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Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)
by Myrtle A. DavisDr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
Apoptosis Methods in Toxicology (Methods in Pharmacology and Toxicology)
by Perpetua M. MugandaThis detailed volume provides a single, valuable reference source formethods that definitively identify and accurately quantify apoptosis. The bookbegins with common methods utilized to detect and quantitate apoptosis, as wellas apoptosis signaling pathways in toxicological and other related research. Itcontinues with multi-parametric and phased apoptosis assays for detecting earlyand late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughputassays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancertherapeutics targeting apoptosis. Written for the Methods in Pharmacologyand Toxicology series, chapters feature step-by-step descriptions of themethodologies, as well as expert tips and implementation advice. Vital and authoritative, Apoptosis Methods inToxicology serves novice scientists as well as experts,utilizing a range of instruments from common laboratory equipment to high-endexpensive and automated machinery capable of performing real time apoptoticmeasurements.
Apoptosis Techniques and Protocols (Neuromethods #29)
by Judes PoirierAn indispensable compendium of state-of-the-art theory and detailed how-to instruction essential for understanding and studying apoptosis. The expert contributors cover such important topics as the histological, biological, and molecular criteria for apoptosis and programmed cell death; necrosis and apoptosis in the CNS; and cellular, invertebrate, animal, and human models of apoptosis in Alzheimer's disease, AIDS, and stroke. The techniques they describe examine the critical steps involved in the apoptosis process, and include PCR analysis of cell-cycle-regulated proteins, histochemical analysis of DNA regulation, DNA laddering analysis, and cytochemical alterations of living cells.
Apoptosis Techniques and Protocols (Neuromethods #37)
by Andréa C. LeblancIn this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.
Apoptosis and Beyond: The Many Ways Cells Die
by James A. RadosevichThese volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #1219)
by Gil Mor Ayesha B. AlveroIn Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway. Chapters focus on assays developed to detect its activation not only in vitro but also in vivo, optimized multiplex analysis, medium- to high-throughput screens, and the cellular process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Apoptosis and Cancer: Methods and Protocols, Second Edition aids scientists as a stand-alone resource for the execution and analysis of the described protocols and as a reference for the study and detection of apoptosis within and outside the area of cancer research.
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #2543)
by David Diaz Hugo BarcenillaThis volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy. Chapters in this book cover topics such as non-destructive, real-time Annexin V apoptosis assay; assessment of the immune response to tumor cell apoptosis and efferocytosis; mass cytometry assessment of cell phenotypes and signaling states in human whole blood; cell cycle analysis of ER stress and autophagy; and simultaneous detection of inflammasome activation and membrane damage during pyroptosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Apoptosis and Cancer: Methods and Protocols is a valuable resource and practical guide for both novice and expert researchers looking into the “meaning of death.”
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #414)
by Ayesha Alvero Gil MorThe aim of Apoptosis and Cancer is to describe the performance of contemporary techniques for studying the biology of apoptosis and its role in cancer. The protocols described will aid both the academic laboratory interested in further characterizing the mechanisms of apoptosis, as well as the industry laboratory, aimed at identifying new target molecules or screening for new compounds with potential clinical use.
Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential
by Kuladip JanaThis book comprehensively reviews the recent advancements in apoptosis research and evaluates its therapeutic targets and strategies in controlling various human diseases. The initial chapter presents the molecular components that regulate apoptosis and its importance for pathogenic processes. The subsequent chapters discuss the molecular mechanisms and signaling pathways involved in apoptosis induction and inhibition. The book also examines the role of mitochondria-driven apoptosis and therapeutic strategies for targeting mitochondria-mediated cell death. Further, the book discusses the role of apoptosis in different diseases, including neurodegeneration, cancer, diabetes, cardiovascular diseases, parasitic infections, autoimmune diseases, reproductive disorders, and infertility. Towards the end, the book outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development. This book is useful for the researchers involved in designing and developing new drugs and drug targets for the treatment of different human diseases.
