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Race to Kindness
by Orion JeanCome join our great race where kindness begins,Where everyone&’s welcome and everyone wins!This inspiring picture book, written by TIME 2021 Kid of the Year Orion Jean, invites readers to join in the kindness movement, because when we dream big and work together, we can change the world.From giving meaningful compliments to sharing your snack to donating used clothes, there are so many ways to be kind that it can be tough to know where to start! Luckily, author and fellow kid Orion Jean has some simple steps we can all take to make the world a better place.Race to Kindness shows children ages 4-8:Many different ways to show kindnessHow much fun taking action can beThat even small acts of kindness can have a big impactYou&’re never too young to make a differenceOrion&’s journey from getting involved with his local community to having a nation-wide impact, giving readers a real-life role model? With rhyming, lyrical text, Race to Kindness is the perfect read-aloud book for:Parents and grandparentsTeachers and educatorsLibrarians and book eventsNonprofits and charities Orion has donated over half a million books to date, but he knows firsthand that even the smallest kind gesture can have a big impact. Solace up your sneakers and join the race to kindness!
Your Life is God's Story: Trusting God’s Plan Through Life’s Ups and Downs
by Tim DilenaBiblical stories and powerful testimonies that encourage faith in God's plan for your life.In Your Life is God's Story, pastor and teacher Tim Dilena guides readers through the faith-building journeys of eleven Bible characters whose ordinary and painful experiences led to unforeseen results. Alongside the Bible stories are powerful testimonies from Tim and people in his life.Your Life is God's Story gives readers a new set of lenses to view experiences and events in life with hope. The hope is seeing how God gets ordinary people to their intended destinies. Readers will gain a renewed passion for persevering through life's challenges to trust God's process.Together, they illustrate how God has a perfect plan for everyone.Your Life is God's Story includes:Stories from 11 biblical people whose destinies were unclear throughout most of their livesExperiences of ordinary believers who have trusted the process, living through big trouble and getting to the other side to give praise to GodQuestions for further reflection and study at the end of every chapter
The Storied Life: Christian Writing as Art and Worship
by Jared C. WilsonWhen writers write, they are getting in touch with the image of God in them. This is true in some way of all artistry, but writers especially create worlds, characters, histories, and transformation--all ex nihilo ("out of nothing").In The Storied Life, veteran author Jared C. Wilson explores the ins and outs of writers and writing, exploring the myriad ways the craft is more about transformation than simply communication. From decades of experience and with his signature wit, Wilson brings well-earned insight, autobiographical reflections, and meaningful meditations to the topic of writing as a way of life and as a way of worship, showing how the concept of Story--our personal stories and God's grand story of redemption--shapes fiction and non-fiction writers alike.Chapters focus on topics like:The liturgy of story.Writing as a spiritual act.Perseverance and endurance.Writing as a calling.Promotion, publishing, and platform.Whether you're a long-time writer or a beginning author, a daily journaler or an occasional dabbler, The Storied Life will help you improve your craft. It will lead you to think more deeply about the disciplines and dispositions needed to write for transformation.
The Hope in Our Scars: Finding the Bride of Christ in the Underground of Disillusionment
by Aimee ByrdAimee Byrd peels back the church's underlying and pervasive theology of power to face the shame that lurks there and find the lasting hope of belonging in Christ.Some things happening in the church these days should provoke our anger. It's racked with scandals of fraud, abuse, cover-up. It's embroiled in racism, misogyny, marginalization, and hatred. The truth is that we have to fight to love Christ's church. Many of us are left wondering what kind of hope can the church offer if its leaders will not care for its wounds, admit their complicity, and move toward true reconciliation with God's people.From the author of Recovering from Biblical Manhood and Womanhood comes a passionate plea to work through our disillusionment with the church and rediscover what's true and beautiful about our covenantal union with Christ.Having tread her own path of disillusionment, Aimee Byrd invites us to see Christ among the chaos so apparent in his church. Along the way, Aimee guides us through deeply theological and personal reflections on how we can:Cultivate healthier forms of trust by recognizing power structures at work.Understand the limits of authority, and free ourselves from tribes and celebrity culture.Take appropriate social risks by speaking up when we're uncomfortable.Rediscover how our stories matter to God. This book is written to those who have been wounded by the church. To those who have suffered abuse at the hands of church leaders and are left with deep scars. To those who are disillusioned or deconstructing their faith, The Hope in Our Scars offers a way forward with a God who walks with us in our affliction and wants to make it into something beautiful.
