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Skeletal Tissue Mechanics

by David P. Fyhrie Neil A. Sharkey David B. Burr R. Bruce Martin

This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

The Engineering Approach to Winter Sports

by Edoardo Sabbioni Stefano Melzi Stefano Maldifassi Federico Cheli Francesco Braghin

The Engineering Approach to Winter Sports presents the state-of-the-art research in the field of winter sports in a harmonized and comprehensive way for a diverse audience of engineers, equipment and facilities designers, and materials scientists. The book examines the physics and chemistry of snow and ice with particular focus on the interaction (friction) between sports equipment and snow/ice, how it is influenced by environmental factors, such as temperature and pressure, as well as by contaminants and how it can be modified through the use of ski waxes or the microtextures of blades or ski soles. The authors also cover, in turn, the different disciplines in winter sports: skiing (both alpine and cross country), skating and jumping, bob sledding and skeleton, hockey and curling, with attention given to both equipment design and on the simulation of gesture and track optimization.

Linear Canonical Transforms

by John T. Sheridan Haldun M. Ozaktas M. Alper Kutay John J. Healy

This book provides a clear and accessible introduction to the essential mathematical foundations of linear canonical transforms from a signals and systems perspective. Substantial attention is devoted to how these transforms relate to optical systems and wave propagation. There is extensive coverage of sampling theory and fast algorithms for numerically approximating the family of transforms. Chapters on topics ranging from digital holography to speckle metrology provide a window on the wide range of applications. This volume will serve as a reference for researchers in the fields of image and signal processing, wave propagation, optical information processing and holography, optical system design and modeling, and quantum optics. It will be of use to graduate students in physics and engineering, as well as for scientists in other areas seeking to learn more about this important yet relatively unfamiliar class of integral transformations.

Nanomaterials in Pharmacology

by Shinji Sakuma Zheng-Rong Lu

This detailed volume aims to introduce nanomaterials as a new therapeutic regimen in treating human diseases. Divided into four sections, it explores inorganic nanomaterials, organic nanomaterials, pharmaceutical properties of nanomaterials, and applications of nanomaterials in medicine. Several examples of inorganic and organic nanomaterials are provided to demonstrate how to design and develop nanomaterials for pharmacological purposes. The key pharmaceutical properties, including biocompatibility, tissue interaction, pharmaceutics, and pharmacokinetics of nanomaterials are discussed with a focus on the safety and pharmaceutical considerations of nanomaterials in translational development. The pharmacological applications of nanomaterials are depicted in treating various human diseases, including cancer, cardiovascular diseases, immune disorders, infectious diseases, gastrointestinal disorders, bone diseases, respiratory disorders, and drug delivery. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of specifics and practical advice that ensures a smooth transition into the lab. Authoritative and enlightening, Nanomaterials in Pharmacology serves as an ideal guide to researchers investigating the potential benefits and risks of nanomaterials in pharmacology in order to avoid the pitfalls and to maximize the potential of this vital field of study.

Ghosts and Lightning

by Trevor Byrne

An outstanding debut novel set in Dublin from a young Irish novelist that echoes the poignant, comical and gritty voices of Roddy Doyle, Patrick McCabe, and Irvine Welsh. Set in contemporary Dublin, this gritty, funny, and compelling novel is also a poignant exploration of grief, poverty, and love. Denny Cullen is just beginning his new life when he's called home to attend his mother's funeral. As he grieves for the loss of his mother, he must come to terms with a changed Dublin full of chaos and desperation, and he must ultimately decide what to keep, and what to leave behind. By turns hilarious and heart-breaking, Denny takes the reader on an unforgettable tour of twenty-first-century Dublin that is as irresistible as an expertly pulled pint of Guinness.From the Trade Paperback edition.

A Return to Love

by Marianne Williamson

Back by popular demand -- and newly updated by the author -- the mega-bestselling spiritual guide in which Marianne Williamson shares her reflections on A Course in Miracles and her insights on the application of love in the search for inner peace.Williamson reveals how we each can become a miracle worker by accepting God and by the expression of love in our daily lives. Whether psychic pain is in the area of relationships, career, or health, she shows us how love is a potent force, the key to inner peace, and how by practicing love we can make our own lives more fulfilling while creating a more peaceful and loving world for our children.