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities (Advances in Experimental Medicine and Biology #930)
by Christopher D. GregoryThis book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Apoptosis in Health and Disease (New Horizons In Therapeutics Ser. #Vol. 3)
by Jr. Robert R. Ruffolo Frank WalshThe impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation
Apoptosis in Normal Development and Cancer
by Mels SluyserIn apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the
Apoptosis: Methods and Protocols, Second Edition (Methods in Molecular Biology #559)
by P. Erhard Ambrus TothThe ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death.
Apoptosome: An up-and-coming therapeutical tool
by Marcello D'Amelio Francesco Cecconi"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome. The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis. This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.
Apoptotic and Non-apoptotic Cell Death (Current Topics in Microbiology and Immunology #403)
by Shigekazu Nagata Hiroyasu NakanoApoptosis is a prototype of regulated cell death and is executed by the sequential activation of caspases, and plays a crucial role in the process for development and tissue homeostasis of multicellular organisms. In the process of apoptosis, dead cells produce a "find me" signal to recruit phagocytes, and present an "eat me" signal. The prompt clearance of dead cells by phagocytes prevents the release of noxious materials from dying cells that may activate the immune system to develop autoimmune diseases. In addition, apoptotic cells release various factors that are involved in inflammation, proliferation, immune tolerance, and tissue repair in a context dependent manner. In addition to apoptosis, current studies revealed various types of non-apoptotic forms of cell death including regulated necrosis, pyroptosis, entosis, and ferroptosis etc. Among them, the regulated necrosis, also called necroptosis, plays a crucial role in ischemic reperfusion injury, drug-induced pancreatitis, and elimination of virus infection. Whereas, pyroptosis is the cell death induced by bacteria or viral infection, and entosis is the killing through the cell-in cell structure. The molecular mechanisms of these cell death processes are currently extensively studied. In this text book, current advances of cell death research and its future direction will be introduced and discussed.
Aporias of Translation: Literature, Philosophy, Education (Contemporary Philosophies and Theories in Education #18)
by Elias SchwielerThis book proposes a new way for scholars in, for example, Education, Literary Studies, and Philosophy to approach texts and other phenomena through the concept and practice of translation. Its interdisciplinary perspective makes the book of value for graduate students and scholars in the Humanities and Social Sciences. The unique take on translation as related to the notion of aporia is applied to a number of seminal and classical texts within literature, poetry, and philosophy, which gives the reader new understandings of the workings of language and what happens within and between languages, as well as within and between disciplines, when some form of interpretation or analysis is at work. Importantly, the book develops the notion of aporias of translation as a way to learn and develop our understanding of texts and phenomena, and thus functions as a pedagogical process, which helps us come to terms with the boundaries of language and academic disciplines.
Aporophobia: Why We Reject the Poor Instead of Helping Them
by Professor Adela CortinaWhy “aporophobia”—rejection of the poor—is one of the most serious problems facing the world today, and how we can fight itIn this revelatory book, acclaimed political philosopher Adela Cortina makes an unprecedented assertion: the biggest problem facing the world today is the rejection of poor people. Because we can’t recognize something we can’t name, she proposes the term “aporophobia” for the pervasive exclusion, stigmatization, and humiliation of the poor, which cuts across xenophobia, racism, antisemitism, and other prejudices. Passionate and powerful, Aporophobia examines where this nearly invisible daily attack on poor people comes from, why it is so harmful, and how we can fight it.Aporophobia traces this universal prejudice’s neurological and social origins and its wide-ranging, pernicious consequences, from unnoticed hate crimes to aporophobia’s threat to democracy. It sheds new light on today’s rampant anti-immigrant feeling, which Cortina argues is better understood as aporophobia than xenophobia. We reject migrants not because of their origin, race, or ethnicity but because they seem to bring problems while offering nothing of value. And this is unforgivable in societies that enshrine economic exchange as the supreme value while forgetting that we can’t create communities worth living in without dignity, generosity, and compassion for all. Yet there is hope, and Cortina explains how we can overcome the moral, social, and political disaster of aporophobia through education and democratic institutions, and how poverty itself can be eradicated if we choose.In a world of migrant crises and economic inequality, Aporophobia is essential for understanding and confronting one of the most serious problems of the twenty-first century.
