- Table View
- List View
Amyloid Proteins: Methods and Protocols (Methods in Molecular Biology #1779)
by Einar M. Sigurdsson María Gasset Miguel CaleroThis third edition volume expands on the previous editions with many new chapters that cover the latest techniques and topics that were not addressed in the previous volumes. The chapters in this book are divided into three parts: Part One covers in vitro assays that focus on a variety of amyloids and how to study these peptides and proteins. Part Two describes cell culture models and assays, and Part Three explores methods on how to extract amyloid from tissue, its detection, and its characterization in vitro or in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, Amyloid Proteins: Methods and Protocols, Third Edition is a valuable resource for both students and scientists who are new to the field, as well as experienced researchers who would like to progress their research with the latest available techniques.
Amyloid Proteins: Methods and Protocols (Methods in Molecular Biology #849)
by Einar M. Sigurdsson María Gasset Miguel CaleroAmyloid diseases are characterized by the deposition of insoluble fibrous amyloid proteins. The word "amyloid" indicates a starch-like compound, and though a misnomer, continues to be the accepted term for this group of protein conformational disorders. The second edition of Amyloid Proteins expands upon the previous edition with current, detailed protocols for the preparation of amyloid and its precursors, specific analytical methods for studying these proteins, cell culture models and assays for production of amyloid proteins, and protocols for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories.
Amyloid and Amyloidosis
by Robert A. Kyle Gilles Grateau Martha SkinnerThis authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl
Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations (Current Clinical Pathology)
by Guillermo A. Herrera Ahmet Dogan Maria M. PickenAbnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Amyloidosis and Fabry Disease: A Clinical Guide
by Diane Xavier de Ávila Humberto Villacorta JuniorThis book presents a multispecialty and multidisciplinary approach on Amyloidosis and Fabry disease. These two “rare” diseases are underdiagnosed and have systemic peculiarities that should be emphasized for diagnosis. In both cases, early diagnosis is important for initiating treatment sooner, achieving better prognosis, and improving patients’ quality of life. The history of these patients, in general, involves a long journey among health professionals to obtain a diagnosis. Even after a patient is diagnosed, there are still difficulties in understanding these complex diseases, managing complications, and defining specific treatment. Therefore, this work will be a valuable resource for many healthcare professionals, including physicians of various specialties, nurses, physiotherapists, and medical students. It will also be of interest to patients who would like to understand Amyloidosis and Fabry disease. The content will give healthcare professionals a clinical perspective and provide insights on proper care. Readers will be able to recognize the symptoms related to each disease and will be guided during diagnosis and treatment. Chapters include an overview on clinical course, and will address neurological, ophthalmological, dermatological, gastrointestinal, hematological and cardiology manifestations, orthopedic care, mutations, expressiveness according to epigenetics and multidisciplinary treatment. Chapter authors from around the world will contribute sharing their experience in managing these diseases.
Amyloidosis: Diagnosis and Treatment (Contemporary Hematology)
by Morie A. Gertz S. Vincent RajkumarAn up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this complex disease.
Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature
by Institute of Medicine of the National AcademiesThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Amyotrophic Lateral Sclerosis, Second Edition
by Michael Swash Robert H Brown Jr Piera PasinelliAmyotrophic lateral sclerosis or motor neurone disease is one of the most debilitating and devastating of the neurological diseases. The only comprehensive textbook available on the topic, this completely reorganized and expanded new edition examines all aspects of ALS from pathology to patient care and provides the reader with a ready reference to help with the difficulties encountered in patient diagnosis and treatment. Undoubtedly an important work in the field, this book will be of great interest to clinical neurologists and trainees, and to all those concerned with the care of people with ALS.
Amyris Biotechnologies: Commercializing Biofuel
by Gary P. Pisano Alison Berkley WagonfeldIn 2009, Amyris Biotechnologies was building a plant in Brazil that used synthetic biology to convert sugarcane into both renewable fuels and renewable chemicals. The Amyris' marketing team was investigating the commercial interest for both types of products, while the research and development team and the operations group were building processes that could accommodate both as well. CEO John Melo hoped to have commercial product available in 2011; however, he realized that pursuing both chemicals and fuels added even more complexity to a business that was already executing multiple development steps in parallel. The case looks at the various strategic and operational decisions facing Melo as he planned the company's optimal commercialization strategy.