Fundamentals of the Mechanics of Solids

by Luciano Galano Paolo Maria Mariano

This distinctive textbook aims to introduce readers to the basic structures of the mechanics of deformable bodies, with a special emphasis on the description of the elastic behavior of simple materials and structures composed by elastic beams. The authors take a deductive rather than inductive approach and start from a few first, foundational principles. A wide selection of exercises, many with hints and solutions, are provided throughout and organized in a way that will allow readers to form a link between abstract mathematical concepts and real-world applications. The text begins with the definition of bodies and deformations, keeping the kinematics of rigid bodies as a special case; the authors also distinguish between material and spatial metrics, defining each one in the pertinent space. Subsequent chapters cover observers and classes of possible changes; forces, torques, and related balances, which are derived from the invariance under classical changes in observers of the power of the external actions over a body, rather than postulated a priori; constitutive structures; variational principles in linear elasticity; the de Saint-Venant problem; yield criteria and a discussion of their role in the representation of material behavi and an overview of some bifurcation phenomena, focusing on the Euler rod. An appendix on tensor algebra and tensor calculus is included for readers who need a brief refresher on these topics. Fundamentals of the Mechanics of Solids is primarily intended for graduate and advanced undergraduate students in various fields of engineering and applied mathematics. Prerequisites include basic courses in calculus, mathematical analysis, and classical mechanics.

Advances and Clinical Practice in Pyrosequencing

by Qinxin Song Guohua Zhou

The aim of this book is to improve pyrosequencing protocols as well as instrumentation for better clinical use by describing improvements and novel applications of pyrosequencing technology. Divided into five parts, the book's thirty chapters explore advances in pyrosequencing template preparation, pyrosequencing technology innovations, multiplex pyrosequencing based on barcodes, the miniaturization of pyrosequencing equipment, as well as various applications. As part of the Springer Protocols program, chapters contain the kind of detail and practical implementation advice to guarantee successful results in the lab. Comprehensive and thorough, Advances and Clinical Practice in Pyrosequencing serves as a valuable reference for researchers who are engaged in personalized medicine, disease control, and DNA diagnosis in numerous other fields.

Vaccine Design

by Sunil Thomas

This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 1: Vaccines for Human Diseases has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases as well as vaccines for drug abuse, allergy, and tumor vaccines are also described in this volume. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 1: Vaccines for Human Diseases aims to ensure successful results in the further study of this vital field.

Vaccine Design

by Sunil Thomas

This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 1: Vaccines for Human Diseases has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases as well as vaccines for drug abuse, allergy, and tumor vaccines are also described in this volume. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 1: Vaccines for Human Diseases aims to ensure successful results in the further study of this vital field.


by Arash Kianianmomeni

This volume provides researchers with up-to-date protocols and takes aclose look at current research and promising applications. Optogenetics:Methods and Protocols contains a collection of recently developed technicalprotocols on optogenetic applications in neuroscience, brain mapping, treatmentof neurological disorders, and restoration of visual function. Severalintroductory and discussion chapters offer a wide overview about sources anddiversity of optogenetic tools, design strategies, and potential applicationsin other fields like plant research. Written in the highly successful Methodsin Molecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls. Cutting edge and thorough, Optogenetic: Methods and Protocols, deliversan interdisciplinary view of optogenetic applications and its potential todevelop as a valuable tool for basic research, as well as biomedical andbiotechnological applications.

Statistical Genomics

by Sean Davis Ewy Mathé

This volume expands on statisticalanalysis of genomic data by discussing cross-cutting groundwork material,public data repositories, common applications, and representative tools foroperating on genomic data. Statistical Genomics: Methods andProtocols is divided into four sections. The first section discussesoverview material and resources that can be applied across topics mentionedthroughout the book. The second section covers prominent public repositoriesfor genomic data. The third section presents several different biologicalapplications of statistical genomics, and the fourth section highlightssoftware tools that can be used to facilitate ad-hoc analysis and dataintegration. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to theirrespective topics, step-by-step, readily reproducible analysis protocols, andtips on troubleshooting and avoiding known pitfalls. Through and practical, StatisticalGenomics: Methods and Protocols, explores a range of both applicationsand tools and is ideal for anyone interested in the statistical analysis ofgenomic data.

