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KRAS: Methods and Protocols (Methods in Molecular Biology #2797)
by Andrew G. Stephen Dominic EspositoThis volume details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, KRAS: Methods and Protocols aims to provide methods that will be instrumental in the development of future clinically approved KRAS therapeutics.
Academic Success in Online Programs: A Resource for College Students (Springer Texts in Education)
by Jacqueline S. StephenThis book provides higher education students with a comprehensive resource to assist them in their academic persistence in an online course or program. It addresses a wide selection of topics emphasizing a myriad of factors that impact a student’s persistence, and ultimate success, in an online program or course. The book helps students to gain insight into the skills, knowledge, and attributes needed to succeed in the autonomous nature of an online learning environment. Thus, this book helps students to proactively engage in activities to prepare for online learning. Information presented in each chapter is drawn from theory and recent research centered on persistence of online students in higher education. It incorporates hands-on practical activities to promote application of theory and research, and encourages students to demonstrate their knowledge, skills, and abilities through the use of reflective and thought-provoking activities. Hence, this book provides online students with an up-to-date resource they can use to develop an awareness of their readiness and preparedness for online learning. Additionally, this book equips students with information and strategies aimed at helping them to address gaps in their skills and knowledge that may present them with barriers to academic success. The content of this book is aligned with widely used student learning outcomes and objectives of first-year student seminar courses and orientation programs for graduate and undergraduate students enrolled in online programs. Furthermore, it is deliberately organized and structured to support an online student’s academic journey as they navigate the online learning environment. As such, these features make it an ideal book for use by students, instructors, and academic advisors or college and university academic support staff.
The Language of the Land: Living Among the Hadzabe in Africa
by James StephensonA rare adventure with the last Stone Age hunting and gathering tribe in Africa.In 1997 James Stephenson arranged to have almost a full year free, a year he wanted to spend among the Hadzabe in Tanzania. He had visited these people several times previously and with every trip his fascination with them deepened, for the Hadzabe are the last hunters and gatherers still living a traditional life in East Africa.At the age of 27, Stephenson intended to spend the year living among the Hadzabe, and, more importantly, living their life, hunting what they hunted, eating what they ate, participating in their dances and ceremonies, consulting with their medicine men and learning their myths and dreams.Armed only with his camera, his art supplies and the open-hearted courage of youth, he set out to visit with a people who have changed little since the Stone Age. He wanted to glimpse the world as they perceived it and learn the wisdom they had wrestled from the land. The Language of the Land, the account of his adventure and what he learned, is travel writing at its best.
Treat them Mean and Keep them Keen
by Gerry Stergiopoulos'I look at the way some women behave when they're dating, and I'm sorry girls, but it's an absolute car crash. The rules of successful dating are simple, but I bet you've been breaking them all.'After seeing too many of his female friends left all dressed up with nowhere to go, Gerry Stergiopoulos, every woman's ultimate best gay friend, has gone on a quest to understand why so many fabulous women have a catastrophic love life.Gerry unflinchingly enters a world of waxing, Spanx pants, dodgy self-help books, internet dating, wingwomen and smirting, to bring you his tried-and-tested History Channel technique, his perfect killer one-liners, the ingenious blackjack-based Scottish Shower system, the unbreakable three-month rule and even some sound lessons from his native Greece. Treat Them Mean and Keep Them Keen is the only dating book that gives it to you straight: it tells you what to hide and just how much to reveal, what to do and when to do it. You might be shocked at what Gerry suggests - but his advice works.
Swingland: Between the Sheets of the Secretive, Sometimes Messy, but Always Adventurous Swinging Lifestyle
by Daniel SternThe wryly amusing and revealing story of one man’s journey into the swinger lifestyle that “transcends most of the usual boundaries of sexuality…and leaves the vanilla world behind” (The New York Times Book Review).An estimated fifteen million strong worldwide, swingers are everywhere—a huge community hiding in plain sight, whose erotic pastime remains a complete mystery to the rest of us. In Swingland, Daniel Stern outs himself and the secretive society he loves, recounting his ten-year transformation from a lonely guy who couldn’t get a date into a veteran sexual adventurer.With wit and infectious enthusiasm, Stern shares all the hard-earned wisdom he’s acquired in America’s swinging underground. He encounters plenty of bumps and bruises along the way, including countless rejections, missed opportunities, and one particular AARP orgy. But slowly and surely, through an impressive series of threesomes, foursomes, and moresomes, this “Vanilla” newbie becomes a much sought-after partner for couples looking to spice up their relationships. Travel with Stern on his exploits, learn a whole new lexicon (there aren’t many single women swingers, or “Unicorns,” but plenty of MFMs, FMFs, MMFMs, and MMMFMs), and gain free, invaluable advice should you decide to take the plunge (be honest, sensitive, and hygienic!).“Equal parts memoir and guide book” (New York Post), Swingland is much more than a “unique, voyeuristic exposé” (Kirkus Reviews). Lovingly written, with a keen sensibility regarding the sensitive and often misunderstood subject, Stern’s narrative is as improbably safe as it is fun—and impossible to put down.
