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Angina
by Graham JacksonThis fourth edition of Angina has been extensively revised and expanded with regard to the increasing importance of managing hyperlipidemia, diagnosing and treating coronary artery disease in women and the elderly, and managing chest pain in the presence of normal coronary arteries. Additionally, the roles of medicine, percutaneous coronary interve
Angina Days
by Günter EichThis is the most comprehensive English translation of the work of Günter Eich, one of the greatest postwar German poets. The author of the POW poem "Inventory," among one of the most famous lyrics in the German language, Eich was rivaled only by Paul Celan as the leading poet in the generation after Gottfried Benn and Bertolt Brecht. Expertly translated and introduced by Michael Hofmann, this collection gathers eighty poems, many drawn from Eich's later work and most of them translated here for the first time. The volume also includes the original German texts on facing pages. As an early member of "Gruppe 47" (from which Günter Grass and Heinrich Böll later shot to prominence), Eich (1907-72) was at the vanguard of an effort to restore German as a language for poetry after the vitriol, propaganda, and lies of the Third Reich. Short and clear, these are timeless poems in which the ominousness of fairy tales meets the delicacy and suggestiveness of Far Eastern poetry. In his late poems, he writes frequently, movingly, and often wryly of infirmity and illness. "To my mind," Hofmann writes, "there's something in Eich of Paul Klee's pictures: both are homemade, modest in scale, immediately delightful, inventive, cogent." Unjustly neglected in English, Eich finds his ideal translator here.
Angina Days: Selected Poems (Facing Pages)
by Günter EichA bilingual edition of one of the most important German poets of the twentieth centuryThis is the most comprehensive English translation of the work of Günter Eich, one of the greatest postwar German poets. The author of the POW poem "Inventory," among one of the most famous lyrics in the German language, Eich was rivaled only by Paul Celan as the leading poet in the generation after Gottfried Benn and Bertolt Brecht. Expertly translated and introduced by Michael Hofmann, this collection gathers eighty poems, many drawn from Eich's later work and most of them translated here for the first time. The volume also includes the original German texts on facing pages.As an early member of "Gruppe 47" (from which Günter Grass and Heinrich Böll later shot to prominence), Eich (1907-72) was at the vanguard of an effort to restore German as a language for poetry after the vitriol, propaganda, and lies of the Third Reich. Short and clear, these are timeless poems in which the ominousness of fairy tales meets the delicacy and suggestiveness of Far Eastern poetry. In his late poems, he writes frequently, movingly, and often wryly of infirmity and illness. "To my mind," Hofmann writes, "there's something in Eich of Paul Klee's pictures: both are homemade, modest in scale, immediately delightful, inventive, cogent."Unjustly neglected in English, Eich finds his ideal translator here.
Angiogenesis Inhibition (Recent Results in Cancer Research #180)
by Torsten Kessler Wolfgang E. Berdel Rüdiger LierschAngiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.
Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets
by Shaker A. Mousa Paul J. DavisThis book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.
Angiogenesis Protocols (Methods in Molecular Biology #1430)
by Stewart G. Martin Peter W. HewettInaddition to updating important core techniques this third edition presents newchapters on assessing leukocyte involvement in angiogenesis, lymphatic cell andpericyte isolation techniques, spheroid and arterial ring based in vitroassays, and on pericyte involvement in angiogenesis. Angiogenesis Protocols,Third Edition also guides readers through new protocols on chorioallantoicmembrane models, corneal pocket assays to assess angio- and lymphangiogenesis,models of muscle angiogenesis, and use of zebrafish embryos to study vascularangiogenesis and senescence. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls. Authoritativeand practical, Angiogenesis Protocols, Third Edition provides not only apractical handbook for key techniques, but also an informative and enjoyableread for all those interested, no matter how directly, in angiogenesis.
Angiogenesis Protocols (Methods in Molecular Biology #467)
by Cliff Murray Stewart MartinAs experimentation and clinical trials with first generation anti-angiogenic agents have yielded results and our understanding of the biology and physiology of blood and lymphatic vessels has increased, a new angiogenesis volume swiftly became a necessity. Angiogenesis Protocols, Second Edition remains true to its original vision of providing a single source for angiogenesis researchers, irrespective of levels of resource and expertise, by collecting a range of methods for cell isolation and assessing angiogenesis in vivo or in vitro. This information, however, is expanded to include chapters on circulating endothelial progenitor cells, angiogenic signalling pathways, imaging of angiogenesis, and measurement of tissue blood flow. Written in the Methods in Molecular BiologyTM series format, the chapters provide step-by-step laboratory protocols, lists of necessary materials and reagents, and a Notes section, which details tips on troubleshooting and avoiding known pitfalls. Extensive and cutting-edge, Angiogenesis Protocols, Second Edition is not only a practical handbook for key techniques, but also an informative and enjoyable read for all those interested, no matter how directly, in angiogenesis.
