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Bioinformatics and Computational Biology in Drug Discovery and Development

by William T. Loging

Computational biology drives discovery through its use of high-throughput informatics approaches. This book provides a road map of the current drug development process and how computational biology approaches play a critical role across the entire drug discovery pipeline. Through the use of previously unpublished, real-life case studies the impact of a range of computational approaches are discussed at various phases of the pipeline. Additionally, a focus section provides innovative visualisation approaches, from both the drug discovery process as well as from other fields that utilise large datasets, recognising the increasing use of such technology. Serving the needs of early career and more experienced scientists, this up-to-date reference provides an essential introduction to the process and background of drug discovery, highlighting how computational researchers can contribute to that pipeline.

Fortnite For Dummies

by Bill Loguidice

Play—and survive—in the game of Fortnite! Zombies. Battle. Survival. Fortnite has it all—and if you want to keep your gameplay going until the bitter end to outlast your competition, this book is the ace in your back pocket! Choose a gaming platform Download and optimize the game Play in each of the gameplay modes Scavenge, loot, and collect resources Avoid death and outlast your opponents Who will be the last person standing? When you want to outlast the competition and make Fortnite yours, this book makes it easier than ever to come out on top.

Vintage Game Consoles: An Inside Look at Apple, Atari, Commodore, Nintendo, and the Greatest Gaming Platforms of All Time

by Bill Loguidice Matt Barton

Vintage Game Consoles tells the story of the most influential videogame platforms of all time, including the Apple II, Commodore 64, Nintendo Entertainment System, Game Boy, Sega Genesis, Sony PlayStation, and many more. It uncovers the details behind the consoles, computers, handhelds, and arcade machines that made videogames possible. Drawing on extensive research and the authors’ own lifelong experience with videogames, Vintage Game Consoles explores each system’s development, history, fan community, its most important games, and information for collectors and emulation enthusiasts. It also features hundreds of exclusive full-color screenshots and images that help bring each system’s unique story to life. Vintage Game Consoles is the ideal book for gamers, students, and professionals who want to know the story behind their favorite computers, handhelds, and consoles, without forgetting about why they play in the first place – the fun! Bill Loguidice is a critically acclaimed technology author who has worked on over a dozen books, including CoCo: The Colorful History of Tandy’s Underdog Computer, written with Boisy G. Pitre. He’s also the co-founder and Managing Director for the popular Website, Armchair Arcade. A noted videogame and computer historian and subject matter expert, Bill personally owns and maintains well over 400 different systems from the 1970s to the present day, including a large volume of associated materials. Matt Barton is an associate professor of English at Saint Cloud State University in Saint Cloud, Minnesota, where he lives with his wife Elizabeth. He’s the producer of the "Matt Chat," a weekly YouTube series featuring in-depth interviews with notable game developers. In addition to the original Vintage Games, which he co-authored with Bill, he’s author of Dungeons & Desktops: The History of Computer Role-Playing Games and Honoring the Code: Conversations with Great Game Designers.

Vintage Games: An Insider Look at the History of Grand Theft Auto, Super Mario, and the Most Influential Games of All Time

by Bill Loguidice Matt Barton

Vintage Games explores the most influential videogames of all time, including Super Mario Bros., Grand Theft Auto III, Doom, The Sims and many more. Drawing on interviews as well as the authors' own lifelong experience with videogames, the book discusses each game's development, predecessors, critical reception, and influence on the industry. It also features hundreds of full-color screenshots and images, including rare photos of game boxes and other materials. Vintage Games is the ideal book for game enthusiasts and professionals who desire a broader understanding of the history of videogames and their evolution from a niche to a global market.

Serious Games Analytics

by Christian Sebastian Loh Yanyan Sheng Dirk Ifenthaler

This volume brings together research on how gameplay data in serious games may be turned into valuable analytics or actionable intelligence for performance measurement, assessment, and improvement. Chapter authors use empirical research methodologies, including existing, experimental, and emerging conceptual frameworks, from various fields, such as: computer science software engineering educational data mining statistics information visualization. Serious games is an emerging field where the games are created using sound learning theories and instructional design principles to maximize learning and training success. But how would stakeholders know what play-learners have done in the game environment, and if the actions performance brings about learning? Could they be playing the game for fun, really learning with evidence of performance improvement, or simply gaming the system, i. e. , finding loopholes to fake that they are making progress? This volume endeavors to answer these questions.

