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Crisis Management for Software Development and Knowledge Transfer

by Sergey V. Zykov

This well structured book discusses lifecycle optimization of software projects for crisis management by means of software engineering methods and tools. Its outcomes are based on lessons learned from the software engineering crisis which started in the 1960s. The book presents a systematic approach to overcome the crisis in software engineering depends which not only depends on technology-related but also on human-related factors. It proposes an adaptive methodology for software product development, which optimizes the software product lifecycle in order to avoid "local" crises of software production. The general lifecycle pattern and its stages are discussed, and their impact on the time and budget of the software product development is analyzed. The book identifies key advantages and disadvantages for various models selected and concludes that there is no "silver bullet", or universal model, which suits all software products equally well. It approaches software architecture in terms of process, data and system perspectives and proposes an incremental methodology for crisis-agile development of large-scale, distributed heterogeneous applications. The book introduces a number of specialized approaches which are widely used in industry but are often ignored in general writings because of their vendor-specificity. In doing so, the book builds a helpful bridge from academic conceptions of software engineering to the world of software engineering practice. With its systematic coverage of different software engineering methodologies and the presented rich systems engineering examples the book will be beneficial for a broader audience.

Machine Learning in Medicine - Cookbook Three

by Aeilko H. Zwinderman Ton J. Cleophas

Unique features of the book involve the following. 1. This book is the third volume of a three volume series of cookbooks entitled "Machine Learning in Medicine - Cookbooks One, Two, and Three". No other self-assessment works for the medical and health care community covering the field of machine learning have been published to date. 2. Each chapter of the book can be studied without the need to consult other chapters, and can, for the readership''s convenience, be downloaded from the internet. Self-assessment examples are available at extras. springer. com. 3. An adequate command of machine learning methodologies is a requirement for physicians and other health workers, particularly now, because the amount of medical computer data files currently doubles every 20 months, and, because, soon, it will be impossible for them to take proper data-based health decisions without the help of machine learning. 4. Given the importance of knowledge of machine learning in the medical and health care community, and the current lack of knowledge of it, the readership will consist of any physician and health worker. 5. The book was written in a simple language in order to enhance readability not only for the advanced but also for the novices. 6. The book is multipurpose, it is an introduction for ignorant, a primer for the inexperienced, and a self-assessment handbook for the advanced. 7. The book, was, particularly, written for jaded physicians and any other health care professionals lacking time to read the entire series of three textbooks. 8. Like the other two cookbooks it contains technical descriptions and self-assessment examples of 20 important computer methodologies for medical data analysis, and it, largely, skips the theoretical and mathematical background. 9. Information of theoretical and mathematical background of the methods described are displayed in a "notes" section at the end of each chapter. 10. Unlike traditional statistical methods, the machine learning methodologies are able to analyze big data including thousands of cases and hundreds of variables. 11. The medical and health care community is little aware of the multidimensional nature of current medical data files, and experimental clinical studies are not helpful to that aim either, because these studies, usually, assume that subgroup characteristics are unimportant, as long as the study is randomized. This is, of course, untrue, because any subgroup characteristic may be vital to an individual at risk. 12. To date, except for a three volume introductary series on the subject entitled "Machine Learning in Medicine Part One, Two, and Thee, 2013, Springer Heidelberg Germany" from the same authors, and the current cookbook series, no books on machine learning in medicine have been published. 13. Another unique feature of the cookbooks is that it was jointly written by two authors from different disciplines, one being a clinician/clinical pharmacologist, one being a mathematician/biostatistician. 14. The authors have also jointly been teaching at universities and institutions throughout Europe and the USA for the past 20 years. 15. The authors have managed to cover the field of medical data analysis in a nonmathematical way for the benefit of medical and health workers. 16. The authors already successfully published many statistics textbooks and self-assessment books, e. g. , the 67 chapter textbook entitled "Statistics Applied to Clinical Studies 5th Edition, 2012, Springer Heidelberg Germany" with downloads of 62,826 copies. 17. The current cookbook makes use, in addition to SPSS statistical software, of various free calculators from the internet, as well as the Konstanz Information Miner (Knime), a widely approved free machine learning package, and the free Weka Data Mining package from New Zealand. 18. The above software packages with hundreds of nodes, the basic processing units including virtually all of the statistical and data mining methods, can be used not only for data analyses, but also for appropriate data stora...

