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¡Atrapa la estrella!
by Brenda Ehrmantraut—No será el mismo juego que solíamos hacer, sino algo muy especial cada atardecer. Cuando un soldado se tiene que ir al otro lado del mundo por su trabajo, él y su hijo juegan a tirar y atrapar la Estrella del Norte. ¡Atrapa la estrella! es una historia clásica que ayudará a las familias a sentirse cerca, aun cuando están lejos. La edición original en inglés, Night Catch, ha sido un título preferido desde el 2005. “... ¡Night Catch es lo mejor de lo mejor!” —Sally Ann Zoll, Directora General, United Through Reading “... un libro elemental en nuestro programa para padres ... ¡Lo recomendamos con entusiasmo!” —Military Child Education Coalition ~ “Not ball as usual in the park, but something special after dark.” When a soldier has to go to the other side of the world for his work, he and his son play a game with the North Star. ¡Atrapa la estrella! is a timeless story that helps families feel connected, even when they are separated. The English edition, Night Catch, has been a favorite since 2005! “... Night Catch is the best of the best! —Sally Ann Zoll, CEO, United Through Reading “... a staple in our Parent to Parent Program … We enthusiastically recommend it! —Military Child Education Coalition
¡Al bebé le encantan los quarks! (Baby Loves Science)
by Ruth SpiroDisponible en edición bilingüe inglés-español, esta exitosa serie ofrece importantes e interesantes temas científicos para hacer pensar a los más pequeños.Con la exactitud de un experto y la sencillez para que lo entienda un niño, Quarks explica los principios físicos y químicos básicos de las partículas (quarks, protones, neutrones, átomos y moléculas) y los relaciona con el mundo del bebé. Contiene atractivas ilustraciones que se complementan con un lenguaje apropiado para que el bebé se maraville. Y no solo el bebé... ¡padres y cuidadores también pueden aprender mucho!Now available in Spanish bilingual editions, this best-selling series offers big, brainy science for the littlest listeners.Accurate enough to satisfy an expert, yet simple enough for Baby, Quarks explores the basics of particle physics and chemistry - quarks, protons, neutrons, atoms and molecules - and ties it all to Baby's world. Beautiful, visually stimulating illustrations complement age-appropriate language to encourage a baby's sense of wonder. Parents and caregivers may learn a thing or two as well!
¡Al bebé le encanta la ingeniería aeroespacial! (Baby Loves Science)
by Ruth SpiroDisponible en edición bilingüe inglés-español, esta exitosa serie ofrece importantes e interesantes temas científicos para hacer pensar a los más pequeños.Con la exactitud de un experto y la sencillez para que lo entienda un niño, este libro explica los principios básicos del vuelo, desde el de las aves y los aviones hasta el de los cohetes, y los relaciona con el mundo del bebé. Contiene atractivas ilustraciones que se complementan con un lenguaje apropiado para que el bebé se maraville. Y no solo el bebé... ¡padres y cuidadores también pueden aprender mucho!Now available in Spanish bilingual editions, this best-selling series offers big, brainy science for the littlest listeners.Accurate enough to satisfy an expert, yet simple enough for Baby, this book explores the basics of flight--from birds to planes and rockets--and ties it all to Baby's world. Beautiful, visually stimulating illustrations complement age-appropriate language to encourage a baby's sense of wonder. Parents and caregivers may learn a thing or two as well!
¡Al bebé le encanta la gravedad! (Baby Loves Science)
by Ruth SpiroNow available in Spanish bilingual editions, this best-selling series offers big, brainy science for the littlest listeners.Accurate enough to satisfy an expert, yet simple enough for baby, this clever board book explores the ups and downs of gravity. When baby drops food from a high chair, why does it fall? Beautiful, visually stimulating illustrations complement age-appropriate language to encourage baby's sense of wonder. Parents and caregivers may learn a thing or two, as well!
