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Prions and Diseases: Volume 1, Physiology and Pathophysiology
by Wen-Quan Zou Pierluigi GambettiVolume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold: Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents (Springer Theses)
by Taotao ZouThis thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Real-World Evidence in a Patient-Centric Digital Era (Chapman & Hall/CRC Biostatistics Series)
by Kelly H Zou Lobna A. Salem Amrit RayReal-world evidence is defined as evidence generated from real-world data outside randomized controlled trials. As scientific discoveries and methodologies continue to advance, real-world data and their companion technologies offer powerful new tools for evidence generation. Real-World Evidence in a Patient-Centric Digital Era provides perspectives, examples, and insights on the innovative application of real-world evidence to meet patient needs and improve healthcare, with a focus on the pharmaceutical industry. This book presents an overview of key analytical issues and best practices. Special attention is paid to the development, methodologies, and other salient features of the statistical and data science techniques that are customarily used to generate real-world evidence. It provides a review of key topics and emerging trends in cutting-edge data science and health innovation. Features: Provides an overview of statistical and analytic methodologies in real-world evidence to generate insights on healthcare, with a special focus on the pharmaceutical industry Examines timely topics of high relevance to industry such as bioethical considerations, regulatory standards, and compliance requirements Highlights emerging and current trends, and provides guidelines for best practices Illustrates methods through examples and use-case studies to demonstrate impact Provides guidance on software choices and digital applications for successful analytics Real-World Evidence in a Patient-Centric Digital Era will be a vital reference for medical researchers, health technology innovators, data scientists, epidemiologists, population health analysts, health economists, outcomes researchers, policymakers, and analysts in the healthcare industry.
Natural Orifice Translumenal Endoscopic Surgery
by Ricardo Zorron Anthony N. Kalloo Facs, Hon Jses Jacques Marescaux Hon Frcs, Facs, Hon Jses Jacques FrcsAre you interested in using NOTES to treat your patients? Do you need a multimedia tool to guide you through all aspects of clinical management? Just as laparoscopic surgery revolutionized surgical practice in the 1980's and 90's, offering genuine competition to traditional open surgery, Natural Orifice Translumenal Endoscopic Surgery (NOTES) presents a genuinely different alternative for surgeons and patients alike as we move forward in the 21st century. Advantages over laparoscopic surgery include lower anesthesia requirements, faster recovery and shorter hospital stays, avoidance of transabdominal wound infections, less immunosuppression, better postoperative pulmonary and diaphragmatic function and of course, the potential for "scarless" abdominal surgery. Combining high-level text with a superb companion website, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas provides you with a hands-on, in-depth and practical multimedia tool on this exciting breakthrough, to consult either on the ward or in surgery. Highlights include: Full coverage of the fundamentals of NOTES, its current clinical applications and techniques, and future perspectives Over 50 outstanding videos illustrating NOTES being performed by the experts Full-color throughout and superbly illustrated with over 250 figures Edited by global leaders and pioneers in the field, who have recruited a world-class contributor team As well being a valuable text for gastroenterologists, GI surgeons and general surgeons, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas will also appeal to urologists, urologic surgeons, gynecologists, gynecologic surgeons, thoracic and ENT surgeons.
Nipple Sparing Mastectomy: Minimally Invasive Video-Assisted Technique
by Sandro Zonta Adele Sgarella Alberta FerrariThis book describes in detail three different techniques for minimally invasive video-assisted breast surgery: nipple-sparing mastectomy with a hand-held external retractor, with a single-port device, and with robotic assistance. All three techniques can be employed for radical treatment of breast cancer or for risk reduction surgery, and the last two are brand new. The techniques are clearly explained with the aid of numerous high-quality illustrations. All surgical stages are covered in detail, and helpful information is provided on key aspects of surgical anatomy, diagnostic workup, instrumentation, and postoperative management. Nipple Sparing Mastectomy is the first manual to cover these techniques, which are likely to become standard in the field of oncological breast surgery. It will be invaluable for breast surgeons who are skilled in nipple-sparing mastectomy and oncoplastic techniques or are working in breast units that offer genetic counseling to high-risk patients.
Handbook of Healthcare Logistics: Bridging the Gap between Theory and Practice (International Series in Operations Research & Management Science #302)
by Maartje E. Zonderland Richard J. Boucherie Erwin W. Hans Nikky KortbeekThis book presents healthcare logistics solutions that have been successfully implemented at a variety of healthcare facilities. In each case, a major challenge is presented, along with the solution approach and implementation steps, followed by the impact on hospital operations. Problems encountered when implementing the results in practice are also discussed.Much of the work presented is drawn from the experiences of members of the Center for Healthcare Operations Improvement and Research (CHOIR) at Twente, along with the CHOIR spin-off company, Rhythm.
Appointment Planning in Outpatient Clinics and Diagnostic Facilities (SpringerBriefs in Health Care Management and Economics)
by Maartje E. ZonderlandAppointment Planning in Outpatient Clinics and Diagnostic Facilities provides a concise overview of the medical and mathematical aspects of appointment planning in healthcare. This SpringerBrief specifically focuses on outpatient clinics and diagnostic facilities. It begins by introducing the topic from a medical perspective, discussing the kinds of clinics and facilities that are out there, while exploring the appointment systems they use and the problems they face. Next, the mathematical aspects of appointment planning are examined, including Markov decision modelling, queueing theory, etc. Subsequently the book addresses implementation issues that may arise, whether they be technical, medical or cultural. Finally Appointment Planning in Outpatient Clinics and Diagnostic Facilities provides an outlook on the appointment systems of the future and what they will require as a consequence of current and future developments in the medical sector.
Ethics for Radiation Protection in Medicine (Series in Medical Physics and Biomedical Engineering)
by Friedo Zölzer Gaston Meskens Jim Malone Christina SkourouThis book presents an up to date ethical framework for radiological protection in medicine. It is consistent with the requirements of the system of radiation protection and with the expectations of medical ethics. It presents an approach rooted in the medical tradition, and alert to contemporary social expectations. It provides readers with a practical framework against which they can assess the safety and acceptability of medical procedures, including patients’ concerns. It will be an invaluable reference for radiologists, radiation oncologists, regulators, medical physicists, technologists, other practitioners, as well as academics, researchers and students of radiation protection in medicine. Features: An authoritative and accessible guide, authored by a team who have contributed to defining the area internationally Includes numerous practical examples/clinical scenarios that illustrate the approach, presenting a pragmatic approach, rather than dwelling on philosophical theories Informed by the latest developments in the thinking of international organizations
Vision, Perception, and Cognition: A Manual for the Evaluation and Treatment of the Adult with Acquired Brain Injury
by Barbara ZoltanVision Perception and Cognition, Fourth Edition is a concisely structured text that expertly addresses clinical reasoning and decision making for the entire evaluation and treatment process of the adult with acquired brain injury. Provided are theoretical information, guidelines for both static and dynamic assessment, information on specific standardized evaluations, guidelines for adaptive and restorative treatment based on described theoretical and evidence-based information, and information on environmental impact of client performance.
Autoethnographies on the Environment and Human Health
by Tara Rava ZolnikovThis book explores the link between individual lives and significant environmental issues affecting millions of people around the world. Zolnikov offers a novel perspective on the environment and human health through autoethnographic stories. Each chapter includes an overview of an environmental risk factor or issue, such as air quality, accompanied by a reflective personal story. Her experiences were gathered around the world and revolve around immersion into local cultures. Learning about environmental health through this qualitative approach will enable readers to understand how issues in the environment are currently affecting people on an individual basis.
Diseases of the Heart, Chest & Breast 2011-2014
by Christoph L. Zollikofer Gustav K. Schulthess Jürg HodlerWritten by internationally renowned experts, this volume deals with imaging of diseases of heart, chest and breast. The different topics are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. This book presents a comprehensive review of current knowledge in imaging of the heart and chest , as well as thoracic interventions and a selection of "hot topics" of breast imaging. It will be particularly relevant for residents in radiology, but also very useful for experienced radiologists and clinicians specializing in thoracic disease and wishing to update their knowledge of this rapidly developing field.
Cracked Open: Liberty, Fertility and the Pursuit of High Tech Babies
by Miriam Zoll Judy Norsigian Michele GoodwinCracked Open is Miriam Zoll's eye-opening account of growing into womanhood with the simultaneous opportunities offered by the U. S. women's movement and new discoveries in reproductive technologies. Influenced by the pervasive media and cultural messages suggesting that science had finally eclipsed Mother Nature, Zoll postponed motherhood until the age of 40. When things didn't progress as she had hoped, she enters a world of medical seduction and bioethical quagmires. Desperate to conceive, she surrenders to unproven treatments and procedures only to learn that the odds of becoming a mother through reproductive technologies are far less than she and her generation had been led to believe.
Missing Pieces: A Chronicle of Living With a Disability
by Irving Kenneth Zolahe personal odyssey of a man with a disability, this passionate book tries to tell as well as analyze what it is like to have a disability in a world that values vigor and health. Zola writes, "Missing Pieces is an unraveling of a social problem in the manner of Black Like Me. Like its author, I, too, am a trained social observer, but for me 'passing' was not an issue. For I already have the stigmata of the disable - the braces, the limp, the cane - though I have spent much of my life denying their existence." The author started out in the role of a social scientist on a seven-day excursion to acquaint himself with an extraordinary experiment in living - Het Dorp, one of the few places in the world designed to promote "the optimum happiness" of those with severe physical disabilities. Neither a medial center nor a nursing home, Het Dorp is a village in the western-most part of the Netherlands. What began as a sociological attempt to describe this unusual setting became, through the author's growing awareness, what can only be called a socio-autobiography. Resuming his prior dependence on a wheelchair, the author experienced his own transformation from someone who is "normal" and "valid" to someone who is "invalid." The routine of Het Dorp became his: he lived in an architecturally modified home, visited the workshops, and shared meals, social events, conversation, and perceptions with the remarkably diverse residents. The author confronts some rarely discussed issues - the self-image of a person with a chronic disability, how one fills one's time, how one deals with authority and dependence, and love and sex. Missing Pieces offers striking insights into an aspect of the human condition shared by nearly 30 million Americans. It is must reading for the general reader, as well as for the rehabilitation counselor, social worker, or social scientist. Author note: Irving Kenneth Zola (1935-1994) was Professor of Sociology at Brandeis University and a founding member and counselor at the Boston Self-Help Center. Nancy Mairs is the author of seven books, including Waist-High in the World: A Life Among the Disabled, and most recently, A Troubled Guest: Life and Death Stories. She lives in Tucson with her husband, George.
Monoclonal Antibodies: The Second Generation
by Heddy ZolaA review of what needs to be done to realise the potential of monoclonal antibodies. The book assesses the competing technologies with advice on the best approach for a particular situation.
