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Antibacterial Surfaces
by Elena Ivanova Russell Crawford'Antibacterial Surfaces' covers the advances being made in the design of antibacterial surfaces, which have the ability to either prevent the initial attachment of bacterial cells, or kill any cells that come into contact with these surfaces. This book discusses the mechanisms associated with the attachment of bacteria to surfaces and the main strategies currently being employed to control the initial attachment processes. These strategies are expanded upon in the subsequent chapters, where the definition and description of antibacterial surfaces are clarified, as are the mechanisms that come into play when determining the effectiveness of an antibacterial surface. Subsequent chapters discuss a number of naturally occurring antibacterial surfaces, the methods currently being used for producing synthetic antibacterial surfaces, and the current and potential applications of such materials. This book will be of great interest to people who work with materials that need to remain free of bacterial films, from designing safer biomedical implants to the production of self-cleaning materials where the prevention of biofilm formation has significant economic advantages.
Antibacterials: Volume I (Topics in Medicinal Chemistry #25)
by Jed F. Fisher Shahriar Mobashery Marvin J. MillerMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors
Antibacterials: Volume II (Topics in Medicinal Chemistry #26)
by Jed F. Fisher Shahriar Mobashery Marvin J. MillerMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors
Antiballistic Missile Defence in the 1980s (Routledge Library Editions: Cold War Security Studies #2)
by Ian Bellany; Coit D. BlackerThis book, first published in 1983, analyses the technical and political developments in the two decades after the 1972 Soviet-American ABM treaty. It signposts the route for discussion of the antiballistic missile question – with its shared tacit assumption that nuclear war is for deterring and not fighting – and examines the dangerous tendency to conduct the ABM debate of the 1980s with the technical and political assumptions of the 1960s.
Antibiofilm Agents: From Diagnosis to Treatment and Prevention (Springer Series on Biofilms #8)
by Iqbal Ahmad Kendra P. RumbaughThis book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.
Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms (Springer Series on Biofilms #11)
by Katharina Richter Kasper Nørskov KraghBacteria and fungi are able to aggregate together or on surfaces in densely packed microcolonies, facilitated by extracellular polymeric substances for cell protection and stability. These biofilms have proven to be extremely hard to eradicate and remove once established. In chronic infections, this condition can result in a high degree of morbidity and mortality as regular antibiotic treatments are ineffective against biofilms. In industrial facilities, the formation of biofilms can ruin production and result in enormous financial losses. In this book, the current state of antibiofilm research is presented by experts from around the world. Novel, cutting-edge techniques and new optimized strategies based on established methods are discussed in chapters focused on biofilm prevention, treatment and control for the application in clinical, industrial and veterinary settings. Antibiofilm strategies, such as chemical and enzymatic treatments, surface modification and coatings, quorum sensing inhibition and dispersal induction, phage therapy, cold plasma treatment, hyperbaric oxygen treatment, and metal-based nanomedicine are covered, among many others. This book contributes to the UN’s Sustainable Development Goal 3: Good Health and Well-Being and is a valuable resource for healthcare professionals, microbiologists, academics and for educators to inform curricula of universities and colleges.
The Antibiotic Alternative: The Natural Guide to Fighting Infection and Maintaining a Healthy Immune System
by Cindy L. JonesAvoid the dangerous overuse of antibiotics by using natural herbal remedies to strengthen your own immune defenses. • Protect yourself and your family from the misuse of antibiotics. • Learn how to control and overcome infections with natural remedies. • Maintain a vibrant and healthy immune system without antibiotic dependency. When antibiotics were discovered they were hailed as the magic bullet that would put an end to the threat of infectious disease. In fact, in 1969 the U.S. Surgeon General stated that "the war against infectious disease has been won." But in the last fifteen years we have faced an alarming increase in cases of bacterial infections that will not respond to antibiotics. What is more, the use of antibiotics in agricultural feeds and the widespread overprescription of antibiotics has deepened the threat of resistant bacteria to potentially epidemic proportions. Even when appropriately prescribed, antibiotics weaken the immune system by altering the body's natural bacterial balance. While antibiotics have their place in treating acute life-threatening conditions, The Antibiotic Alternative shows how the best defense against infectious disease is to strengthen your own immune system. With advice on stress management and diet and complete monographs of a dozen readily available herbs, Dr. Jones shows you how to ward off infectious disease naturally without antibiotic overdependence. She provides directions for making herbal teas, salves, and tinctures and includes specific herbal recommendations for more than twenty common ailments ranging from acne to wound treatment.