Amá, Your Story Is Mine: Walking Out of the Shadows of Abuse
by Ercenia CedeñoIn the preface to her memoir, Ercenia "Alice" Cedeño recalls the secrecy and turmoil that marked her youth: "I spent most of my growing years mad at my mother and wanting her to change to fit in with the rest of the world," she writes. "When my sisters and I wanted her to visit our friends' mothers, she would say, 'Why do people need to know other peoples' lives?' Looking back, I wonder if she was really saying, 'I don't want them to know our business.' There was so much to hide." Now bringing those hidden memories to light, Amá, Your Story Is Mine traces the hardship, violence, deceit, and defiance that shaped the identity of two generations of women in Alice's family. Born in the mountains of northern Mexico, Alice's mother married at age 14 into a family rife with passion that often turned to anger. After losing several infant children to disease, the young couple crossed into the United States seeking a better life. Unfolding in a series of powerful vignettes, Amá, Your Story Is Mine describes in captivating detail a daring matriarch who found herself having to protect her children from their own father while facing the challenges of cultural discrimination. By turns wry and tender, Alice's recollections offer a rare memoir that fully encompasses the Latina experience in the United States.
Amácio Mazzaropi in the Film and Culture of Brazil: After Cinema Novo
by Eva Paulino BuenoAmácio Mazzaropi's work is a unique instance in Brazilian culture - as an artist not connected with the subsidized film industry, he developed a singular voice and represents a segment of the population usually either ignored or viewed with contempt by the established, experimental filmmakers.
Amédée, The New Tenant, Victims of Duty: Three Plays (Books That Changed the World)
by Eugène IonescoThree hilarious and provocative plays by the absurdist pioneer who remains “one of the most important and influential figures in the modern theater” (Library Journal).The author of such modern classics as The Bald Soprano, Exit the King, Rhinoceros, and The Chairs, Eugene Ionesco’s plays have become emblematic of Absurdist theatre and the French avant-garde. This essential collection combines The New Tenant with Amédée and Victims of Duty—plays Richard Gilman has called, along with The Killer, Ionesco’s “greatest plays, works of the same solidity, fulness, and permanence as [those of] his predecessors in the dramatic revolution that began with Ibsen and is still going on.”In Amédée, the title character and his wife have a problem—not so much the corpse in their bedroom as the fact that it’s been there for fifteen years and is now growing, slowly but surely crowding them out of their apartment.In The New Tenant, a similar crowding is caused by an excess of furniture—as Harold Hobson said in the London Times, “there is not a dramatist . . . who can make furniture speak as eloquently as Ionesco, and here he makes it the perfect, the terrifying symbol of the deranged mind.”In Victims of Duty, Ionesco parodies the conformity of modern life by plunging his characters into an obscure search for “mallot with a t.”
Améfrica in Letters: Literary Interventions from Mexico to the Southern Cone (Hispanic Issues)
by Paulette Ramsay Juan Eduardo Wolf Eliseo Jacob Juan Guillermo Sánchez Martínez Michael Handelsman Gloria Chacón Ángela Castro Isis Barra Costa Diana Rodríguez Quevedo Mamadou BadianeTraditional histories of Black letters in Latin America have delimited their geographic scope to the Caribbean while also omitting intertwined Afro-Indigenous discourses. Inspired by the legacy of Amefrican thinker Lélia Gonzalez, Améfrica in Letters highlights the Black poets, songwriters, novelists, essayists, and bloggers who have created a counter-multiculturalist literary history on the Latin American mainland. To capture a sense of the variety of their contributions, this book spans Mexico, Central America, the Andes, and the Southern Cone—highlighting the transcontinental nature of the legacy of Black writing and its impact beyond national boundaries. The writers examined in the volume engage with regional intellectual frameworks while putting into circulation a demand for a recalibration of the Hispanophone and Lusophone contexts in which they and other Afrodescendants reside.