Machine Learning in Medicine - Cookbook Two

by Aeilko H. Zwinderman Ton J. Cleophas

The amount of data medical databases doubles every 20 months, and physicians are at a loss to analyze them. Also, traditional data analysis has difficulty to identify outliers and patterns in big data and data with multiple exposure / outcome variables and analysis-rules for surveys and questionnaires, currently common methods of data collection, are, essentially, missing. Consequently, proper data-based health decisions will soon be impossible. Obviously, it is time that medical and health professionals mastered their reluctance to use machine learning methods and this was the main incentive for the authors to complete a series of three textbooks entitled "Machine Learning in Medicine Part One, Two and Three, Springer Heidelberg Germany, 2012-2013", describing in a nonmathematical way over sixty machine learning methodologies, as available in SPSS statistical software and other major software programs. Although well received, it came to our attention that physicians and students often lacked time to read the entire books, and requested a small book, without background information and theoretical discussions and highlighting technical details. For this reason we produced a 100 page cookbook, entitled "Machine Learning in Medicine - Cookbook One", with data examples available at extras. springer. com for self-assessment and with reference to the above textbooks for background information. Already at the completion of this cookbook we came to realize, that many essential methods were not covered. The current volume, entitled "Machine Learning in Medicine - Cookbook Two" is complementary to the first and also intended for providing a more balanced view of the field and thus, as a must-read not only for physicians and students, but also for any one involved in the process and progress of health and health care. Similarly to Machine Learning in Medicine - Cookbook One, the current work will describe stepwise analyses of over twenty machine learning methods, that are, likewise, based on the three major machine learning methodologies: Cluster methodologies (Chaps. 1-3) Linear methodologies (Chaps. 4-11) Rules methodologies (Chaps. 12-20) In extras. springer. com the data files of the examples are given, as well as XML (Extended Mark up Language), SPS (Syntax) and ZIP (compressed) files for outcome predictions in future patients. In addition to condensed versions of the methods, fully described in the above three textbooks, an introduction is given to SPSS Modeler (SPSS' data mining workbench) in the Chaps. 15, 18, 19, while improved statistical methods like various automated analyses and Monte Carlo simulation models are in the Chaps. 1, 5, 7 and 8. We should emphasize that all of the methods described have been successfully applied in practice by the authors, both of them professors in applied statistics and machine learning at the European Community College of Pharmaceutical Medicine in Lyon France. We recommend the current work not only as a training companion to investigators and students, because of plenty of step by step analyses given, but also as a brief introductory text to jaded clinicians new to the methods. For the latter purpose, background and theoretical information have been replaced with the appropriate references to the above textbooks, while single sections addressing "general purposes", "main scientific questions" and "conclusions" are given in place. Finally, we will demonstrate that modern machine learning performs sometimes better than traditional statistics does. Machine learning may have little options for adjusting confounding and interaction, but you can add propensity scores and interaction variables to almost any machine learning method.

