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Nutritional Toxicology
by Lishi ZhangThis book provides a broad overview of the chemicals in food that have the potential to induce adverse health effects. Nutritional Toxicology is an interaction of nutrition, toxicology, biochemistry and food science, etc. Its main research scope involves the effects of nutrients on metabolisms of toxicants and their mechanisms, the interaction of the toxicants and contaminants originated from diet with nutrients and nutrition process, the adverse health outcome of nutrients excess, as well as methodology of research and related food and nutrition regulation process. Also the risk assessment of toxicants and contaminants in foods, and risk benefit assessment of nutrients (dietary supplementation) has become an emerging topic. This book provides novel and provocative insights into the fields of nutrition, food science and toxicology. It also offers a state-of-the-art report on recent discoveries concerning nutritional toxicology and where the field is going. It mainly focuses on advances made over the past 20 years. It will benefit graduate students, researchers and food and nutrition related regulation parties.
Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium (Advances in Experimental Medicine and Biology #814)
by Lubo Zhang Charles A. DucsayTo celebrate the Center for Perinatal Biology's 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M. D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease.
Modeling the Injury Flow and Treatment after Major Earthquakes
by Lulu ZhangThis book discuss a series of earthquake emergency medical rescue complex models, which can provide theoretical support for medical disaster rescue work in the future. This book consists of three parts. The first part is an introduction (chapter 1) which makes an overview of the purpose, meaning, methods and relative theory using in the research. The second part (chapter 2 to 8) includes "casualty flow" related factors such as the occurrences of earthquake casualty, the Length of Stay among the Hospitalized Patients, the medical evacuation in earthquake and rescue force related factors such as the medical rescue forces allocation in earthquake, the organization and command of earthquake rescue forces, Location and Distribution of Medical Rescue Institutions and from peacetime to wartime in hospital. The third part (chapter 9) is a summary including conclusion and policy-making suggestion.
An Investigation Report on Large Public Hospital Reforms in China (Current Chinese Economic Report Series #0)
by Lulu Zhang Meina Li Feng Ye Tao Ding Peng KangThis book provides a comprehensive understanding of public hospital reform in China, which is a hot topic for China's new round of health sector reform. The authors use rich data from both health provider side and service user side and conduct a cross-sectional study in China with some comparative analysis between different locations. It provides the audience with a big picture of China's public hospital and other components of health system as well. The book reviews the main policy measurements in the public hospital reforms and evaluates how these policies influence public hospitals' practices, especially on hospital governance and internal management.
Chronic Rhinosinusitis: The mucosal concept
by Luo Zhang Claus BachertChronic rhinosinusitis (CRS) is one of the most common health care complaints, with the prevalence of 5-12% worldwide. This book aims to present the new findings in mechanism, diagnosis and management of this widespread condition to clinical practitioners. All practical information about CRS is compiled; therefore busy clinicians would not have to perform exhaustive literature studies to diagnose CRS.This book firstly presents the advances in the understanding of epidemiology, genetics, mechanisms, phenotypes, and immunology of this disorder. In the following chapters, details in clinical diagnosis of CRS are summarized, especially clinical characteristics in paediatric CRS. Later chapters introduce medical, surgical, and innovative treatments of CRS, with brief case studies. The role of allergies, asthma, allergic fungal rhinosinusitis, and systemic diseases are also discussed. With the illustrative figures, this book is a comprehensive and quick reference to otolaryngologists, paediatricians, family care physicians, allergists, professional clinical staff, and medical students.
Atlas of Human Body Ultrasound Scanning: Methods and Diagnostic Applications
by Mei ZhangThis atlas describes the diagnosis practice and cases of human body ultrasound. It includes anatomic section, standard scan ultrasonogram of every organ, scanning methods and key points, measurement methods, normal value ranges, and clinical significances of every sections. Providing basic information and fundamental principles of ultrasonic diagnosis, it discusses ultrasound scanning of 14 organs in individual chapters. Each section sonography is accompanied by the scanning method, section structure, measuring method and clinical application. The uniform structure and detailed instructions make this atlas an easy-to-use resource for residents to refer to when they encounter specific ultrasound diagnostic problems.
Get Through MRCPsych CASC: Mock Examination Papers (Get Through)
by Melvyn W. Zhang Cyrus S. Ho Roger C. Ho Basant K. PuriThis book is intended for psychiatric trainees sitting the CASC component of the MRCPsych exam. Written by authors with recent exam experience and long-term expertise in the field, the text provides 175 stations closely matched to the subjects that appear in the actual exam, along with concise synopses and guidelines for how to target your revision to enable recall of the most relevant information.
