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Advancing East Asian Regionalism (Politics in Asia)
by Nicholas Thomas Melissa G. CurleyDevelopments in East Asia have progressed rapidly in terms of regionalism since the 1997 crisis. The end of the Asian miracle called into question not only the capacity of regional states to meet the needs of their attendant peoples, but also challenged the viability of regional organizations, such as ASEAN, to adapt and respond to the changing circumstances. Advancing East Asian Regionalism looks at the ways in which ASEAN has expanded since the crisis, and evaluates the potential of East Asia to come together in a regional formation - one capable of representing the region as a whole - akin to the European Community. It draws upon the knowledge and perspectives of academics and policy makers actively engaged in the contradictory issues of regionalism. Coupling case study material on regionalism, institutions, and sectoral cooperation, with theoretical debates on regionalization, this book is an invaluable resource that pushes our understanding of East Asian regionalism forward.
Advancing Edge Artificial Intelligence: System Contexts (River Publishers Series in Communications and Networking)
by Ovidiu Vermesan Dave MarplesThe intersection of AI, the Internet of Things (IoT) and edge computing has kindled the edge AI revolution that promises to redefine how we perceive and interact with the physical world through intelligent devices. Edge AI moves intelligence from the network centre to the devices at its edge, entrusting these endpoints to analyse data locally, make decisions, and provide real-time responses.Recent advances in power-efficient high-performance embedded silicon make edge AI a viable proposition, albeit one requiring new distributed architectures and novel design concepts. Moving decision-making closer to the edge makes responses faster and systems more reliable, while the constant pressure to reduce network bandwidth demand and the need to contain spiralling data storage and operations costs help justify the engineering investment necessary to embrace this new paradigm. Moving to decentralised operation opens the door to a multitude of novel applications, covering immersive technologies and autonomous systems across fields as diverse as healthcare and industrial automation, personal assistance and prognostics, surgery, and process control. In the best tradition of systems engineering, the first stage of this transition process is understanding the application domain for edge AI deployment, the ""system context"".This book presents some key topics and early thinking from the EdgeAI* project, covering data backhaul technologies, lifecycle management, mechanisms for developing AIs at the edge and techniques for interacting with those AIs. It provides examples of application domains before concluding with a review of how edge AI systems can be understood by their users. It also examines and presents new results based on current investigations and activities in edge AI technologies, considering the future trends in autonomic systems, hyperautomation, AI engineering, generative AI, connectivity, and cybersecurity mesh.This book aims to empower the reader with the knowledge and insights needed to understand and embrace the transformative power of edge AI technology. The extensively referenced chapters, contributed by experts and thought leaders in the field, are recommended to anyone interested in developing edge AI systems.*Edge AI Technologies for Optimised Performance Embedded Processing" (EdgeAI) Key Digital Technologies (KDT) Joint Undertaking (JU) European research project. https://https://edge-ai-tech.eu/
Advancing Education: School Leadership in Action (Routledge Library Editions: Education Management)
by William Walker Robin Farquhar Meredydd HughesOriginally published in 1991. Compiled by prominent figures in the educational administration field across the Commonwealth for the twentieth anniversary of the foundation of the Commonwealth Council for Educational Administration (CCEA) this imaginative and forward-looking book is for practitioners and academics world-wide. The book illuminates significant issues in educational administration; sensitizes readers to the rapidity and inevitability of change in the field; guides well-informed administrative action; provides a comprehensive overview of emergent developments in the study and practice of educational administration; and demonstrates the leadership of the CCEA as a professional association. Having regard to differences of national context, universal issues of policy and practice are explored and two key leadership roles are described and analysed, namely, that of school principal / head teacher, and that of school superintendent / education officer.
