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This volume of the Handbook of Neurochemistry and Molecular Neurobiology focuses on neurochemical aspects of schizophrenia. Chapters cover the full range of schizophrenia symptoms and anatomical pathologies from neurochemical and molecular biology perspectives. Topics include changes in neurotransmitter systems, alteration in receptors, neurotransmitter release, genetic factors, protein alterations, and redox dysregulation.
A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.
This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.
A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field. Beginning with the overviews of various cell cycle regulations, this title presents the most current protocols and state-of-the-art techniques used to generate latest findings in cell cycle regulation, such as protocols to analyze cell cycle events and molecules. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Control: Mechanisms and Protocols, Second Edition will be a valuable resource for a wide audience, ranging from the experienced cell cycle researchers looking for new approaches to the junior graduate students giving their first steps in cell cycle research.
This book introduces the exciting intersection of technology and fashion known as wearable computing. Learn about the future of electronics in clothing and testiles, and be a part of creating that future! Crafting Wearables begins with the history of the field, then covers current practices and future trends. You will gain deeper insight into the strategy behind the design of wearable devices while learning about the tools and materials needed to start your own wearables toolbox. In a time when consumer electronics are becoming smaller and seamlessly integrated into our lives, it is important to understand how technology can improve and augment your lifestyle. Wearables are in a sense the most organic and natural interface we can design, yet there is still doubt about how quickly wearable technologies will become the cultural norm. Furthermore, skills that have become less valuable over the years, such as sewing, are making a return with the wearables movement. Gives a better understanding of wearable technology and how it has evolved Teaches basic skills and techniques to familiarize you with the tools and materials Showcases breakthrough designs and discoveries that impact our everyday interactions What you'll learn Learn the history of how technology in fashion has evolved over time Discover interesting materials and fabrics for use in wearable technology Glimpse new tools for designing wearable technology and fashion Rediscover sewing and related skills that every wearables enthusiast should learn Learn how new techniques in textile manufacturing could disrupt the fashion industry Understand and respond to the cultural and societal developments around wearables Who this book is for Crafting Wearables is written for the curious designer, engineer, or creative who is looking for insight into the world of fashion technology. It is for someone who wants to start exploring wearables with basic projects and dig deeper into the methods and tools of an expert. Crafting Wearables is intended to impart comprehensive general knowledge of the state of wearables in different industries while providing a well-curated list of example projects and resources by which to begin your personal journey into e-textiles. It is a wonderful read for those who are looking to expand their understanding of fashion and technology from both a hands-on and research based perspective.
Quirky Quantum Concepts explains the more important and more difficult concepts in theoretical quantum mechanics, especially those which are consistently neglected or confusing in many common expositions. The emphasis is on physical understanding, which is necessary for the development of new, cutting edge science. In particular, this book explains the basis for many standard quantum methods, which are too often presented without sufficient motivation or interpretation. The book is not a simplification or popularization: it is real science for real scientists. Physics includes math, and this book does not shy away from it, but neither does it hide behind it. Without conceptual understanding, math is gibberish. The discussions here provide the experimental and theoretical reasoning behind some of the great discoveries, so the reader may see how discoveries arise from a rational process of thinking, a process which Quirky Quantum Concepts makes accessible to its readers. Quirky Quantum Concepts is therefore a supplement to almost any existing quantum mechanics text. Students and scientists will appreciate the combination of conversational style, which promotes understanding, with thorough scientific accuracy.
Diet quality is a broad term that encapsulates both perceived and actual practices, personal preferences and cultural diversity. Measuring dietary quality can be problematic and includes investigating food types, the number or size of portions or their frequency. Diet quality may also be related to the type of food being ingested, snacking and other eating habits. Manufactured beverages and fast food may also be included as well as microbiological quality and attempts to improve single food items such as meats or vegetables. In this book, Diet Quality: An Evidence-Based Approach, Volume 1 all of the major facets of diet quality in relation to health outcomes are covered. This important new text includes methods for determining diet quality while adopting a holistic approach to impart information on the major areas of concern or knowledge. Chapters link in measurable indices of health such as obesity, pregnancy outcomes, cancer and cancer outcomes, and mortality. This book represents a diverse set of subject matters and seeks to fill a gap in the literature at a time when there is an increasing awareness that well being is associated with the qualitative nature of diets. Contributors are authors of international and national standing and emerging fields of science are incorporated. Diet Quality: An Evidence-Based Approach, Volume 1 is a useful new text designed for nutritionists, dietitians, clinicians, epidemiologist, policy makers and health care professionals of various disciplines.