Angiogenesis Protocols (Methods in Molecular Medicine #46)
by J. Clifford MurrayA comprehensive collection of key techniques for assessing the formation of new blood vessels in both whole tissues and cell culture. These readily reproducible methods range from low-cost in vitro assays to cutting-edge in vivo models, such as the dorsal window chamber, which demands high levels of surgical skill as well as relatively expensive, custom-made equipment. Timely and highly practical, Angiogenesis Protocols is a gold-standard resource for today's angiogenesis investigator, providing easy access to a wide variety of proven assays suitable for laboratories with greatly differing technical expertise, materials, and financial resources.
Angiogenesis and Anti-Angiogenesis in Hematological Malignancies
by Domenico RibattiIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases
by Józef Dulak Alicja Józkowicz Agnieszka ŁobodaThe book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed - aggravated or impaired - vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.
Angiogenesis in Adipose Tissue
by Yihai CaoAngiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
Angiogenesis in Health, Disease and Malignancy
by Ali SalajeghehThis book is about "Angiogenesis". A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
Angiogenesis-Based Dermatology
by Jack L. ArbiserThis book provides a complete overview of all aspects of angiogenesis in dermatology. This is a guide to the principles of angiogenesis that will allow all involved in dermatology from the medical student and nurse practitioner to the experienced dermatologist to apply these principles for the treatment of patients. <P><P> Angiogenesis is a principle that can be used to guide treatment of diseases of any organ system. Dermatology may be the first specialty to be guided by the principle of angiogenesis because the lesions are visible and response can be easily monitored. Dermatologists already inhibit angiogenesis as part of their treatment of multiple common dermatologic disorders, including acne, warts, and nonmelanoma skin cancer.
Angiogenesis: From Basic Science to Clinical Applications
by Napoleone FerraraWhy a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic
Angiogenesis: Methods and Protocols (Methods in Molecular Biology #2441)
by Andrew V. BenestThis detailed book builds on the foundation of lymphatic protocols with tools to aid in the interpretation of large datasets created by angiogenesis research. For example, this includes protocols to explore how transcriptional phenotyping can be achieved, both in terms of exploring tissue-specific heterogeneity to the use of database mining of existing datasets. Similarly, bioinformatic techniques run alongside protocols for transcript analysis, cell biology, pathology, as well as physiological and developmental angiogenesis models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Angiogenesis: Methods and Protocols provides a meaningful compendium of practical approaches to angiogenesis and endothelial cell biology research.
Angiography and Plaque Imaging: Advanced Segmentation Techniques (Biomedical Engineering Ser.)
by Jasjit S. Suri Swamy LaxminarayanRecent, rapid advances in mathematical engineering and applied mathematics have opened the door to solving complex problems in angiography imaging. For the first time, this book presents the different medical imaging modalities--MR, CT, x-ray, and ultrasound--for performing angiography and its analysis. Pioneers from a variety of relevant disciplin
Angioplasty and Stenting of Carotid and Supra-aortic Trunks
by Michel Henry Dimitrios Kiskinis Takao Ohki Kyriakos Strigaris Antonio Polydorou Chief PatronAlthough carotid endarectomy (CEA) has long been considered the gold standard technique, recent studies report that short- and long-term results with carotid angioplasty and stenting(CAS) are comparable to those with CEA in a significant number of cases. Covering clinical assessment, techniques and devices, medical treatment, and more, Angioplasty
Angiostrongyliasis: Global Status 2010 edition
by Dr Stephen Berger Gideon InformaticsAngiostrongyliasis: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status of the disease 4. Status of the disease in a specific country 5. References Angiostrongyliasis: Global Status includes separate sections on Angiostrongyliasis, and Angiostrongyliasis - abdominal.
Angiotensin Protocols (Methods in Molecular Medicine #51)
by Donna H. WangDonna Wang and a panel of hands-on experts describe in step-by-step detail all the major molecular, biochemical, and functional techniques now used in probing the renin-angiotensin system. These range from the use of embryonic gene targeting to create of mutant strains, to the functional investigation of components of the renin-angiotensin system. Comprehensive and highly practical, Angiotensin Protocols translates expert knowledge into readily reproducible methods that enable all biomedical investigators successfully to explore the role of angiotensin in health and disease today.
Angiotensin-(1-7): A Comprehensive Review
by Robson Augusto Souza SantosThis is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015).Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.