Howard Stern Comes Again
by Howard SternOver his unrivaled four-decade career in radio, Howard Stern has interviewed thousands of personalities—discussing sex, relationships, money, fame, spirituality, and success with the boldest of bold-faced names. But which interviews are his favorites? It&’s one of the questions he gets asked most frequently. Howard Stern Comes Again delivers his answer.Rock stars and rap gods. Comedy legends and A-list actors. Supermodels and centerfolds. Moguls and mobsters. A president. This book is a feast of conversation and more, as between the lines Stern offers his definitive autobiography—a magnum opus of confession and personal exploration. Tracy Morgan opens up about his near-fatal car crash. Lady Gaga divulges her history with cocaine. Madonna reminisces on her relationship with Tupac Shakur. Bill Murray waxes philosophical on the purpose of life. Jerry Seinfeld offers a master class on comedy. Harvey Weinstein denies the existence of the so-called casting couch. An impressive array of creative visionaries weigh in on what Stern calls &“the climb&”—the stories of how they struggled and eventually prevailed. As he writes in the introduction, &“If you&’re having trouble finding motivation in life and you&’re looking for that extra kick in the ass, you will find it in these pages.&” Interspersed throughout are rare selections from the Howard Stern Show archives with Donald Trump that depict his own climb: transforming from Manhattan tabloid fixture to reality TV star to president of the United States. Stern also tells of his Moby Dick-like quest to land an interview with Hillary Clinton in the run-up to the 2016 election—one of many newly written revelations from the author. He speaks with extraordinary candor about a variety of subjects, including his overwhelming insecurity early in his career, his revolutionary move from terrestrial radio to SiriusXM, and his belief in the power of psychotherapy. As Stern insightfully notes in the introduction: &“The interviews collected here represent my best work and show my personal evolution. But they don&’t just show my evolution. Gathered together like this, they show the evolution of popular culture over the past quarter century.&”
The Periodic Table of CRICKET
by John SternWelcome to The Periodic Table of Cricket. Here you'll find the essential elements - batsmen and bowlers past and present - that have left a lasting legacy on this great sport.As with chemical elements, these international personalities have been arranged based on their characteristics in and out of play. Instead of metals and non-metals, here we have patient and determined defensive players, from Jack Hobbs to Hanif Mohammad and Alastair Cook transitioning to fast-paced and attacking players including Shane Warne, Fred Trueman and 'white lightning' Allan Donald with a whole host of others in between.See how the best international players stack up against each other in this original guide to cricket.
The Balance Within: The Science Connecting Health and Emotions
by Esther M. SternbergA thrilling scientific detective story, The Balance Within tells how researchers finally uncovered the elusive mind-body connection and what it means for our health. Since ancient times humans have felt intuitively that emotions and health are linked, and recently there has been much popular speculation about this notion. But until now, without compelling evidence, it has been impossible to say for sure that such a connection really exists and especially how it works. Now, that evidence has been discovered.In this beautifully written book, Dr. Esther Sternberg, whose discoveries were pivotal in helping to solve this mystery, provides first hand accounts of the breakthrough experiments that revealed the physical mechanisms - the nerves, cells, and hormones - used by the brain and immune system to communicate with each other. She describes just how stress can make us more susceptible to all types of illnesses, and how the immune system can alter our moods. Finally, she explains how our understanding of these connections in scientific terms is helping to answer such crucial questions as "Does stress make you sick?" "Is a positive outlook the key to better health?" and "How do our personal relationships, work, and other aspects of our lives affect our health?"A fascinating, elegantly written portrait of this rapidly emerging field with enormous potential for finding new ways to treat disease and cope with stress, The Balance Within is essential reading for anyone interested in making their body and mind whole again.
