- Table View
- List View
Apology For The Woman Writing
by Jenny DiskiMarie de Gournay was eighteen when she read, and was overwhelmed by, the essays of the French philosopher Montaigne. She had to be revived with hellebore. When she finally met Montaigne, she stabbed herself with a hairpin until the blood ran in order to show her devotion. He made her his adopted daughter for the two months they knew each other. He died four years later, after which, though scorned by intellectuals, she became his editor. Jenny Diski engages with this passionate and confused relationship between 'father and daughter', old writer/young acolyte, possible lovers, using both their voices. Much of their story is about absence of the people they love. In Jenny Diski's hands it becomes a fascinating tale.
Apology For The Woman Writing
by Jenny DiskiMarie de Gournay was eighteen when she read, and was overwhelmed by, the essays of the French philosopher Montaigne. She had to be revived with hellebore. When she finally met Montaigne, she stabbed herself with a hairpin until the blood ran in order to show her devotion. He made her his adopted daughter for the two months they knew each other. He died four years later, after which, though scorned by intellectuals, she became his editor. Jenny Diski engages with this passionate and confused relationship between 'father and daughter', old writer/young acolyte, possible lovers, using both their voices. Much of their story is about absence of the people they love. In Jenny Diski's hands it becomes a fascinating tale.
An Apology Gone Horribly Wrong: A Novel
by William HammesAn Apology Gone Horribly Wrong is a romantic comedy set in the mid-1980s that explores deep wounds and the role trust plays in everyday life.When Sam Milton tries to apologize to the beautiful Chantell León, a top recording artist, for a minor traffic accident, the apology goes horribly wrong. Having already fumbled the apology once in the moment, Sam makes it worse by chasing Chantell down at Universal Studios, sending Chantell into a tirade on national TV, and pleading with her fans for protection. The situation continues to spin out of control as a vigilante mob goes looking for Sam. Within hours, Sam loses everything, including his house, finances and reputation.Fortunately, a friend of Sam&’s is able to get the two together in hopes of resolving the situation. To avoid a huge multimillion dollar lawsuit, Sam comes up with a plan to let Chantell reimburse everything she has taken from him by completing six simple tasks. Although each is simple in nature and starts out easy, each sequential task becomes more difficult and requires her to have more and more trust in someone she doesn&’t trust at all. As the pair moves through their journey, feelings develop, and they realize God is using them to vet out deep wounds. However, things don&’t go as planned and, soon, massive amounts of trust will be required of each. Can they learn to trust each other and heal their emotional wounds despite all they&’ve been through?
The Apology Impulse: How the Business World Ruined Sorry and Why We Can’t Stop Saying It
by Cary Cooper Sean O'MearaSaying sorry is in crisis. On one hand there are anxious PR aficionados and social media teams dishing out apologies with alarming frequency. On the other there are people and organizations who have done truly terrible things issuing much-delayed statements of mild regret. We have become addicted to apologies but immune from saying sorry. In January 2018 there were 35 public apologies from high-profile organizations and individuals. That's more than one per day. Between them, in 2017, the likes of Facebook, Mercedes Benz and United Airlines issued over 2,000 words of apologies for their transgressions. Alarmingly, the word 'sorry' didn't appear once. This perfectly timed book examines the psychology, motivations and even the economic rationale of giving an apology in the age of outrage culture and on-demand contrition. It reveals the tricks and techniques we all use to evade, reframe and divert from what we did and demonstrates how professionals do it best. Providing lessons for businesses and organizations, you'll find out how to give meaningful apologies and know when to say sorry, or not say it at all. The Apology Impulse is the perfect playbook for anyone - from social media executive through to online influencers and CEOs - who apologise way too much and say sorry far too infrequently.