Weather derivatives are financial instruments that can be used by organizations or individuals as part of a risk management strategy to minimize risk associated with adverse or unexpected weather conditions. Just as traditional contingent claims, a weather derivative has an underlying measure, such as: rainfall, wind, snow or temperature. Nearly $1 trillion of the U.S. economy is directly exposed to weather-related risk. More precisely, almost 30% of the U.S. economy and 70% of U.S. companies are affected by weather. The purpose of this monograph is to conduct an in-depth analysis of financial products that are traded in the weather market. Presenting a pricing and modeling approach for weather derivatives written on various underlying weather variables will help students, researchers, and industry professionals accurately price weather derivatives, and will provide strategies for effectively hedging against weather-related risk. This book will link the mathematical aspects of the modeling procedure of weather variables to the financial markets and the pricing of weather derivatives. Very little has been published in the area of weather risk, and this volume will appeal to graduate-level students and researchers studying financial mathematics, risk management, or energy finance, in addition to investors and professionals within the financial services industry.
Advances in Laparoscopy of the Abdominal Wall Hernia is fully illustrated, comprehensive guide which describes in detail the most up-to-date techniques used in the laparoscopic repair of hernias. Written by world renowned authors, this manual reviews laparoscopic techniques used in the repair of inguinal hernias and ventral incisional hernias. Among the topics explored within this updated, engaging and informative text are: * Techniques such as Extraperitoneal (TEP) and transabdominal (TAPP) hernia repair * Fundamentals of ventral hernia repair * A detailed overview of mesh fixation in laparoscopic surgery * Methods to deal with rarer hernias and those of atypical location Advances in Laparoscopy of the Abdominal Wall Hernia is a valuable reference tool that would be of great benefit to surgeons and medical practitioners working in this field.
This book focuses on interactive segmentation techniques, which have been extensively studied in recent decades. Interactive segmentation emphasizes clear extraction of objects of interest, whose locations are roughly indicated by human interactions based on high level perception. This book will first introduce classic graph-cut segmentation algorithms and then discuss state-of-the-art techniques, including graph matching methods, region merging and label propagation, clustering methods, and segmentation methods based on edge detection. A comparative analysis of these methods will be provided with quantitative and qualitative performance evaluation, which will be illustrated using natural and synthetic images. Also, extensive statistical performance comparisons will be made. Pros and cons of these interactive segmentation methods will be pointed out, and their applications will be discussed. There have been only a few surveys on interactive segmentation techniques, and those surveys do not cover recent state-of-the art techniques. By providing comprehensive up-to-date survey on the fast developing topic and the performance evaluation, this book can help readers learn interactive segmentation techniques quickly and thoroughly.
This book provides an undergraduate introduction to discrete and continuous-time Markov chains and their applications. A large focus is placed on the first step analysis technique and its applications to average hitting times and ruin probabilities. Classical topics such as recurrence and transience, stationary and limiting distributions, as well as branching processes, are also covered. Two major examples (gambling processes and random walks) are treated in detail from the beginning, before the general theory itself is presented in the subsequent chapters. An introduction to discrete-time martingales and their relation to ruin probabilities and mean exit times is also provided, and the book includes a chapter on spatial Poisson processes with some recent results on moment identities and deviation inequalities for Poisson stochastic integrals. The concepts presented are illustrated by examples and by 72 exercises and their complete solutions.