Get Through MRCPsych Paper B: Mock Examination Papers (Get Through Ser.)
by Melvyn WB Zhang Cyrus SH Ho Roger CM Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists, are the most important exams for psychiatric trainees to achieve specialist accreditation. Written by authors with recent exam success and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper B: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper B exam.
Get Through MRCPsych Paper A2: Mock Examination Papers
by Melvyn Wb Zhang Cyrus Sh Ho Roger Ho Ian H Treasaden Basant K PuriThe MRCPsych examinations, conducted by the Royal College of Psychiatrists are the most important exams for psychiatric trainee to achieve specialist accreditation. Written by authors with previous exam experience and edited by the distinguished team behind Revision Notes in Psychiatry, Get Through MRCPsych Paper A: Mock Examination Papers provides candidates with the most realistic and up-to-date MCQ and EMIs, closely matched to themes appearing most often in the Paper A exam.
Diagnostic Imaging of Novel Coronavirus Pneumonia
by Minming Zhang Bin LinThis book presents radiological findings in patients with 2019 Novel Coronavirus Pneumonia (COVID-19). It starts with a general review of COVID-19 Pneumonia discovery, including etiology characteristics, transmission routes and pathogenic mechanisms. In the following chapters, details in clinical classification, imaging manifestations in different groups, and imaging features of family aggregated coronavirus pneumonia are introduced. In addition, key points in differential diagnosis of COVID-19 Pneumonia are summarized in the last chapter. The book provides a valuable reference source for radiologists and doctors working in the area of COVID-19 Pneumonia.
Essentials in Bone and Soft-Tissue Pathology
by Paul J. Zhang Jasvir S. Khurana Edward F. MccarthyEssentials in Bone and Soft-Tissue Pathology is a concise and well-illustrated handbook that captures the salient points of the most common problems in bone and soft-tissue pathology. The volume includes the most important diagnostic features of common musculoskeletal lesions. This book is a short text directed primarily at residents in pathology and other individuals interested in the field of orthopedic pathology, including medical students, orthopedic surgeons, radiologists, and practicing pathologists who do not see these cases on a day to day basis.
Nanotoxicity: Methods And Protocols (Methods in Molecular Biology #1894)
by Qunwei ZhangThis volume explores the latest techniques used to investigate nanotoxicity. The protocols covered in this book range from routine nanotoxicity assays to genomic and proteomic approaches in vivo and in vitro. The chapters discuss specific topics such as preparation and utilization of 3D human liver microtissue models; assessment of ovarian granulosa cells with exposure to nanoparticles; DNA methylation analysis; evaluation of genotoxicity of nanoparticles in mouse models; and studying nanotoxicity using embryonic zebrafish. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Nanotoxicity: Methods and Protocols is a valuable resource for researchers and postgraduate students in the fields of toxicology, environmental science, pharmacological sciences, and clinical medicine. This volume also serves as a starting point for researchers interested in learning more about this developing field.
Energy-Efficient Algorithms and Protocols for Wireless Body Sensor Networks
by Rongrong Zhang Jihong YuThis book provides a systematic treatment of the theoretical foundation and algorithmic tools necessary in the design of energy-efficient algorithms and protocols in wireless body sensor networks (WBSNs). These problems addressed in the book are of both fundamental and practical importance. Specifically, the book delivers a comprehensive treatment on the following problems ranging from theoretical modeling and analysis, to practical algorithm design and optimization: energy-efficient clustering-based leader election algorithms in WBSNs; MAC protocol for duty-cycling WBSNs with concurrent traffic; multi-channel broadcast algorithms in duty-cycling WBSNs; and energy-efficient sleep scheduling algorithms in WBSNs. Target readers of the book are researchers and advanced-level engineering students interested in acquiring in-depth knowledge on the topic and on WBSNs and their applications, both from theoretical and engineering perspective.
Surgery for Recurrent Soft Tissue Sarcoma: Barrier Resection and Reconstruction
by Ruming ZhangThis book addresses surgical management for recurrent soft tissue sarcomas (RSTS) based on a wealth of clinical cases. With aim to reduce recurrence rate, a surgical strategy of barrier resection plus repair reconstruction referring to natural barriers in human body for enhancing curative effect is presented in details. The first part introduces the general theory of surgical treatment for RSTS. The second part is a portfolio of clinical cases, showing the essential of the surgical strategy from hundreds of cases with tumour of different anatomical sites. Each case report is composed of detailed medical history, radiographic images and operational photos. It will help readers to make proper decisions on the basis of specific purposes. This book will be of benefit to oncologists, orthopaedic surgeons, general surgeon, plastic surgeons, and medical students.