Paranoia: The madness that makes history
by Luigi ZojaLuigi Zoja presents an insightful analysis of the use and misuse of paranoia throughout history and in contemporary society. Zoja combines history with depth psychology, contemporary politics and tragic literature, resulting in a clear and balanced analysis presented with rare clarity. The devastating impact of paranoia on societies is explored in detail. Focusing on the contagious aspects of paranoia and its infectious, self-replicating dynamics, Zoja takes such diverse examples as Ajax and George W. Bush, Cain and the American Holocaust, Hitler, Stalin and Othello to illustrate his argument. He reconstructs the emblematic arguments that paranoia has promoted in Western history and examines how the power of the modern media and mass communication has affected how it spreads. Paranoia clearly examines how leaders lose control of their influence, how the collective unconscious acquires an autonomous life and how seductive its effects can be - more so than any political, religious or ideological discourse. This gripping study will be essential reading for depth and analytical psychologists, and academics and students of history, cultural studies, psychology, classical studies, literary studies, anthropology and sociology.
Modeling and Simulation of Infectious Diseases: Microscale Transmission, Decontamination and Macroscale Propagation
by Tarek I. ZohdiThe COVID-19 pandemic that started in 2019-2020 has led to a gigantic increase in modeling and simulation of infectious diseases. There are numerous topics associated with this epoch-changing event, such as (a) disease propagation, (b) transmission, (c) decontamination, and (d) vaccines. This is an evolving field. The targeted objective of this book is to expose researchers to key topics in this area, in a very concise manner. The topics selected for discussion have evolved with the progression of the pandemic. Beyond the introductory chapter on basic mathematics, optimization, and machine learning, the book covers four themes in modeling and simulation infectious diseases, specifically: Part 1: Macroscale disease propagation, Part 2: Microscale disease transmission and ventilation system design, Part 3: Ultraviolet viral decontamination, and Part 4: Vaccine design and immune response. It is important to emphasize that the rapid speed at which the simulations operate makes the presented computational tools easily deployable as digital twins, i.e., digital replicas of complex systems that can be inexpensively and safely optimized in a virtual setting and then used in the physical world afterward, thus reducing the costs of experiments and also accelerating development of new technologies.
Obsessive Compulsive Disorder
by Joseph ZoharA clear summary of what is known about a highly prevalent and debilitating disorder that affects nearly as many people as does asthma. Expert authors review the biological basis for the disorder and describe both pharmacological and psychological approaches to treatment.
Facilitating Resilience and Recovery Following Trauma
by Lori A. Zoellner Norah C. FeenyThis volume synthesizes cutting-edge research on natural processes of resilience and recovery, highlighting implications for trauma treatment and prevention. Prominent experts examine what enables many trauma survivors to heal over time without intervention, as well what causes others to develop long-term psychiatric problems. Identifying key, modifiable risk and resilience factors--such as cognitions and beliefs, avoidance, pain, and social support--the book provides recommendations for when (and when not) to intervene to promote recovery. Illustrative case examples are included. A section on specific populations discusses children, military personnel, and low socioeconomic status or marginalized communities.
Synthetic Sequences in Organic Chemistry
by Jerome ZoellerDrawing on the vast amount of experience the author has gained from working in industrial and university laboratories, this collection of excerpt reports contains essential details from literature relevant to the synthesis of compounds on a milligram to kilogram scale. The excerpts are composed using ChemDraw software and compiled in a Word document. A number of the compounds that have eluded efficient preparation in the past are now presented. Material which will improve any chemist's existing synthetic methodology can be found here. Each of the six chapters, with eighty excerpts, illustrates a novel application of syntheses selected from twenty-first-century literature. Features: This professional text describes many of the classical and contemporary methods of synthesis that have recently found great value in the preparation of needed target compounds in the required quantities. Each example is extracted from a specific literature publication, which the user then would examine for details. This user-friendly professional text provides enormous aid in designing synthetic sequences. Appeals to a broad audience in both academic and industrial laboratories, basically any chemist in need of designing a synthetic sequence or just selecting a single reaction. Author has a vast amount of experience gained from working in academic and industrial laboratories.
3D Printing in Bone Surgery
by Carmine Zoccali Pietro Ruggieri Francesco BenazzoFilling a gap in the literature, this is the first book to comprehensively discuss 3D printing applied to bone surgery. It provides both the scientific basics and practical applications, with a special focus on 3D-printed, custom-made titanium prostheses (3DPCMP) used for bone reconstruction following tumor resection. Initially applied to pelvic and scapular prostheses – because of their of highly complex anatomy – this technology is increasingly being adopted in other fields of orthopedics, such as limb surgery, traumatology and degenerative diseases. Throughout the book, experts from various fields share their knowledge, describing 3D printing applied to the reconstruction of different bone segments, reviewing each application and comparing it with traditional reconstruction. They also present real-world case studies from their clinical practice. Uniquely responding to the growing interest surrounding 3D printing for bone reconstruction, this book is invaluable for orthopedic, neuro- , head and neck as well as maxillofacial surgeons wishing to gain insights into this new and promising field.
What is Science?: Myths and Reality
by Jordanka ZlatanovaIn a multitude of ways, science affects the life of almost every person on earth. From medicine and nutrition to communication and transportation, the products of scientific research have changed human life. These changes have mostly taken place in the last two centuries, so rapidly that the average person is unable to keep informed. A consequence of this "information gap" has been the increasing suspicion of science and scientists. The lack of true understanding of science, especially of "fundamental" research, motivates this effort to narrow this gap by explaining scientific endeavor and the data-driven worldviews of scientists. Key Features Fills an existing void in the understanding of science among the general population Is written in a nontechnical language to facilitate understanding Covers a wide range of science-related subjects: The value of "basic research" How scientists work by sharing results and ideas How science is funded by governments and private entities Addresses the possible dangers of research and how society deals with such risks Expresses the viewpoint of an author with extensive experience working in laboratories all over the world
Brain-Machine Interface: Circuits and Systems
by Amir ZjajoThis book provides a complete overview of significant design challenges in respect to circuit miniaturization and power reduction of the neural recording system, along with circuit topologies, architecture trends, and (post-silicon) circuit optimization algorithms. The introduced novel circuits for signal conditioning, quantization, and classification, as well as system configurations focus on optimized power-per-area performance, from the spatial resolution (i. e. number of channels), feasible wireless data bandwidth and information quality to the delivered power of implantable system.
Me Before/ Me After: A Group Rehabilitation Programme for Brain Injury Survivors
by Leyla ZiyalMe Before, Me After is a complete programme for professionals who run rehabilitation groups for brain injury survivors. The programme's overarching goal is to retrieve the person behind the injury by helping survivors master the consequences of their brain injury. The approach combines CBT principles that develop awareness and recognition of mental events with CBT techniques that are instrumental in achieving behaviour change. The manual focuses on the three aspects of acquired brain injury that are integral to achieving gains through rehabilitation: 1) Change-awareness: develops awareness of the changes that are consequent upon brain injury. 2) Change-investigation: helps understand why these changes occur; how we interpret them and how we cope with them. 3) Change-mastery: helps gain mastery over these changes by developing and mobilising adaptive capability. Including extensive resources for practitioners, clients and support workers, this comprehensive manual provides everything you need in order to run the most effective brain injury rehabilitation groups in one place.
Biomaterials in Clinical Practice: Advances in Clinical Research and Medical Devices
by Fatima Zivic Nenad Grujovic Saverio Affatato Miroslav Trajanovic Matthias Schnabelrauch Kwang Leong ChoyThis book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials - polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications - before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization - chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity - an d reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.
Oncoimmunology
by Laurence Zitvogel Guido KroemerIn this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Extreme Measures: Finding a Better Path to the End of Life
by Jessica Nutik ZitterAn ICU and Palliative Care specialist featured in the Oscar-nominated Netflix documentary Extremis offers a framework for a better way to exit life that will change our medical culture at the deepest levelIn medical school, no one teaches you how to let a patient die. Jessica Zitter became a doctor because she wanted to be a hero. She elected to specialize in critical care—to become an ICU physician—and imagined herself swooping in to rescue patients from the brink of death. But then during her first code she found herself cracking the ribs of a patient so old and frail it was unimaginable he would ever come back to life. She began to question her choice. Extreme Measures charts Zitter’s journey from wanting to be one kind of hero to becoming another—a doctor who prioritizes the patient’s values and preferences in an environment where the default choice is the extreme use of technology. In our current medical culture, the old and the ill are put on what she terms the End-of-Life Conveyor belt. They are intubated, catheterized, and even shelved away in care facilities to suffer their final days alone, confused, and often in pain. In her work Zitter has learned what patients fear more than death itself: the prospect of dying badly. She builds bridges between patients and caregivers, formulates plans to allay patients’ pain and anxiety, and enlists the support of loved ones so that life can end well, even beautifully. Filled with rich patient stories that make a compelling medical narrative, Extreme Measures enlarges the national conversation as it thoughtfully and compassionately examines an experience that defines being human.
Ultrasonic Exposimetry
by Marvin C. Ziskin Peter A. LewinUltrasonic Exposimetry presents the fundamentals of ultrasonics and discusses the theoretical background of acoustic wave generation and reception. Measurements, instrumentation, and interpretation of measured data (including error analysis) are examined in detail.
Platelets, Haemostasis and Inflammation (Cardiac and Vascular Biology #5)
by Andreas Zirlik Christoph Bode Meinrad GawazThe book depicts the various roles of platelets in a variety of cardio-metabolic diseases. Traditional and non-traditional platelet functions are described in detail in atherosclerosis, metabolic syndrome, diabetes, myocardial infarction, and other vascular pathologies. Particular focus is put on platelets as a link between haemostasis and inflammation contributing to both. Last but not least the books links the most recent advances in basic sciences with promising novel therapeutic applications and first results of clinical trials. The book is written for biomedical scientists in the sub disciplines vascular biology, biochemistry and immunology; and it as well will be of interest and value for academic physicians like cardiologists, hematologists, general internists and vascular surgeons.
Patient Safety: Perspectives on Evidence, Information and Knowledge Transfer
by Lorri ZippererPatient Safety: Perspectives on Evidence, Information and Knowledge Transfer provides background on the patient safety movement, systems safety, human error and other key philosophies that support change and innovation in the reduction of medical error. The book draws from multidisciplinary areas within the acute care environment to share models that support the proactive changes necessary to provide safe care delivery. The publication discusses how the tenets of safety (described in the beginning of the book) can be actively applied in the field to make evidence, information and knowledge (EIK) sharing processes reliable, effective and safe. This is a wide-ranging and important book that is designed to raise awareness of the latent risks for patient safety that are present in the EIK identification, acquisition and distribution processes, structures, and systems of many healthcare institutions across the world. The expert contributors offer systemic, evidence-based improvement processes, assessment concepts and innovative activities to identify these risks to minimize their potential to adversely impact care. These ideas are presented to create opportunities for the field to design and use strategies that enable meaningful implementation and management of EIK. Their thoughts will enable healthcare staff to see EIK as a tangible element contributing toward sustainable patient safety improvements.