América del Norte
by Nicolás Medina MoraMoving between New York City, Mexico City, and Iowa City, a young member of the Mexican elite sees his life splinter in a centuries-spanning debut that blends the Latin American traditions of Roberto Bolaño and Fernanda Melchor with the autofiction of US writers like Ben Lerner and Teju Cole.Sebastián lived a childhood of privilege in Mexico City. Now in his twenties, he has a degree from Yale, an American girlfriend, and a slot in the University of Iowa&’s MFA program.But Sebastián&’s life is shaken by the Trump administration&’s restrictions on immigrants, his mother&’s terminal cancer, the cracks in his relationship, and his father&’s forced resignation at the hands of Mexico&’s new president. As he struggles through the Trump and López Obrador years, Sebastián must confront his father&’s role in the Mexican drug war and navigate his whiteness in Mexican contexts even as he is often perceived as a person of color in the US. As he does so, the novel moves through centuries of Mexican literary history, from the 17th century letters of a peevishly polymathic Spanish colonizer to the contemporary packaging of Mexican writers for a US audience.Split between the US and Mexico, this stunning debut explores whiteness, power, immigration, and the history of Mexican literature, to wrestle with the contradictory relationship between two countries bound by geography and torn apart by politics.
América's Dream: A Novel
by Esmeralda SantiagoAmérica Gonzalez is a hotel housekeeper on an island off the coast of Puerto Rico, cleaning up after wealthy foreigners who don't look her In the eye. Her alcoholic mother resents her; her married boyfriend, Correa, beats her; and their fourteen-year-old daughter thinks life would be better anywhere but with América. So when América is offered the chance to work as alive-in housekeeper and nanny for a family in Westchester County, New York, she takes it as a sign that a door to escape has been opened. Yet even as América revels in the comparative luxury of her new life, daring to care about a man other than Correa, she is faced with dramatic proof that no matter what she does, she can't get away from her past.
Américanas, Autocracy, and Autobiographical Innovation: Overwriting the Dictator (Routledge Auto/Biography Studies)
by Lisa Ortiz-VilarelleOverwriting the Dictator is literary study of life writing and dictatorship in Americas. Its focus is women who have attempted to rewrite, or overwrite, discourses of womanhood and nationalism in the dictatorships of their nations of origin. The project covers five 20th century autocratic governments: the totalitarianism of Rafael Trujillo’s regime in the Dominican Republic, the dynasty of the Somoza family in Nicaragua, the charismatic, yet polemical impact of Juan and Eva Perón on the proletariat of Argentina, the controversial rule of Fidel Castro following Cuba’s 1959 revolution, and Augusto Pinochet’s coup d'état that transformed Chile into a police state. Each chapter traces emerging patterns of experimentation with autobiographical form and determines how specific autocratic methods of control suppress certain methods of self-representation and enable others. The book foregrounds ways in which women’s self-representation produces a counter-narrative that critiques and undermines dictatorial power with the depiction of women as self-aware, resisting subjects engaged in repositioning their gendered narratives of national identity.
Amériques transculturelles - Transcultural Americas (Cultural Transfers)
by Afef BenessaiehLa transculturalité constitue une nouvelle façon de concevoir les cultures, c’est-àdire non plus comme des îlots distincts, mais plutôt comme des réseaux interactifs de sens et de pratiques. Ces identités transculturelles qui n’entrent pas aisément dans le seul moule d’une nation ou d’une ethnie abondent particulièrement dans les Amériques, par exemple les Chicanos, les Franco-Ontariens, les Créoles et les immigrants de deuxième et de troisième génération. De Québec à l’Argentine, cet ouvrage se penche sur ces identités qui se construisent au carrefour de la similitude et de la différence.
An "I Love You" Prayer
by Amy ParkerChildren will be reminded that God shows His love in a lot of ways including rainbows, flowers, and special friends!These adorable illustrations and sweet rhymes are perfect for showing little ones the importance of saying "I love you!" and thanking God for His love. The art by Frank Endersby will be a favorite for kids and parents alike. Families will want to leave room on their bookshelves for other titles in the Time to Pray series, including A Pumpkin Prayer.
An (Abbreviated) Perspective on Entrepreneurship
by Mitchell B. Weiss Benjamin HenkesAmong the many competing definitions of entrepreneurship, the one adopted in The Entrepreneurial Manager at HBS was authored by Howard Stevenson in the 1980s and elaborated on in the decades since. Stevenson provided a managerial take on the term; he described entrepreneurship as a distinct approach to management. That approach is the subject of this brief note. The note provides his definition of entrepreneurship ("the pursuit of opportunity without regard to resources currently controlled") and six domains that differentiate entrepreneurial managers from administrative managers.