This book provides a detailed update on the applications of Serious Games in Healthcare and Education sector. In short, it provides an all rounded research and industry updates about the current and future advances in this area. These are the two sectors that are developing rapidly with direct applications of serious games. With advances in technologies and a new perspective on patient engagement and public expectations, the healthcare sector is increasingly turning to serious games to solve problems. Subconscious Learning via Games and Social Media will share expert opinions on the development and application of game technologies for health-related serious games. Our commercial and non-commercial expert comes from different aspects of the healthcare system from clinicians to therapist. The scope ranges from population health to specific medical domain applications. In the education sector, digital games have a great potential to improve learning of both adults and children. It is important to understand how to design games that could create long term behavioral change rather than short term alterations. In these chapters, we discuss how the serious games should be designed and deployed for both adults and children.
This book makes the area of integration of renewable energy into the existing electricity grid accessible to engineers and researchers. This is a self-contained text which has models of power system devices and control theory necessary to understand and tune controllers in use currently. The new research in renewable energy integration is put into perspective by comparing the change in the system dynamics as compared to the traditional electricity grid. The emergence of the voltage stability problem is motivated by extensive examples. Various methods to mitigate this problem are discussed bringing out their merits clearly. As a solution to the voltage stability problem, the book covers the use of FACTS devices and basic control methods. An important contribution of this book is to introduce advanced control methods for voltage stability. It covers the application of output feedback methods with a special emphasis on how to bound modelling uncertainties and the use of robust control theory to design controllers for practical power systems. Special emphasis is given to designing controllers for FACTS devices to improve low-voltage ride-through capability of induction generators. As generally PV is connected in low voltage distribution area, this book also provides a systematic control design for the PV unit in distribution systems. The theory is amply illustrated with large IEEE Test systems with multiple generators and dynamic load. Controllers are designed using Matlab and tested using full system models in PSSE.
The prodigal son of Copper Ridge, Oregon, has finally come home The man who ruined Rebecca Bear's life just strolled back into it with one heck of an offer. Years ago, Gage West's recklessness left Rebecca scarred inside and out. Now he wants to make amends by gifting her the building that houses her souvenir store. Rebecca won't take Gage's charity, but she's willing to make a deal with the sexy, reclusive cowboy. Yet keeping her enemy close is growing dangerously appealing... He's the wild West brother, the bad seed of Copper Ridge. That's why Gage needs the absolution Rebecca offers. He just didn't expect to need her. After years of regretting his past, he knows where his future lies-with this strong, irresistible woman who could make a black sheep come home to stay...
From New York Times bestselling author Jodi Thomas comes the first book in a compelling, emotionally resonant series set in a remote west Texas town-where family can be made by blood or by choice Rancher Staten Kirkland, the last descendant of Ransom Canyon's founding father, is rugged and practical to the last. <P><P>No one knows that when his troubling memories threaten to overwhelm him, he runs to lovely, reclusive Quinn O'Grady...or that she has her own secret that no one living knows. Young Lucas Reyes has his eye on the prize-college, and the chance to become something more than a ranch hand's son. But one night, one wrong decision, will set his life on a course even he hadn't imagined. Yancy Grey is running hard from his troubled past. He doesn't plan to stick around Ransom Canyon, just long enough to learn the town's weaknesses and how to use them for personal gain. Only Yancy, a common criminal since he was old enough to reach a car's pedals, isn't prepared for what he encounters. In this dramatic new series, the lives, loves and ambitions of four families will converge, set against a landscape that can be as unforgiving as it is beautiful, where passion, property and pride are worth fighting-and even dying-for.
The tougher they are, the harder they fall... Professional mercenary Dare Macintosh lives by one hard-and-fast rule: business should never be personal. If a cause appeals to him and the price is right, he'll take the mission he's offered. But then the lovely Molly Alexander asks him to help her track down the men who'd had her kidnapped-and for the first time, Dare's tempted to combine work with pleasure. Fiercely independent, Molly vows to trust no one until she's uncovered the truth. Could the enemy be her powerful estranged father? The ex-fiancé who still holds a grudge? Or the not-so-shy fan of her bestselling novels? As the danger heats up around them, the only anchor Molly has is Dare himself. But what she feels for him just might be the most frightening thing of all...