SPSS for Starters and 2nd Levelers

by Aeilko H. Zwinderman Ton J. Cleophas

For medical and health workers this book is a must-have, because statistical methods in these fields are vital, and no equivalent work is available. For medical and health students this is equally true. A unique point is its low threshold, textually simple and at the same time full of self-assessment opportunities. Other unique points are the succinctness of the chapters with 3 to 6 pages, the presence of entire-commands-texts of the statistical methodologies reviewed and the fact that dull scientific texts imposing an unnecessary burden on busy and jaded professionals have been left out. For readers requesting more background, theoretical and mathematical information a note section with references is in each chapter. The first edition in 2010 was the first publication of a complete overview of SPSS methodologies for medical and health statistics. Well over 100,000 copies of various chapters were sold within the first year of publication. Reasons for a rewrite were four. First, many important comments from readers urged for a rewrite. Second, SPSS has produced many updates and upgrades, with relevant novel and improved methodologies. Third, the authors felt that the chapter texts needed some improvements for better readability: chapters have now been classified according the outcome data helpful for choosing your analysis rapidly, a schematic overview of data, and explanatory graphs have been added. Fourth, current data are increasingly complex and many i mportant methods for analysis were missing in the first edition. For that latter purpose some more advanced methods seemed unavoidable, like hierarchical loglinear methods, gamma and Tweedie regressions and random intercept analyses. In order for the contents of the book to remain covered by the title, the authors renamed the book: SPSS for Starters and 2nd Levelers. Special care was, nonetheless, taken to keep things as simple as possible. Medical and health professionals tend to dislike software syntax. Therefore, virtually no syntax, but, rather, simple menu commands are given. The arithmetic is still of a no-more-than high-school level. Step-by-step analyses of different statistical methodologies are given with the help of 60 SPSS data files available through the internet. Because of the lack of time of this busy group of people, the authors have given every effort to produce a text as succinct as possible.

Insurance Economics

by Peter Zweifel Roland Eisen

Insurance Economics brings together the economic analysis of decision making under risk, risk management and demand for insurance by individuals and corporations, objectives pursued and management tools used by insurance companies, the regulation of insurance, and the division of labor between private and social insurance. Appropriete both for advanced undergraduate and graduate students of economics, management, and finance, this text provides the background required to understand current research. Predictions derived from theoretical argument are not only stated but confronted with empirical evidence. Throughout the book, conclusions summarize results, helping readers to check their knowledge and understanding. Issues discussed include paradoxa in decision making under risk, selection of favorable risks by insurers, the possibility of a "death spiral" in insurance markets, and future challenges such as re-regulation in the wake of the 2007-09 financial crisis and the increasing availability of generic information.

Advances in Transplant Dermatology

by Fiona Zwald Marc D. Brown

This book provides an informative update on scientific advances relating to transplant dermatology that may be applicable to clinical practice. Commentary is provided on the emerging role of viruses in transplant dermatology, the management of skin disease secondary to transplant medication, sunscreen use in transplant recipients, the role of revision of immunosuppression, and advances in photodynamic therapy. The latest staging and management criteria for high-risk squamous cell carcinoma and the implications for clinical practice are then analyzed. Finally, the management of other cutaneous malignancies is discussed, covering malignant melanoma, Merkel cell carcinoma, and rarer tumors that also behave aggressively and require special consideration in solid organ transplant patients. Each particular advance is addressed in an individual chapter by leaders in the field. The book both expands current knowledge and complements previous textbooks on the subject.

High-Resolution Extreme Ultraviolet Microscopy

by Michael Werner Zürch

This thesis describes novel approaches and implementation of high-resolution microscopy in the extreme ultraviolet light regime. Using coherent ultrafast laser-generated short wavelength radiation for illuminating samples allows imaging beyond the resolution of visible-light microscopes. Michael Zürch gives a comprehensive overview of the fundamentals and techniques involved, starting from the laser-based frequency conversion scheme and its technical implementation as well as general considerations of diffraction-based imaging at nanoscopic spatial resolution. Experiments on digital in-line holography and coherent diffraction imaging of artificial and biologic specimens are demonstrated and discussed in this book. In the field of biologic imaging, a novel award-winning cell classification scheme and its first experimental application for identifying breast cancer cells are introduced. Finally, this book presents a newly developed technique of generating structured illumination by means of so-called optical vortex beams in the extreme ultraviolet regime and proposes its general usability for super-resolution imaging.


by Leon Zurawicki

Over the last 10 years advances in the new field of neuromarketing have yielded a host of findings which defy common stereotypes about consumer behavior. Reason and emotions do not necessarily appear as opposing forces. Rather, they complement one another. Hence, it reveals that consumers utilize mental accounting processes different from those assumed in marketers' logical inferences when it comes to time, problems with rating and choosing, and in post-purchase evaluation. People are often guided by illusions not only when they perceive the outside world but also when planning their actions - and consumer behavior is no exception. Strengthening the control over their own desires and the ability to navigate the maze of data are crucial skills consumers can gain to benefit themselves, marketers and the public. Understanding the mind of the consumer is the hardest task faced by business researchers. This book presents the first analytical perspective on the brain - and biometric studies which open a new frontier in market research.