Biology of Stem Cells and the Molecular Basis of the Stem State (Stem Cell Biology and Regenerative Medicine)
by Dov ZiporiBiology of Stem Cells and the Molecular Basis of the Stem State concentrates upon adult stem cells, particularly on mesenchymal cell populations, which is the author's area of expertise. The text offers the reader a detailed description of the emergence of stem cell research and the dogmas that were created during the first decades of analysis of stem cell properties, particularly those of hemopoietic stem cells. Biology of Stem Cells and the Molecular Basis of the Stem State also introduces the reader to the commonly accepted notions regarding stem cell biology, with an emphasis on an alternative view of stemness, i.e. the stem state. In keeping with the popularity of this topic, Biology of Stem Cells and the Molecular Basis of the Stem State addresses the major controversies and points of dispute, among researchers in the stem cell field. Overall, Biology of Stem Cells and the Molecular Basis of the Stem State presents a well-rounded dialogue about stem cells as it not only concentrates upon the biological elements of stem cell, but also addresses the controversy and hype currently enveloping this popular subject.
The Psycho-Biology Of Language: AN INTRODUCTION TO DYNAMIC PHILOLOGY (International Library Of Psychology Ser.)
by George Kingsley ZipfThis is Volume XXI in a series of twenty-one on the Cognitive Psychology. Orignally published in 1936, this is a study on the introduction to Dynamic Philology.
Advanced Medical Intuition: Six Underlying Causes Of Illness And Unique Healing Methods (Medical Intuition #2)
by Tina M. ZionAdvanced Medical Intuition is power packed with information. This book is the next step to take after reading Tina Zion's book, Become a Medical Intuitive: The Complete Developmental Course.
Infectious Lesions of the Central Nervous System
by Vsevolod ZinserlingThis book discusses all aspects infectious CNS pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on meningitis and encephalitis of different bacterial and viral aetiologies, influenza, COVID-19 and other viral and bacterial generalized infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infection, as well as pathological changes in different age groups including newborns. A special chapter is devoted to the probable role of biological pathogens in noninfectious brain pathology.
Infectious Pathology of the Respiratory Tract
by Vsevolod ZinserlingThis book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on pneumonias of different bacterial aetiologies, influenza, and other viral infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infections and virus-bacterial pneumonias, as well as pathological changes in modern tuberculosis, lung granuloma, and respiratory tract inflammation in different age groups.
Optical Imaging of Cancer
by Kurt R. Zinn Eben RosenthalTo describe principles of optical imaging including chemistry and physics of fluorescence, limitations/advantages of optical imaging compared to metabolic and anatomic imaging. Describe hardware adapted for small animal imaging and for clinical applications: endoscopes and operative microscopes. Outline FDA approved and newer optical imaging probes. Include discussion of chemistry and linkage to other proteins. Review current techniques to image cancer and the development of techniques to specifically image cancer cells. Review use of exploiting differences in tissue autofluorescence to diagnose and treat cancer. Include agents such as 5-aminoleculinic acid. Review mechanisms that require proteolytic processing within the tumor to become active fluorophores. Review use of cancer selective proteins to localize probes to cancer cells: include toxins, antibodies, and minibodies. Introduction of plasmids, viruses or other genetic material may be used to express fluorescent agents in vivo. This chapter will review multiple vectors and delivery mechanisms of optical imaging cassettes.Preclinical investigations into the use of optical contrast agents for the detection of primary tumors in conventional and orthotopic models will be discussed. Preclinical investigations into the use of optical contrast agents for the detection of metastatic tumors in mouse models will be discussed. Use of targeted and non-specific optical contrast agents have been used for the detection of sentinel lymph node detection. These applications and how they differ from other applications will be discussed. Because of the unique difficulty of identifying tumor from normal tissue in brain tissue, a separate chapter would be needed. More clinical data is available for this cancer type than any other. Discussion of potential clinical applications for optical imaging and an assessment of the potential market.
Fluorescence Lifetime Imaging Ophthalmoscopy
by Martin Zinkernagel Chantal DysliThis book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Dog Health and Nutrition for Dummies
by M. Christine ZinkHelp your dog enjoy a longer and healthier life with the latest in conventional and alternative veterinary medicine.
Canine Sports Medicine and Rehabilitation
by Chris Zink Janet B. Van DykeCanine Sports Medicine and Rehabilitation, Second Edition offers a thoroughly revised and updated new edition of this gold standard reference for all aspects of sports medicine and rehabilitation, encompassing basic science and integrated veterinary and physical therapy approaches. Presents current, state-of-the-art information on sports medicine and rehabilitation in dogs Offers perspectives from an international list of expert authors Covers all topics related to veterinary care of the canine athlete and all active dogs Includes illustrations and photographs throughout to demonstrate key concepts Provides clinical cases that set the information in context
A Clinician's Guide to Sperm DNA and Chromatin Damage
by Armand Zini Ashok AgarwalThis comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.
AARP Special Edition: for a Longer, Leaner, Healthier Life!: The fast, effective weight-loss plan to save you 10, 20, 30 pounds--or more!
by David Zinczenko Eat ThisLose 10, 20, 30 pounds or more, and put yourself back in control of your weight, your health, and your life! Don't diet, don't sacrifice, and don't waste money or time on expensive weight-loss foods. In fact, you can start dropping pounds today while eating all your favorite foods--from pizza and pasta to burgers, and even dessert. From the editors of the bestselling series Eat This, Not That! comes a unique diet program that strips away added sugars and melts fat--from your belly first. The trick: a series of simple swaps that will ensure you're eating the very best options from your favorite restaurants and grocery store brands. Discover how easy it is to indulge your way to a flat belly while protecting your brain and striking a blow against heart disease, diabetes, and more. Eat This, Not That! for a Longer, Leaner, Healthier Life is based on four easy-to-remember nutrition rules: * Use our simple guide to ensure you're always making the smartest, healthiest, leanest choice in any restaurant or grocery store. * Enjoy rich, creamy, healthy fats, so you never feel hungry or deprived, even while your metabolism is revving on high. * Reduce added sugars--without sacrificing flavor--with a series of simple tips that will help you enjoy your favorite desserts, without gaining an ounce! * Power up your day with 10 essential LONGER LIFE Superfoods for maximum health and rapid weight loss. Get ready to drop that extra weight faster than you've ever imagined--and enjoy every bite!
Eat This Not That! For Kids!
by David Zinczenko Matt GouldingIt's no secret that children are getting fatter: 17% of this country's youth are overweight or obese, and the number of diabetic children has nearly quadrupled in the past thirty years. Now, to help combat the problem, David Zinczenko, editor-in-chief of Men's Health, and co-author Matt Goulding have created Eat This, Not That! for Kids. This must-have guide for concerned parents offers detailed analysis and nutritional tips on thousands of the most popular food choices for kids. Covering the best and worst options available at the most popular restaurants in the country as well as the healthiest-and most harmful-foods in the supermarket aisles, if kids are eating it, this book is probably analyzing it. Other features include:-Restaurant Report Cards on the best chain restaurants for your kids-Drink This, Not That! for Kids-The 20 Worst Kids' Meals in America-10 Healthy" Foods that Aren't-The 8 Foods You Should Feed Your Kid Every Day"
Partial Truths: How Fractions Distort Our Thinking
by James C. ZimringA fast-food chain once tried to compete with McDonald’s quarter-pounder by introducing a third-pound hamburger—only for it to flop when consumers thought a third pound was less than a quarter pound because three is less than four. Separately, a rash of suicides by teenagers who played Dungeons and Dragons caused a panic in parents and the media. They thought D&D was causing teenage suicides—when in fact teenage D&D players died by suicide at a much lower rate than the national average. Errors of this type can be found from antiquity to the present, from the Peloponnesian War to the COVID-19 pandemic. How and why do we keep falling into these traps?James C. Zimring argues that many of the mistakes that the human mind consistently makes boil down to misperceiving fractions. We see slews of statistics that are essentially fractions, such as percentages, probabilities, frequencies, and rates, and we tend to misinterpret them. Sometimes bad actors manipulate us by cherry-picking data or distorting how information is presented; other times, sloppy communicators inadvertently mislead us. In many cases, we fool ourselves and have only our own minds to blame. Zimring also explores the counterintuitive reason that these flaws might benefit us, demonstrating that individual error can be highly advantageous to problem solving by groups. Blending key scientific research in cognitive psychology with accessible real-life examples, Partial Truths helps readers spot the fallacies lurking in everyday information, from politics to the criminal justice system, from religion to science, from business strategies to New Age culture.
Meine Frau hat Krebs: Wie gehen wir als Paar mit der Erkrankung um
by Tanja Zimmermann Jochen ErnstDieser Ratgeber richtet sich an Paare, bei denen die Frau an Krebs erkrankt ist, und er bietet besonders den PartnerInnen Unterstützung zur Bewältigung der aufkommenden Belastungen und Herausforderungen. Eine Krebsdiagnose hat Auswirkungen auf nahezu alle Lebensbereiche: auf die Partnerschaft, den Alltag, auf das berufliche und soziale Umfeld. Die Krankheit kann aber auch die Sicht auf das Leben und den Tod nachhaltig verändern und mit teilweise schmerzlichen Erfahrungen verbunden sein. Einfühlsam und konkret sprechen die erfahrenen Autoren alle wesentlichen Punkte an. Das Buch ist praxisbezogen und die Kapitel werden durch viele Beispielen und Übungen ergänzt. Rat, Informationen und Hilfe für Betroffene und Angehörige!
Pediatric Liver Tumors
by Arthur Zimmermann Dietrich Von Schweinitz Giorgio Perilongo Marcio MalogolowkinThe field of liver tumors in children has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improved diagnostic procedures, refined methods of pretreatment tumor staging, the implementation of highly efficient chemotherapy and surgery, detailed monitoring of toxicity, and careful follow-up strategies. International controlled trials have played a key role in these advances, and many leading figures in the trials are among the editors and authors of this book. Their principal goal in Hepatic Tumors in Children is to provide the reader with a complete update on this complex and rapidly evolving field. All aspects of an impressive success story are covered, disclosing how the outcome of a previously devastating disease has been so dramatically improved. This book will prove essential reading for all who are involved in the care of children with liver tumors.