Jacalyn Duffin's History of Medicine has for ten years been one of the leading texts used to teach medical and nursing students the history of their profession. It has also been widely used in history courses and by general readers. An accessible overview of medical history, this new edition is greatly expanded, including more information on medicine in the United States, Great Britain, and in other European countries. The book continues to be organized conceptually around the major fields of medical endeavor such as anatomy, pharmacology, obstetrics, and psychiatry and has grown to include a new chapter on public health.Years of pedagogic experience, medical developments, and reader feedback have led to new sections throughout the book on topics including bioethics, forensics, genetics, reproductive technology, clinical trials, and recent outbreaks of BSE, West Nile Virus, SARS, and anthrax. Up to date and filled with pithy examples and teaching tools such as a searchable online bibliography, History of Medicine continues to demonstrate the power of historical research to inform current health care practice and enhance cultural understanding.
In the early history of Halifax (1749-1766), debt litigation was extremely common. People from all classes frequently used litigation and its use in private matters was higher than almost all places in the British Empire in the 18th century. In Law, Debt, and Merchant Power, James Muir offers an extensive analysis of the civil cases of the time as well as the reasons behind their frequency. Muir's lively and detailed account of the individuals involved in litigation reveals a paradoxical society where debtors were also debt-collectors. Law, Debt, and Merchant Power demonstrates how important the law was for people in their business affairs and how they shaped it for their own ends.
Neoliberalism is among the most commonly used concepts in the social sciences. Furthermore, it is one of the most influential factors that have shaped the formation of public policy and politics. In Governing Practices, Michelle Brady and Randy Lippert bring together prominent scholars in sociology, criminology, anthropology, geography, and policy studies to extend and refine the current conversation about neoliberalism. The collection argues that a new methodological approach to analyzing contemporary policy and political change is needed. United by the common influence of Foucault's governmentality approach and an ethnographic imaginary, the collection presents original research on a diverse range of case studies including public-private partnerships, the governance of condos, community and state statistics, nanopolitics, philanthropy, education reform, and pay-day lending. These diverse studies add considerable depth to studies on governmentality and neoliberalism through a focus on governmental practices that have not previously been the focus of sustained analysis.
Borders in Service traces the intersection of service labour and national identity across global call centres in seven countries: El Salvador, Guatemala, Guyana, Mauritius, Morocco, the Philippines, and the US-Mexico border. While most studies on offshore call centres have focused on India this collection explores the experiences of call center workers in many of the newly emerging hubs of transnational service work. In this collection, Kiran Mirchandani and Winifred Poster have gathered a wide range of contributors to explore the dynamics within global call centres. Such dynamics include: language, speech, accent issues, expressions of consumer sentiment, physical space, and organizational, human resource, and labour policies. By grounding the theoretical debates on nationhood and labour in the realities of daily life in global call centres, Mirchandani and Poster have created a timely, accessible and revealing collection that will change what we know about offshored customer service work.
Despite Canada's economic success over the past thirty years, the country's ranking in productivity has continued to decline when compared to other industrialized nations. Economic experts and pundits repeatedly call for means of improving productivity, arguing that it is the lynchpin to prosperity. However, there is growing evidence to the contrary. In Productivity and Prosperity, Karen Foster zeroes in on the paradox of productivity: that it is the key to economic prosperity and yet its connection to well-being and median incomes has all but disappeared. Drawing together three case studies including the development of Statistics Canada, the National Productivity Council, and the evolution of the Atlantic Canada Opportunities Agency, Foster argues that there is a 'productivist regime' guiding policy development in Canada and abroad. By analyzing and critiquing the inherent assumptions of productivism the author destabilizes the myth that economic growth is essential for quality of life.
Oil is the source of wealth and economic opportunity. Oil is also the root source of global conflict, toxicity and economic disparity. When did oil become such a powerful commodity--during, and in the immediate aftermath of, the First World War.In his groundbreaking book The First World Oil War, Timothy C. Winegard argues that beginning with the First World War, oil became the preeminent commodity to safeguard national security and promote domestic prosperity. For the first time in history, territory was specifically conquered to possess oil fields and resources; vital cogs in the continuation of the industrialized warfare of the Twentieth Century. This original and pioneering study analyzes the evolution of oil as a catalyst for both war and diplomacy, and connects the events of the First World War to contemporary petroleum geo-politics and international aggression.