Taking Flutter to the Web: Learn how to build cross-platform UIs for web and mobile platforms using Flutter for Web

by Damodar Lohani

A web developer's guide to using Flutter for building responsive and adaptive web UIs using mobile solutionsKey FeaturesBuild a native, mobile-like experience for your web apps using FlutterExplore a systematic and synchronized learning path for web developers to learn FlutterDesign an MVVM structure for scalability and performance with this practical guideBook DescriptionUsing a shared codebase in addition to an extensive range of tools in the Flutter ecosystem optimized for browsers, the Flutter framework has expanded to enable you to bring your mobile apps to the web. You'll find out how web developers can leverage the Flutter framework for web apps with this hands-on guide.Taking Flutter to the Web will help you learn all about the Flutter ecosystem by covering the tools and project structure that allows you to easily integrate Flutter into your web stack. You'll understand the concepts of cross-platform UI development and how they can be applied to web platforms. As you explore Flutter on the web, you'll become well-versed with using Flutter as an alternative UI platform for building adaptive and responsive designs for web apps.By the end of this Flutter book, you'll have built and deployed a complete Flutter app for the web and have a roadmap ready to target the web for your existing Flutter mobile apps.What you will learnUnderstand the concepts necessary for designing, building, and deploying a Flutter web appGet the hang of Flutter internals to make the most of the frameworkBuild complete web applications with Flutter from architecture to deploymentAutomate UI design for your web apps using FlutterExplore Flutter's integration with Appwrite for backend developmentDiscover advanced concepts in frontend web development, such as state management and PWAWho this book is forThis book is for Flutter mobile developers and Dart programmers who want to consolidate their Flutter knowledge and use it to build responsive web applications.

Business Process Management Workshops: BPM 2013 International Workshops, Beijing, China, August 26, 2013, Revised Papers (Lecture Notes in Business Information Processing #171)

by Niels Lohmann Minseok Song Petia Wohed

This book constitutes the refereed proceedings of nine international workshops held in Beijing, China, in conjunction with the 11th International Conference on Business Process Management, BPM 2013, in August 2013. The nine workshops comprised Business Process Intelligence (BPI 2013), Business Process Management and Social Software (BPMS2 2013), Data- and Artifact-Centric BPM (DAB 2013), Decision Mining and Modeling for Business Processes (DeMiMoP 2013), Emerging Topics in Business Process Management (ETBPM 2013), Process-Aware Logistics Systems (PALS 2013), Process Model Collections: Management and Reuse (PMC-MR 2013), Security in Business Processes (SBP 2013) and Theory and Applications of Process Visualization (TAProViz 2013). The 38 revised full papers presented were carefully reviewed and selected from 74 submissions.

Data-ism: Inside the Big Data Revolution

by Steve Lohr

Coal, iron ore and oil were the fuel of the Industrial Revolution. Today's economies and governments are powered by something far less tangible: the explosive abundance of digital data.Steve Lohr, the New York Times' chief technology reporter, charts the ascent of Data-ism, the dominating philosophy of the day in which data is at the forefront of everything and decisions of all kinds are based on data analysis rather than experience and intuition. Taking us behind the scenes and introducing the DOPs (Data Oriented-People), the key personalities behind this revolution, he reveals how consuming the bits and bytes of the masses is transforming the nature of business and governance in unforeseen ways. But what are losing in the process and what new dangers await?