Advancing Educational Equity for Students of Mexican Descent: Creating an Asset-based Bicultural Continuum Model (Routledge Research in Educational Equality and Diversity)
by Andrea Romero Iliana ReyesDrawing on participatory action research conducted with students, parents, families, and school staff in a Southwest community in the United States, this volume contests the interpretation of the achievement gap for students of Mexican descent in the American education system and highlights asset-based approaches that can facilitate students’ academic success. By presenting the Asset-Based Bicultural Continuum Model (ABC) and demonstrating the applications in a variety of family, school, and community-based initiatives, this volume demonstrates how community and cultural wealth can be harnessed to increase educational opportunities for Latino students. The ABC model offers new strategies which capitalize on the bicultural and linguistic assets rooted in local communities and offers place-based strategies driven by communities themselves in order to be tailored to students’ strengths. The text makes a significant contribution to understanding the social ecology of Latinx students’ experiences and offers a new direction for effective and evidence-based academic and health programs across the United States. This book will be a valuable resource for researchers and academics with an interest in the sociology of education, multicultural education, urban education, and bilingual education. It will be of particular interest to those with a focus on Hispanic and Latino studies.
Advancing Effective Obesity Communications: Proceedings of a Workshop
by Engineering Medicine National Academies of SciencesOn September 16, 2019, the Roundtable on Obesity Solutions of the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine, held a public workshop, Advancing Effective Obesity Communications, in Washington, DC. The workshop explored effective communication of obesity-related issues by providing an overview of the current communications environment and addressing the complexity of identifying key audiences and developing targeted messages. Speakers discussed communications strategies to reach specific intermediary audiences, such as the public, decision makers, and policy makers. The workshop also explored challenges in communicating about obesity issues, which include aligning the intended meaning of messages with an individual’s perception of and response to those messages, addressing obesity bias and stigma through communications, and addressing misinformation. This publication summarizes the presentations and discussions that occurred at the workshop.
Advancing Empire: English Interests and Overseas Expansion, 1613–1688
by Roper L. H.In Advancing Empire, L. H. Roper explores the origins and early development of English overseas expansion. Roper focuses on the networks of aristocrats, merchants, and colonial-imperialists who worked to control the transport and production of exotic commodities, such as tobacco and sugar, as well as the labor required to produce them. He is primarily interested in the relationship between the English state and the people it governed, the role of that state in imperial development, the socio-political character of English colonies and English relations with Asians, Africans, American Indians, and other Europeans overseas. The activities stimulated the expansion and integration of global territorial and commercial interests that became the British Empire in the eighteenth century. In exploring these activities from a wider perspective, Roper offers a novel conclusion that revises popular analyses of the English Empire and of Anglo-America.
Advancing Energy Policy: Lessons on the integration of Social Sciences and Humanities
by Chris Foulds Rosie RobisonThis open access book advocates for the Social Sciences and Humanities to be more involved in energy policymaking. It forms part of the European platform for energy-related Social Sciences and Humanities’ activities, and works on the premise that crossing disciplines is essential. All of its contributions are highly interdisciplinary, with each chapter grounded in at least three different Social Sciences and Humanities disciplines. These varying perspectives come together to cover an array of issues relevant to the energy transition, including: energy poverty, justice, political ecology, governance, behaviours, imaginaries, systems approaches, modelling, as well as the particular challenges faced by interdisciplinary work. As a whole, the book presents new ideas for future energy policy, particularly at the European level. It is a valuable resource for energy researchers interested in interdisciplinary and society-relevant perspectives. Those working outside the Social Sciences and Humanities will find this book an accessible way of learning more about how these subjects can constructively contribute to energy policy.
Advancing Engineering Education Beyond COVID: A Guide for Educators
by Ivan Gratchev Hugo G. EspinosaEducators, are you ready to meet the challenge of cultivating the next generation of engineers in a post-COVID-19 context? Current engineering student cohorts are unique to their predecessors: they are more diverse and have experienced unprecedented disruption to their education due to the COVID-19 pandemic. They will also play a more significant role in contributing to global sustainability efforts. Innovating engineering education is of vital importance for preparing students to confront society’s most significant sustainability issues: our future depends on it. Advancing Engineering Education Beyond COVID: A Guide for Educators offers invaluable insights on topics such as implementing active-learning activities in hybrid modes; developing effective and engaging online resources; creating psychologically safe learning environments that support academic achievement and mental health; and embedding sustainability within engineering education. Students’ own perspectives of online learning are also incorporated, with the inclusion of a chapter authored by undergraduate engineering students. This book consolidates the expertise of leading authorities within engineering education, providing an essential resource for educators responsible for shaping the next generation of engineers in a post-COVID-19 world.