The Active Female

by Mimi Zumwalt Reid L. Norman Jacalyn J. Robert- McComb

The purpose of the The Active Female: Health Issues Throughout the Lifespan, 2nd Edition is twofold: (1) to increase the awareness of wellness and fitness issues for active females and their family members; and (2) to provide an avenue for medical practitioners, allied health professionals, health educators, and certified individuals in sports medicine to gain critical, updated knowledge of a field specific to active females. Part I of the book offers a foundation to help the reader understand the interrelationship among body image concerns, the female reproductive cycle, and musculoskeletal anatomy/physiology of females that makes their health risks and concerns unique. Reproductive health is discussed by a prominent researcher in reproduction/endocrinology. An overview of the Female Athlete Triad which is a syndrome of three interrelated conditions (isordered eating, menstrual disturbances and bone loss) is presented in Part II. Physicians and certified professionals in sports medicine discuss the individual components of the triad, relating not only to the athletic female but also to the recreationally active woman throughout the lifespan. In Part III, Prevention and management of common musculoskeletal injuries is addressed by a female orthopedic surgeon who sub-specializes in treating female athletes. Finally, appropriate exercise and nutritional guidelines for active females are discussed in Parts IV-V of the book by certified professionals and licensed physicians in sports medicine. An invaluable addition to the literature, The Active Female: Health Issues Throughout the Lifespan, 2nd Edition will be of great interest to physicians, allied health care practitioners, medical/other wellness educators, and students who are interested in advancing women's health issues. Sports medicine specialists, family practitioners, gynecologists, team physicians, residents in sports medicine, athletic trainers, health educators, nurses, physicians assistants, physical therapists, sport psychologists, counselors, athletic trainers, and other members of the sports medicine team should also find this title of significant interest.

Electroanalysis in Biomedical and Pharmaceutical Sciences

by Petr Zuman Jean-Michel Kauffmann Sibel A. Ozkan

Through this monograph, the pharmaceutical chemist gets familiar with the possibilities electroanalytical methods offer for validated analyses of drug compounds and pharmaceuticals. The presentation focuses on the techniques most frequently used in practical applications, particularly voltammetry and polarography. The authors present the information in such a way that the reader can judge whether the application of such techniques offers advantages for solving a particular analytical problem. Basics of individual electroanalytical techniques are outlined using as simple language as possible, with a minimum of mathematical apparatus. For each electroanalytical technique, the physical and chemical processes as well as the instrumentation are described. The authors also cover procedures for the identification of electroactive groups and the chemical and electrochemical processes involved. Understanding the principles of such processes is essential for finding optimum analytical conditions in the most reliable way. Added to this is the validation of such analytical procedures. A particularly valuable feature of this book are extensive tables listing numerous validated examples of practical applications. Various Indices according to the drug type, the electroactive group and the type of method as well as a subject and author index are also provided for easy reference.

Emerging Values in Health Care: The Challenge for Professionals

by Paquita De Zulueta David Badcott Chris Swift Srikant Sarangi Bronwen Davies Paul Ballard Andrew Edgar Chrissie Hockley Stephen Pattison Alan Nathan Brian Hurwitz Julia Mckeown Kieran Sweeney Derek Sellman Lynn Knight Moira Dumma Heather Skirton Huw Thomas Roisin Pill Ben Hannigan

Professional values in healthcare are in a state of constant and increasingly rapid change. While all professions now emphasise teamwork and collegiality in practice, fewer are inclined to consider shared or differing values across professions. This interdisciplinary volume explains how health care professions and their values have changed over the last forty years, charting where they have come from, where they are now, and how they might develop in the future. There is coverage of a wide range of different professions within healthcare, from GPs, mental health nurses, adult nurses and pharmacists, to NHS managers and chaplains. Chapters are followed by critical responses from senior healthcare practitioners. This original and insightful book will be a valuable resource for academics, researchers, senior healthcare professionals and healthcare managers.