The Boy From Clearwater: Book 2
by Pei-Yun YuThe "glorious" sequel to Freeman Award-winning The Boy from Clearwater After his imprisonment in Green Island, Kun-lin struggles to pick up where he left off ten years earlier. He reconnects with his childhood crush Kimiko and finds work as an editor, jumping from publisher to publisher until finally settling at an advertising company. But when manhua publishing becomes victim to censorship, and many of his friends lose their jobs, Kun-lin takes matters into his own hands. He starts a children’s magazine, Prince, for a group of unemployed artists and his old inmates who cannot find work anywhere else. Kun-lin’s life finally seems to be looking up... but how long will this last? Forty years later, Kun-lin serves as a volunteer at the White Terror Memorial Park, promoting human rights education. There, he meets Yu Pei-Yun, a young college professor who provides him with an opportunity to reminisce on his past and how he picked himself up after grappling with bankruptcy and depression. With the end of martial law, Kun-lin and other former New-Lifers felt compelled to mobilize to rehabilitate fellow White Terror victims, forcing him to face his past head-on. While navigating his changing homeland, he must conciliate all parts of himself––the victim and the savior, the patriot and the rebel, a father to the future generation and a son to the old Taiwan––before he can bury the ghosts of his past. P R A I S E ★ "Yu, Zhou, and King bear glorious witness to little-known tragic history by empathetically spotlighting an everyday superhero who survived—and thrives." –Booklist (starred) ★ "An accessible, timely account of Taiwan’s struggles for democracy and human rights as experienced through a personal lens." –Kirkus (starred) "Triumphant and rewarding." –Foreword
Joyful Song: A Naming Story
by Lesléa NewmanWhat a happy day! Zachary’s baby sister will have her naming ceremony. In the temple! With his moms, the congregation, and all their friends! He’s so excited he can barely contain it. On the walk from their home, they meet neighbor after neighbor who want to know the baby’s name. But – not yet! – his mothers tell him. The tradition is to have a great reveal at the ceremony. So they invite each neighbor to come along. A colorful, diverse parade blooms along the route, until…At last it’s time, and Zachary gets to reveal his sister’s name…What is it? A truly joyful moment for everyone.
Queer Power Couples: On Love and Possibility
by Hannah Murphy WinterThis photographic celebration of queer love and excellence gathers fourteen LGBTQ+ power couples, offering a glimpse into the journeys that led to their meaningful relationships and thriving careers.From designer Debbie Millman’s ardent courtship of writer Roxane Gay to the romantic and creative relationship forged between Perfume Genius bandmates Mike Hadreas and Alan Wyffels on stage during their first world tour, this beautiful book offers a closer look into the lives of fourteen inspiring LGBTQ+ couples and the meet-cutes, success stories, and personal reflections that made them the role models they are today. These icons come from a range of backgrounds—they are trailblazers who lead research labs, kitchens, and news organizations; create life-giving art and music; and tell queer stories in award-winning books, films, and television shows.With in-depth original interviews by journalist Hannah Murphy Winter and intimate photography by their wife, Billie Winter, this diverse collection is a jubilant celebration of queer love and an empowering reminder to younger LGBTQ+ generations of their limitless possibilities.AMAZING PROFILES: This superlative collection features more than twenty-five queer leaders in film and TV, the music industry, journalism, academia, fine art, and nonprofits. Read about showrunner ND Stevenson and comic artist Molly Knox Ostertag, astrologer Chani Nicholas and nonprofit founder Sonya Passi, director Anthony Hemingway and actor Steven Norfleet, chefs Aisha Ibrahim and Samantha Beaird, and many more inspiring figures. BEAUTIFUL IMAGES: Intimate, joyful, and moving, the photography of Billie Winter captures a diverse group of queer icons in the worlds they have built for themselves. Her candid, organic images of the couples share intimate moments of laughter, conversation, and comfortable silence. And at the end of every photoshoot, she asked the couples to photograph each other — capturing the couples' love and connection with a vulnerability that only they could. This gorgeous book presents LGBTQ+ relationships in all their multiplicity.OWN VOICES: This is a book about queer power couples created by a queer couple. In-depth original interviews conducted by journalist Hannah Murphy Winter offer insightful context into the lives and careers of the LGBTQ+ changemakers, and photographs by her wife, Billie Winter, capture genuine, unscripted moments between the subjects. This is a meaningful gift for queer folks, allies who want to learn more about queer culture, and anyone who wants to uplift the stories of the LGBTQ+ community.Perfect for:Queer young people and adults and their loved onesAllies, advocates, and activistsFans of portrait anthologies and storytelling projects like Humans of New YorkFans of LGBTQ+ photography books like Loving: a Photographic History of Men In Love 1850s–1950s, We Are Everywhere, and Queer Love In ColorGift-giving for birthdays, weddings, anniversaries, Valentine’s Day, Pride Month, and other special occasions
Shopkeeping: Stories, Advice, and Observations
by Peter MillerA love letter to the small shop, and shop owners everywhere, by beloved bookseller Peter Miller.For more than four decades, Peter Miller has run a design bookshop that shares his name in Seattle. He has also written three of his own books, manuals about cooking and about food and about eating together. In Shopkeeping, Miller writes for the first time about his other love: shopkeeping."There is a tradition of shopkeeping, a tradition of codes, etiquette, and customs. For the most part, it is an oral history, passed along, person to person. You learn to be a retailer—not by going to college, but by going to work. You learn from people who have learned how to run a shop." [from the Introduction]Over ten chapters, Miller crafts stories from the bookshop floor with wry humor and skillful storytelling. Readers will laugh out loud as they come to understand along the way that small shops characterize our towns and cities, making them unique, special, and worth visiting and living near. An essay collection for book and bookshop lovers, small business owners, and Seattle natives, transplants, and visitors, Shopkeeping captures the art and heart of running a local shop cherished by the community that surrounds it.