Apology to the Young Addict: A Memoir
by James BrownHusband, addict, father, skeptic. Now sixty—with years of sobriety under his belt—the celebrated author of The Los Angeles Diaries and This River returns with his most moving work yet.Opening with the tragic tale of an elderly couple consumed by opioid addiction and moving through the horrors of a Las Vegas massacre to the loss of a beloved sponsor, these essays draw on Brown’s personal journey to illustrate how an individual life, in all its messiness and charm, can offer a blueprint for healing. From writing about finding a new path in life while raising three sons, to making peace with the family whose ghosts have haunted him, and helping the next generation of addicts overcome their disease, this haunting and hopeful book is a reinvention of the recovery story and a lasting testimony from the master of the modern memoir.“The third panel in Brown’s masterwork triptych on addiction from youth to sixty, Apology to the Young Addict also accomplishes at last a staggeringly rare mercy—on the ghosts of memory, the ravages of disease, the brutal hypocrisies of religion, and finally—most shockingly—on himself.” —Gina Frangello, author of Every Kind of Wanting and A Life in Men
Apomixis in Angiosperms: Mechanisms, Occurrences, and Biotechnology
by Diego Hojsgaard Thammineni PullaiahApomixis is a difficult-to-analyse trait with a complex molecular basis and a substantive effect on the biology of a species. Thus, apomixis is an interesting characteristic for researchers and students working in different fields of plant science and agriculture, and technological advances are enabling and making apomixis studies more common. Apomixis in Angiosperms: Mechanisms, Occurrences, and Biotechnology provides a systematic introduction to the mechanisms and developmental types of apomixis along with an overview of alternative methodologies for identifying apomixis and a detailed reassessment of the occurrences of apomictic species among angiosperm families. Optional methods are illustrated with examples of all types of apomixis and biological levels of analysis, i.e. cells, ovules, seeds and offspring. Data on apomictic species are collected in tables along with information on ploidy, type of apomixis and references. Occurrences of apomixis are briefly discussed in phylogenetic and evolutionary contexts. An outline of the molecular basis of apomixis in plants is presented, together with prospects and challenges that remain for its biotechnological exploitation. This book: Provides a systematic overview of the mechanisms of apomixis, developmental types and methodology for apomixis research. Reassesses apomixis at the species level in angiosperm families. Contains tables summarizing relevant information on apomixis. Analyses occurrences of apomixis in phylogenetic and evolutionary contexts. Outlines the molecular basis and biotechnological perspective of apomixis breeding. This book presents an accessible overview of apomixis research and a curated dataset of apomictic species. It serves as a reference book for students, researchers and citizen scientists interested in apomixis, as well as researchers, business innovators and entrepreneurs pursuing apomixis breeding. It can also be used as a textbook in graduate courses on plant reproduction. Diego Hojsgaard Taxonomy and Evolutionary Biology, Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany, and Faculty of Exact, Chemical and Natural Sciences, National University of Misiones, Posadas, Argentina. Thammineni Pullaiah Department of Botany, Sri Krishnadevaraya University, Anantapur, India.
Apomixis in Angiosperms
by Tamara N. NaumovaApomixis in Angiosperms: Nucellar and Integumentary Embryony is based on original cytoembryological data and critically reviewed literature on more than 250 species from 57 families of angiosperms. The book covers the complete process of nucellar and integumentary embryo formation and viable seed development within species, families, and among angiosperms in general. Many species (some of which are economically important) characterized by adventive embryony are listed. The book also provides an original simple classification of apomixis and offers a new approach to differentiating embryological structures in cases of apomixis and amphimixis.Apomixis in Angiosperms: Nucellar and Integumentary Embryony will be a useful reference for embryologists, botanists, cytologists, geneticists, and plant breeders. It will also benefit any researcher interested in studying somatic embryo formation in tissue culture.
Apomixis in Plants
by Lenn JerlingApomixis in Plants presents a comprehensive review of different aspects of asexual seed formation in plants. This is important in plant research since apomixis could greatly facilitate breeding in important crops. It is also interesting theoretically because it carries problems related to genetic variation and evolution to its extreme.The book features a broad selection of topics, including a historical review of ideas and landmarks in the field; comparisons with other types of asexual reproduction in higher plants and with related phenomena in animals and related plants; a presentation of cytology and embryology of apomicts and the diversified terminology in the field; views on the genetic background of apomixis and environmental effects on its expression; and the interrelation between apomixis and other traits. Additional topics covered include classical and modern theories of sexual versus asexual reproduction; geographical and taxonomical trends in apomicts; ecological implications of apomixis, and a review of future possibilities for using apomixis in plant breeding. Apomixis in Plants is an important reference volume for researchers and students in all areas of botany, ecology, and plant breeding.
Apophatic Elements in the Theory and Practice of Psychoanalysis: Pseudo-Dionysius and C.G. Jung (Research In Analytical Psychology And Jungian Studies)
by David HendersonHow can the psychotherapist think about not knowing? Is psychoanalysis a contemplative practice? This book explores the possibility that there are resources in philosophy and theology which can help psychoanalysts and psychotherapists think more clearly about the unknown and the unknowable. The book applies the lens of apophasis to psychoanalysis,
Apophatic Paths from Europe to China: Regions without Borders (SUNY series in Chinese Philosophy and Culture)
by William FrankeIn Apophatic Paths from Europe to China, William Franke brings his original philosophy of the unsayable, previously developed from Western sources such as ancient Neoplatonism, medieval mysticism, and postmodern negative theology, into dialogue with Eastern traditions of thought. In particular, he compares the Daoist Way of Chinese wisdom with Western apophatic thought that likewise pivots on recognizing the nonexistent, the unthinkable, and the unsayable. Leveraging François Jullien's exegesis of the Chinese classics' challenge to rethink the very basis of life and consciousness, Franke proposes negative theology as an analogue to the Chinese model of thought, which has long been recognized for its special attunement to silence at the limits of language. Crucial to Franke's agenda is the endeavor to discern and renew the claim of universality, rethought and reconfigured within the predicament of philosophy today considered specifically as a cultural or, more exactly, intercultural predicament.
Apophthegmata
by Elaine Fantham Betty I. Knott-Sharpe Desiderius ErasmusAssembled for the young Prince William of Cleves, Erasmus' Apophthegmata consists of thousands of sayings and anecdotes collected from Greek and Latin literature for the moral education of the future ruler. Betty I. Knott and Elaine Fantham's annotated translation of the aphorisms and Erasmus' commentary on them makes this once popular literary and educational text accessible to modern audiences. The introduction discusses the origins of the Apophthegmata, the contents of the collection, and Erasmus' sources.