Data-ism: The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else

by Steve Lohr

By one estimate, 90 percent of all of the data in history was created in the last two years. In 2014, International Data Corporation calculated the data universe at 4.4 zettabytes, or 4.4 trillion gigabytes. That much information, in volume, could fill enough slender iPad Air tablets to create a stack two-thirds of the way to the moon. Now, that's Big Data.Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. The vital raw material of today's information economy is data.In Data-ism, New York Times reporter Steve Lohr explains how big-data technology is ushering in a revolution in proportions that promise to be the basis of the next wave of efficiency and innovation across the economy. But more is at work here than technology. Big data is also the vehicle for a point of view, or philosophy, about how decisions will be—and perhaps should be—made in the future. Lohr investigates the benefits of data while also examining its dark side. Data-ism is about this next phase, in which vast Internet-scale data sets are used for discovery and prediction in virtually every field. It shows how this new revolution will change decision making—by relying more on data and analysis, and less on intuition and experience—and transform the nature of leadership and management. Focusing on young entrepreneurs at the forefront of data science as well as on giant companies such as IBM that are making big bets on data science for the future of their businesses, Data-ism is a field guide to what is ahead, explaining how individuals and institutions will need to exploit, protect, and manage data to stay competitive in the coming years. With rich examples of how the rise of big data is affecting everyday life, Data-ism also raises provocative questions about policy and practice that have wide implications for everyone.The age of data-ism is here. But are we ready to handle its consequences, good and bad?

Cyber Mayday and the Day After: A Leader's Guide to Preparing, Managing, and Recovering from Inevitable Business Disruptions

by Daniel Lohrmann Shamane Tan

Successfully lead your company through the worst crises with this first-hand look at emergency leadership Cyber security failures made for splashy headlines in recent years, giving us some of the most spectacular stories of the year. From the Solar Winds hack to the Colonial Pipeline ransomware event, these incidents highlighted the centrality of competent crisis leadership. Cyber Mayday and the Day After offers readers a roadmap to leading organizations through dramatic emergencies by mining the wisdom of C-level executives from around the globe. It’s loaded with interviews with managers and leaders who've been through the crucible and survived to tell the tale. From former FBI agents to Chief Information Security Officers, these leaders led their companies and agencies through the worst of times and share their hands-on wisdom. In this book, you’ll find out: What leaders wish they'd known before an emergency and how they've created a crisis game plan for future situations How executive-level media responses can maintain – or shatter – consumer and public trust in your firm How to use communication, coordination, teamwork, and partnerships with vendors and law enforcement to implement your crisis response Cyber Mayday and the Day After is a must-read experience that offers managers, executives, and other current or aspiring leaders a first-hand look at how to lead others through rapidly evolving crises.

Principles of Modeling: Essays Dedicated to Edward A. Lee on the Occasion of His 60th Birthday (Lecture Notes in Computer Science #10760)

by Marten Lohstroh Patricia Derler Marjan Sirjani

This Festschrift is published in honor of Edward A. Lee, Robert S. Pepper Distinguished Professor Emeritus and Professor in the Graduate School in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley, USA, on the occasion of his 60th birthday.The title of this Festschrift is “Principles of Modeling" because Edward A. Lee has long been devoted to research that centers on the role of models in science and engineering. He has been examining the use and limitations of models, their formal properties, their role in cognition and interplay with creativity, and their ability to represent reality and physics. The Festschrift contains 29 papers that feature the broad range of Edward A. Lee’s research topics; such as embedded systems; real-time computing; computer architecture; modeling and simulation, and systems design.

Computational Techniques for Intelligence Analysis: A Cognitive Approach

by Vincenzo Loia Francesco Orciuoli Angelo Gaeta

This book focuses on the definition and implementation of data-driven computational tools supporting decision-making along heterogeneous intelligence scenarios. Intelligence analysis includes methodologies, activities, and tools aimed at obtaining complex information from a set of isolated data gathered from different sensors. The tools aim at increasing the level of situation awareness of decision-makers through the construction of abstract structures supporting human operators in reasoning and making decisions. This book appeals to students, professionals, and academic researchers in computational intelligence and approximate reasoning applications. It is a comprehensive textbook on the subject, supported with case studies and practical examples in Python. The readers will learn how to define decision support systems for the intelligence analysis through the application of situation awareness and granular computing for information processing.