Biology and Management of Unusual Plasma Cell Dyscrasias
by Todd M. Zimmerman Shaji K. KumarThis unique book focuses on the non-myeloma plasma cell dyscrasias. A key resource for this group of diseases, the book features the latest in emerging knowledge and therapeutic developments, including novel therapies. Each disease-specific chapter discusses biology, disease course, and appropriate therapeutic interventions, covering plasma cell leukemia, plasmacytoma, POEMS Syndrome and Castleman's Disease, Waldenström macroglobulinemia, immunoglobin deposition disease, and cryoglobulinemic syndromes, among others. The only book dedicated to this intriguing family of diseases, Biology and Management of Unusual Plasma Cell Dyscrasias will be a long-lasting reference for clinicians and scientists alike.
Pearls and Pitfalls in Cardiovascular Imaging
by Zimmerman, Stefan L. and Fishman, Elliot K. Stefan L. Zimmerman Elliot K. FishmanCardiovascular imagers are faced with the challenge of interpreting cases that include artifacts, unusual findings, or anatomic variants on an almost daily basis. These studies can result in confusion and may lead to misdiagnosis even for the most experienced imager. This book provides an approachable reference for practising cardiovascular imagers to aid with both commonly and uncommonly encountered entities that can result in inappropriate patient management. Through the focused use of case examples, this book reviews 100 conditions that can be seen in clinical practice, including pseudotumors, artifacts, anatomic variants, mimics, and unusual diagnoses. Each highly illustrated case follows a standard format, allowing readers to learn from real-life examples and provides an accessible and rapid source of reference for the improved interpretation of cardiovascular imaging and enhanced patient care. This text will be invaluable to radiologists, cardiologists, and trainees.
Retirement Migration from the U.S. to Latin American Colonial Cities (International Perspectives on Aging #27)
by Sheryl Zimmerman Philip D. Sloane Johanna SilbersackThis book provides a comprehensive overview of a growing phenomenon in migration: retired Americans moving to Latin America. Through in-depth profiles of two of the most popular destinations – Cuenca, Ecuador and San Miguel de Allende, Mexico, the book provides a unique commentary on the social forces shaping this new diaspora and its impact on the settings to which retirees relocate. Sections of the book address the lives and activities of retirees themselves; their impact on real estate, business development, and gentrification within historic cities; the availability and access to medical and long-term care services; and the role of governmental policies in attracting immigrant retirees and shaping their societal impact. Concluding sections provide guidance for potential retirees and for cities and countries interested in attracting these new immigrants while minimizing adverse impact on local culture and quality of life. Carefully researched and extensively illustrated with photographs, maps, figures, and tables, the book serves as an important new resource for scientists and policy makers, as well as for baby boomers who have retired abroad or are considering doing so.
Assisted Living: Needs, Practices, and Policies in Residential Care for the Elderly
by Sheryl ZimmermanWith the number of elderly persons needing long-term care expected to double to 14 million over the next two decades, assisted living has become the popular choice for housing or care. Assisted living represents a promising model of long-term care that blurs the sharp distinction between nursing homes and community-based care and reduces the gap between receiving long-term care in one's own home and in an "institution." Assisted Living: Needs, Practices, and Policies in Residential Care for the Elderly examines the evolving field of residential care and focuses on national issues of regulation, reimbursement, and staffing. The book is based on a four-state study of assisted living facilities and describes the facilities, the persons residing in them and their needs, and how the services vary by facility. Because one-third to two-thirds of residents in assisted living facilities have cognitive impairment, special attention is devoted to dementia care. The book also focuses on how today's long-term health care environment evolved, and it examines the future direction and implications of assisted living.Assisted Living: Needs, Practices, and Policies in Residential Care for the Elderly brings together a group of nationally recognized experts to help define the types of residential care that should be encouraged and sets guidelines for selecting an appropriate type of facility.
The Doula Guide to Birth
by Rachel Zimmerman Ananda LoweHere is your guide to the fastest-growing trend in childbirth—a tradition as old as motherhood itself. Doulas,or professional labor assistants, have led thousands of expectant women through the birthing process in a way that’s safe and meaningful, and that creates the birth and postbirth experience all mothers long for. What exactly dodoulas do? How to find one that suitsyou. What are the “trade secrets” only doulas know but every woman should be aware of (even if youdon’thave a doula)? InThe Doula Guide to Birth,senior-level doula Ananda Lowe and award-winning health reporter Rachel Zimmerman have written a most comprehensive book that draws on the wisdom of these skilled experts, whose experience with doctors, midwives, nurses, and hospitals makes them invaluable advocates before, during, and after birth. * Labor techniques anyone can use * Pain medication: do you, don’t you—and when? * What dads and loved ones need and can do best * When should youreallygo to the hospital in labor? * How to prepare for unexpected medical procedures, including cesareans and epidural * Postpartum—what it’s really like * A clip-out chart of labor techniques, birth plan worksheets, and much more Combining science, wit, warmth, and support, as well as the inspirational stories of dozens of mothers and their partners, you’ll find the “doula viewpoint” on every major pregnancy and delivery issue, making this one of the most important childbirth books you’ll ever read and recommend.
Interview Guide for Evaluating DSM-5 Psychiatric Disorders and the Mental Status Examination
by Mark Zimmerman<p>This book provides questions for evaluating psychiatric disorders. DSM-5 lists the disorders and their criteria, but it does not guide the beginner in inquiry for them. Students and clinicians in training are relatively unfamiliar with psychiatric diagnoses, and they cannot possibly remember all of the disorders and their corresponding diagnostic criteria within a short period of study. Moreover, it is often not obvious what questions to ask to determine the symptom's presence. How do you inquire for thought withdrawal, delusions of reference, panic attacks, obsessions, identity disturbance, mood instability, etc? Even more basic, how do you begin the interview? <p>The Interview Guide consists of questions for the most common DSM-5 diagnoses including the personality disorders. This book is not a standardized interview, to be started on page x and followed until page xx. Rather it is a quick reference to be used in the context of a clinical interview. If a patient complains of depression, the interviewer can turn to the section on major depression and assess the relevant symptoms. If there is a suggestion of excessive drug or alcohol use, the interviewer can refer to the long list of questions for diagnosing a drug or alcohol use disorder.</p>
Interview Guide For Evaluating DSM-5-TR Psychiatric Disorders and the Mental Status Examination
by Mark ZimmermanThis book provides questions for evaluating psychiatric disorders. DSM-5-TR lists the disorders and their criteria, but it does not guide the beginner in inquiry for them. Students and clinicians in training are relatively unfamiliar with psychiatric diagnoses, and they cannot possibly remember all of the disorders and their corresponding diagnostic criteria within a short period of study. Moreover, it is often not obvious what questions to ask to determine the symptom's presence. How do you inquire for thought withdrawal, delusions of reference, panic attacks, obsessions, identity disturbance, mood instability, etc., Even more basic, how do you begin the interview? The Interview Guide consists of questions for the most common DSM-5 diagnoses including personality disorders. This book is not a standardized interview, to be started on page x and followed until page xx. Rather it is a quick reference to be used in the context of a clinical interview. If a patient complains of depression, the interviewer can turn to the section on major depression and assess the relevant symptoms. The book is organized by diagnosis and contains 9 sections.
The A. D. D. Nutrition Solution: A Drug-Free Thirty-Day Plan
by Marcia ZimmermanThe first scientifically proven, effective, all-natural nutritional alternative to the much-prescribed drug Ritalin. Attention deficit disorder is a nutritional deficiency, not a psychological condition. This is the revolutionary discovery Marcia Zimmerman made during her ten years of research as a nutritional biochemist. That conclusion led her to develop a diet that addresses the specific needs of the 17 million adults and children suffering from ADD. Her easy-to-follow thirty-day plan has been proven just as effective as Ritalin in relieving the symptoms of ADD. Learn: - How women should boost their nutrition before conception to prevent ADD in their children. - Why boys are much likelier to be tagged as ADD than girls - How to get a reliable ADD diagnosis Reasons why parents prefer a diet plan to prescription drugs for ADD children - The effects of brain allergies on attention span - Foods to avoid that may exacerbate ADD - Fats and oils we all need to stay focused - Calming effects of carbohydrates - Concentration-enhancing protein - Why to stay away from simple sugars - The dangers of artificial food ingredients, and much more This important book will help us curb the epidemic growth of ADD in this country and change the way we treat those who have it now by addressing its source instead of merely treating its symptoms.
Diseases of Swine
by Jeffrey J. Zimmerman Locke A. Karriker Alejandro Ramirez Kent J. Schwartz Gregory W. Stevenson Jianqiang ZhangProvides a fully revised Eleventh Edition of the definitive reference to swine health and disease Diseases of Swine has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. Diseases of Swine covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. A key reference for anyone involved in the swine industry, Diseases of Swine, Eleventh Edition: Presents a thorough revision to the gold-standard reference on pig health and disease Features full color images throughout the book Includes information on the most current advances in the field Provides comprehensive information on swine welfare and behavior Offers a reorganized format to make the information more accessible Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, Diseases of Swine, Eleventh Edition is an essential guide to swine health.
Researching Health Together: Engaging Patients and Stakeholders, From Topic Identification to Policy Change
by Emily B. ZimmermanThe challenges of addressing health disparities, the ethical imperative to include stakeholders in research, and the slow translation of research evidence into practice are all driving a movement towards more community-based and participatory approaches to research. Researching Health Together brings together authors who have produced innovative methods or implemented projects focused on different stages of the research process, from question development to evaluation and translation. Editor Emily B. Zimmerman gathers exemplary new methods and projects into one place for the benefit of students designing research projects and proposals, those learning stakeholder-engaged methods, and those involved in implementing and funding stakeholder-engaged projects. Each chapter addresses: how engagement was conceptualized, organized, and implemented; how engagement was evaluated; impacts on processes and outcomes of the project; and facilitators, barriers, and lessons learned. The book serves as a core textbook for courses in community-based health research at the graduate level.
Researching Health Together: Engaging Patients and Stakeholders, From Topic Identification to Policy Change
by Emily B. ZimmermanThe challenges of addressing health disparities, the ethical imperative to include stakeholders in research, and the slow translation of research evidence into practice are all driving a movement towards more community-based and participatory approaches to research. Researching Health Together brings together authors who have produced innovative methods or implemented projects focused on different stages of the research process, from question development to evaluation and translation. Editor Emily B. Zimmerman gathers exemplary new methods and projects into one place for the benefit of students designing research projects and proposals, those learning stakeholder-engaged methods, and those involved in implementing and funding stakeholder-engaged projects. Each chapter addresses: how engagement was conceptualized, organized, and implemented; how engagement was evaluated; impacts on processes and outcomes of the project; and facilitators, barriers, and lessons learned. The book serves as a core textbook for courses in community-based health research at the graduate level.