Hydroxyapatite Coatings for Biomedical Applications (Advances In Materials Science And Engineering Ser.)
by Sam ZhangHydroxyapatite coatings are of great importance in the biological and biomedical coatings fields, especially in the current era of nanotechnology and bioapplications. With a bonelike structure that promotes osseointegration, hydroxyapatite coating can be applied to otherwise bioinactive implants to make their surface bioactive, thus achieving faster healing and recovery. In addition to applications in orthopedic and dental implants, this coating can also be used in drug delivery. Hydroxyapatite Coatings for Biomedical Applications explores developments in the processing and property characterization and applications of hydroxyapatite to provide timely information for active researchers and newcomers alike. In eight carefully reviewed chapters, hydroxyapatite experts from the United States, Japan, Singapore, and China present the latest on topics ranging from deposition processes to biomedical applications in implants and drug delivery. This book discusses: Magnetron sputtering and electrochemical deposition The modification of hydroxyapatite properties by sol–gel deposition to incorporate other elements found in natural bones, such as zinc, magnesium, and fluorine The use of pure hydroxyapatite in drug delivery applications The growth or self-assembly of hydroxyapatite on shape memory alloy Hydroxyapatite composite coatings—with carbon nanotubes, titanium dioxide (TiO2), and others—on the titanium alloy Offering valuable insights and a wealth of data, including numerous tables and figures, this is a rich source of information for research on hydroxyapatite coatings. Each chapter also covers material that provides an accessible stepping stone for those who are new to the field.
Progress in Cancer Immunotherapy
by Shuren ZhangThisbook provides readers an extensive overview of recent progress in basicand clinical research on cancer immunotherapy. Thanks to rapid advances inmolecular biology and immunology, it has become increasingly evident thatcancer growth is influenced by host immune responses. With the success of anumber of clinical trials, immunotherapy has become a promising treatmentmodality of cancer. This book covers five major topics, including monoclonalantibodies, biological response modifiers, cancer vaccines, adoptive cellulartherapy and oncolytic viruses. It also examines the combination of differentimmune strategies as well as the combination of immunotherapy with othertreatments to increase anti-tumor effects. Throughthecomprehensive discussion of the topic, the book sheds valuable new light on thetreatment of tumors.
Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine
by Shusheng Zhang Sai Bi Xinyue SongThis book describes the rational design, development and application of nucleic acid amplification strategies for biosensing, bioimaging and biomedicine. It consists of fifteen chapters demonstrating the use of these strategies in various areas, including fluorescence techniques, Chemiluminescence biosensors, electrochemiluminescence biosensors, colorimetric assays, surface plasmon resonance technologies, electrochemical DNA sensors, photoelectrochemical biosensor, nanopore sensors, quartz crystal microbalance, fluorescence imaging, surface-enhanced Raman spectroscopy, in vitro and in vivo metal ions detection, theranostics and microdroplet chips. Offering a collection of reviews illustrating the latest advances in biochemical analysis and therapeutics, the book shares valuable insights into current challenges and future prospects, making it a valuable resource for a wide readership in the various fields of biosensing, bioimaging and biomedicine.
Diagnostic Imaging of Lung Cancers
by Song ZhangThis book systematically covers diagnostic imaging of lung cancers, including epithelial tumors, mesenchymal tumors, and hematolymphoid tumors, with emphasis on relationship between classification, molecular pathology, clinical findings, imaging manifestations and pathological discussion. In each chapter, selective cases and wealthy of typical illustrations are presented for helping readers to have an in-depth understanding of key points in differential diagnosis of different types of lung cancers. It will be an ideal reference for physicians involved in the diagnosis and treatment of lung cancers.
Diagnostic Imaging of Mediastinal Diseases
by Song ZhangThis book systematically introduces the clinical and imaging characteristics of mediastinal diseases, with emphasis on the essential relationship between clinical diseases and imaging, and on imaging diagnosis and differential diagnosis. This book systematically expounds the etiology, clinical and imaging manifestations, diagnosis, differential diagnosis and treatment of diseases, supplemented by a large number of cases to focus on analysis, focus on clinical thinking, and strive to combine theory with practice, so that readers have a systematic and in-depth understanding of diagnosis and treatment and differential diagnosis of related diseases.