Antibiotic and Antifungal Therapies in Dermatology
by Jón Hjaltalín Ólafsson Roderick James HayThis book is an up-to-date practical guide to the treatment of both common and unusual bacterial, fungal, and protozoal skin infections. Antibiotics and other treatment options for common skin diseases such as acne, rosacea, erysipelas, and impetigo are extensively discussed, and a thorough update is provided on therapies for fungal infections in the nails, hair, and skin. Current treatments for skin symptoms associated with sexually transmitted diseases are also explored in detail. A range of mycobacterial infections are discussed, and a further chapter considers the treatment of protozoal infections, including leishmaniasis, which are often unfamiliar to practitioners in the Western world. This handy book, with its helpful graphics and clear lists of symptoms, treatments, and practical tips, will be an ideal quick reference for the busy practitioner.
Antibiotic Basics for Clinicians: The Abcs Of Choosing The Right Antibacterial Agent (Point (lippincott Williams And Wilkins) Ser.)
by Alan HauserPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Popular as a classroom text, for review, and as a clinical quick-reference, this time-saving resource helps medical students master the rationale behind antibiotic selection for common bacterial pathogens and infectious diseases. Updated content reflects the latest antibiotic medications available on the market, and new full-color illustrations strengthen users’ understanding of the application of antibiotic drug treatment.
Antibiotic Development and Resistance
by Diarmaid Hughes Dan I. AnderssonThe increasing resistance of bacteria towards all current classes of antibiotics is now a serious health problem in both developed and developing countries. Antibiotic Development and Resistance presents 15 chapters that explore the medical issues raised by this development and review the relevant literature. The book begins by reviewing the global
Antibiotic Discovery and Development
by Michael J. Pucci Thomas J. DoughertyThis volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Antibiotic Drug Resistance
by José‐Luis Capelo‐Martínez Gilberto IgrejasThis book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
The Antibiotic Era: Reform, Resistance, and the Pursuit of a Rational Therapeutics
by Scott H. PodolskyA compelling analysis of nearly seven decades of antibiotic reform, framing our current efforts to stave off a post-antibiotic era.Winner of the CHOICE Outstanding Academic Title of the Choice ACRLIn The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the media.During the post–World War II "wonder drug" revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs. Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibiotics—indeed, about a post-antibiotic era—are widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.
Antibiotic Optimization: Concepts and Strategies in Clinical Practice (Infectious Disease And Therapy Ser. #Vol. 34)
by Robert C. Owens Jr. Paul G. Ambrose Charles H. NightingaleThis book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Antibiotic Pharmacodynamics (Methods in Pharmacology and Toxicology)
by Keith A. Rodvold John C. Rotschafer David R. AndesThis text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
by Jeffrey Lipman Jason A. Roberts Andrew A. UdyThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Antibiotic Policies: Controlling Hospital Acquired Infection
by Ian M. Gould Jos W.M. MeerThe first book was on "Theory and Practice" of antibiotic stewardship in its broadest sense -the how to do it and the do's and don'ts. The second, on "Controlling resistance" was very much on the relationships between use and resistance and beginning to home in on the hospital as the main generator of resistance, but mainly looking at it from a disease/clinical perspective. The last 3 chapters on MRSA, ended where the 3rd book will take off. "Controlling HAI " will concentrate on specific MDR organisms highlighting their roles in the current pandemic of HAI and emphasizing that the big issue is not so much infection control but antibiotic control, in the same way that antibiotic over-reliance/ over-use has caused the problem in the first place. Up 'till now the emphasis for controlling MRSA, C diff and all the other MDROs has very much been on IC, which clearly isn't working. This book will gather all the evidence for the increasingly popular view that much more must be done in the area of antibiotic policies/ stewardship, especially when we are in danger of a "post antibiotic" era, due to a real shortage of new agents in the pipeline.
Antibiotic Residue and Resistance in Seafood Safety and Quality
by Asem Sanjit Singh Manoharmayum Shaya Devi Upendra NongthombaThis book embark explores the global antibiotic trends in seafood, and delves into the intricate interplay between antibiotic consumption and its ramifications within the seafood industry. The nuanced effects of processing techniques on antibiotic residue levels in seafood are investigated, elucidating the prevalence of antibiotics and their metabolites within these commodities. The book also peers into the microbial realm of seafood, revealing the intricacies of resistance mechanisms, prevalence rates, pathogenicity, and related phenomena. It then explores the antibiotic alternatives in aquatic environments, including the utilization of nanoparticles and plant extracts. Artificial intelligence integration and sensor development for antibiotic residue detection ensures quality assurance and consumer safety within the seafood industry, and has been well-covered in this volume. This edited volume is beneficial for graduate students in fisheries science, life sciences, animal biotechnology, zoology, and microbiology. This can be a reference material for fisheries professionals, scientific communities, researchers, and scholars as well, for navigating the global antibiotic trends in seafood.