Autism: Current Theories and Evidence (Current Clinical Neurology)
by Andrew W. ZimmermanCreative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.
Bone and Joint Infections: From Microbiology to Diagnostics and Treatment
by Werner ZimmerliBONE AND JOINT INFECTIONS Explore this comprehensive presentation of bone and joint infections, including non-implant and implant-associated orthopedic infectionsIn the newly revised Second Edition of Bone and Joint Infections: From Microbiology to Diagnostics and Treatment, accomplished researcher and author Werner Zimmerli delivers a comprehensive overview of the most recent developments in the subject of bone and joint infection. Covering much of the new information appearing over the last five years, the book includes four new chapters presenting the diagnostic approach in bone and joint infections, discussing the identification of pathogens by non-culture techniques, management of multi-resistant bacteria in bone and joint infections by bacteriophages, and unusual microorganisms in periprosthetic joint infections.Many of the chapters are also updated to include new information on topics like eubacterial PCR, multiplex PCR, and the shotgun metagenomics approach. These subjects are of increased applicability and interest to increase the fraction of cases with identified pathogens. The book also helps clinicians to understand MRI-based images and rapidly interpret and plan for comprehensive therapy.Readers will also benefit from the inclusion of:A thorough introduction to the pharmacokinetics and pharmacodynamics of antibiotics in bone and preclinical models of infection in bone and joint surgeryAn exploration of native joint arthritis in children and adults, as well as an overview of septic arthritis of axial jointsA practical discussion of the general aspects of periprosthetic joint infection, as well as specific aspects of periprosthetic joint infection after total hip and knee, shoulder, elbow, and ankle arthroplastyA concise treatment of osteomyelitis in children and adultsPerfect for infectious disease specialists, microbiologists, orthopedic and trauma surgeons, and internists, Bone and Joint Infections: From Microbiology to Diagnostics and Treatment will also earn a place in the libraries of professionals working in the implant industry and pharmaceuticals, as well as clinical pharmacologists and rheumatologists.
Funktionelle Anatomie: Grundlagen sportlicher Leistung und Bewegung
by Philipp Zimmer Hans-Joachim AppellWie funktioniert der menschliche aufrechte Gang? Welche Muskeln sind beteiligt? Wie werden die auf den Fuß einwirkenden Kräfte beim Lauf abgefedert? Experten erläutern hier alle grundlegenden und wichtigen Details zu Aufbau und Funktion des menschlichen Körpers: das Zusammenspiel der Bestandteile des Bewegungsapparates – Knochen, Sehnen und Muskeln, die Bewegungssteuerung und -kontrolle durch das Zentrale Nervensystem sowie alle für sportliche Leistung und Bewegung notwendigen Körpersysteme.Die 5. Auflage wurde komplett überarbeitet und enthält Prüfungsfragen, die über die App Springer Nature Flashcards abgerufen werden können. Der eigene Wissenstand zu einem Thema kann mittels Fragen und Antworten einfach und spielerisch abgefragt werden.
The Conversation on Biotechnology (Critical Conversations)
by Marc ZimmerFrom the contributors to The Conversation, this collection of essays by leading experts in biotechnology provides foundational knowledge on a range of topics, from CRISPR gene sequencing to the ethics of GMOs and "designer babies."In The Conversation on Biotechnology, editor Marc Zimmer collects essays from The Conversation U.S. by top scholars and experts in the field, who present a primer on the latest biotechnology research, the overwhelming possibilities it offers, and the risks of its abuse. From an overview of CRISPR technology and gene editing in GMOs to the ethical questions surrounding "designer babies" and other applications of biotechnology in humans, it highlights the major implications biotechnology will bring for health and society. Topics range from the spectacular use of light to fire individual neurons in the brain to making plant-based meats; from curbing diseases with genetically modified mosquitoes to looking back on 40 years of opinions on IVF babies.The Critical Conversations series collects essays from top scholars on timely topics, including water, biotechnology, gender diversity, gun culture, and more, originally published on the independent news site The Conversation U.S.Contributors: Nathan Ahlgren, Ivan Anishchenko, Trine Antonsen, Jennifer Barfield, Pedro Belda-Ferre, Ari Berkowitz, Adeline Boettcher, Jason Delbourne, Kevin Doxzen, Mo Ebrahimkhani, Eleanor Feingold, J. Benjamin Hurlbut, Cecile Janssens, Samira Kiani, Amanda Kowalczyk, Mariana Lamas, Andrew Lapworth, Rebecca Mackelprang, Kathleen Merrigan, Saman Naghieh, Sean Nee, Dimitri Perrin, Christopher Preston, Jason Rasgon, Penny Riggs, Jason Robert, Oliver Rogoyski, Gary Samore, Sahotra Sarkar, George E. Seidel, Patricia A. Stapleton, Craig W. Stevens, Paul B. Thompson, Christopher Tuggle, Vikramaditya G. Yadav, Marc Zimmer
Lighting Up the Brain: The Science of Optogenetics
by Marc ZimmerWhat if neuroscientists could look inside the human brain and watch individual brain cells send signals to one another? What if they could then control these brain cells to direct thoughts and actions? This may sound like science fiction, but it's actually a scientific revolution called optogenetics. Neuroscientists would like to use this new technology on human brains to uncover secrets about how the brain processes information and drives human behavior. Doctors hope to use optogenetics to restore sight and to treat Alzheimer's disease, Parkinson's disease, depression, and other debilitating or deadly health problems. Discover how the innovative work of leaders in the field is poised to radically transform science, medicine, and human health.
Natural Killer Cells
by Jacques ZimmerNatural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
A Planet of Viruses: Third Edition
by Carl ZimmerIn 2020, an invisible germ—a virus—wholly upended our lives. We’re most familiar with the viruses that give us colds or Covid-19. But viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in deep caves miles underground. Fully revised and updated, with new illustrations and a new chapter about coronaviruses and the spread of Covid-19, this third edition of Carl Zimmer’s A Planet of Viruses pulls back the veil on this hidden world. It presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate as long as life endures.
Soul Made Flesh: The Discovery of the Brain--and How it Changed the World
by Carl ZimmerIn this unprecedented history of a scientific revolution, award-winning author and journalist Carl Zimmer tells the definitive story of the dawn of the age of the brain and modern consciousness. Told here for the first time, the dramatic tale of how the secrets of the brain were discovered in seventeenth-century England unfolds against a turbulent backdrop of civil war, the Great Fire of London, and plague. At the beginning of that chaotic century, no one knew how the brain worked or even what it looked like intact. But by the century's close, even the most common conceptions and dominant philosophies had been completely overturned, supplanted by a radical new vision of man, God, and the universe. Presiding over the rise of this new scientific paradigm was the founder of modern neurology, Thomas Willis, a fascinating, sympathetic, even heroic figure at the center of an extraordinary group of scientists and philosophers known as the Oxford circle. Chronicled here in vivid detail are their groundbreaking revelations and the often gory experiments that first enshrined the brain as the physical seat of intelligence -- and the seat of the human soul. Soul Made Flesh conveys a contagious appreciation for the brain, its structure, and its many marvelous functions, and the implications for human identity, mind, and morality.
Prehypertension and Cardiometabolic Syndrome (Updates in Hypertension and Cardiovascular Protection)
by Reuven Zimlichman Stevo Julius Giuseppe ManciaThis book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines.While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation.In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.
Practical Clinical Electrophysiology
by Peter J. Zimetbaum Mark E. JosephsonNow completely revised and in brilliant full color, Practical Clinical Electrophysiology, 2nd Edition, provides a clinically focused, highly readable approach to the diagnosis and management of arrhythmias. Co-authored by Dr. Peter Zimetbaum, Dr. Alfred Buxton and Dr. Mark Josephson, all affiliated with Harvard University, this practical reference offers concise coverage of the major arrhythmia disorders encountered in the clinic as well as the electrophysiology lab, including pharmacologic treatments. It’s an ideal resource for internists, cardiologists, cardiology fellows, and physician extenders who need a complete understanding of electrophysiology but who do not specialize in this area.
Watching Our Weights: The Contradictions of Televising Fatness in the “Obesity Epidemic”
by Melissa ZimdarsWatching Our Weights explores the competing and contradictory fat representations on television that are related to weight-loss and health, medicalization and disease, and body positivity and fat acceptance. While television—especially reality television—is typically understood to promote individual self-discipline and expert interventions as necessary for transforming fat bodies into thin bodies, fat representations and narratives on television also create space for alternative as well as resistant discourses of the body. Melissa Zimdars thus examines the resistance inherent within TV representations and narratives of fatness as a global health issue, the inherent and overt resistance found across stories of medicalized fatness, and programs that actively avoid dieting narratives in favor of less oppressive ways of thinking about the fat body. Watching Our Weights weaves together analyses of media industry lore and decisions, communication and health policies, medical research, activist projects, popular culture, and media texts to establish both how television shapes our knowledge of fatness and how fatness helps us better understand contemporary television.
Transplant Psychiatry: A Case-Based Approach to Clinical Challenges
by Paula C. Zimbrean Yelizaveta Sher Catherine Crone Andrea F. DiMartiniThis book addresses the challenges clinicians face when working with patients facing complicated medical diagnosis for which transplantation is considered. Written by experts in transplant psychiatry, each chapter approaches a common psychiatric challenge faced by transplant candidates and recipients. Chapters meticulously share clinical expertise that provides a framework for future discussions without neglecting the fact that each transplant patient is unique in the complexity of their medical diagnosis. Additionally, the book examines complex issues including transplant-related posttraumatic stress disorder, post-transplant cognitive impairment, the collaboration between mental health and transplant clinicians, substance use and a wide range of other complicated topics.Transplant Psychiatry is an excellent case-based guide to mental healthcare delivery for all clinicians who may work with transplant patients, including psychiatrists, psychologists and mental health professionals, transplant surgeons, internal medicine specialists, hematologists, transplant social workers and transplant coordinators.
Perioperative Psychiatry: A Guide To Behavioral Healthcare For The Surgical Patient
by Paula C. Zimbrean Mark A. Oldham Hochang Benjamin LeeThis book provides a comprehensive review of mental health topics for pre- and postsurgical patients. The book discusses general aspects of psychiatric care during the immediate pre- and postsurgical phase, such as pain management, psychopharmacological management or legal aspects of informed consent. The volume dedicates one section to specific subspecialties, including cardiac surgery, neurosurgery, organ transplantation, plastic surgery, bariatric surgery, and many others. Each of these chapters address preoperative psychiatric risk factors, evaluations, impact, and management recommendations for prevention and treatment of the most common psychiatric complications. The final section reviews the current dilemmas and questions for future research in this field, including delirium and capacity evaluation. The text concludes with commentary written by experts in the fields of consultation-liaison psychiatry and surgery on future directions and considerations. Perioperative Psychiatry is a valuable resource for psychiatrists, psychologists, surgeons, trainees, nurses, social workers, and all medical professionals concerned with the behavioral health of surgical patients.