An A From Miss Keller
by Patricia PolaccoHow did Patricia Polacco become a writer? A perfect companion to the classic Thank You, Mr. Falker, The Art of Miss Chew, and Mr. Wayne’s Masterpiece, this book celebrates a teacher who inspired a young Patricia Polacco to become the writer and storyteller she is today. Trisha is nervous about being chosen for Miss Keller’s writing class. “Killer Keller” demands that her students dazzle her with their writing, and rumor has it that she has never given an A. The rumors turn out to be all too true—there’s just no pleasing Miss Keller. Then an unexpected loss leaves Trisha heartbroken. Thoughts of teachers and grades forgotten, she pours out her soul in a personal narrative. And when Miss Keller reads it, she tells Trisha, “You’ve given your words wings.”
An A from Miss Keller
by Patricia PolaccoTrisha wants to write something that will please her demanding writing teacher, who is rumored to have never given a student an A.
An A to Z Practical Guide to Emotional and Behavioural Difficulties
by Harry Ayers Cesia PrytysThe aim of this practical and user-friendly A to Z handbook is to enable the interested reader to gain quick and easy access to entries relating to or associated with emotional and behavioral difficulties. It focuses on adult problems as well as those of children and adolescents. The entries clearly and succinctly define and explain emotional behavioral terms and some of the different ways in which emotional and behavioral problems can be approached or treated. Where appropriate, entries are accompanied by a brief bibliography. Useful addresses and contact phone numbers are also provided where appropriate. This guide is useful for all teachers, mentors, social workers, educational social workers, educational psychologists, counselors, care workers, students and other professionals and voluntary workers in allied fields. It will also be of interest to parents and carers.
An A to Z Practical Guide to Learning Difficulties
by Harry Ayers Francesca GrayAccessing up-to-date information about general and specific learning difficulties is made easy, with this indispensable reference book. Covering difficulties that relate to children, adolescents and adults, it includes: crucial legislation to keep practitioners 'in the know' useful addresses, telephone numbers and websites It also includes explanations of leaning difficulties including those less than well-known syndromes such as semantic pragmatic difficulties.
An A-Z Collection of Behaviour Tales: From Angry Ant to Zestless Zebra
by Susan PerrowThis must-have collection of behavior tales offers "story medicine" as a creative strategy for parenting, teaching, and counselling. Telling the right story at the right time can help children face challenges and change behavior. <p><p> All 42 stories begin with an undesirable or out-of-balance situation. Through metaphor and imaginative story journeys, they lead to a desirable resolution. The stories can lead to nurturing positive values in children. <p><p> Following the alphabet from A to Z, each behavior is identified in the story title--angry, anxious, bullying, demanding, fussy, greedy, jealous, loud, obnoxious, quibbling, uncooperative, and so on. <p><p> The stories, some humorous, some serious, are especially relevant for children of three to nine years of age, as well as the child in every adult! They are for telling and adapting--turn them into homemade picture books or puppet shows, or even create new tales based on them. Pencil-drawn illustrations by Allmut French accompany each story.
An A-Z of Animal Symbolism: Your complete guide to over 150 animal symbols
by Aurore PramilLearn to interpret the messages the animal world has for you!A bird knocks insistently on your window, your cat brings you a lizard, you find yourself face to face with a spider or you dream of an elephant ... what if each animal had a message for you? Animals have always been a source of fascination for humans - we love to watch them, learn about them and keep them as pets. But what if animals could actually communicate with us? In this complete guide, you'll find everything you need to know about the symbolism and signs of more than 150 animals, whether they appear to you in a dream or 'happen' to cross your path. You'll learn their individual characteristics as well as the elements and seasons they're associated with. You'll also discover what these encounters mean for different aspects of your life including love, career, family and health. Messages from the animal world are always filled with compassion but animals aren't there to flatter your ego. Rather, they aim to help you advance in consciousness in your life's journey. Sometimes you'll receive an encouraging sign that confirms you're on the right path or guidance to help you move forward. Other times, an animal will deliver a deeper lesson for you to explore, because that's how we learn. More than anything, their messages can open avenues of questioning and help to make your way forward clearer. The animals wish you well; they want you to hear their messages. Let them become your guides!