¡A soñar con la ciencia!
by Michelle SchaubDesde la astronomía hasta la física, la química y la geología, este libro ilustrado de STEM ayudará a los niños a decir buenas noches con ciencias. ¡Ahora en español!From astronomy to physics to chemistry to geology, this STEM picture book will help kids say goodnight with science. Now in Spanish!Doce niños y niñas. Una docena de horas de dormir. ¡Infinitas maneras de ayudar a los niños pequeños a emocionarse por explorar y tener dulces sueños sobre once ramas de la ciencia en este libro donde las buenas noches conocen información científica!Incluye texto final para más información acerca de cada área de estudio.Twelve kids. A dozen bedtimes. Endless ways to help young kids get excited to explore and have sweet dreams about eleven branches of science in this goodnight meets science information book!Includes back matter for further information about each area of study.
x+y: A mathematician's manifesto for rethinking gender
by Eugenia ChengScience and maths have never been the preserve of lone geniuses: collaboration has always been at the heart of intellectual endeavour. But to this day, men like Einstein remain the pervasive archetype of genius, and the intellectual contributions of women past and present have gone unacknowledged. x+y is one mathematician's manifesto for how we can fix that - and why that requires rethinking how we think about thinking itself.In her illuminating new book, Royal Society Book Prize finalist Eugenia Cheng reveals how mathematics can help us escape gendered stereotypes by giving us new structures based on character, not gender. By reframing intellectual endeavour beyond the myth of the lone genius, she shows that the real key to success is thinking more collaboratively. Through her radical new framework for understanding traditional ideas about gender and thinking, Cheng shows us how one small but powerful change to the way we think could make the world a better place for men and women alike.
t zero
by Italo CalvinoA collection of stories about time, space, and the evolution of the universe in which the author blends mathematics with poetic imagination. "Calvino does what very few writers can do: he describes imaginary worlds with the most extraordinary precision and beauty" (Gore Vidal, New York Review of Books). Translated by William Weaver. A Helen and Kurt Wolff Book
smART: Use Your Eyes to Boost Your Brain (Adapted from the New York Times bestseller Visual Intelligence)
by Amy E. HermanI Spy and Where&’s Waldo? get a revolutionary twist in this self-directed, interactive book that teaches young readers how to fully engage their brains to think critically and creatively.What would you say if I told you that looking at art could give you the confidence you need to speak up in class? Or that learning the history of donuts could help you think like a super spy and train like the CIA? smART teaches readers how to process information using paintings, sculptures, and photographs that instantly translates to real world situations and is also fun! With three simple steps (1) How to SEE, (2) How to THINK about what you see, and (3) How to TALK about what you see, readers learn how to think critically and creatively, a skill that only requires you to open your eyes and actively engage your brain.
siRNA Design
by Debra J. TaxmanThe discovery of RNA interference (RNAi) as a methodology for gene silencing has revolutionized biological research, providing an invaluable avenue for therapeutics, and small interfering RNA (siRNA) is the most common strategy utilized for enacting RNAi. siRNA Design: Methods and Protocols offers expertly crafted guidelines and protocols for the selection of siRNA targeting sequences, for the strategic incorporation of chemical modifications, and for advantageous structural modifications to the classic siRNA design. Protocols are provided for using endogenous cellular machinery to produce siRNA from optimized precursor short hairpin RNA (shRNA) and artificial microRNA (amiRNA) molecules. Strategies are also described for specific applications such as immunostimulatory siRNA that may provide therapeutic benefit against viral infections in mammals, the simultaneous targeting of multiple siRNAs, and siRNA-mediated crop virus resistance. The design of RNAi for gene silencing in embryonic, invertebrate, and plant systems requires a variety of unique approaches, several of which are described towards the end of this volume. Written for the highly successful Methods in Molecular BiologyTM series, this work contains the kind of detailed description and implementation advice that guarantees successful results. Authoritative and easy to use, siRNA Design: Methods and Protocols will provide researchers, educators, clinicians, and biotech specialists with a broad understanding of the issues in RNAi and how they can be overcome strategically through design.
sEMG-based Control Strategy for a Hand Exoskeleton System (Springer Theses)
by Nicola SeccianiThis book reports on the design and testing of an sEMG-based control strategy for a fully-wearable low-cost hand exoskeleton. It describes in detail the modifications carried out to the electronics of a previous prototype, covering in turn the implementation of an innovative sEMG classifier for predicting the wearer's motor intention and driving the exoskeleton accordingly. While similar classifier have been widely used for motor intention prediction, their application to wearable device control has been neglected so far. Thus, this book fills a gap in the literature providing readers with extensive information and a source of inspiration for the future design and control of medical and assistive devices.