Einmal Vollgas, immer Vollgas?
by Andreas ZimberDieses Buch zeigt mit dem PsyGeMa-Präventionsprogramm leitenden Führungskräften, wie sie mit Stress und Belastung möglichst gesund umgehen können – und zwar vor der Entstehung psychischer Erkrankungen. Psychische Probleme im Management? Viele reden davon, aber in den Firmen und bei vielen Betroffenen ist das Thema noch immer tabu. Symptome werden aus Schamgefühl verdrängt oder verschwiegen. Das PsyGeMa-Präventionsprogramm beschreibt den Prozess der Entstehung psychischer Erkrankungen bei Führungskräften anhand typischer Belastungskonstellationen. Der Leser kann die individuell passende Situation auswählen und findet dazu die jeweils geeigneten Werkzeuge. Der Ratgeber bietet die - für eine ständig gegen Zeitnot kämpfende Lesergruppe unverzichtbare - Möglichkeit, einzelne Kapitel herauszugreifen, andere zu überspringen oder quer zu lesen. Aus dem Inhalt: Augen zu und durch? – Warum Leistung anmacht und wo Stoppsignale sinnvolle Botschaften sind – „Mir passiert das nicht“? – Strategien für nachhaltige Lösungen: für sich selbst, für den Mitarbeiter, für das Unternehmen.Der Autor: Andreas Zimber ist Diplom-Psychologe, Personalentwickler (M. A.), Dr. phil. und Professor für Wirtschaftspsychologie. Er lebt in Heidelberg und arbeitet als Hochschuldozent, Unternehmensberater, Referent und Autor.
Führen und gesund bleiben: Ein Präventionsprogramm für Führungskräfte in Sandwich-Positionen
by Andreas ZimberFührungskräfte in Sandwich-Positionen erfahren in diesem Buch in 5 Schritten mit dem PsyGeMa-Präventionsprogramm, wie sie mit Stress und Belastung möglichst gesund umgehen können. Untersuchungen zeigen, dass Menschen in Sandwich-Positionen mit wenig Entscheidungsspielraum hoch gefährdet sind, psychische Probleme zu entwickeln. Wer darum weiß, kann zeitig gegensteuern und einen für sich angemessenen Umgang mit Rolle und Herausforderung finden. Die fünf Schritte: (1) Belastungen reduzieren, (2) mit Belastungssituationen konstruktiv umgehen, (3) gesundheitsgefährdende Einstellungen erkennen und ändern, (4) sich gesundheitsbewusst verhalten, (5) aus dem Teufelskreis austreten.Geschrieben für ... (1) Menschen in Führungspositionen, die Selbsthilfe im Umgang mit arbeitsbedingten psychischen Belastungen suchen, Stressfolgen und Erkrankungen langfristig vorbeugen möchten, (2) Therapeuten und Coaches, die nach geeigneten Beratungs- und Therapiewerkzeugen für psychisch belastete Führungskräfte suchen.Der Autor: Andreas Zimber ist Diplom-Psychologe, Personalentwickler (M. A.), Dr. phil. und Professor für Wirtschaftspsychologie. Er lebt in Heidelberg und arbeitet als Hochschuldozent, Unternehmensberater, Referent und Autor.
Military Psychology, Second Edition
by Eric A. Zillmer Carrie KennedyWidely regarded as the authoritative reference in the field, this book comprehensively explores the psychological needs of today's service members and how to meet them effectively. Expert contributors review best practices for conducting fitness-for-duty evaluations and other types of assessments, treating frequently encountered clinical problems, responding to disasters, and promoting the health and well-being of all personnel. The book also examines the role of mental health professionals in enhancing operational readiness, with chapters on crisis and hostage negotiation, understanding terrorists, and more. New to This Edition The latest scientific knowledge, clinical interventions, and training recommendations. Chapter on acute combat stress. Chapter on post-deployment problems, including PTSD and depression. Chapter on military psychology ethics. Coverage of blast concussion screening and evaluation.
Connections Between Sexuality and Aggression
by Dolf ZillmannThis is the only available comprehensive monograph on interrelations and interdependencies between agonistic and sexual behaviors. Integrating theory and research from biology, anthropology, neurophysiology, endocrinology, psychophysiology, and psychology, this book focuses on the mechanisms that govern the mutual influences between sexuality and aggression in behavior sequences and especially in admixtures of aggressive-sexual behaviors. This book places human agonistic and sexual behaviors into an evolutionary context. It offers a Weltbild of human aggressive-sexual behaviors by tracing their biological and developmental origins and examines the plasticity and manipulability of connections between agonistic and sexual behaviors. Strategies for the maximization of sexual pleasures are elaborated , and intervention treatments--aiming at the control of violent behaviors--are considered. Coercive sexuality is given special attention. Prevalent motive ascriptions to rape are called into question and the motivation that dominates rape is reinterpreted in the context of pleasure maximization. This second edition brings the coverage of pertinent research up to date. It advances the exploration of aggressive-sexual behaviors by further integrating the research contributions from various disciplines, and by refining and unifying theory capable of explaining the behavioral phenomena under consideration. COPY FOR ZILLMANN MAILER Zillmann examines issues such as sexual access through aggression, the involvement of agonistic behavior within sexuality, sex-aggression fusion, the consequences of anticipatory imagination concerning sexuality, and aspects of libido loss due to excitatory habituation. This book also: * traces connection between sexuality and aggression in nonhuman species, especially in nonhuman primates, * subjects human behavior to comparative and evolutionary analysis, * examines connectedness in neurological and endocrinological terms, * details both central and autonomic commonalities between sexual and aggressive behaviors, * outlines sexual dimorphism and chromosomal-endocrine aberrations, * pays special attention to adrenal commonalities in sexual and aggressive behaviors and the fusion of these behaviors, and * examines aggressive-sexual connectedness in the analysis of motivation and emotion. Zillmann finally proposes new explanations for the numerous documented associations between sexuality and aggression. These proposals combine biological, neuroendocrine, autonomic, and cognitive aspects of aggressive and sexual behaviors. A trichotomy of excitatory interdependencies is developed for fight, flight, and coition. In the nomenclature of emotion, this trichotomy concerns the interdependencies between aggressiveness, fear, and sexual impulsion. A considerable amount of research evidence is aggregated in support of these interdependencies. The author ultimately examines the exploitation of the existing connections between sexual and aggressive behaviors, especially the exploitation that serves the enhancement of sexual pleasure. In this context he arrives at novel, and perhaps distressing, characterizations of sexual coercion. However, he also explores sexual boredom and discusses remedies in the framework of his theorizing. Last but not least, sexual aggression, and sexual and aggressive behaviors independently, are placed into an evolutionary context. Recognition and acknowledgment of the archaic nature of many aspects of sexual and aggressive behaviors, in contrast to the comparatively vernal development of behavior-guiding contemplation, leads him to a unique and provocative proposal of the function of aggression in the realm of sexuality.
The Language of Trauma: War and Technology in Hoffmann, Freud, and Kafka
by John ZilcoskyFrom the Napoleonic Wars to the invention of the railway to the shell shock of World War I, writers tried to give voice to the suffering that war and industrial technology had wrought all around them. Yet they, like the doctors who treated these victims, repeatedly ran up against the incapacity of language to describe such anguish; those who suffered trauma, those who tried to heal it, and those who represented it were all unable to find the appropriate words. In The Language of Trauma, John Zilcosky uncovers the reactions of three major central European writers – E.T.A. Hoffmann, Sigmund Freud, and Franz Kafka – to the birth of modern trauma in the nineteenth and early twentieth centuries. Zilcosky makes the case that Hoffmann, Freud, and Kafka managed to find the language of trauma precisely by not attempting to name the trauma conclusively and instead allowing their writing to mimic the experience itself. Just as the victims’ symptoms seemed not to correspond to a physical cause, the writers’ words did not connect directly to the objects of the world. While doctors attempted to overcome this indeterminacy, these writers embraced and investigated it; they sought a language that described language’s tragic limits and that, in so doing, exemplified the wider literary and philosophical crisis of their time. Zilcosky boldly argues that this linguistic scepticism emerged together with the medical inability to name the experience of trauma. He thereby places trauma where it belongs: at the heart of both medicine’s diagnostic predicament and modern literature’s most daring experiments.
Active Implants and Scaffolds for Tissue Regeneration (Studies in Mechanobiology, Tissue Engineering and Biomaterials #8)
by Meital ZilbermanActive implants are actually drug or protein-eluting implants that induce healing effects, in addition to their regular task, such as support. This effect is achieved by controlled release of the active agent to the surrounding tissue. This book will give a broad overview of biomaterial platforms used as basic elements of drug-eluting implants. It will include mainly coatings for vascular stents with controlled release of antiproliferative agents, wound dressings with controlled release of antibacterial agents, drug-eluting vascular grafts, protein-eluting scaffolds for tissue regeneration, drug-eluting platforms for dental and other applications. Thus, both internal and external implants are described. The drug-eluting implants will be described in terms of matrix formats and polymers, incorporated drugs and their release profiles from the implants, as well as implant functioning. Smart polymeric systems, such as crosslinked poly-lactones, thermo and pH-sensitive hydrogels and poly(amido-amines), as well as novel basic structural elements, such as composite fibers and films, and nanostructures will be thoroughly described. The effect of the processing parameters on the microstructure and on the resulting drug release profiles, mechanical and physical properties, and other relevant properties, will be emphasized. The described new biomaterials approaches for active implants enhance the tools available for creating clinically important biomedical applications.
The Johns Hopkins High-Yield Review for Orthopaedic Surgery
by Bashir ZikriaThe Johns Hopkins High-Yield Review for Orthopaedic Surgery is a compact, concise study tool to help residents prepare for Part 1 of the American Board of Orthopaedic Surgery (ABOS) examination and the Orthopaedic In-Training Examination (OITE). The book is also ideal for seasoned clinicians studying for the ABOS recertification exams and motivated medical students preparing for orthopaedic surgery rotations. With its numerous illustrations, streamlined structure and heavily bulleted text, the book is designed as a ‘memory-jogger’ to supplement basic knowledge of fundamental orthopaedic surgery principles and procedures.
Rehabilitation of Visual Disorders After Brain Injury: 2nd Edition (Neuropsychological Rehabilitation: A Modular Handbook Ser.)
by Josef ZihlDespite a long research tradition in visual neuroscience, the rehabilitation of cerebral visual deficits has, until recently, been neglected. This book is the first to report systematic observations on spontaneous recovery of cerebral visual deficits after acquired brain injury, and the outcome of treating these deficits. The whole range of human visual functions and capacities is covered: visual field, visual acuity and contrast sensitivity, visual adaptation, colour vision, visual space perception, and visual cognition. Additionally, there is a special section devoted to patients with central scotoma. All treatment procedures described are empirically founded.