Cybersecurity in Humanities and Social Sciences: A Research Methods Approach

by Hugo Loiseau Daniel Ventre Hartmut Aden

The humanities and social sciences are interested in the cybersecurity object since its emergence in the security debates, at the beginning of the 2000s. This scientific production is thus still relatively young, but diversified, mobilizing at the same time political science, international relations, sociology , law, information science, security studies, surveillance studies, strategic studies, polemology. There is, however, no actual cybersecurity studies. After two decades of scientific production on this subject, we thought it essential to take stock of the research methods that could be mobilized, imagined and invented by the researchers. The research methodology on the subject "cybersecurity" has, paradoxically, been the subject of relatively few publications to date. This dimension is essential. It is the initial phase by which any researcher, seasoned or young doctoral student, must pass, to define his subject of study, delimit the contours, ask the research questions, and choose the methods of treatment. It is this methodological dimension that our book proposes to treat. The questions the authors were asked to answer were: how can cybersecurity be defined? What disciplines in the humanities and social sciences are studying, and how, cybersecurity? What is the place of pluralism or interdisciplinarity? How are the research topics chosen, the questions defined? How, concretely, to study cybersecurity: tools, methods, theories, organization of research, research fields, data ...? How are discipline-specific theories useful for understanding and studying cybersecurity? Has cybersecurity had an impact on scientific theories?

SPEECH ENHANCEMENT: Theory And Practice

by Philipos C. Loizou

With the proliferation of mobile devices and hearing devices, including hearing aids and cochlear implants, there is a growing and pressing need to design algorithms that can improve speech intelligibility without sacrificing quality. Responding to this need, Speech Enhancement: Theory and Practice, Second Edition introduces readers to the basic problems of speech enhancement and the various algorithms proposed to solve these problems. Updated and expanded, this second edition of the bestselling textbook broadens its scope to include evaluation measures and enhancement algorithms aimed at improving speech intelligibility. Fundamentals, Algorithms, Evaluation, and Future Steps Organized into four parts, the book begins with a review of the fundamentals needed to understand and design better speech enhancement algorithms. The second part describes all the major enhancement algorithms and, because these require an estimate of the noise spectrum, also covers noise estimation algorithms. The third part of the book looks at the measures used to assess the performance, in terms of speech quality and intelligibility, of speech enhancement methods. It also evaluates and compares several of the algorithms. The fourth part presents binary mask algorithms for improving speech intelligibility under ideal conditions. In addition, it suggests steps that can be taken to realize the full potential of these algorithms under realistic conditions.

Crowd-Powered Mobile Computing and Smart Things

by Seng W. Loke

This SpringerBrief provides a synergistic overview of technology trends by emphasizing five linked perspectives: crowd+cloud machines, extreme cooperation with smart things, scalable context-awareness, drone services for mobile crowds and social links in mobile crowds. The authors also highlight issues and challenges at the intersection of these trends. Topics covered include cloud computing, Internet of Things, mobile and wearable computing, crowd computing, the culture of thing sharing, collective computing, and swarm dynamics. The brief is a useful resource and a starting point for researchers, students or anyone interested in the contemporary computing landscape.

From Distributed Quantum Computing to Quantum Internet Computing: An Introduction

by Seng W. Loke

From Distributed Quantum Computing to Quantum Internet Computing Understand the future of the internet with this accessible guide Quantum computing, which draws upon the principles of quantum mechanics to perform computing functions unrestricted by the binary language of ordinary computing, has developed with extraordinary speed in recent years. Progress in quantum computing and its related technological subfields, including quantum internet, has been rapid enough to suggest that we are living in a “new Quantum Age.” To understand the future of the internet, it’s now essential to understand the present and future of quantum computing and quantum internet computing. This book provides a groundbreaking overview of this field of technology and its latest developments. It provides readers with a working knowledge of the key topics required to connect quantum computing to the future of distributed computing and the internet, including important issues like quantum protocols, distributed quantum computations, fundamental computations in the quantum internet architecture, and more. The result is an accessible and essential reference for any reader looking to better understand quantum technologies. From Distributed Quantum Computing to Quantum Internet Computing readers will also find: Detailed discussion of topics including qubit states, entanglement, quantum gates, and more. Mathematical background for underlying key concepts. Worked out examples that aim to initiate readers into the emerging area of quantum internet computing. This book is ideal for researchers and graduate students in quantum computing, quantum internet, quantum communications, and related fields, as well as Computer Scientists and Information Technology students and researchers who want an introductory overview to quantum internet computing.