q-RASAR: A Path to Predictive Cheminformatics (SpringerBriefs in Molecular Science)
by Kunal Roy Arkaprava BanerjeeThis brief offers an introduction to the fascinating new field of quantitative read-across structure-activity relationships (q-RASAR) as a cheminformatics modeling approach in the background of quantitative structure-activity relationships (QSAR) and read-across (RA) as data gap-filling methods. It discusses the genesis and model development of q-RASAR models demonstrating practical examples. It also showcases successful case studies on the application of q-RASAR modeling in medicinal chemistry, predictive toxicology, and materials sciences. The book also includes the tools used for q-RASAR model development for new users. It is a valuable resource for researchers and students interested in grasping the development algorithm of q-RASAR models and their application within specific research domains.
piRNA: Methods and Protocols (Methods in Molecular Biology #2509)
by Nicholas F. Parrish Yuka W. IwasakiThis detailed volume explores newly-developed methods in PIWI-interacting RNAs (piRNAs) research, methods currently applied to other ncRNAs involved in nuclear regulation which can be used to study piRNAs, and piRNA methods applied in non-classical organisms. It also includes several bioinformatic and biophysical methods related to piRNA studies, consistent with the increasing importance of high-throughput sequencing and computational methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, piRNA: Methods and Protocols serves as an ideal guide for researchers seeking to elucidate the numerous mysteries of this area of multicellular biology.
pH-Messung: Der Leitfaden für Praktiker
by Ralf DegnerEin Buch fur Praktiker, das auch dem erfahrenen Profi noch einiges Neues bietet. Themen wie die Kalibrierung und die Qualitatssicherung werden Sie aus einem vollig neuen Blickwinkel betrachten. Anwendung: Sie erhalten eine Vielzahl an Beispielen fur die praktische pH-Messung in den verschiedensten Materialen, sei es die Online-Messung im Abwasser, die Kontrollmessung von Textilien oder die Profil-Messung in Seen. Empfehlungen zu allen Komponenten der Messeinrichtung machen das Buch auch fur die Beschaffung zu einer wertvollen Unterlage. Grundlagen: Sie erhalten eine Einfuhrung daruber, was der pH-Wert ist, wie die Messkette funktioniert und wie sich Storungen auswirken. Sie erfahren alles, was notig ist, um das Verhalten einer pH-Messkette richtig beurteilen zu konnen. Qualitatssicherung: Das Umsetzen der Prufmitteluberwachung beeinflusst die bisher gewohnten Verfahrensablaufe erheblich. Lesen Sie wie die Qualitatssicherung speziell fur die pH-Messung ablauft und welche Unsicherheit Ihre Messergebnisse haben konnen. Dieses Buch ist ein 'Muss' fur alle, die * in irgend einer Weise mit pH-Messung zu tun haben * Normen, Gebrauchs- und Prufanweisungen fur die pH-Messung erstellen * pH-Messeinrichtungen herstellen.
p53 Protocols, 2nd Edition
by Swati Palit Deb Sumitra DebThe second edition of p53 Protocols expands upon the first edition with progress in p53 research since the publication of the first edition. In p53 Protocols, Second Edition expert researchers in the field detail many of the methods that address the challenging questions of the p53 field. These methods include the identification of the target genes and binding partners of gain of function p53 mutants, methods to determine stress response, autophagy or senescence induced by p53, cell cycle analysis, analysis of different phases of DNA replication modified by p53, and generation of pluripotent stem cells. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, p53 Protocols, Second Edition seeks to aid scientists in the further study into p53 and other tumor suppressors.
p53 Protocols
by Swati Palit Deb Sumitra DebAn indispensable collection of novel techniques that have proven most useful for studying the physiological properties of p53 both in vitro and in vivo. The techniques provide proven solutions to problems in studying the purification, target identification, gene expression, quantitation, interaction, signaling, transactivation, and transrepression of p53. The methods are also useful for delineating the functions of other proteins that may act as tumor or growth suppressors. Each technique includes step-by-step instructions, troubleshooting notes, a theoretical review, and discussion of associated problems that might arise during the course of investigation.