Neural Stem Cells
by Tanja Zigova Juan R. Sanchez-Ramos Paul R. SanbergIn Neural Stem Cells: Methods and Protocols, internationally recognized experts from academic, clinical, and pharmaceutical laboratories describe in great detail the most frequently used cellular, molecular, and electrophysiological methods to isolate, characterize, and utilize neural stem cells. These readily reproducible techniques introduce the various sources of stem/progenitor cells, provide a wide range of conditions for their culture, and make it possible to define their properties in culture. Additional techniques are designed to help researchers identify endogenous stem cells as well as exogenous stem cells after transplantation in the brain. The protocols range from the simplest methods of isolation and characterization of neural cell properties to such very sophisticated methods as characterizing gene expression, telomerase assays, and cell cycle kinetics.
A Clinician's Brief Guide to the Mental Health Act (A Clinician's Brief Guide)
by Tony Zigmond Nick BrindleA 'how to' book guiding clinicians through the mental health legislation that they need to understand and use in their daily practice, covering the Mental Health Act 1983 and subsequent amendments. This revised and updated edition incorporates new acts, such as the Policing and Crime Act 2017 and Mental Capacity (Amendment) Act 2019. It also covers the findings and implications from Professor Sir Simon Wessely's 2018 review of the Mental Health Act in a new chapter. Written by two leading psychiatrists with many years of experience in using the mental health legislation and in running mental health law courses, this book outlines how changes to statutes and case law have a direct bearing on day-to-day psychiatric practice and why it is important that clinicians of all disciplines have access to and understand the legislation. This is the go-to guide for all clinicians, doctors and nurses working in mental health services.
The First Three Years and Beyond: Brain Development and Social Policy
by Edward F. Zigler Matia Finn-Stevenson Nancy W. HallDrawing on the latest research from the social sciences and studies on the brain to answer questions and exploring what they mean for social policy and child and family development, this book offers recommendations for child care and development based on current brain research and its implications. A must-read for parents and policy makers alike.
Polyneuropathie: So überwinden Sie quälende Nervenschmerzen
by Udo ZifkoDer Ratgeber erklärt in einer zweiten aktualisierten Auflage einfach und verständlich das Krankheitsbild, deutet mögliche Frühwarnsignale oder Symptome anhand von Beispielen, und zeigt den Weg zur gesicherten Diagnose mit Vorstellung der unterschiedlichen medizinischen Verfahren. Zudem werden die therapeutischen Möglichkeiten samt Selbsthilfe der Patienten vorgestellt. Kribbeln und Stechen, brennende Schmerzen, aber auch Taubheit in bestimmten Körperteilen können erste Anzeichen für eine Polyneuropathie sein. Gerade in den letzten Jahren konnten in der Polyneuropathie-Forschung große Fortschritte erzielt werden, die in diesem Buch hautnah weitergegeben werden. Vorgestellt werden nicht nur ein breites Spektrum an erfolgsversprechenden Behandlungen, sondern auch eine Reihe von Selbsthilfemaßnahmen. Ergänzt wird das Buch mit praxisnahen Fallbeispielen, einem umfangreichen Serviceteil mit hilfreichen Adressen sowie Antworten auf häufige Patientenfragen. Die Neuauflage wurde erweitert mit aktuellen Informationen zu den Cannabinoiden, zum Schmerzpflaster sowie zu komplementären therapeutischen Methoden und Ernährungstipps. Das Buch richtet sich in erster Linie an alle Betroffene und deren Angehörigen, bietet aber auch für Allgemeinmediziner oder Vertreter anderer Gesundheitsberufen einen guten Überblick zum Krankheitsbild und den therapeutischen Ansätzen.
Polyneuropathie: So überwinden Sie quälende Nervenschmerzen
by Udo ZifkoKribbeln und Stechen, brennende Schmerzen, aber auch Taubheit in bestimmten Körperteilen können erste Anzeichen für eine Polyneuropathie sein. Der Ratgeber erklärt in einer dritten aktualisierten Auflage einfach und verständlich das Krankheitsbild, deutet mögliche Frühwarnsignale oder Symptome anhand von Beispielen, und zeigt den Weg zur gesicherten Diagnose mit Vorstellung der unterschiedlichen medizinischen Verfahren. Zudem werden die therapeutischen Möglichkeiten samt Selbsthilfe der Patienten beschrieben. Vorgestellt werden nicht nur ein breites Spektrum an erfolgsversprechenden Behandlungen, sondern auch eine Reihe von Selbsthilfemaßnahmen. Ergänzt wird das Buch mit praxisnahen Fallbeispielen, einem umfangreichen Serviceteil mit hilfreichen Adressen sowie Antworten auf häufige Patientenfragen. Die Neuauflage wurde erweitert mit aktuellen Informationen zu Covid-19, Long Covid und hilfreichen Bewegungsübungen. Das Buch richtet sich in erster Linie an alle Betroffene und deren Angehörigen, bietet aber auch für Allgemeinmediziner oder Vertreter anderer Gesundheitsberufen einen guten Überblick zum Krankheitsbild und den therapeutischen Ansätzen.
Musikermedizin in der Physiotherapie und Ergotherapie: Befund und Behandlung spielbedingter Beschwerden
by Clemens ZiesenitzIn diesem Buch werden die theoretischen Grundlagen der Musikermedizin sowie die besonderen Anforderungen und Belastungen von professionellen Musikerinnen und Musikern praxisorientiert vermittelt. Der herausfordernde Berufsalltag kann durch die asymmetrische Haltung, der statischen Beanspruchung am Instrument oder durch langanhaltende, repetitive Bewegungsabfolgen zu muskulären Dysbalancen oder Überlastungssyndromen führen. Der Autor beschreibt anhand häufiger Störungsbilder die Befunderhebung und Behandlung in der Physiotherapie und Ergotherapie Das Praxisbuch erweitert das Wissen auf diesem spezialisierten Gebiet und hilft dabei, Musikerinnen und Musiker bestmöglich zu unterstützen, um typische Beschwerden vorzubeugen und ihre Leistungsfähigkeit zu steigern.
Parietale Osteopathie: Über 60 Übungen für Automobilisation und Kräftigung
by Clemens ZiesenitzDieses Praxisbuch liefert Osteopathen und Physiotherapeuten Übungen für Patienten zur Automobilisation von Gelenkdysfunktionen und ergänzende Kräftigung für die stabilisierende Muskulatur. Sie suchen nach Übungsalternativen in verschiedenen Ausgangsstellungen? Sie fragen sich, was bei der Mobilisation der ersten Rippe mit Hilfe der Mm. Scaleni zu beachten ist? Oder ob sich die Greenman-Technik zur Behandlung einer ERS der Halswirbelsäule eignet? In diesem Buch werden Sie fündig!Aus dem Inhalt:• Grundlagen der Schmerzphysiologie• Automobilisation für Dysfunktionen an Becken, Wirbelsäule und Rippengelenken• Integrierende Stabilisationsübungen• Indikationen, KontraindikationenPlus: Videos via Springer Nature MoreMedia-App und Handouts für Patienten!Erweitern Sie Ihr Behandlungsrepertoire um über 60 effektive Eigenübungen, die Ihre Patienten ohne viel Aufwand in den Alltag integrieren können!
Intraocular Inflammation
by Manfred Zierhut Carlos Pavesio Shigeaki Ohno Fernando Oréfice Narsing A. RaoThis well-structured and lavishly illustrated book is a comprehensive reference on intraocular inflammation that encompasses all anatomic forms, settings and etiologies. Individual sections are devoted to uveitis associated with systemic disorders, uveitis syndromes restricted to the eye, bacterial uveitis, viral uveitis, fungal uveitis, parasitic uveitis, uveitis caused by other microbes, traumatic uveitis, and masquerade syndromes. Chapters on the different forms of uveitis are in a homogeneous reader-friendly format, with identification of core messages, explanation of etiology and pathogenesis, up-to-date information on diagnostics and differential diagnosis and guidance on the most appropriate forms of treatment and prognosis. Helpful flow charts are included to assist in identification of potential underlying disorders and the reader will also have online access to one hundred informative case reports demonstrating the different courses of intraocular inflammation. The authors are world experts keen to share their vast experience with the reader. Intraocular Inflammation will be a valuable resource for all physicians who deal with patients with inflammatory eye disease.
Muscle Metabolism
by Juleen R. Zierath Harriet Wallberg-HenrikssonDiabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
Ethical Issues in Cardiovascular Medicine (Routledge Annals of Bioethics)
by David M. Zientek Mark J. CherryThis book provides an exploration of the ethics of cardiology practice. It provides a variety of frameworks for analyzing ethical issues that arise in cardiovascular medicine. Cardiovascular medicine—the diagnosis and treatment of congenital and acquired diseases of the heart, major arteries, and veins—has seen rapid change in diagnosis, treatment, and the organization of practice in the last half of the twentieth and the beginning of the twenty first century. The complexity of these developments has resulted in increasing subspecialization, and many practitioners are challenged to stay abreast with the latest developments in cardiology. These changes also bring with them various ethical challenges. The chapters in this volume are divided by five broad areas of practice: beginning-of-life, end-of-life, transplantation and allocation of expensive or scarce resources, professionalism, and research. The case-based approach presented across the volume provides a perspective that will allow readers to reason through current and future ethical issues as they arise in this rapidly changing field. Ethical Issues in Cardiovascular Medicine will be of interest to researchers working in bioethics, clinical ethics, and the philosophy of medicine, as well as practicing physicians, nurses, and students who work in cardiovascular medicine.
Atlas of Whole Body Contouring: A Practical Guide
by Richard J. Zienowicz Ercan KaracaogluThis atlas presents current and proven strategies and techniques for body contouring in plastic and reconstructive surgery. In the majority of plastic surgeries, and likewise in body contouring surgeries, surgeons don't have the luxury of long learning curves. The book's simple, descriptive, and didactic structure addresses this issue. The topics have been carefully selected to avoid redundancies and, where there is more than one surgical option to choose from, expert contributors present the technique that has been broadly accepted as ‘the procedure of choice’. The easily accessible information will guide surgeons in their daily practice, helping them minimize complications and achieve consistent results. The book also presents a number of complicated cases, supported by descriptive figures and high-quality illustrations, offering a unique resource for plastic surgeons around the globe.
