groundbreaking idea and solution? In Breakthrough, you’ll find a powerful framework for bringing innovation and creativity to the surface not just once, but on a regular, daily basis. In Breakthrough, bestselling author, acclaimed speaker, and life optimization coach David Nurse provides an actionable and clearly organized structure for maximizing your breakthrough ideas. Breakthrough outlines easy-to-follow steps for outperforming your potential: An accessible blueprint—backed by scientific data and years of case studies with the top athletes, entrepreneurial minds, and leaders throughout the world—to unlocking your creative potential Conclusive proof that busts the myths of the lone genius, unpredictable ‘a-ha’ lightbulb moments, and little happy accidents Ways to promote an environment and mindset in which groundbreaking new ideas can flow and occur naturally and seamlessly based on a repeatable formula A must-read for any athlete, manager, executive, or parent tasked with delivering dynamic results in a flash, Breakthrough also belongs on the bookshelves of product design professionals, marketers, and other creative types who seek to consistently exceed expectations. Breakthrough is not about going from good to great; it’s about going from great to outstanding!
Breakthrough: Our Guerilla War to Expose Fraud and Save Democracy
by James O'KeefeIn this New York Times bestseller, controversial ambush journalist James O'Keefe takes a hard-hitting look at how the media and government conspire to protect the status quo: "A spine-tingling, true crime thriller about the quest for truth in the age of media obfuscation" (Gavin McInnes, FOX News contributor).Hailed by David Weigel in Slate as having "had more of an impact on the 2012 election than any journalist," James O'Keefe is young, brash, and provocative: a new breed of guerrilla reporter for the twenty-first century. He and his associates have famously infiltrated some of America's most protected organizations and institutions. Now, in Breakthrough, O'Keefe chronicles the harrowing undercover investigation that opened America's eyes to the chicanery of its state houses and the duplicity of the White House during one of the most compromised election campaigns in our nation's history: the 2012 presidential race. Of all his controversial sting operations, this was the one that his late mentor, Andrew Breitbart, called "his most consequential." While still on federal probation, O'Keefe organized an army of citizen journalists, planned a series of video stings to reveal the American system's vulnerability to voter fraud, and went nose to nose with the most powerful political machine in the world. Along the way, O'Keefe found disheartening evidence that Americans are not nearly as free as we may believe, but also showed just how much real change ordinary citizens can bring about when they are willing to risk the wrath of the powerful. Free of ideology, Breakthrough is at its core a clarion call for a more ethical society. Despite being vilified and libeled by an establishment media dedicated to suppressing the truth, James O'Keefe has dared to break through the firewall and reshape public opinion by showing things as they really are.
Breakthrough
by James O'KeefeIn this hard-hitting look at the way media and government conspire to protect the status quo, controversial ambush journalist James O'Keefe shows the reader what happens when a young citizen journalist challenges some of America's most powerful and protected organizations.James O'Keefe has been on the front lines of journalism since his student days at Rutgers. In Breakthrough, he takes the reader through his effrts to expose the duplicity of Planned Parenthood, ACORN, Medicaid, NPR, the New Jersey Educational Association, labor unions and politicians. He shows how the major media slandered him at almost every turn, how state officials harassed him, and how federal officials arrested him and his colleagues on contrived charges in New Orleans. While still on federal probation, legal necessity forced O'Keefe to train an army of citizen journalists to take on what mentor Andrew Breitbart called his "most consequential" investigation to date: a series of video stings that revealed the total vulnerability of American elections to vote fraud. O'Keefe tells the story of his team's harrowing adventures, as O'Keefe learns that we are not nearly as free a people as we think we are. Breakthrough shows the opportunity that still exists for independent journalists to break through the media firewall, reshape public opinion, and inspire political reform.
Breakthrough: The Quest for Life-Changing Medicines
by Dr William PaoMeet the doctors, scientists, patients and campaigners tackling the world&’s worst diseases We often hear about the dark side of the pharmaceutical industry – from extortionate pricing to the opioid epidemic. But there&’s another story to be told. Through the story of eight revolutionary treatments, Dr William Pao cuts to the innovative heart of medical science and celebrates the tireless work of those fighting for better care. Behind each of these medicines – whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol – there stands a cast of characters and a wealth of stories. The trajectory from the laboratory to the local chemist is rarely a straight line. Eureka moments are few are far between. Drug hunting demands leaps of imagination and lateral thinking, the accumulation of the knowledge and expertise of many, and – nearly always – a hefty dollop of luck. Breakthrough documents these journeys and grants a privileged look at the stories behind the medicines that improve – and very often save – our lives.