Apopka
by Apopka Historical SocietyApopka, Florida, started out as a place once dubbed "Big Potato" by the Native Americans of the area and was formerly known as the "Fern City," but it is now most notably considered the "Indoor Foliage Capitol of the World." Once-thriving fragrant citrus groves have been replaced by climate-controlled greenhouses and fields of landscaped nurseries and subdivisions. The second largest city in Orange County, Apopka is located in the northwest region of the county. It functions today as a bedroom community for Orlando and boasts the history of a community filled with a deep sense of pride.
Apoptosis: Methods and Protocols, Second Edition (Methods in Molecular Biology #559)
by P. Erhard Ambrus TothThe ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death.
Apoptosis
by Douglas R. Green John C. ReedApoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Apoptosis and Beyond: The Many Ways Cells Die
by James A. RadosevichThese volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #414)
by Ayesha Alvero Gil MorThe aim of Apoptosis and Cancer is to describe the performance of contemporary techniques for studying the biology of apoptosis and its role in cancer. The protocols described will aid both the academic laboratory interested in further characterizing the mechanisms of apoptosis, as well as the industry laboratory, aimed at identifying new target molecules or screening for new compounds with potential clinical use.
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #2543)
by Hugo Barcenilla David DiazThis volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy. Chapters in this book cover topics such as non-destructive, real-time Annexin V apoptosis assay; assessment of the immune response to tumor cell apoptosis and efferocytosis; mass cytometry assessment of cell phenotypes and signaling states in human whole blood; cell cycle analysis of ER stress and autophagy; and simultaneous detection of inflammasome activation and membrane damage during pyroptosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Apoptosis and Cancer: Methods and Protocols is a valuable resource and practical guide for both novice and expert researchers looking into the “meaning of death.”
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #1219)
by Gil Mor Ayesha B. AlveroIn Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway. Chapters focus on assays developed to detect its activation not only in vitro but also in vivo, optimized multiplex analysis, medium- to high-throughput screens, and the cellular process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Apoptosis and Cancer: Methods and Protocols, Second Edition aids scientists as a stand-alone resource for the execution and analysis of the described protocols and as a reference for the study and detection of apoptosis within and outside the area of cancer research.
Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential
by Kuladip JanaThis book comprehensively reviews the recent advancements in apoptosis research and evaluates its therapeutic targets and strategies in controlling various human diseases. The initial chapter presents the molecular components that regulate apoptosis and its importance for pathogenic processes. The subsequent chapters discuss the molecular mechanisms and signaling pathways involved in apoptosis induction and inhibition. The book also examines the role of mitochondria-driven apoptosis and therapeutic strategies for targeting mitochondria-mediated cell death. Further, the book discusses the role of apoptosis in different diseases, including neurodegeneration, cancer, diabetes, cardiovascular diseases, parasitic infections, autoimmune diseases, reproductive disorders, and infertility. Towards the end, the book outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development. This book is useful for the researchers involved in designing and developing new drugs and drug targets for the treatment of different human diseases.
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities (Advances in Experimental Medicine and Biology #930)
by Christopher D. GregoryThis book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Apoptosis in Health and Disease (New Horizons In Therapeutics Ser. #Vol. 3)
by Robert R. Ruffolo Jr. Frank WalshThe impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation
Apoptosis in Normal Development and Cancer
by Mels SluyserIn apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the
Apoptosis Methods and Protocols (Methods in Molecular Biology #282)
by Hugh J. BradyA collection of cutting-edge techniques for detecting and quantifying apoptosis, understanding its biochemistry, and for identifying the genes and proteins that regulate and carry it out. Described in step-by-step detail, these readily reproducible methods range from flow cytometry and immunohistochemical procedures to kinase activity assays, yeast two-hybrid screening, and the cloning of novel genes by differential expression. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Apoptosis Methods and Protocols constitutes a key technical reference to the significant methodologies used in the field, as well as offering novice and experienced researchers alike powerful tools to illuminate the phenomenon of programmed cell death.
Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)
by Myrtle A. DavisDr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
Apoptosis Methods in Toxicology (Methods in Pharmacology and Toxicology)
by Perpetua M. MugandaThis detailed volume provides a single, valuable reference source formethods that definitively identify and accurately quantify apoptosis. The bookbegins with common methods utilized to detect and quantitate apoptosis, as wellas apoptosis signaling pathways in toxicological and other related research. Itcontinues with multi-parametric and phased apoptosis assays for detecting earlyand late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughputassays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancertherapeutics targeting apoptosis. Written for the Methods in Pharmacologyand Toxicology series, chapters feature step-by-step descriptions of themethodologies, as well as expert tips and implementation advice. Vital and authoritative, Apoptosis Methods inToxicology serves novice scientists as well as experts,utilizing a range of instruments from common laboratory equipment to high-endexpensive and automated machinery capable of performing real time apoptoticmeasurements.