ncRNAs: The Unarguable Biological Function to Environmental Constrains
by Muhammad Waseem Sajid Fiaz Channapatna S. PrakashNon-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but play pivotal roles in regulating gene expression and cellular processes. Emerging evidence suggests that ncRNAs have evolved as key regulators in mediating adaptive responses to environmental constraints. By modulating gene expression, ncRNAs enable organisms to fine-tune their physiological and cellular processes to maintain homeostasis under different environmental conditions. Understanding the biological function of ncRNAs in response to environmental stimuli is crucial for unraveling the complex regulatory networks that underlie adaptation and survival. This book explores various types of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), and their involvement in the modulation of gene expression networks in plants to adapt to changing environmental conditions. Additionally, the book discusses the mechanisms by which ncRNAs interact with their target molecules, such as mRNAs and proteins, to exert regulatory effects. This information about nRNA response to environmental stresses - acting as regulators of cellular processes and stress-related signaling pathways for improving crop production - are lying unorganized in different articles of journals and edited books. Therefore, it is time demanding to publish a book dealing with these aspects. The introduction discusses the significance of understanding ncRNA-mediated regulation in the context of adaptation and survival in changing environmental conditions. By providing a comprehensive overview, this sets the stage for the subsequent chapters. Chapters then delve into the role of ncRNAs in epigenetic regulation and transgenerational effects, and explore how ncRNAs participate in shaping the epigenome and influencing heritable gene expression without altering the DNA sequence. This book discusses the implications of ncRNA-mediated epigenetic regulation in adapting to environmental challenges and its potential transgenerational effects. It summarizes key findings and highlights the importance of ncRNA-mediated regulation in responding to environmental constraints, emphasizing the unarguable biological function of ncRNAs and their role as critical regulators in adaptation and survival.
n-Culturalism in Managing Work and Life: A New Within Individual Multicultural Model (Springer Series in Emerging Cultural Perspectives in Work, Organizational, and Personnel Studies)
by Andre A. PekertiThis book introduces the concept of n-Culturalism – a play on the notation of sub-sample size indicating that multiple and different samples can exist within a body of work/research. It suggests that n-Culturals are a different type of multicultural individual, with different skills and abilities. At the same time, it contends that because n-Culturals represent a different type of multicultural, they also face different challenges that many non-multicultural individuals do not encounter. Lastly, it discusses the idea that being multicultural is manageable and offers opportunities for those who embrace it rather than avoid it.
myWorld Interactive Middle Grades Geography 2019 National Survey (Student Edition Grade 6/8)
by Prentice-Hall StaffmyWorld Interactive Middle Grades Geography 2019 National Survey (Student Edition Grade 6/8)
modern Crises And Traditional Strategies
by Roy EllenThe 1990s have seen a growing interest in the role of local ecological knowledge in the context of sustainable development, and particularly in providing a set of responses to which populations may resort in times of political, economic and environmental instability. The period 1996-2003 in island southeast Asia represents a critical test case for understanding how this might work. The key issues explored in this book are the creation, erosion and transmission of ecological knowledge, and hybridization between traditional and scientifically-based knowledge, amongst populations facing environmental stress (e.g. 1997 El Niño), political conflict and economic hazards. The book will also evaluate positive examples of how traditional knowledge has enabled local populations to cope with these kinds of insecurity.
microRNAs in Toxicology and Medicine
by Saura C. SahuDuring the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. Divided into six parts, topics covered include:microRNA and toxicology - including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancermicroRNAs and disease statesmicroRNAs and stem cellsmicroRNAs and genomicsmicroRNAs and epigenomicsmicroRNAs and biomarkers - including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitismicroRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government.
microRNA: Medical Evidence
by Gaetano SantulliThis volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today's initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Scienceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
microRNA: Cancer
by Gaetano SantulliThis volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content. microRNA: Cancer is an ideal companion to both microRNA: Basic Science andmicroRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
microRNA: Basic Science
by Gaetano SantulliThis volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and more. Throughout, numerous color photographs, diagrams of molecular pathways, and tables enhance the text. microRNA: Basic Science is an ideal companion to both microRNA: Medical Evidenceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
miRNomics: MicroRNA Biology and Computational Analysis (Methods in Molecular Biology #2257)
by Malik Yousef Jens AllmerThis second edition presents an up-to-date overview of the current state-of-the-art protocols and aims to miRNomics into a broader perspective. Chapters detail methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, miRNomics: MicroRNA Biology and Computational Analysis, Second Edition ensures successful results in the further study of this vital field.
miRNomics: MicroRNA Biology and Computational Analysis
by Malik Yousef Jens AllmerIn miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.