Macroprudential Regulation and Policy for the Islamic Financial Industry

by Muhamed Zulkhibri Abdul Ghafar Ismail Sutan Emir Hidayat

This volume aims to discuss thecurrent research, theory, methodology and applications of macropreudentialregulation and policy for the Islamic financial industry. Published incooperation with the Islamic Research and Training Institute (IRTI), this book featurescontributions from a workshop presented in collaboration with the UniversityCollege of Bahrain (UCB) in Manama, Bahrain, aimed to bring together experts inIslamic banking and regulation and financial economics. This resulting booksheds light on how macroprudential policy may be implemented in the Islamicfinancial system, and indicates current challenges and their effects oneconomic growth, financial stability and monetary regulation. Macroprudential policyis increasingly seen as a way of dealing with the different dimensions ofsystemic risk. But many central banks, bank supervisors and regulators havelimited experience with macroprudential tools, particularly in the Islamicfinancial industry. Given the complementarities between monetary policy andfinancial stability, it appears that central banks would always play animportant role in macroprudential policy. But how should macroprudential policybest interact with monetary policy? It is becoming more pressing for the centralbanks to conduct monetary policy in which its conventional banking systemoperates side by side with Islamic banking system. This question has receivedincreasing attention in the research literature but there is much we still needto learn. This is why new insights from research on macroprudential policy -which has gained important impetus in recent years - are so valuable. Featuringcontributions on topics such as macroprudential regulation, policy, tools andinstruments; governance, systematic risk, monetary policy, and bank leverage,the editors provide a collection of comprehensive research covering the mostimportant issues on macroprudential policy and regulation for the Islamicfinancial industry. This volume is expected to be a significant contribution tothe literature in the field of Islamic finance and evaluation of publicpolicies to promote the development for Islamic financial industry. It is alsoserved as a key text for students, academics, researchers, policy-makers in thefield of Islamic finance.

Computing the Optical Properties of Large Systems

by Tim Joachim Zuehlsdorff

This work addresses the computation of excited-state properties of systems containing thousands of atoms. To achieve this, the author combines the linear response formulation of time-dependent density functional theory (TDDFT) with linear-scaling techniques known from ground-state density-functional theory. This extends the range of TDDFT, which on its own cannot tackle many of the large and interesting systems in materials science and computational biology. The strengths of the approach developed in this work are demonstrated on a number of problems involving large-scale systems, including exciton coupling in the Fenna-Matthews-Olson complex and the investigation of low-lying excitations in doped p-terphenyl organic crystals.

Anxiety-Free Kids: An Interactive Guide for Parents and Children

by Bonnie Zucker

Anxiety-Free Kids (2nd ed.) offers parents strategies that help children become happy and worry free, methods that relieve a child's excessive anxieties and phobias, and tools for fostering interaction and family-oriented solutions. Using a unique companion approach that offers two books in one-a practical, reader-friendly book for parents and a fun workbook for kids-this solutions-oriented guide utilizes the cognitive-behavioral approach to therapy and integrates the parent in the child's self-help process. Research has shown that if left untreated, children with anxiety disorders are at higher risk to perform poorly in school, to have less-developed social skills, and to be more vulnerable to substance abuse. Covering the six most commonly occurring anxiety disorders-generalized anxiety, separation anxiety, specific phobias, social phobias, panic disorder, and obsessive-compulsive disorder-this book gives kids and parents successful strategies for achieving relaxation, conquering worries, challenging faulty thinking patterns, developing positive self-talk, and facing one's fears.