Apostasy
by Gino Diiorio1m, 2f / Drama Sheila Gold, 55, a successful Jewish businesswoman suffering from terminal cancer, is spending the end of her life in a comfortable hospice where her only companion is her 30 year old daughter, Rachel. The two have a tense relationship as Rachel has spent most of her adult life working at Planned Parenthood and is generally a disappointment to her entrepreneurial mother. While in the hospice Sheila has become fascinated by a late night televangelist, Dr. Julian Strong, a black man in his 50's. She finds his message inspiring and comforting and she writes Strong, offering to make a sizable donation to his ministry. Much to her surprise, Strong flies out to visit Sheila, presumably to see her sign the check in person. His physical presence is even greater than his TV persona and the two fall head over heels in love. Sheila begins to toy with the idea of converting to Christianity and spending her final days with Strong's church in California. This revelation upsets her daughter to no end as Rachel is certain that Strong is a crook, promising hope and salvation, when all he really wants is to come between her and her inheritance. Is Strong truly in love with Sheila or is he only out for her money? Sheila must choose between her daughter and a new love and lifestyle, in what will certainly be her final days. "When Sheila Gold announces to her grown daughter, Rachel, that she is thinking of trading in her barely used Judaism for late-model, born-again Christianity, it looks as if we're being set up for a play about religious faith. But Gino DiIorio has something else up his sleeve in Apostasy, the absorbing new drama running through Aug. 13 at the New Jersey Repertory Company in Long Branch. Sheila's flirtation with Jesus is going to turn into a flirtation of an entirely differe
Apostasy from the Gospel (The\complete Works Of John Owen Ser.)
by John Owen Shawn D. Wright Lee Gatiss Joel R. BeekeVolume 14 of The Complete Works of John Owen Warns Christians about the Dangers of Apostasy Regarded as one of the greatest theologians in history, 17th-century pastor John Owen remains influential among those interested in Puritan and Reformed theology. The Complete Works of John Owen brings together all of Owen’s original theological writing, including never-before-published work, reformatted for modern readers in 40 user-friendly volumes. Volume 14, Apostasy from the Gospel, features Owen’s book-length treatise on the threat of heresy, the need for repentance, and the importance of preserving biblical purity of doctrine, holiness, and worship. With extensive introductions by editor Joel R. Beeke, this volume also includes outlines, footnotes, and other supporting resources. Released over a number of years, The Complete Works of John Owen will inspire a new generation of Bible readers and scholars to deeper faith. Edited and Formatted for Modern Readers: Presents Owen’s original work, newly typeset with outlines, text breaks, headings, and footnotes Informative New Introductions: Provide historical, theological, and personal context Supporting Resources Enhance Reading: Include extensive annotations with sources, definitions, and translations of ancient languages Part of the Complete Works of John Owen Collection: Will release 40 hardcover volumes through 2028 Perfect for Churches and Schools: Ideal for students, pastors, theologians, and those interested in the Holy Spirit and the Puritans
Apostate Englishman: Grey Owl the Writer and the Myths
by Albert BrazIn the 1930s Grey Owl was considered the foremost conservationist and nature writer in the world. He owed his fame largely to his four internationally bestselling books, which he supported with a series of extremely popular illustrated lectures across North America and Great Britain. His reputation was transformed radically, however, after he died in April 1938, and it was revealed that he was not of mixed Scottish-Apache ancestry, as he had often claimed, but in fact an Englishman named Archie Belaney. Born into a privileged family in the dominant culture of his time, what compelled him to flee to a far less powerful one? Albert Braz’s Apostate Englishman: Grey Owl the Writer and the Myths is the first comprehensive study of Grey Owl’s cultural and political image in light of his own writings. While the denunciations of Grey Owl after his death are often interpreted as a rejection of his appropriation of another culture, Braz argues that what troubled many people was not only that Grey Owl deceived them about his identity, but also that he had forsaken European culture for the North American Indigenous way of life. That is, he committed cultural apostasy.