Angiotensin-converting Enzyme Inhibitors vs. Angiotensin Receptor Blockers: A Critical Analysis of Antihypertensive Strategies: A Machine-Generated Literature Overview
by Mukesh NandaveThis book delves into the various aspects of the renin-angiotensin-aldosterone system (RAAS) and its role in cardiovascular disorders. It explores the use of anti-hypertensive agents, with a focus on (ACE) angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs). The chapters cover topics such as the preferred use of ACE inhibitors over ARBs in high-risk patients, the impact of these agents on insulin resistance, their role in acute heart failure and peripheral artery disease, and their immunomodulatory activity in hypertensive patients. Additionally, the book examines the role of ACE inhibitors and ARBs in COVID-19 patients and provides insights into recent trends in managing hypertension through RAAS inhibition. It serves as a valuable resource for researchers, clinicians, and healthcare professionals involved in the field of cardiovascular medicine.
Angkor and the Khmer Civilization (Second)
by Michael D. Coe Damian EvansAn authoritative survey of Angkor and the Khmer civilization which incorporates revelations from new discoveries in the past decade that are rewriting history. The ancient city of Angkor in Cambodia has fascinated scholars and visitors alike since its rediscovery in the mid-nineteenth century. All are wonderstruck by the beauty and multiplicity of the sculptures that adorn its temples and structures and are overwhelmed by the sheer size of Angkor. There is nothing to equal it in the archaeological world. A great deal was already known about the history of Angkor and the brilliant Khmer civilization that built it thanks to pioneering work by archaeologists and scholars, but our knowledge has now been completely revolutionized by cutting-edge technology. Airborne laser scanning (LiDAR) has revealed entire cities that were previously unknown and a complex urban landscape with highways and waterways, profoundly transforming our interpretations of the development and supposed decline of Angkor. In this comprehensive edition of Angkor and the Khmer Civilization, respected archaeologist Michael Coe is joined by Damian Evans, who led this remarkable program of scientific exploration, to present the results and implications of these groundbreaking discoveries that are rewriting history.
Angle Resolved Photoemission Spectroscopy of Delafossite Metals (Springer Theses)
by Veronika SunkoThis thesis describes the results of angle resolved photoemission spectroscopy experiments on delafossite oxide metals, and theoretical work explaining these observations. The study was motivated by the extraordinarily high conductivity of the non-magnetic delafossites PdCoO2 and PtCoO2, the measurement of whose electronic structure is reported and discussed. Two unexpected effects were observed in the course of the investigation; each is described and analysed in detail. Firstly, a previously unrecognised type of spectroscopic signal, allowing the non-magnetic probe of photoemission to become sensitive to spin-spin correlations, was observed in the antiferromagnetic PdCrO2. Its origin was identified as the Kondo-like coupling of itinerant and Mott insulating electrons. Furthermore, surface states exhibiting an unusually large Rashba-like spin-splitting were observed on the transition metal terminated surfaces of delafossites. The large inversion symmetry breaking energy scale, a consequence of the unusual structure of the surface layer, is identified as the origin of the effect.
Angle of Attack (An Alex Morgan Thriller #1)
by Leo J. MaloneyReal-life Black Ops veteran Leo J. Maloney launches an electrifying new series featuring Alex Morgan, daughter of legendary operative Dan Morgan and a formidable force in her own right.ANGLE OF ATTACK Alex Morgan&’s new mission for Zeta plunges her into a web of danger threatening Europe&’s glamorous Formula One racing circuit. It quickly escalates into a race against time to track down a missing supply of weapons-grade plutonium headed for North America. From a secret prison in Iran to the glittering casinos of Monaco, to the jungles of Malaysia, and to the dark side of Montreal, Alex is up against a deadly and far-reaching conspiracy. Each step of the way, she&’s dogged by a shadowy figure determined to destroy her. Alex has the grit to deal with any external threat, but this is a new kind of peril from a source shockingly close to home—one that will make Alex question everything she once believed... Praise for Leo J. Maloney and His Novels &”Fine writing and real insider knowledge.&” —Lee Child &“Rings with authenticity.&” —John Gilstrap &“Everything a thriller reader wants.&” —Ben Coes &“The new master of the modern spy game.&” —Mark Sullivan &“A ripping story!&” —Meg Gardiner
Angle of Attack (The Gabe Wager Novels #4)
by Rex BurnsA tip about a murdered mob boss forces Gabe Wager to reopen a cold caseA year ago, Marco Scorvelli was murdered while picking up his morning paper. A sawed-off shotgun put a hole in his stomach, and streaked the inside of his sports coat with the mob boss&’s innards. As Scorvelli crawled towards his front door, the killer left the shotgun angled neatly on the sidewalk. No prints were recovered, and no headway was ever made on the case. Now a reliable underworld source passes a message to homicide detective Gabe Wager. The killing wasn&’t ordered by a rival family, but by Scorvelli&’s brother, in an attempt to take control of the organization. After a year of peace, a war is about to erupt between Denver&’s Italian and Hispanic crime syndicates, and Gabe Wager will be in the middle, trying to keep the city from burning to the ground.