Cardiac Surgery: Operations on the Heart and Great Vessels in Adults and Children
by Gerhard Ziemer Axel HaverichThis text describes and illustrates with some 700 detailed anatomic and surgical drawings the whole spectrum of surgical procedures employed to treat acquired and congenital diseases of the heart and great vessels in adults and children.A rather traditional chapter on history of cardiac surgery precedes chapters dedicated to quality improvement, followed by ICU management in adult and pediatric cardiac surgery, and techniques of extracorporeal circulation in both age groups.Further special topics are cardiovascular tissue engineering, minimally invasive cardiac surgery, endovascular treatment of aortic diseases, and cardiac assist devices, including total artificial heart.Written by 71 internationally recognized experts from 40 cardiac units in Central Europe and North America, this book will be invaluable not only for both novice and experienced surgeons, but also for all physicians, nurses, and technicians caring for patients with heart disease of any type, at any age.
Genotype Phenotype Coupling: Methods and Protocols (Methods in Molecular Biology #2070)
by Stefan Zielonka Simon KrahThis volume aims at providing state-of-the-art protocols detailing ribosome display, cDNA display, phage display, yeast surface display, and mammalian display. Chapters guide readers through methods and protocols on in vitro methods over prokaryotic display systems, lower eukaryotes, and mammalian cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of all necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotype Phenotype Coupling aims to provide an overview of current technologies in this exciting and continuously evolving field.
The Transcervical Approach in Thoracic Surgery
by Marcin Zieliński Ramón Rami-PortaUse of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors' experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea and esophagus and miscellaneous items including the role of robotic surgery.
The Acute Management of Surgical Disease
by Martin D. Zielinski Oscar GuillamondeguiEmergency General Surgery has become a cornerstone of Acute Care Surgery over the past decade. Once the scope of community general surgeons, the growing complexity of patients with acute surgical diseases has increasingly driven their care to tertiary referral centers. The aging population confounds this problem further as these patients present with more complex comorbidities, life-threatening physiology, and progressively severe anatomic disease severity. To ensure better outcomes, the practice has evolved to focus on evidence-based practice management guidelines in order to standardize care and optimize outcomes.The purpose of this text is to be a comprehensive volume for patients with acute surgical diseases. There will be three sections, each comprised of multiple chapters. The first section will be a comprehensive analysis of the background of Emergency General Surgery. The goal of this section will be to provide the reader background into the acute surgical practice and to introduce the reader to the important concepts discussed in the remainder of the textbook. The second section will be the largest and will discuss specific acute surgical diseases. Individual chapters will outline the diagnostic approach, current treatment standards, operative approaches, and expected outcomes with an emphasis on practice management guideline implementation into practice. As acute surgical diseases and surgical critical care are integral to each other, the last section will be Critical Care for the Acute Care Surgeon. These topics will focus on the critical care concepts essential to surgeons who care for acute diseases.This comprehensive text is targeted to any surgeon who takes emergency call for any of the listed diseases including community and referral general and vascular surgeons. In addition, this would be an excellent resource for all general surgery residents. Lastly, this would also serve as a resource to intensivists who care for acute surgical patients.
Drugs for HER-2-positive Breast Cancer
by Christoph C. Zielinski Rupert Bartsch Thomas W. Grunt Maria SibiliaGrowth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting.
Handleiding medisch wetenschappelijk onderzoek
by G. A. Zielhuis P.H.J.M. Heydendael J. C. Maltha P.L.C.M. RielDe moderne geneeskunde is in belangrijke mate gefundeerd op resultaten van medisch-wetenschappelijk onderzoek. Nieuwe inzichten in preventie, diagnose en prognose van ziekten kunnen alleen tot stand komen door degelijk uitgevoerd wetenschappelijk onderzoek. Evenzo kan de effectiviteit van een behandeling alleen door middel van goed onderzoek worden geëvalueerd. Kortom, medisch-wetenschappelijk onderzoek onderbouwt de toepassing van geneeskunde. Op basis van een 12-stappenplan biedt de Handleiding medisch-wetenschappelijk onderzoek de lezer een praktische handreiking bij de opzet en uitvoering van onderzoek. Een uitstekend hulpmiddel voor de: -arts(-assistent) die een wetenschappelijk artikel wil publiceren; -junior onderzoeker bij de aanvang van een onderzoek; -student die een scriptie of wetenschappelijk verslag wil schrijven; Deze achtste druk is geheel geactualiseerd. Er ligt nu meer nadruk op de context waarin het onderzoek plaatsvindt: wat is de relevantie voor mens en maatschappij, welke belangen zijn er, en hoe kan onderzoek integer en transparant blijven. Het aantal vormen van onderzoek is uitgebreid, o. a. met chirurgisch onderzoek, laboratoriumexperimenten, Big Data en data-gedreven studies. Actuele ontwikkelingen op het gebied van wetenschappelijke informatievoorziening, open access, organisatie en financiering en wetenschappelijke toetsing zijn verwerkt. Met moderne voorbeelden wordt ook de laboratoriumonderzoeker aangesproken. Het volledige boek is ook digitaal beschikbaar met samenvattingen en toetsvragen per hoofdstuk en interessante en verdiepende links.
Bio-Inspired Information Pathways: From Neuroscience to Neurotronics (Springer Series on Bio- and Neurosystems #16)
by Martin Ziegler Thomas Mussenbrock Hermann KohlstedtThis open access book offers a timely and comprehensive review of the field of neurotronics. Gathering cutting-edge contributions from neuroscientists, biologists, psychologists, as well as physicists, microelectronics engineers and information scientists, it gives extensive information on fundamental information pathways in selected nervous systems. It also highlights their relevance as building blocks for novel computing architectures, such as bio-inspired electronic devices, neuromorphic architectures, memristive devices, adaptive sensors and emergent, pulsed-coupled oscillatory networks. All in all, this book offers a unique bridge between fundamental research in neuroscience, neural information processing, nonlinear dynamics, and self-organization, and advanced practical applications concerning the fabrication of hardware-oriented computing.
Notfallmedizin
by Thomas ZiegenfußDieses Lehrbuch bietet Ihnen einen vollständigen Überblick über alle prüfungsrelevanten Inhalte der Notfallmedizin. Es leitet Sie leicht verständlich von den Grundlagen bis zur Praxis durch das gesamte Wissen. Profitieren Sie von der langjährigen Erfahrung des Autors, der sorgfältig das Wesentliche für Sie ausgewählt und aufbereitet hat.Der InhaltDiese aktualisierte Neuauflage berücksichtigt die Leitlinien des European Resuscitation Council 2020. Zahlreiche Abbildungen und das bewährte didaktische Konzept ermöglichen ein effizientes Lernen:Prüfungsteil – Für eine optimale Vorbereitung auf FallstudienCave- und Merksätze – Bringen das Wichtigste auf den PunktPraxistipps – Stellen einen anschaulichen Bezug zur Notfallpraxis herDer AutorDr. Thomas Ziegenfuß ist Chefarzt der Abteilung für Anästhesie und Intensivmedizin des St. Josef-Krankenhauses in Moers. An der Klinik für Anästhesiologie und Intensivmedizin der Universitätskliniken des Saarlandes war er Oberarzt, langjähriger Einsatzleiter für den Notarztdienst und Leitender Notarzt.
Information and Communication Technologies for Ageing Well and e-Health: 5th International Conference, ICT4AWE 2019, Heraklion, Crete, Greece, May 2–4, 2019, Revised Selected Papers (Communications in Computer and Information Science #1219)
by Martina Ziefle Leszek A. MaciaszekThis book constitutes the thoroughly refereed proceedings of the third International Conference on Communication Technologies for Ageing Well and e-Health, ICT4AWE 2019, held in Heraklion, Crete, Greece in May 2019.The 9 full papers presented were carefully reviewed and selected from 52 submissions. The papers aim at contributing to the understanding of relevant trends of current research on ICT for Ageing Well and eHealth including the ambient assisted living.
Information and Communication Technologies for Ageing Well and e-Health: 6th International Conference, ICT4AWE 2020, Prague, Czech Republic, May 3–5, 2020, Revised Selected Papers (Communications in Computer and Information Science #1387)
by Martina Ziefle Nick Guldemond Leszek A. MaciaszekThis book constitutes the revised, selected and extended papers of the 6th International Conference on Communication Technologies for Ageing Well and e-Health, ICT4AWE 2020, held in Prague, Czech Republic, in May 2020. Due to the COVID-19 pandemic the conference was held online. The 7 full papers presented were carefully reviewed and selected from 50 submissions. The papers present most recent research on best practices, innovation and technical improvements in the fields of age and health care, education, psychology, social coordination and ambient assisted living.
Rethinking Lean in Healthcare: A Business Novel on How a Hospital Restored Quality Patient Care and Obtained Financial Stability Using Lean
by Thomas G. ZidelThis book deals with a hospital's struggle to secure and maintain financial stability. In the story, the leadership team of a fictional hospital adopts the tools and principles associated with the Toyota Production System or Lean. The story takes the reader through leadership's arduous journey from rejecting the methodology to embracing it, to successful implementation. This book is important because many of our nation's hospitals are besieged with financial difficulties with declining reimbursement and the public is losing confidence in our hospital's ability to provide quality care without error. Lean can provide relief from these issues but only if it is properly implemented.
Lean Done Right: Achieve and Maintain Reform in Your Healthcare Organization (ACHE Management)
by Thomas ZidelWinner of the Axiom Business Book Award Silver Medal - Operations Management and Shingo Research and Professional Publication Award! Your healthcare organization cannot afford to waste time, money, or resources on an improper Lean implementation. You want to create a culture of continuous improvement, not a regime of tools that address problem areas but have short-lived results. Lean Done Right: Achieve and Maintain Reform in Your Healthcare Organization provides a roadmap for launching a transformative and sustainable Lean initiative. The Lean implementation model focuses on strategically directed action, developing a lean organizational culture, and enhancing the care delivery system. Chapters include: Death by Kaizen Event A Lean Implementation Model Strategically Directed Action The Culture-Creating Path Implement the Value Stream Work Plan The System-Creating Path Instructor Resources: PowerPoint slides of the exhibits from selected chapters.
Function-Oriented Bioengineered Skin Equivalents: Continuous Development Towards Complete Skin Replication (SpringerBriefs in Molecular Science)
by Tanja Zidarič Karin Stana Kleinschek Uroš Maver Tina MaverThe book Function-oriented bioengineered skin equivalents - continuous development towards complete skin replication aims to provide potential readers with a comprehensive summary of the available information on various in vitro skin models, from historical background to different modeling approaches and their applications. Particular emphasis is placed on presenting the current technological components available for the development of engineered skin equivalents by summarizing advances in cell cultivation, materials science, and bioengineering. Using examples of the current-state-of-art, we describe the advantages, limitations, and challenges of developing in vitro skin models for successful use in clinical applications and skin-related research.