A Course in Mathematical Statistics and Large Sample Theory

by Victor Patrangenaru Lizhen Lin Rabi Bhattacharya

This graduate-level textbook is primarily aimed at graduate students of statistics, mathematics, science, and engineering who have had an undergraduate course in statistics, an upper division course in analysis, and some acquaintance with measure theoretic probability. It provides a rigorous presentation of the core of mathematical statistics. Part I of this book constitutes a one-semester course on basic parametric mathematical statistics. Part II deals with the large sample theory of statistics - parametric and nonparametric, and its contents may be covered in one semester as well. Part III provides brief accounts of a number of topics of current interest for practitioners and other disciplines whose work involves statistical methods.

Movement Disorders: A Video Atlas

by Roongroj Bhidayasiri Daniel Tarsy

Movement Disorders: A Video Atlas is a practical and concise title offering an introduction to the field of movement disorders, which is expanding rapidly with the involvement of various disciplines and specialties. The unique feature of the book is the accompanying video content, comprising common cases in each category of movement disorders. The video clips come from Dr. Tarsy's personal video collection at Beth Israel Deaconess Medical Center and Dr. Bhidayasiri's personal collection at Chulalongkorn University and UCLA. The video is on an accompanying DVD and can also be found at Each case includes expert narration from Dr. Tarsy. Rather than focusing on rare cases, the authors emphasize typical cases, with good history and physical signs. Unique, easy to read, with highly instructive supporting video content, Movement Disorders: A Video Atlas is an indispensable reference for all clinicians interested in the fascinating field of movement disorders.

Cardiovascular Hemodynamics

by John C. Stephens Joseph M. Martin Arman T. Askari Saif Anwaruddin

A basic understanding of cardiovascular physiology is essential for optimal patient care. This practical book provides a concise tutorial of all the essential aspects of cardiovascular hemodynamics and the techniques used to assess cardiovascular performance. A high-yield reference, this book is replete with figures, tracings, tables, and clinical pearls that reinforce the basic tenets of hemodynamics. From identifying key findings of the patient history and physical exam to correlating hemodynamic tracings with acute clinical presentations, this book arms the reader with the tools necessary to handle any hemodynamic-related situation.

Plant Proteomics

by Stefanie Wienkoop Wolfram Weckwerth Setsuko Komatsu Jesus V. Jorrin-Novo

Plant Proteomics: Methods and Protocols, Second Edition presents recent advances made in the field of proteomics and their application to plant biology and translational research. In recent years, improvements in techniques and protocols for high-throughput proteomics have been made at all workflow stages, from wet (sampling, tissue and cell fractionation, protein extraction, depletion, purification, separation, MS analysis, quantification) to dry lab (experimental design, algorithms for protein identification, bioinformatics tools for data analysis, databases, and repositories). Divided into nine convenient sections, chapters cover topics such as applications of gel-free, label- or label-free, imaging and targeted approaches to experimental model systems, crops and orphan species, as well as the study and analysis of PTMs, protein interactions, and specific families of proteins, and finally proteomics in translational research. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Plant Proteomics: Methods and Protocols, Second Edition seeks to serve both professionals and novices looking to exploit the full potential of proteomics in plant biology research.

Monoclonal Antibodies

by Nicolas Fischer Vincent Ossipow

Monoclonal Antibodies: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed modern approaches to isolate and characterize monoclonal antibodies against carefully selected epitopes. This edition includes new chapters covering the key steps to generate high quality monoclonals via different methods, from antigen generation to epitope mapping and quality control of the purified IgG. Chapters are divided into four parts corresponding to four distinct objectives. Part I covers monoclonal antibody generation, Part II deals with monoclonal antibody expression and purification, Part III presents methods for monoclonal antibody characterization and modification, and Part IV describes selected applications of monoclonal antibodies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoclonal Antibodies: Methods and Protocols, Second Edition provides crucial initial steps of monoclonal antibody generation and characterization with state-of-the art protocols.