Transformational Creativity: Learning for a Better Future
by Robert J. Sternberg Sareh KaramiThis edited volume brings together leading scholars in diverse disciplines to share their best thinking on how creativity can be conceived of, taught for, and deployed to serve rather than undermine humanity. Transformational creativity, as defined in this book, is creativity deployed to make a positive, meaningful, and potentially enduring difference to the world. Transformational creativity is compared to transactional creativity, which is creativity deployed in search of a reward, whether externally or internally generated.
The Life and Opinions of Tristram Shandy, Gentleman: Volume 3 Of The Florida Edition Of The Works Of Laurence Sterne (Florida Edition Of The Works Of Laurence Sterne Ser. #Vol. Iii)
by Laurence SterneSterne's utterly original novel - the meandering, maddening 'autobiography' of one of literature's oldest comic characters.Doomed to become the ‘sport of fortune’ by an interruption at the crucial moment of conception, Tristram Shandy’s life lurches from one mishap to another: his nose crushed by the doctor’s forceps during birth, christened with the wrong name, an unfortunate incident involving a slamming sash window… Discover the anti-autobiography of the hilarious Tristram Shandy. WITH A NEW INTRODUCTION BY TOM MCCARTHY ‘Tristram Shandy is one of the funniest novels in the English language. It's also one of the first great experimental literary works’ Independent
The Life and Opinions of Tristram Shandy, Gentleman: Volume 3 Of The Florida Edition Of The Works Of Laurence Sterne (Florida Edition Of The Works Of Laurence Sterne Ser. #Vol. Iii)
by Laurence Sterne'L-d! said my mother, what is all this story about? - A COCK and a BULL, said Yorick - And one of the best of its kind, I ever heard'Laurence Sterne's great masterpiece of bawdy humour and rich satire defies any attempt to categorize it, with a rich metafictional narrative that might classify it as the first 'postmodern' novel. Part novel, part digression, its gloriously disordered narrative interweaves the birth and life of the unfortunate 'hero' Tristram Shandy, the eccentric philosophy of his father Walter, the amours and military obsessions of Uncle Toby, and a host of other characters, including Dr Slop, Corporal Trim and the parson Yorick. A joyful celebration of the endless possibilities of the art of fiction, Tristram Shandy is also a wry demonstration of its limitations.The text and notes of this volume are based on the acclaimed Florida Edition, with a critical introduction by Melvyn New and Christopher Ricks's introductory essay from the first Penguin Classics edition.'The book that I would never tire of ... Sterne was about 250 years ahead of his time'Roy Porter, author of Enlightenment: Britain And The Creation Of The Modern World
A Sentimental Journey
by Laurence SterneWhen Yorick, the roving narrator of Sterne's innovative final novel, sets off for France on a whim, he produces no ordinary travelogue. Jolting along in his coach from Calais, through Paris, and on towards the Italian border, the amiable parson is blithely unconcerned by famous views or monuments, but he engages us with tales of his encounters with all manner of people, from counts and noblewomen to beggars and chambermaids. And as drama piles upon drama, anecdote, flirtation and digression, Yorick's destination takes second place to an exhilarating voyage of emotional and erotic exploration. Interweaving sharp wit with warm humour, irony with sentiment, A Sentimental Journey paints a captivating picture of an Englishman's adventures abroad.
Tristram Shandy: Volume 3 Of The Florida Edition Of The Works Of Laurence Sterne (The Penguin English Library #Vol. Iii)
by Laurence SterneThe Penguin English Library Edition of Tristram Shandy by Laurence Sterne'I am got, I know not how, into a cold unmetaphorical vein of infamous writing, and cannot take a plumb-lift out of it for my soul; so must be obliged to go on writing like a Dutch commentator to the end of the chapter, unless something be done ...'Laurence Sterne's great masterpiece of bawdy humour and rich satire defies any attempt to categorize it. Part novel, part digression, its gloriously disordered narrative interweaves the birth and life of the unfortunate 'hero' Tristram Shandy, the eccentric philosophy of his father Walter, the amours and military obsessions of Uncle Toby, and a host of other characters, including Dr Slop, Corporal Trim and the parson Yorick. A joyful celebration of the endless possibilities of the art of fiction, Tristram Shandy is also a wry demonstration of its limitations.The Penguin English Library - 100 editions of the best fiction in English, from the eighteenth century and the very first novels to the beginning of the First World War.
Brink of Reality: New Canadian Documentary Film and Video
by Peter StevenIn Brink of Reality, Peter Steven examines the convergence of video-art and social-issue documentary, from the 1940s to the present. No other book has explored contemporary Canadian documentary so thoroughly, or provided as broad a view of the state of the art in the 1990s.