Breakthrough: Eight Steps to Wellness -- Life-altering Secrets from Today's Cutting-edge Doctors
by Suzanne SomersToday's most trusted advocate of antiaging medicine, Suzanne Somers, deepens her commitment to helping people lead healthier, happier lives by opening their eyes to cutting-edge, proven remedies and preventative care that most doctors just aren't talking about with patients: longevity medicine and the more progressive study of bioidentical hormones. As we age, certain hormones diminish, creating an imbalance that can set off everything from perimenopause to cancer, beginning as early as our thirties. This hormonal imbalance is causing many to feel depressed, anxious, fatigued, sexless, sleepless, and ultimately ill, sometimes even terminally. What's more, Somers and twenty doctors in the field of anti-aging medicine argue that the processed chemicals in foods and pharmaceuticals we ply ourselves with are actually slowly eroding our bodies and minds. So we're getting slammed twice. From estrogen dominance to deceptive thyroid problems, people are suffering, and most don't have access to the treatment they truly need to get better and thrive ... until now. Breakthrough explores cutting-edge science and delivers smart, proactive advice on the newest treatments for breakthrough health and longevity.In addition to being a pioneer in a rapidly growing health field, Somers is a passionate, caring individual whose own life was derailed by disease and brought back to unimaginable, feel good heights that she wants you, too, to experience.
Breakthrough!: 5 Essential Strategies for Freedom, Healing, and Wholeness
by Marcus WarnerMany of us read our Bibles and pray, but we can still feel fragile, tired, and defeated. This is the book we&’ve longed for.We need a breakthrough. We need healing. From our pasts. And from our present battles. But sometimes we feel stuck or despairing—as if nothing is ever going to change. Dr. Marcus Warner shows us the pathway to healing and maturity.Breakthrough! goes beyond the usual one-size-fits-all answers. Written from a Christian perspective, this book takes the Bible and brain science—with the Holy Spirit—and provides an integrative approach to building emotional resilience that changes lives.As you explore five strategies—Be aware of your body, unleash your beliefs, increase your belonging, listen to the Spirit, and defeat demons (BUILD)—you will discover a breakthrough. Our memories and hearts can heal. We can mature and grow in Christ. Whether you&’re at your end or simply in need of some spiritual vivacity, this book will not disappoint.Breakthrough! is an excellent resource for Christian counselors, providing essential tools and helpful exercises. It is also for the brokenhearted and those ministering to the weary and brokenhearted. Discover and develop a hope-filled pathway to Christian maturity.
Breakthrough Agile: The Five Key Business Processes for Cultural Transformation
by Christian CaterAgile is being adopted within every type of organization across the world. It is no longer used specifically for software development. This book shows how anyone can adopt the systems of an agile organization within their organization. The book contains a blueprint on how to start a transformation initiative.Starting with a high-level overview of what companies are seeking to achieve with a transformation platform, the book describes the common approaches used in today’s business world. The book’s discussion includes how common themes between the different types of transformation platforms are more a direct result of five cultural business processes.Currently, there are three main transformation platforms practiced within the business world: Lean Six-Sigma, Lean, and Agile. After a brief comparison showing the similarities and differences of these platforms, the book presents a blueprint for a successful Agile Transformation within any type of organization by focusing on five common cultural processes.The five cultural business processes discussed are decision making, conflict resolution, rewards and recognition, project management, and strategic deployment. In this book, each detailed discussion of the cultural business process includes real-life examples showing the agile systems and how they are applied, sustained, and the value they drive.The tour de force for the book is a theory that for any transformation to succeed, organizations need to change their values and principles in these business cultural processes to align with the value and principles of the transformation platform. Regardless of the platform, successful transformations only give the company the value they are seeking when the values and principles of the organization change. This usually means leaders need to change how they lead throughout the organization from the most senior level to front-line leaders.Essentially, these five cultural processes influence peoples’ behaviors more than the application of any transformation system or tactics within the transformation platforms.
Breakthrough! The Bible for Young Catholics
by Brian Singer-Towns Nora Bradbury-Haehl Lisa-Marie Calderone-Stewart Shirley Kelter Marilyn Kielbasa Larry Schatz Victoria SheppAs the title suggests,Breakthrough! The Bible for Young Catholics highlights what happens throughout salvation history between God and humanity. God breaks through and connects with human history, thereby establishing a relationship with humanity. Using the Good News translation, Breakthrough! The Bible for Young Catholics was created for young people leaving childhood and entering adolescence. Its ten special features were created to help make the Bible easier for young people to read and understand. They will learn about the great people of the Bible, and will see how God has been breaking through in human history and connecting with humanity for thousands of years. Most important, they will discover, in the Bible, how God's messages to key people of faith have meaning for life today.