Advancing Entrepreneurship Education in Universities: Concepts and Practices for Teaching and Support
by Robert James CrammondIn the context of the changing nature of universities, this book discusses the progression of enterprise and entrepreneurship education, and conceptualises ‘best practice’ with the aim of enhancing teaching and support for entrepreneurs. Including an overview of entrepreneurship, teaching entrepreneurship, enterprising universities and industrial ecosystems, the author also discusses stakeholder theory and analysis, concluding with a perspective on effective and enterprising learning spaces. An insightful read for researchers, educators and policy-makers, this comprehensive overview provides up-to-date literature and case studies to describe the need for entrepreneurship education, its growth, the influence of key institutional stakeholders, and the future of programme delivery and assessment.
Advancing Entrepreneurship in the United Arab Emirates: Start-up Challenges And Opportunities
by Wasif A. MinhasExplores the role of the entrepreneurs within the economic theory frameworks and types of contribution they make.<P><P> Delves deep into social structures and relationships that heavily influence Emirati behaviour and uncovers how these constructs affect entrepreneurship in the region.<P> Highlights contrasting notions of how entrepreneurship can or should be supported and compares these notions with how entrepreneurship is being supported within the UAE.<P> Discusses the potential and role of accelerators and incubators in advancing entrepreneurship.<P> Reflecting increasing investment in entrepreneurship in the United Arab Emirates (UAE), this new book offers extensive coverage of the factors that enable Emiratis to start and grow a business. Exploring the challenges faced by local start-ups, this book provides insight into the way that entrepreneurship is both perceived and governed in the UAE and how this differs to other countries. The author builds on rich empirical research to propose a model of entrepreneurship which is specific to the UAE, taking into account the role of culture, family and government support. This innovative book underlines the importance of human behaviour in creating successful Emirati start-ups and business opportunities.
Advancing Environmental Education Practice (Cornell Series in Environmental Education)
by Marianne E. KrasnyIn this important intervention, change-agent Marianne E. Krasny challenges the knowledge-attitudes-behavior pathway that underpins much of environmental education practice; i.e., the assumption that environmental knowledge and attitudes lead to environmental behaviors. Krasny shows that certain types of knowledge are more likely than others to influence behaviors, and that generally it is more effective to work with existing attitudes than to try to change them. The chapters expand the purview of potential outcomes of environmental education beyond knowledge and attitudes to include nature connectedness, sense of place, efficacy, identity, norms, social capital, youth assets, and individual wellbeing.Advancing Environmental Education Practice also shows how, by constructing theories of change for their environmental education programs, environmental educators can target specific intermediate outcomes likely to lead to environmental behaviors and collective action, and plan activities to achieve those intermediate outcomes. In some cases, directly engaging program participants in the desired behavior or collective action can lead to changes in efficacy, sense of place, and other intermediate outcomes, which in turn foster future environmental actions. Finally, Advancing Environmental Education Practice shares twenty-four surveys that assess changes in environmental behaviors and intermediate outcomes, and provides guidelines for qualitative evaluations.Thanks to generous funding from the Cornell Department of Natural Resources, the ebook editions of this book are available as Open Access volumes from Cornell Open (cornellopen.org) and other Open Access repositories.
Advancing Environmental Justice for Marginalized Communities in India: Progress, Challenges and Opportunities
by Aruna Kumar Malik Alan P. Diduck Kirit PatelThis interdisciplinary collection examines social equity and environmental justice in India. It assesses the effectiveness of environmental policies and institutions in rendering justice for marginalized communities while ensuring protection of the environment. It also analyses the influence of the neoliberal state and its political economies on the development and outcomes of these policies and institutions. The book provides a unique perspective on environmental justice because of its consistent emphasis on social justice, rather than the prevailing predominant analyses from legal or environmental perspectives. It explores the themes of effectiveness and equity as they pertain to public policy instruments, such as environmental impact assessment, environmental licensing and enforcement, public hearings, and environmental activism strategies. The four interlinked dimensions of environmental justice, namely recognitional justice, procedural justice, distributive justice, and restorative justice, provide the core of the book’s conceptual framework. The contributions draw on ideas and methods from development studies, environmental geography, environmental law and policy, natural resource management, public administration, and political economy The book concludes by considering planning, policy and institutional reforms and community-based initiatives that are needed to promote and protect environmental justice in India. Offering an important reference for researchers and scholars, this book will appeal to those in law, geography, environmental studies, natural resource management, development studies, sociology, and political science. It will also be of interest to community-based researchers, environmentalists and other civil society activists, natural resource managers, and policy makers.