No-Nonsense Guide to Global Media, 2nd Edition (No-Nonsense Guides #9)
by Peter StevenPeter Steven explores the full spectrum of communications around the world, from the mega-corporations to the citizen reporters, from the newsrooms of Washington to the film industry of Nigeria. Steven examines the continuously shifting communications landscape, with a focus on how the media is responding to declining advertising revenues, social media sites, portable devices, and Asia’s growing influence and power. With an emphasis on diverse small-scale media production that exist only through their contact with specific audiences, Steven invites us to question how the media reflects society, and he asks: are we passive recipients? Or do we play a part in constructing our world?
Penny: A Graphic Memoir
by Karl StevensThis colorful graphic novel features the philosophical and existential musings of a cat named Penny.Told through a collection of stories, Penny: A Graphic Memoir wanders through her colorful imagination as she recalls her humble beginnings on the streets of New York and waxes poetic about the realities of her sheltered life living in an apartment with her owners.Filled with ennui, angst, and vivid dreams, Penny proves that being a cat is more profound than we once thought. A unique blend of high art and humor, Penny: A Graphic Memoir perfectly portrays one cat's struggles between her animal instincts, her philosophical reflections, and the lush creature comforts of a life with human servants.• DISTINCTIVE, BEAUTIFUL, AND FUNNY: Reading like a highbrow Garfield, this unique dose of sardonic wit and cat content combines humor and storytelling with Karl Stevens' very realistic illustration style. Fresh and imaginative, this graphic novel feels familiar and accessible, featuring one of the world's most beloved animals.• IMPRESSIVE AND DECORATED AUTHOR: Karl Stevens has written four graphic novels, and his comics have appeared regularly in the New Yorker, Village Voice, and Boston Phoenix. His work has been well received all around, and The Lodger was a Los Angeles Times Book Prize finalist.• UNIQUE GIFT FOR CAT LOVERS: For cat lovers who have all the classic cat humor books, this is something new that's both unique but familiar, combining a new voice with stunning artwork in a fresh format. For anyone who wonders what their cat is thinking, this book is pitch-perfect, and the gorgeous artwork and package make it a delightful present.
Explorer's Guide Berkshire: A Complete Guide (Explorer's Great Destinations #0)
by Lauren R. StevensA fully-updated eighth edition to the guidebook that launched the Great Destinations series. A rich cultural landscape has grown from the natural splendor of the Berkshire Hills of Western Massachusetts, making it a favorite place for travelers of all types. This all-new edition of the original guide to the Berkshires includes information on history, transportation, accommodations, dining, arts, spa retreats, outdoor recreation, and shopping. It covers every corner of the Berkshires, from Great Barrington and Sheffield in the South to the northern towns of Williamstown and North Adamshome of the Massachusetts Museum of Contemporary Art. Stay at the legendary Red Lion Inn and enjoy an evening of classical music at Tanglewood. Spend a night at a reasonably-priced B&B after a day of hiking the trails of Mt. Greylock. Experience a weekend retreat at the world-famous Kripalu Center for Yoga and Health. With helpful maps and lodging and dining indexes to aid you, you won't find a more complete guide to the Berkshires.
Escape, Evasion and Revenge: The True Story of a German-Jewish RAF Pilot Who Bombed Berlin and Became a PoW
by Marc H. Stevens&“A truly remarkable story . . . Marc Stevens has produced a fitting tribute to his father . . . who played a full part in the defeat of Nazi Germany.&” —HistoryOfWar.org Peter Stevens was a German-Jewish refugee who escaped Nazi persecution as a teenager in 1933. He joined the RAF in 1939 and after eighteen months of pilot training he started flying bombing missions against his own country. He completed twenty-two missions before being shot down and taken prisoner by the Nazis in September 1941. To escape became his raison d&’être and his great advantage was that he was in his native country. He was recaptured after each of his several escapes, but the Nazis never realized his true identity. He took part in the logistics and planning of several major breakouts, including The Great Escape, but was never successful in getting back to England. After liberation, when the true nature of his exploits came to light, he was awarded the Military Cross. He then served as a British spy at the beginning of the Cold War before emigrating to Canada to resume a normal life. This is the story of a heavily conflicted young man, alone in a world that is in the midst of destruction. He is afforded an opportunity to help his persecuted people to obtain a small measure of revenge. It is at once a sad yet uplifting tale of thankless and unheralded heroism.&“This is a wartime career that would make any son proud, but Steven&’s real triumph is in writing a biography that will satisfy the most discerning historian.&” —National Defence Journal
Cream Buns and Crime: Tips, Tricks, and Tales from the Detective Society (A Murder Most Unladylike Mystery)
by Robin StevensLearn more about Daisy and Hazel&’s detecting process and unravel three brand-new mini-mysteries in this short story companion to the Murder Most Unladylike series.Daisy Wells and Hazel Wong are famous for the murder cases they have solved—but there are many other mysteries in the pages of Hazel&’s casebook, including the macabre Case of the Deepdean Vampire, the baffling Case of the Blue Violet, and even their very first case of all: the Case of Lavinia&’s Missing Tie. Packed with these brilliant new mini-mysteries and peppered with Daisy and Hazel&’s own detecting tips, tricks, and facts, this is the perfect book for fans and budding members of the Detective Society.