Exploration and Meaning Making in the Learning of Science

by Bernard Zubrowski

This book provides a broad and deep rationale for various pedagogical practices associated with the teaching of science. The main thesis of this book is that the exploratory phase of scientific inquiry is undervalued and its purpose misunderstood. Furthermore, there is a need for an expanded conception or alternative way of thinking about the so called learning cycle that has been frequently cited as the pedagogical model for a fair number of curriculum programs. A pedagogical model is proposed that recognizes learning cycles as ones that build on each other in an in-depth developmental manner. It presents an alternative paradigm that gives more attention to the motivation of students and assigns an essential role for student input. The overall goal is to move the reader to think more holistically about the practice of science education. This original and unorthodox book summarizes the author's present thinking about curriculum design and direct work with students. The author draws upon his varied experiences to present a case for the importance of direct engagement with phenomena and materials. He argues that this practice is more than a matter of motivating students to become engaged in inquiry. The first four chapters lay out different levels of a pedagogical approach and an overall theoretical orientation. The middle chapters focus on what might be called sensory knowledge. These are concerned with the role of different sensory engagement, movement as related to gestural representation and the role of empathy in exploration. The last four chapters are about the role of aesthetic, play, variable exploration and metaphor in their shaping of science education experiences. Each chapter is introduced with a scenario or case study describing the behavior and talk of elementary or middle school students. The intention of these scenarios is to help the reader stay grounded while considering the more abstract development of research reports and broader philosophical issues.

Action Leadership

by Ortrun Zuber-Skerritt

Action leadership is a creative, innovative, collaborative and self-developed way to lead. It eschews the hierarchical structure usually associated with leadership and is based instead on the democratic values of freedom, equality, inclusion and self-realization. It take responsibility for, not control over, people through networking and orchestrating human energy towards a holistic outcome that benefits the common interest. Action leaders are passionate people who abide by the motto that "Learning does not mean to fill a barrel but rather to ignite a flame" in others. And in this time of rapid economic, political, technological, social and ecological changes, action leadership and action leaders are precisely what's needed to improve how people and organizations engage constructively to address the myriad complex issues challenging society at all levels. Action Leadership: Towards a Participatory Paradigm explains and illustrates how action leadership can be developed through participatory action learning and action research (PALAR). It addresses real-life issues by people who choose to work collaboratively towards shared goals while developing their learning, insights, knowledge, people skills and personal relationships through involvement in a PALAR project. The book provides a conceptual framework for action leadership and for the integrative, practical theory of PALAR; and examples of applications in higher education, management education for organization development, and community development. Readers are encouraged to adopt, adapt and further develop the evolving concepts of action leadership and PALAR in a participatory paradigm of learning, research and development.

Electromagnetic Fields and Waves in Fractional Dimensional Space

by Muhammad Zubair Qaisar Abbas Naqvi Muhammad Junaid Mughal

This book presents the concept of fractional dimensional space applied to the use of electromagnetic fields and waves. It provides demonstrates the advantages in studying the behavior of electromagnetic fields and waves in fractal media. The book presents novel fractional space generalization of the differential electromagnetic equations is provided as well as a new form of vector differential operators is formulated in fractional space. Using these modified vector differential operators, the classical Maxwell's electromagnetic equations are worked out. The Laplace's, Poisson's and Helmholtz's equations in fractional space are derived by using modified vector differential operators.

Symmetric Discontinuous Galerkin Methods for 1-D Waves

by Enrique Zuazua Aurora Marica

This work describes the propagation properties of the so-called symmetric interior penalty discontinuous Galerkin (SIPG) approximations of the 1-d wave equation. This is done by means of linear approximations on uniform meshes. First, a careful Fourier analysis is constructed, highlighting the coexistence of two Fourier spectral branches or spectral diagrams (physical and spurious) related to the two components of the numerical solution (averages and jumps). Efficient filtering mechanisms are also developed by means of techniques previously proved to be appropriate for classical schemes like finite differences or P1-classical finite elements. In particular, the work presents a proof that the uniform observability property is recovered uniformly by considering initial data with null jumps and averages given by a bi-grid filtering algorithm. Finally, the book explains how these results can be extended to other more sophisticated conforming and non-conforming finite element methods, in particular to quadratic finite elements, local discontinuous Galerkin methods and a version of the SIPG method adding penalization on the normal derivatives of the numerical solution at the grid points. This work is the first publication to contain a rigorous analysis of the discontinuous Galerkin methods for wave control problems. It will be of interest to a range of researchers specializing in wave approximations.