Discrete Calculus

by Jonathan R. Polimeni Leo J. Grady

The field of discrete calculus, also known as "discrete exterior calculus", focuses on finding a proper set of definitions and differential operators that make it possible to operate the machinery of multivariate calculus on a finite, discrete space. In contrast to traditional goals of finding an accurate discretization of conventional multivariate calculus, discrete calculus establishes a separate, equivalent calculus that operates purely in the discrete space without any reference to an underlying continuous process. This unique text brings together into a single framework current research in the three areas of discrete calculus, complex networks, and algorithmic content extraction. Although there have been a few intersections in the literature between these disciplines, they have developed largely independently of one another, yet researchers working in any one of these three areas can strongly benefit from the tools and techniques being used in the others. Many example applications from several fields of computational science are provided to demonstrate the usefulness of this framework to a broad range of problems. Readers are assumed to be familiar with the basics of vector calculus, graph theory, and linear algebra. Topics and features: presents a thorough review of discrete calculus, with a focus on key concepts required for successful application; unifies many standard image processing algorithms into a common framework for viewing a wide variety of standard algorithms in filtering, clustering, and manifold learning that may be applied to processing data associated with a graph or network; explains how discrete calculus provides a natural definition of "low-frequency" on a graph, which then yields filtering and denoising algorithms; discusses how filtering algorithms can give rise to clustering algorithms, which can be used to develop manifold learning and data discovery methods; examines ranking algorithms, as well as algorithms for analyzing the structure of a network. Graduate students and researchers interested in discrete calculus, complex networks, image processing and computer graphics will find this text/reference a clear introduction to the foundations of discrete calculus as well as a useful guide to have readily available for their work. Dr. Leo J. Grady is a Senior Research Scientist with Siemens Corporate Research in Princeton, New Jersey, USA. Dr. Jonathan R. Polimeni is a Research Fellow at the Massachusetts General Hospital in Boston, Massachusetts, USA, and Instructor in Radiology at Harvard Medical School, Boston, Massachusetts, USA.

Analysis and Geometry of Markov Diffusion Operators

by Michel Ledoux Ivan Gentil Dominique Bakry

The present volume is an extensive monograph on the analytic and geometric aspects of Markov diffusion operators. It focuses on the geometric curvature properties of the underlying structure in order to study convergence to equilibrium, spectral bounds, functional inequalities such as Poincaré, Sobolev or logarithmic Sobolev inequalities, and various bounds on solutions of evolution equations. At the same time, it covers a large class of evolution and partial differential equations. The book is intended to serve as an introduction to the subject and to be accessible for beginning and advanced scientists and non-specialists. Simultaneously, it covers a wide range of results and techniques from the early developments in the mid-eighties to the latest achievements. As such, students and researchers interested in the modern aspects of Markov diffusion operators and semigroups and their connections to analytic functional inequalities, probabilistic convergence to equilibrium and geometric curvature will find it especially useful. Selected chapters can also be used for advanced courses on the topic.

Preventive Methods for Coastal Protection: Towards the Use of Ocean Dynamics for Pollution Control

by Tarmo Soomere Ewald Quak

The aim of the book is to present for non-specialist researchers as well as for experts a comprehensive overview of the background, key ideas, basic methods, implementation details and a selection of solutions offered by a novel technology for the optimisation of the location of dangerous offshore activities in terms of environmental criteria, as developed in the course of the BalticWay project. The book consists of two parts. The first part introduces the basic principles of ocean modeling and depicts the long way from the generic principles to the practical modeling of oil spills and of the propagation of other adverse impacts. The second part focuses on the techniques for solving the inverse problem of the quantification of offshore areas with respect to their potential to serve as a source of environmental danger to vulnerable regions (such as spawning, nursing or also tourist areas). The chapters are written in a tutorial style; they are mostly self-contained and understandable for non-specialist researchers and students. They are carefully peer-reviewed by international experts. The goal was to produce a book that highlights all key steps, methods, models and data sets it is necessary to combine in order to produce a practically usable technology and/or decision support system for a particular sea region. Thus the book is useful not only as a description and a manual of this particular technology but also as a roadmap highlighting the complicated technical issues of ocean modeling for practical purposes. It describes the approaches taken by the authors in an understandable way and thus is useful for educational purposes, such as a course in industrially and environmentally relevant applications of ocean modeling.