Design and Analysis of Pragmatic Trials (Chapman & Hall/CRC Biostatistics Series)
by Song Zhang Chul Ahn Hong ZhuThis book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that need to be addressed by statisticians at the design stage. It discusses the advantages and disadvantages of each type of PCT, and provides sample size formulas, sensitivity analyses, and examples for sample size calculation. The generalized estimating equation (GEE) method will be employed to derive sample size formulas for various types of outcomes from the exponential family, including continuous, binary, and count variables. Experimental designs that have been frequently employed in PCTs will be discussed, including cluster randomized designs, matched-pair cluster randomized design, stratified cluster randomized design, stepped-wedge cluster randomized design, longitudinal cluster randomized design, and crossover cluster randomized design. It demonstrates that the GEE approach is flexible to accommodate pragmatic issues such as hierarchical correlation structures, different missing data patterns, randomly varying cluster sizes, etc. It has been reported that the GEE approach leads to under-estimated variance with limited numbers of clusters. The remedy for this limitation is investigated for the design of PCTs. This book can assist practitioners in the design of PCTs by providing a description of the advantages and disadvantages of various PCTs and sample size formulas that address various pragmatic issues, facilitating the proper implementation of PCTs to improve health care. It can also serve as a textbook for biostatistics students at the graduate level to enhance their knowledge or skill in clinical trial design. Key Features: Discuss the advantages and disadvantages of each type of PCTs, and provide sample size formulas, sensitivity analyses, and examples. Address an unmet need for guidance books on sample size calculations for PCTs; A wide variety of experimental designs adopted by PCTs are covered; The sample size solutions can be readily implemented due to the accommodation of common pragmatic issues encountered in real-world practice; Useful to both academic and industrial biostatisticians involved in clinical trial design; Can be used as a textbook for graduate students majoring in statistics and biostatistics.
Towards Healthy Settlements: Health Implications of Residential Suburbanization in Guangzhou (Urban Sustainability)
by Tianyao ZhangThis book aims to formulate recommendations for achieving a healthy neighborhood living environment for the middle-income people in China‘s suburbs. In China, the expeditious urbanization triggers the prosperous commodity housing development, which further grows with the spatial restructuring and socioeconomic transition. Residential suburbanization is generated, accompanied with the emergence of new-middle class and the change of lifestyle. However, the health effects of suburbanization in China are overlooked. This book investigates the health performance of suburban residents and the effects of suburban living on residents‘ health. This book also examines the resident-environment transaction modes to unfold the underlying mechanism of suburban living affecting residents’ health. Suburban residents had to passively adapt to their residential environment, which is the obstacle for achieving a health-promoting environment. The institutional dynamics determining the health performance of suburban living environment were addressed with the roles of governments, developers, planners, housing managers, residents‘ committee, and ordinary residents in commodity housing development. The book found no institutional support for the creation of health-promoting environments, especially with default of governments and excessive dependence on developers for public service facilities and the absence of civil society. Thus, the book proposes that institutional innovations are necessary in term of embedding the health dimension in all sectors of the society, enlisting collaboration between public and private sectors, and between health and non-health sectors, and thus cultivating the optimization of residents-environment transactions to create health-promoting environments.
Advanced Statistics in Regulatory Critical Clinical Initiatives (Chapman & Hall/CRC Biostatistics Series)
by Wei ZhangAdvanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on biopharmaceutical research and development. Advanced Statistics in Regulatory Critical Clinical Initiatives provides innovative ways to resolve common challenges in statistical research of rare diseases such small sample sizes and provides guidance for combined use of data. With analysis from regulatory and scientific perspectives this book is an ideal companion for researchers in biostatistics, pharmaceutical development, and policy makers in related fields.Key Features: Provides better understanding of innovative design and analysis of each critical clinical initiatives which may be used in regulatory review/approval of drug development. Makes recommendations to evaluate submissions accurately and reliably. Proposes innovative study designs and statistical methods for oncology and/or rare disease drug development. Provides insight regarding current regulatory guidance on drug development such as gene therapy and rare diseases.
Computer-Aided Drug Discovery (Methods in Pharmacology and Toxicology)
by Wei ZhangThis detailed volume examines computer-aided drug discovery(CADD), a crucial component of modern drug discovery programs that is widelyutilized to identity and optimize bioactive compounds for the development ofnew drugs. With a focus on the methods that are commonly used in the earlystage of drug discovery, chapters explore computer simulation, structureprediction, conformational sampling, binding site mapping, docking and scoring,in silico screening, and fragment-based drug design. In addition to the state-of-the-arttheoretical concept, this book also includes step-by-step, readily reproduciblecomputational protocols as well as examples of various CADD strategies. The limitations and potential pitfalls ofdifferent computational methods are discussed by experts, and tips and advicefor their applications are suggested. Practical and thorough, Computer-AidedDrug Discovery serves as an ideal addition to the Methods in Pharmacology and Toxicology series, guiding researcherstoward their lab's goals with this exciting and versatile technology.
Biotechnology in China I: From Bioreaction to Bioseparation and Bioremediation (Advances in Biochemical Engineering/Biotechnology #113)
by Wei Zhang Feng-Wu Bai Jian-Jiang ZhongThis book examines tends in modern biotechnology. It covers all aspects of this interdisciplinary technology, from chemistry to computer science.
Synthetic Biology of Cyanobacteria (Advances in Experimental Medicine and Biology #1080)
by Weiwen Zhang Xinyu SongThis volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.