JIMD Reports, Volume 17

by Johannes Zschocke K. Michael Gibson Garry Brown Eva Morava Verena Peters

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Hepatitis B Virus in Human Diseases

by Fabien Zoulim Yun-Fan Liaw

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational science including the viral life cycle, the immunopathogenesis of virus induced chronic hepatitis, the mechanism of virus induced liver cancer, and their potential applications for the clinical management of patients. The clinical aspects of this chronic viral infection are reviewed in detail with important chapters on the global epidemiology, the natural history of the disease, co-infections with its satellite virus HDV or HIV, and management of special patient populations. A major emphasis is made on the management of antiviral therapy and the recent international guidelines for the treatment of hepatitis B. Finally, the book reviews the current state of the art regarding immunoprophylaxis to prevent the spread of the virus and its major clinical consequences. The new advances and perspectives in the development of improved antiviral treatments are also discussed. Hepatitis B Virus in Human Diseases will serve as a very useful resource for students, physicians and researchers dealing with, and interested in, this challenging chronic viral infection. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

Physical-Layer Security for Cooperative Relay Networks

by Yulong Zou Jia Zhu

This book presents physical-layer security as a promising paradigm for achieving the information-theoretic secrecy required for wireless networks. It explains how wireless networks are extremely vulnerable to eavesdropping attacks and discusses a range of security techniques including information-theoretic security, artificial noise aided security, security-oriented beamforming, and diversity assisted security approaches. It also provides an overview of the cooperative relaying methods for wireless networks such as orthogonal relaying, non-orthogonal relaying, and relay selection. Chapters explore the relay-selection designs for improving wireless secrecy against eavesdropping in time-varying fading environments and a joint relay and jammer selection for wireless physical-layer security, where a relay is used to assist the transmission from the source to destination and a friendly jammer is employed to transmit an artificial noise for confusing the eavesdropper. Additionally, the security-reliability tradeoff (SRT) is mathematically characterized for wireless communications and two main relay-selection schemes, the single-relay and multi-relay selection, are devised for the wireless SRT improvement. In the single-relay selection, only the single best relay is chosen for assisting the wireless transmission, while the multi-relay selection invokes multiple relays for simultaneously forwarding the source transmission to the destination. Physical-Layer Security for Cooperative Relay Networks is designed for researchers and professionals working with networking or wireless security. Advanced-level students interested in networks, wireless, or privacy will also find this book a useful resource.

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

by Taotao Zou

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.

Web Technologies and Applications

by Lei Zou Rong Zhang Xiaoyan Yang Liang Hong Kang Chen Ruichu Cai

This bookconstitutes the refereed proceedings of the workshops held at the 17thAsia-Pacific Web Conference, APWeb 2015, in Guangzhou, China, in September2015. The 15 fullpapers were carefully reviewed and selected from various submissions. The volumepresents the papers that have been accepted for the following workshops: BigData Applications in Telecoms, BDAT 2015, Big Social Data, BSD 2015, and WebData Mining and Applications, WDMA 2015. The papers cover various issues in thearea of the World Wide Web with the underlying technologies and applications.

Current Developments in Web Based Learning

by Di Zou Dickson K. W. Chiu Zhiguo Gong

This bookconstitutes the thoroughly revised selected papers of the workshops of the 14thInternational Conference of Web Based Learning, ICWL 2015, held in Guangzhou,China, in November 2015. This volumecomprises papers of three workshops: 1. The 5thInternational Symposium on Knowledge Management and E-Learning, KMEL 2015 2. Thefirst International Workshop on User Modeling for Web Based Learning, IWUM 2015 3. TheInternational Workshop on Learning Analytics

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