Advancing Equality: How Constitutional Rights Can Make a Difference Worldwide
by Jody Heymann Aleta Sprague Amy RaubIn a world where basic human rights are under attack and discrimination is widespread, Advancing Equality reminds us of the critical role of constitutions in creating and protecting equal rights. Combining a comparative analysis of equal rights in the constitutions of all 193 United Nations member countries with inspiring stories of activism and powerful court cases from around the globe, the book traces the trends in constitution drafting over the past half century and examines how stronger protections against discrimination have transformed lives. Looking at equal rights across gender, race and ethnicity, religion, sexual orientation and gender identity, disability, social class, and migration status, the authors uncover which groups are increasingly guaranteed equal rights in constitutions, whether or not these rights on paper have been translated into practice, and which nations lag behind. Serving as a comprehensive call to action for anyone who cares about their country’s future, Advancing Equality challenges us to remember how far we all still must go for equal rights for all.
Advancing Equity Planning Now
by Edited by Norman Krumholz and Kathryn Wertheim HexterWhat can planners do to restore equity to their craft? Drawing upon the perspectives of a diverse group of planning experts, Advancing Equity Planning Now places the concepts of fairness and equal access squarely in the center of planning research and practice. Editors Norman Krumholz and Kathryn Wertheim Hexter provide essential resources for city leaders and planners, as well as for students and others, interested in shaping the built environment for a more just world.Advancing Equity Planning Now remind us that equity has always been an integral consideration in the planning profession. The historic roots of that ethical commitment go back more than a century. Yet a trend of growing inequality in America, as well as other recent socio-economic changes that divide the wealthiest from the middle and working classes, challenge the notion that a rising economic tide lifts all boats. When planning becomes mere place-making for elites, urban and regional planners need to return to the fundamentals of their profession. Although they have not always done so, planners are well-positioned to advocate for greater equity in public policies that address the multiple objectives of urban planning including housing, transportation, economic development, and the removal of noxious land uses in neighborhoods.Thanks to generous funding from Cleveland State University, the ebook editions of this book are available as Open Access volumes from Cornell Open (cornellopen.org) and other repositories.
Advancing Equity and Achievement in America's Diverse Schools: Inclusive Theories, Policies, and Practices
by Sonya Douglass Horsford Camille M. WilsonAdvancing Equity and Achievement in America’s Diverse Schools illustrates how educators, students, families and community partners can work in strategic ways to build on social, cultural, and ethnic diversity to advance educational equity and achievement. By drawing on the latest data on demographic change, constructions of culture and cultural difference, and the politics of school reform in urban, rural, and suburban school communities, this volume looks toward solutions and strategies for meaningful educational improvement. Contributors consider both the diversity of youth and families served in public schools, and the culture of U.S. schooling, highlighting the influence of policy and reform agendas; students’ identities and agency; experiences and approaches of diverse educators; and the workings of effective school partnerships. Chapters also focus on those often overlooked in educational scholarship such as Native Americans, students experiencing poverty and/or homelessness, Muslim students, students with special needs, and students and educators who are lesbian, gay, bisexual, transgender, intersex, or queer. In all, this edited collection stresses the need for high quality education that is inclusive, culturally responsive and unifying so all students can experience academic success. This book is a meaningful resource for educators, policymakers, and community-based leaders interested in doing such transformative work.
Advancing Equity-Focused School Counseling for All Students: Confronting Disproportionality Across PreK-12 Schools
by Sam Steen Shekila Melchior Amber Brenae Sansbury-ScottUsing author narratives, this book brings attention to racial disparities that currently exist in schools within the historical context of pivotal legal cases in America while emphasizing the importance of assessing and supporting students through a culturally appropriate lens that recognizes student strengths. The authors provide current and historical frameworks through which school counselors can develop a more socially just and liberation-orientated school counseling program. These frameworks center and unveil the ways in which social rank, segregation, and racism influence development, particularly for Black and Brown children. The book underscores the value of community partnerships and the role of strategic partnerships to support a college culture, particularly for student populations with historically limited access to higher education. Readers will also learn about misconceptions of racially and ethnically minoritized children and the related impacts on misdiagnosis and overrepresentation in special education. School counselors looking to ensure equity and social justice within their classrooms, analyze their own privilege, and support students of all backgrounds will find this timely text indispensable in creating a program that fosters understanding and growth.