Apostle
by Tom BissellA profound and moving journey into the heart of Christianity that explores the mysterious and often paradoxical lives and legacies of the Twelve Apostles--a book both for those of the faith and for others who seek to understand Christianity from the outside in. Peter, Matthew, Thomas, John: Who were these men? What was their relationship to Jesus? Tom Bissell provides rich and surprising answers to these ancient, elusive questions. He examines not just who these men were (and weren't), but also how their identities have taken shape over the course of two millennia. Ultimately, Bissell finds that the story of the apostles is the story of early Christianity: its competing versions of Jesus's ministry, its countless schisms, and its ultimate evolution from an obscure Jewish sect to the global faith we know today in all its forms and permutations. In his quest to understand the underpinnings of the world's largest religion, Bissell embarks on a years-long pilgrimage to the supposed tombs of the Twelve Apostles. He travels from Jerusalem and Rome to Turkey, Greece, Spain, France, India, and Kyrgyzstan, vividly capturing the rich diversity of Christianity's worldwide reach. Along the way, he engages with a host of characters--priests, paupers, a Vatican archaeologist, a Palestinian taxi driver, a Russian monk--posing sharp questions that range from the religious to the philosophical to the political. Written with warmth, empathy, and rare acumen, Apostle is a brilliant synthesis of travel writing, biblical history, and a deep, lifelong relationship with Christianity. The result is an unusual, erudite, and at times hilarious book--a religious, intellectual, and personal adventure fit for believers, scholars, and wanderers alike.From the Hardcover edition.
Apostle Lodge
by Paul MendelsonFrom the author of the acclaimed The First Rule of Survival, praised by Lee Child as 'excellent and uncompromising', comes Paul Mendelson's explosive latest thriller.Apostle Lodge looks out over the ocean, an award-winning mansion built by a renowned architect. Stark and minimal, its black opaque windows hide a terrible secret. As Colonel Vaughn De Vries investigates the depraved crime committed within its walls, he believes there may be more than one killer on the loose, all with connections to a charismatic man who as a child, drowned his sister and shattered his family.And his work is not over yet.'A jaw-droppingly brilliant crime thriller. Imagine The Killing moved to Cape Town and into the landscape of the hot and dusty African veld' Philip Glenister'Mendelson plots so smoothly and writes so powerfully' The Guardian
Apostle Lodge (Col Vaughn de Vries #4)
by Paul MendelsonFrom the author of the acclaimed The First Rule of Survival, praised by Lee Child as 'excellent and uncompromising', comes Paul Mendelson's explosive latest thriller.Apostle Lodge looks out over the ocean, an award-winning mansion built by a renowned architect. Stark and minimal, its black opaque windows hide a terrible secret. As Colonel Vaughn de Vries investigates the depraved crime committed within its walls, he believes there may be more than one killer on the loose, all with connections to a charismatic man who, as a child, drowned his sister and shattered his family.And his work is not over yet.'A jaw-droppingly brilliant crime thriller. Imagine The Killing moved to Cape Town and into the landscape of the hot and dusty African veld' Philip Glenister'Mendelson plots so smoothly and writes so powerfully' The Guardian
Apostle Paul (Get to Know)
by Nancy I. SandersApostle Paul—part of the Get to Know series—is a unique biography about Paul. Focusing on the life and character of this Biblical hero, using color photographs, maps, and other visual resources to tell the whole story, young biography fans will come to learn more about this man of the God, his writings, his impact on the early church, and the role he plays in history.Featuring a bibliography and scriptural references throughout, this is sure to become a favorite for young readers and for first book reports.
Apostle Paul: A Novel
by James CannonThe iconic Saint Paul - in his lifetime a scholar, prosecutor for the high court of the Jews, accomplice in murder, adventurer, traveler, orator, writer, advocate, and organizer of a new faith - was in fact a Jewish-Hellenistic citizen of the Roman Empire, a man who by the force of his intellect and indomitable will changed the course of history. Eventually he became the leader of the movement that delivered the social and moral authority of Christianity to a pagan world. Given a message - that man and woman had a purpose in earthly life and a future beyond the grave - he carried it first and unsuccessfully to his fellow Jews, then successfully to the gentiles and all mankind. His quality of mind and ability to exhort and persuade, his personal commitment to ethical conduct and values, and his courage and indefatigability made Paul one of the continuing forces in the progress of Western civilization.Author James Cannon has written about political leaders as a journalist, has served with leaders in public life, and has written feature stories while on the staffs of Time and Newsweek. Now he has taken the story of one of the most momentous quests in history and brought it to life with a vitality and immediacy that is at once gripping, informative, and inspiring.