Breakthrough Branding: How Smart Entrepreneurs And Intrapreneurs Transform A Small Idea Into A Big Brand
by Catherine KaputaEven the smallest idea can have BIG impact when positioned correctly. Breakthrough Branding shows entrepreneurs, intrapreneurs, and small businesses alike the secrets to transforming a brainstorm into big bucks. From the grassroots growth of beverage brands like Red Bull, Honest Tea, and Innocent, to the exploding growth of digital brands like Twitter, Weibo, and Groupon; from the cult appeal of stores like Forever 21, to the success of virtual retailers like Zappos - successful companies of all types and sizes begin with three things: ambition, a winning idea, and a brand strategy. Branding expert Catherine Kaputa uses dozens of international brand histories to demonstrate what makes a brand thrive, and provides you with the tools to do the same. Learn how to define your audience, create a standout personality, and position yourself as superior to the competition - all by utilizing the power of branding! Packed with thoughtful reader exercises and filled with leading-edge social media strategies, Breakthrough Branding teaches novice start-ups to seasoned professionals how to leverage their assets to create a successful business.
Breakthrough Branding: How Smart Entrepreneurs and Intrapreneurs Transform a Small Idea into a Big Brand
by Catherine KaputaEven the smallest idea can have BIG impact when positioned correctly. Breakthrough Branding shows entrepreneurs, intrapreneurs, and small businesses alike the secrets to transforming a brainstorm into big bucks. From the grassroots growth of beverage brands like Red Bull, Honest Tea, and Innocent, to the exploding growth of digital brands like Twitter, Weibo, and Groupon; from the cult appeal of stores like Forever 21, to the success of virtual retailers like Zappos — successful companies of all types and sizes begin with three things: ambition, a winning idea, and a brand strategy. Branding expert Catherine Kaputa uses dozens of international brand histories to demonstrate what makes a brand thrive, and provides you with the tools to do the same. Learn how to define your audience, create a standout personality, and position yourself as superior to the competition — all by utilizing the power of branding! Packed with thoughtful reader exercises and filled with leading-edge social media strategies, Breakthrough Branding teaches novice start-ups to seasoned professionals how to leverage their assets to create a successful business.
Breakthrough Business Analysis: Implementing and Sustaiing and Value-Based Practice
by Kathleen B HassTraditional business analysis jobs are going away and are not coming back. BA tools are growing up, and typical BA tasks are being automated and commoditized. Instead of being regarded as documenters, BAs are being sought out to focus on strategy, innovation, and leadership.Breakthrough Business Analysis: Implementing and Sustaining a Value-Based Practice provides a framework for implementing a BA practice that is strategically positioned and value-based. Realizing the positive impacts of a value-based BA practice could very well mean the difference between success and failure for businesses negotiating 21st century challenges.Value-based business analysis centers on strategy execution, world-class enterprise capabilities, and delivery of innovative products and services. The framework for implementing and sustaining a value-based BA practice involves three phases:1. Readiness: &“Is our organization ready?&”2. Implementation: &“How do we build the BA practice?&”3. Sustainability: &“How do we institutionalize and continue to improve BA practices?&”Take the lead and be your organization's champion of a value-based, breakthrough BA practice that is focused on value to the customer and wealth to the bottom line.
Breakthrough Business Development: A 90-Day Plan to Build Your Client Base and Take Your Business to the Next Level
by Duncan MacPherson David MillerIncrease Profits, Be more Organized, attract a Higher Quality & Quantity of Referrals, Run Your Business so That It Doesn't Run You, Take Your Business to the Next Level... With Breakthrough Business Development! Breakthrough Business Development shows you how to attract and keep great clients, while running a profitable and efficient business. It helps every knowledge-for-profit professional to maximize your most valuable client relationships, and to develop a personalized business development plan to mine the untapped potential in your business. Praise for the Pareto System, Featured in Breakthrough Business Development. "I am just beside myself on the results gathered so far from instituting the Pareto System. I use an agenda for meetings now and have formulated a standard package given to new clients. Already I have sent out twenty thank-you cards to new referrals. I even got a referral from a referral if that makes sense. Some clients didn't know that I was still expanding my business. I am also finding advocates that I didn't classify as such. Opening twenty accounts in this short time span is amazing but already I have another ten leads in the pipeline. You guys were right, it does work." "We have been building client relationships for 45 years... Pareto Systems successfully helped us to pause and then guided us through the process of defining the appropriate business structure and systems which will strengthen and enhance our best client relationships. We are now focusing on a comprehensive, systematized program for select clients. The results have been amazing-client satisfaction is way up and so are revenues."
BREAKTHROUGH BUSINESS MODELS: Drug Development for Rare and Neglected Diseases and Individualized Therapies
by Institute of Medicine of the National AcademiesThe process for developing new drug and biologic products is extraordinarily expensive and time-consuming. Although large pharmaceutical companies may be able to afford the cost of development because they can expect a large return on investment, organizations developing drugs to treat rare and neglected diseases are unable to rely on such returns. On June 23, 2008, the Institute of Medicine's Forum on Drug Discovery, Development, and Translation held a public workshop, "Breakthrough Business Models: Drug Development for Rare and Neglected Diseases and Individualized Therapies," which sought to explore new and innovative strategies for developing drugs for rare and neglected diseases.