Topological Microfluidics: Nematic Liquid Cystals and Nematic Colloids in Microfluidic Environment

by Anupam Sengupta

This work represents one of the first comprehensive attempts to seamlessly integrate two highly active interdisciplinary domains in soft matter science - microfluidics and liquid crystals (LCs). Motivated by the lack of fundamental experiments, Dr. Sengupta initiated systematic investigation of LC flows at micro scales, gaining new insights that are also suggestive of novel applications. By tailoring the surface anchoring of the LC molecules and the channel dimensions, different topological constraints were controllably introduced within the microfluidic devices. These topological constraints were further manipulated using a flow field, paving the way for Topological Microfluidics. Harnessing topology on a microfluidic platform, as described in this thesis, opens up capabilities beyond the conventional viscous-dominated microfluidics, promising potential applications in targeted delivery and sorting systems, self-assembled motifs, and novel metamaterial fabrications.

Molecular Vaccines

by Matthias Giese

This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.

Mapping Spatial Relations, Their Perceptions and Dynamics

by Ekkehard Schönherr Susanne Rau

This book is the product of an eponymous workshop, which took place in Erfurt in May, 2012, and which has since then been supplemented with four further contributions. The topics focus on the potential mapping of perceived urban space and spatial hierarchies as a consequence of social usage (undertaken by a variety of active participants) together with spatio-temporal changes as a result of factors such as demographic urban growth and decline. Historians, cartographers and geographers are brought together to present and discuss different models, ideas and new methods of spatial analysis and modes of representing changes in perceptions. The two main subjects are: the epistemology of spatial change and the question of (historical) media and adequate presentation. This work represents a first step toward the development of a new model for mapping urban changes and spatial relations concerning the past, present and future.

The Boundary-Scan Handbook

by Kenneth P. Parker

Aimed at electronics industry professionals, this 4th edition of the Boundary Scan Handbook describes recent changes to the IEEE1149. 1 Standard Test Access Port and Boundary-Scan Architecture. This updated edition features new chapters on the possible effects of the changes on the work of the practicing test engineers and the new 1149. 8. 1 standard. Anyone needing to understand the basics of boundary scan and its practical industrial implementation will need this book. Provides an overview of the recent changes to the 1149. 1 standard and the effect of the changes on the work of test engineers; Explains the new IEEE 1149. 8. 1 subsidiary standard and applications; Describes the latest updates on the supplementary IEEE testing standards. In particular, addresses: IEEE Std 1149. 1 Digital Boundary-Scan IEEE Std 1149. 4 Analog Boundary-Scan IEEE Std 1149. 6 Advanced I/O Testing IEEE Std 1149. 8. 1 Passive Component Testing IEEE Std 1149. 1-2013 The 2013 Revision of 114 9. 1IEEE Std 1532 In-System Configuration IEEE Std 1149. 6-2015 The 2015 Revision of 1149. 6

Surface Analysis and Techniques in Biology

by Vincent S. Smentkowski

This book summarizes the main surface analysis techniques that are being used to study biological specimens/systems. The compilation of chapters in this book highlight the benefits that surface analysis provides. The outer layer of bulk solid or liquid samples is referred to as the surface of the sample/material. At the surface, the composition, microstructure, phase, chemical bonding, electronic states, and/or texture is often different than that of the bulk material. The outer surface is where many material interactions/reactions take place. This is especially true biomaterials which may be fabricated into bio-devices and in turn implanted into tissues and organs. Surfaces of biomaterials (synthetic or modified natural materials) are of critical importance since the surface is typically the only part of the biomaterial/bio-device that comes in contact with the biological system. Analytical techniques are required to characterize the surface of biomaterials and quantify their impact in real-world biological systems. Surface analysis of biological materials started in the 1960's and the number of researchers working in this area have increased very rapidly since then, a number of advances have been made to standard surface analytical instrumentation, and a number of new instruments have been introduced.

Showing 3,026 through 3,050 of 14,086 results


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