Mobile Networks and Management: 10th EAI International Conference, MONAMI 2020, Chiba, Japan, November 10–12, 2020, Proceedings (Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering #338)

by Seng W. Loke Zhi Liu Kien Nguyen Guoming Tang Zhen Ling

This book constitutes the refereed post-conference proceedings of the 10th International Conference on Mobile Networks and Management, MONAMI 2020, held in Chiba, Japan, in November 2020. The conference was held virtually due to the COVID-19 pandemic.The 19 full papers were carefully reviewed and selected from 41 submissions. The papers are divided into groups of content as follows: Application of artificial intelligence for smart city; Advanced technology in edge computing; Recent advances in mobile communications and computing; Emerging technologies and applications in mobile networks and management.

The Automated City: Internet of Things and Ubiquitous Artificial Intelligence

by Seng W. Loke Andry Rakotonirainy

The book outlines the concept of the Automated City, in the context of smart city research and development. While there have been many other perspectives on the smart city such as the participatory city and the data-centric city, this book focuses on automation for the smart city based on current and emerging technologies such as the Internet of Things, Artificial Intelligence and Robotics. The book attempts to provide a balanced view, outlining the promises and potential of the Automated City as well as the perils and challenges of widespread automation in the city. The book discusses, at some depth, automated vehicles, urban robots and urban drones as emerging technologies that will automate many aspects of city life and operation, drawing on current work and research literature. The book also considers broader perspectives of the future city, in the context of automation in the smart city, including aspirational visions of cities, transportation, new business models, and socio-technological challenges, from urban edge computing, ethics of the Automated City and smart devices, to large scale cooperating autonomous systems in the city.

Worst-Case Execution Time Aware Compilation Techniques for Real-Time Systems

by Paul Lokuciejewski Peter Marwedel

For real-time systems, the worst-case execution time (WCET) is the key objective to be considered. Traditionally, code for real-time systems is generated without taking this objective into account and the WCET is computed only after code generation. Worst-Case Execution Time Aware Compilation Techniques for Real-Time Systems presents the first comprehensive approach integrating WCET considerations into the code generation process. Based on the proposed reconciliation between a compiler and a timing analyzer, a wide range of novel optimization techniques is provided. Among others, the techniques cover source code and assembly level optimizations, exploit machine learning techniques and address the design of modern systems that have to meet multiple objectives. Using these optimizations, the WCET of real-time applications can be reduced by about 30% to 45% on the average. This opens opportunities for decreasing clock speeds, costs and energy consumption of embedded processors. The proposed techniques can be used for all types real-time systems, including automotive and avionics IT systems.

Real World Windows 8 App Development with JavaScript

by Elizabeth Lomasky Edward Moemeka

Learn from the new set of cutting-edge Windows 8 expert developers, and get the low-down from an author with experience from the front line of Windows 8 app development. Theory is all well and good, but when it comes down to it, you can't beat practical advice from someone who's been there and done it. Real World Windows 8 App Development with JavaScript dives into the topics that are essential for making the most of this new platform for application development. You will discover important tips, such as adding monetization options after the project is published on the store to avoid issues with the go-live API, steering clear of problems with the current roaming infrastructure, and how to include health and activity monitoring components built into your app to give you more advanced usage telemetry than that offered by the Windows store. This book is for developers, by a developer who has already fought these battles. You will come away from this book with all the tools, ideas, and inspiration to create successful Windows 8 JavaScript apps.You will learn how to make the most of Microsoft's APIs for hooking into Windows 8 on all devices, including the core ideas of the Promise and the asynchronous programming model, along with new ideas such as contracts and charms that make life easier for you as a developer and give the user a strong unified experience. The release of Windows 8 ushers in a virtually limitless market for developers wanting to publish apps to a worldwide market. Real World Windows 8 App Development with JavaScript addresses developers who aim to break into this market by providing detailed and highly practical explanations of Windows 8 development and samples from an author who's been there an earned the experience. The real world examples in the book adhere to the stylistic guidelines Microsoft has put in place to maintain a consistent look and feel for all applications on this platform. This book includes: Detailed descriptions of Windows 8 App Development Samples emphasizing the use of JavaScript and HTML 5 Adherence to Windows 8 guidelines for successful app acceptance