Advancing Ethnography in Corporate Environments: Challenges and Emerging Opportunities
by Brigitte JordanIn this innovative volume, twelve leading scholars from corporate research labs and independent consultancies tackle the most fundamental and contentious issues in corporate ethnography. Organized in pairs of chapters in which two experts consider different sides of an important topic, these provocative encounters go beyond stale rehearsals of method and theory to explore the entanglements that practitioners wrestle with on a daily basis. The discussions are situated within the broader universe of ethnographic method and theory, as well as grounded in the practical realities of using ethnography to solve problems in the business world. The book represents important advances in the field and is ideal for students and scholars as well as for corporate practitioners and decision makers.
Advancing Executive Coaching
by Gina Hernez-Broome Lisa A. BoyceFor anyone who coaches leaders, this book addresses the most critical issues impacting the future of leadership coaching as an organizational development initiative. It is organized around a Leadership Coaching Framework that employs a systems approach to frame the myriad issues. In addition to the introductory chapter that provides an overview of the book, the sixteen contributed chapters are grouped into three sections with the final chapter providing a review of the major themes in the volume with a discussion integrating the global discussions and future directions for leadership coaching.
Advancing Folkloristics
by Debra Lattanzi Shutika Trevor J. Blank Kay Turner Anika Wilson Andrea Kitta Solimar Otero Margaret A. Mills Lynne S. McNeill Cory W. Thorne Phyllis M. May-Machunda Jeanmarie Rouhier-Willoughby Guillermo De Los Reyes Gregory Hansen Betty J. Belanus Anthony Guest-Scott Wanda G. Addison Norma Elia CantúAn unprecedented number of folklorists are addressing issues of class, race, gender, and sexuality in academic and public spaces in the US, raising the question: How can folklorists contribute to these contemporary political affairs? Since the nature of folkloristics transcends binaries, can it help others develop critical personal narratives?Advancing Folkloristics covers topics such as queer, feminist, and postcolonial scholarship in folkloristics. Contributors investigate how to apply folkloristic approaches in nonfolklore classrooms, how to maintain a folklorist identity without a "folklorist" job title, and how to use folkloristic knowledge to interact with others outside of the discipline. The chapters, which range from theoretical reorientations to personal experiences of folklore work, all demonstrate the kinds of work folklorists are well-suited to and promote the areas in which folkloristics is poised to expand and excel. Advancing Folkloristics presents a clear picture of folklore studies today and articulates how it must adapt in the future.
Advancing Food Integrity: GMO Regulation, Agroecology, and Urban Agriculture
by Gabriela SteierKey features: Presents summaries of key points after each chapter and includes color graphs to visualize the big-picture concepts Demonstrates how urban rooftop farms (URFs) can contribute to city greening and climate change mitigation worldwide while providing fresh locally-sourced produce for growing urban populations Provides cutting-edge ideas from the the emerging field of food law and places international and comparative legal concepts into an accessible context for non-lawyers Examines major disputes surrounding food products that have been brought before the World Trade Organization (WTO) to illustrate how trade trends have pushed toward GMO proliferation Uses examples of food labeling, pollinator protection, pesticide permitting, invasive species control, and GMO regulatory policy in the US and the EU to illustrate various methods of bringing public law to the forefront in the struggle toward achieving food integrity The proliferation of Genetically Modified Organisms (GMOs) in our increasingly globalized food system is trivializing the inherent risks to a sustainable world. Responding to the realities of climate change, urbanization, and a GMO-dominated industrialized food system, Gabriela Steier's seminal work addresses the interrelationship of these cutting-edge topics within a scholarly, legal context. In Advancing Food Integrity: GMO Regulation, Agroecology, and Urban Agriculture, Steier defines food integrity as the optimal measure of environmental sustainability and climate change resilience combined with food safety, security, and sovereignty for the farm-to-fork production and distribution of any food product. The book starts with a discussion of the food system and explores whether private law has sufficiently protected food or whether public law control is needed to safeguard food integrity. It proceeds to show how the proliferation of GMOs creates food insecurity by denying people’s access to food through food system centralization. Steier discusses how current industrial agricultural policy downplays the dangers of GMO monocultures to crop diversity and biodiversity, thereby weakening food production systems. Striving to promote agroecology by providing a fresh and compelling narrative of interdisciplinary questions, Steier explores how farming can be geared toward more sustainable and environmentally friendly practices worldwide in the future. This book belongs in the libraries of all those interested in food law, environmental law, agroecology, sustainable agriculture, and urban living practices.