Antibiotic Resistance (Handbook of Experimental Pharmacology #211)
by Anthony R.M. CoatesThis book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.
Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies - Workshop Summary
by Institute of Medicine of the National AcademiesYears of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.
Antibiotic Resistance in the Environment: A Worldwide Overview (The Handbook of Environmental Chemistry #91)
by Célia M. Manaia Erica Donner Ivone Vaz-Moreira Peiying HongThis book provides a multidisciplinary review of antibiotic resistance and unravels the complex and interrelated roles of environmental sources, including pharmaceutical industry effluents, hospital and domestic effluents, wildlife and drinking water. Antibiotic resistance is a global public health issue in which the interface between humans, animals and the environment is particularly relevant. The contrasts seen across different environmental compartments and world regions, which are due to climate, social and policy differences, mean that this problem needs to be analyzed from a multi-geographic and multi-cultural angle. Bringing together contributions from researchers on different continents with expertise in antibiotic resistance in a range of different environmental compartments, the book offers a detailed reflection on the paths that make antibiotic resistance a global threat, and the state-of- the-art in antibiotic resistance surveillance and risk assessment in complex environmental matrices.
Antibiotic Resistance Methods and Protocols: Methods And Protocols (Methods in Molecular Medicine #48)
by Stephen H. GillespieStephen Gillespie and a panel of leading clinical and diagnostic microbiologists describe a series of detailed molecular and physical methods designed to study the growing problem of antibiotic resistance, as well as facilitate new antibiotic research programs for its effective redress. The techniques range widely from those that provide rapid diagnosis via DNA amplification and phage display, to those for plotting the transmission of resistant organisms and investigating their epidemiology. The methods are readily adaptable to a wide range of resistant bacterial organisms. Practical and wide-ranging, Antibiotic Resistance: Methods and Protocols provides a collection of indispensable techniques not only for illuminating the basic biology of antimicrobial resistance, but also for developing and implementing new diagnostic and epidemiological tools.
Antibiotic Resistance Protocols: Second Edition (Methods in Molecular Biology #1736)
by Stephen H. GillespieStephen Gillespie and a panel of leading clinical and diagnostic microbiologists describe a series of detailed molecular and physical methods designed to study the growing problems of anitbiotic resistance, as well as facilitate new antibiotic research programs for its effective redress. The techniques range widely from those that provide rapid diagnosis via DNA amplification and phase display, to those for plitting the transmission of resistant organisms and investigating their epidemiology. The methods are readily adaptable to a wide range of resistant bacterial organisms.
Antibiotic Resistance Protocols: Second Edition (Methods in Molecular Biology #2833)
by Stephen H. GillespieThis fully updated edition explores current techniques for research into antibiotic resistance. The book begins with how samples are collected, strains isolated and sequenced, and the results integrated in the microbiological workflow. It continues with novel methods to test resistance and interactions between antibiotics, physiological conditions, or using innovative tools like the hollow fiber or Raman spectroscopy, as well as mathematical models that can describe resistance within host. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Antibiotic Resistance Protocols, Fourth Edition serves as an ideal guide for answering questions on how to control antibiotic resistance, to develop new agents, and to address the problems posed by microbes that have become resistant to our antibiotics.
Antibiotic Resistance Protocols: Second Edition (Methods in Molecular Biology #642)
by Stephen H. Gillespie Timothy D. MchughSince the publication of the popular first edition, genomic methods have become more accessible, allowing antibiotic researchers to probe not only the sequence of antibiotic resistance determinants but the mechanism whereby they are expressed and regulated. That, in concert with array technology and an understanding of the importance of biofilms, has greatly expanded antibiotic resistance knowledge. In order to reflect the growing field, Antibiotic Resistance Protocols, Second Edition fully updates and builds upon its first edition with contributions from leading researchers. Beginning with chapters on epidemiology and population genetics, the book continues with sections covering genomics and gene expressions, fitness mutation and physiology, and the detection of resistance. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Antibiotic Resistance Protocols, Second Edition brings together examples of a diverse range of modern techniques applied in antibiotic research in order to best aid scientists in planning their own future research.