VB & VBA in a Nutshell: The Language

by Paul Lomax

For Visual Basic and VBA programmers, this book boils down the essentials of the VB and VBA languages into a single volume, including undocumented and little-documented areas essential to everyday programming. The convenient alphabetical reference to all functions, procedures, statements, and keywords allows programmers to use this book both as a standard reference guide and as a tool for troubleshooting and identifying programming problems.

VBScript Pocket Reference

by Paul Lomax Ron Petrusha Matt Childs

Microsoft's Visual Basic Scripting Edition (VBScript), a subset of Visual Basic for Applications, is a powerful language for Internet application development, where it can serve as a scripting language for server-side, client-side, and system scripting. Whether you're developing code for Active Server Pages, client-side scripts for Internet Explorer, code for Outlook forms, or scripts for Windows Script Host, VBScript Pocket Reference will be your constant companion. Don't let the pocket-friendly format fool you. Based on the bestselling VBScript in a Nutshell, this small book details every VBScript language element--every statement, function, and object--both in VBScript itself, and in the Microsoft Scripting Runtime Library. There's a special emphasis on the following details: The syntax, using standard code conventions The arguments accepted by the function or procedure, if any exist Entries are arranged alphabetically by topic, so that you can, for instance, easily find details about that string-handling function that you can't quite remember. In addition, appendixes list VBScript operators and VBScript intrinsic constants. Regardless of how much VBScript programming experience you have, the VBScript Pocket Reference is the book you'll pick up time and time again as your standard quick reference guide to the VBScript language. It is indispensable for anyone writing scripts with VBScript.

VB.NET Language in a Nutshell, 2nd Edition

by Paul Lomax Ron Petrusha Steven Roman

It introduces the .NET Framework Class Library and programming with attributes. The bulk of the book presents an alphabetical reference to Visual Basic .NET statements, procedures, functions, and objects. Also included is a CD-ROM that allows the reference section of the book to integrate with Visual Studio .NET.

Machine Learning Meets Medical Imaging

by Herve Lombaert Kanwal K. Bhatia

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VMware Cloud on AWS: Insights on the First VMware Enterprise-Proven SaaS Solution

by Christophe Lombard

Learn how VMware has brought its enterprise-class software-defined Data Center software to the AWS Cloud. This book will show how to enable customers to run production applications across VMware vSphere®-based private, public, and hybrid cloud environments, with optimized access to AWS services. The book begins by introducing the value of VMware Cloud on AWS and talking about the different use cases that can be addressed by this SaaS solution and how it can accelerate cloud migration. In subsequent chapters, you’ll adopt a more pragmatic approach with practical examples of how to successfully plan, design and deploy VMware Cloud on AWS.VMware Cloud on AWS also covers technical requirements as well as the different options to prepare for a successful deployment and make the right decision to interconnect the solution to any existing environment through a dedicated link. In a dedicated chapter, it approaches the challenge of migrating workloads on the platform and address all the current capabilities offered by the solution and more specifically HCX, the Hybrid Cloud Extension offering that works in concert with VMware Cloud on AWS to facilitate moving complex workloads to the cloud.You’ll also review the advanced networking and security options available in the platform that help reinforce the level of security with features like traditional Gateway Firewall, Distributed Firewall, Micro-segmentation, Identity Firewall, and IDS/IPS. The book concludes with best practices to address operation tasks and get valuable insights into the VMware Cloud on AWS deployment.What You'll LearnPlan and Deploy VMware Cloud on AWSMigrate your workloads to the cloud with VMware Cloud on AWS and HCXSecure workloads on VMware Cloud on AWSOperate VMware Cloud on AWSWho This Book Is For IT Administrators, CIOs, Consultants, Cloud Architects, Implementation Specialists, Presales Specialists, and Sales Specialists.

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