Between 1995 and 2005, the government of Alberta undertook major reforms to the way water is governed in the arid southern part of the province. Among the most significant reforms was the imposition of moratoria on new water licenses, the introduction of a market for buying and selling existing water licenses, and the adoption of a "conservation holdback" mechanism for returning some licensed water to the environment.In Water Policy Reform in Southern Alberta, B. Timothy Heinmiller looks at how and why these (and other) reforms were adopted after nearly a century of stasis on water policy. The study analyses over three decades of policy decisions, beginning with the Progressive Conservative victory in 1972 to the last major policy reform in 2007. Applying the Advocacy Coalition Framework, process tracing methodologies, and content analysis, the author isolates, identifies and reconstructs the actors and processes that shaped over thirty years of water policy in Alberta. Water Policy Reform in Southern Alberta offers important insights on the management of natural resources and the factors influencing meaningful policy change.
This book offers a review of the use ofextended ablation plasmas as nonlinear media for HHG of high-order harmonicgeneration (HHG). The book describes the different experimentalapproaches, shows the advantages and limitations regarding HHG efficiency anddiscusses the particular processes that take place at longer interactionlengths, including propagation and quasi-phase matching effects. Itdescribes the most recent approaches to harmonic generation in the extremeultraviolet (XUV) range with the use of extended plasma plumes, and how thesediffer from more commonly-used gas-jet sources. The main focus is on studiesusing extended plasmas, but some new findings from HHG experiments in narrowplasma plumes are also discussed. It also describes how quasi-phase-matching inmodulated plasmas, as demonstrated in recent studies, has revealed differentmeans of tuning enhanced harmonic groups in the XUV region. After an introduction to the fundamentaltheoretical and experimental aspects of HHG, a review of the most importantresults of HHG in narrow plasmas is presented, including recent studies ofsmall-sized plasma plumes as emitters of high-order harmonics. In Chapter 2,various findings in the application of extended plasmas for harmonic generationare analyzed. One of the most important applications of extended plasmas, thequasi-phase-matching of generated harmonics, is demonstrated in Chapter 3,including various approaches to the modification of perforated plasma plumes. Chapter 4 depicts the nonlinear optical features of extended plasmas producedon the surfaces of different non-metal materials. Chapter 5 is dedicatedto the analysis of new opportunities for extended plasma induced HHG. Theadvantages of the application of long plasma plumes for HHG, such as resonanceenhancement and double-pulse method, are discussed in Chapter 6. Finally, asummary section brings together all of these findings and discuss theperspectives of extended plasma formations for efficient HHG and nonlinearoptical plasma spectroscopy. The book will be useful for students andscholars working in this highly multidisciplinary domain involving materialscience, nonlinear optics and laser spectroscopy. It brings the new researcherto the very frontier of the physics of the interaction between laser andextended plasma; for the expert it will serve as an essential guide andindicate directions for future research.
This book deals with the various aspects viz. , the disease, geographical distribution, symptoms on different hosts, host range, yield losses, and disease assessment method, while detailed description on pathogen include taxonomic position, phylogeny, variability, sporulation, perpetuation, and spore germination, host-parasite interactions in the form of seed infection, disease cycle, process of infection, and pathogenesis, epidemiology, forecasting, fine structures, biochemical changes, and phytotoxins, host defence mechanism, techniques to study host-parasite relationships, and management practices including cultural, chemical, biological control practices, and deployment of host resistance. The last section deals with gaps in our understanding, and knowledge about management of these diseases, techniques for the diagnosis of disease and offer suggestions for future research priorities. Each aspect has been vividly illustrated with photographs, histograms, figures, tables, electron micrographs for stimulating, effective and easy reading and understanding. We are sure that this comprehensive encyclopaedic treatise on "Alternaria diseases of crucifers" will be of immense use to the researchers, teachers, students and all others who are interested in the diagnosis and management of Alternaria diseases of crucifers world over. Four species of Alternaria are wide spread and most devastating on cruciferous oil yielding crops, vegetables, forage crops, ornamental plants, and numerous weeds all over the world. The damage to the plants is in the form of infections on seed in the soil during sowing, on seedlings during emergence and growth, on stem, leaves, inflorescence, pods and finally to the seed causing yield losses in seed quantity and quality.
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