Monkey House Blues: A Shanghai Prison Memoir
by Dominic StevensonIn 1993, Dominic Stevenson left a comfortable life with his girlfriend in Kyoto, Japan, to travel to China. His journey took him to some of the most inhospitable and dangerous places in the world, from the poppy fields of the Afghan-Pakistan border to the ancient trade routes of the Silk Road, before he was arrested for drug smuggling while boarding a boat from Shanghai to Japan. After eight months on remand in a Chinese police lock-up, Stevenson was sentenced to two and a half years in one of the biggest prisons in the world, the Shanghai Municipal Prison aka 'The Monkey House'. There, he was imprisoned alongside just five westerners amongst five thousand Chinese criminals in a block for death row inmates and political prisoners, where the guards drank green tea and let the prison run itself. The experience led him to reflect on his previous life in Japan, India and Thailand, during which time he took on a varied array of jobs, including English teacher, karaoke-bar host, factory worker, busker, crystal seller and dope smuggler. From Afghan gun shops to Tibetan monasteries, Thai brothels and the stirrings of the rave culture in Goa, Monkey House Blues is a tale of discovery and rediscovery, of friendship and betrayal.
The Strange Case of Dr Jekyll and Mr Hyde and Other Tales of Terror
by Robert Louis StevensonEveryone has a dark side.Dr Jekyll has discovered the ultimate drug. A chemical that can turn him into something else. Suddenly, he can unleash his deepest cruelties in the guise of the sinister Hyde. Transforming himself at will, he roams the streets of fog-bound London as his monstrous alter-ego.It seems he is master of his fate.It seems he is in complete control.But soon he will discover that his double life comes at a hideous price...
The Strange Case of Dr Jekyll And Mr Hyde & the Suicide Club
by Robert Louis StevensonDr Jekyll faces awful consequences when he lets his dark side run wild with a potion that changes him into the disgustingly evil Mr Hyde.
Treasure Island
by Robert Louis StevensonBursting with rich descriptive detail, discover the classic world of Treasure Island.Fifteen men on the dead man's chest-Yo-ho-ho, and a bottle of rum!When young Jim Hawkins discovers a map showing the way to Captain Flint's treasure, he and Squire Trelawney set sail on the Hispaniola to search for the gold. Little do they know that among their crew is the dastardly pirate Long John Silver. Silver has a devious plan to keep the gold all to himself. Can brave Jim outwit the most infamous pirate ever to sail the high seas? Will he escape from Treasure Island alive?BACKSTORY: Learn the truth about pirates and add to your seafaring vocabulary!
Treasure Island
by Robert Louis Stevenson'Who can think of a pirate without conjuring up the image of Long John Silver?' Daily MailWhen young Jim Hawkins discovers a treasure map in a pirate's chest in his parents' inn, he is drawn into a world of danger and adventure. He joins the crew setting sail to the Caribbean to seek out the booty and over the course of the voyage confronts mutiny, murder and the charismatic and devious Long John Silver. WITH AN INTRODUCTION BY ANDREW MOTION
Treasure Island (Puffin Classics)
by Robert Louis StevensonPuffin Classics: the definitive collection of timeless stories, for every child. The HISPANIOLA still lay where she had anchored; but, sure enough, there was the Jolly Roger--the black flag of piracy--flying from her peak. Following the death of bloodthirsty buccaneer Captain Flint, young Jim Hawkins finds himself with the key to a fortune - he has discovered a map that will lead him to the fabled Treasure Island. But a gang of villains, wild beasts and deadly swashbucklers stand between him and the stash of gold. Not to mention the most infamous pirate ever to sail the high seas . . . The original pirate adventure story, this timeless classic includes a wonderfully funny introduction by award-winning author Eoin Colfer, a behind-the-scenes journey, an author profile, a guide to who's who, activities and more!