Advancing Frontiers in Mycology & Mycotechnology: Basic and Applied Aspects of Fungi
by Tulasi Satyanarayana Sunil Kumar Deshmukh Mukund V. DeshpandeThe book provides an introduction to the basics of fungi, discussing various types ranging from edible mushrooms to Neurospora – a model system for genetics and epigenetics. After addressing the classification and biodiversity of fungi, and fungi in different ecological niches, it describes the latest applications of fungi, their role in sustainable environments and in alleviating stress in plants, as well as their role in causing plant and animal diseases. Further chapters explore the advances in fungal interactions research and their implications for various systems, and discuss plant-pathogen interactions. The book also features a section on bioprospecting, and is an extremely interesting and informative read for anybody involved in the field of mycology, microbiology and biotechnology teaching and research.
Advancing Future-Orientation in Policymaking: Institutions, Individuals and Risks (Routledge Research on Social and Political Elites)
by Lauri Rapeli Vesa KoskimaaThis book argues that, under certain societal and institutional conditions, party-, interest group- and bureaucracy-based elites can interact positively to extend political timeframes beyond short electoral terms and foster reasoned long-term planning for democratic decision-making.Focusing on Finland within a broader analytic framework and comparative context, it unearths institutions and practices that give the elites capacity to curtail democratic short-sightedness and offer long-term solutions for contemporary threats such as economic globalization, climate change and geopolitical competition. The study also reveals factors that condition the operative capacity of futureregarding institutions.This book will be of key interest to scholars, students and practitioners of political science, public policy and administration, elites and management and futures studies.The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non- Commercial (CC-BY-NC) 4.0 license.
Advancing Gender Equality in Bangladesh: Twenty Years of BRAC’s Gender Quality Action Learning Programme (Routledge ISS Gender, Sexuality and Development Studies)
by Carol Miller Aruna Rao David Kelleher Rieky Stuart Sheepa Hafiza Hasne Ara BegumIn 1994, BRAC, the world's largest NGO, made headlines by putting women's rights centre stage in Bangladesh, one of the poorest countries in the world. The Gender Quality Action Learning (GQAL) Programme was one of the very first large-scale efforts to mainstream gender equality and aimed to weave objectives of gender equality throughout its own microfinance, education and health services. Advancing Gender Equality in Bangladesh describes the history, implementation, and outcome of this major 20-year initiative and discusses the lessons learnt throughout the fight to achieve gender equality outcomes in an effort to provide a tangible framework for future organizations interested in promoting gender equality and social inclusion. At a time when many gender equality programmes are still relatively young, this book offers a unique opportunity to track 20 years of intervention within a theoretical and cultural context and provides a platform for ongoing discussion about the roles of empowerment and gender transformation as agents for social change. This book provides an in-depth analysis of how strategies for change have operated in practice and will be of considerable interest to students, researchers and practitioners of international development, gender studies and social justice theory as well as those interested in a new practical methodology of the gender role framework.
Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics (Springer Theses)
by Kevin M. KooThis book presents a unique concept of merging nanotechnology and novel urinary biomarkers for accurate early prostate cancer detection, discussing an entire progressive pipeline of innovative new strategies in biosensor development, from a simple colorimetric system to a complex system for simultaneous multiple biomarker sensing. For newcomers to the field of nucleic acid biosensing, it also describes various isothermal amplification and amplification-free strategies, which are currently the main research areas. Lastly, the book introduces and demonstrates the notion of clinical nanobiosensor validation toward clinical translation: the ultimate aim of researchers in the biosensor field. This book is a valuable reference resource learners seeking inspiration for cancer biosensor development.
Advancing Gene-Targeted Therapies for Central Nervous System Disorders: Proceedings Of A Workshop
by Engineering Medicine National Academies of SciencesOn April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.