Feeling Asian American: Racial Flexibility Between Assimilation and Oppression (NWSA / UIP First Book Prize)
by Wen LiuAsian Americans have become the love-hate subject of the American psyche: at times celebrated as the model minority, at other times hated as foreigners. Wen Liu examines contemporary Asian American identity formation while placing it within a historical and ongoing narrative of racial injury. The flexible racial status of Asian Americans oscillates between oppression by the white majority and offers to assimilate into its ranks. Identity emerges from the tensions produced between those two poles. Liu dismisses the idea of Asian Americans as a coherent racial population. Instead, she examines them as a raced, gendered, classed, and sexualized group producing varying physical and imaginary boundaries of nation, geography, and citizenship. Her analysis reveals repeated norms and acts that capture Asian Americanness as part of a racial imagination that buttresses capitalism, white supremacy, neoliberalism, and the US empire. An innovative challenge to persistent myths, Feeling Asian American ranges from the wartime origins of Asian American psychology to anti-Asian attacks to present Asian Americanness as a complex political assemblage.
Radical Brown: Keeping the Promise to America's Children (Race and Education)
by Margaret Beale Spencer Nancy E. DowdA rallying cry for equitable education informed by a revolutionary re-reading of Brown v. Board of Education, on the 70th anniversary of the ruling
Individuals and Societies for the IB MYP 3
by Paul GraceA concept-driven and assessment-focused approach to Individual and societies teaching and learning.- Approaches each chapter with statements of inquiry framed by key and related concepts, set in a global context- Supports every aspect of assessment using tasks designed by an experienced MYP educator- Differentiates and extends learning with research projects and interdisciplinary opportunities- Applies global contexts in meaningful ways to offer an MYP Individual and societies programme with an internationally-minded perspective
The Botanist: a gripping new thriller from The Sunday Times bestselling author (Washington Poe #5)
by M. W. Craven'Mesmerising, macabre and murderously funny. The Botanist is M.W. Craven at his sinister best. I couldn't love this series more' Chris Whitaker'Another classy thriller from the king of Cumbrian crime' Paul FinchThis is going to be the longest week of Washington Poe's life...Detective Sergeant Washington Poe can count on one hand the number of friends he has. And he'd still have his thumb left. There's the guilelessly innocent civilian analyst, Tilly Bradshaw of course. Insanely brilliant, she's a bit of a social hand grenade. He's known his beleaguered boss, Detective Inspector Stephanie Flynn for years as he has his nearest neighbour, full-time shepherd/part-time dog sitter, Victoria.And then there's Estelle Doyle. Dark and dangerous and sexy as hell. It's true the caustic pathologist has never walked down the sunny side of the street, but has she gone too far this time? Shot twice in the head, her father's murder appears to be an open and shut case. Estelle has firearms discharge residue on her hands, and, in a house surrounded by fresh snow, hers are the only footprints. Since her arrest she's only said three words: 'Tell Washington Poe.'Meanwhile, a poisoner called the Botanist is sending the nation's most reviled people poems and pressed flowers. Twisted and ingenious, he seems to be able to walk through walls and, despite the advance notice given to his victims, and regardless of the security measures taken, he is able to kill with impunity.Poe hates locked room mysteries and now he has two to solve. To unravel them he's going to have to draw on every resource he has: Tilly Bradshaw, an organised crime boss, even an alcoholic ex-journalist. Because if he doesn't, the bodies are going to keep piling up . . .Praise for The Botanist: 'Unputdownable, gripping, clever and with a rich seam of trademark Craven humour running through it' Imran Mahmood'A sinful treat' Vaseem Khan'Fast, furious, and utterly enjoyable.' Keith NixonPraise for M W Craven:The Curator shortlisted for the VN Thriller of the Year 2022 & longlisted for the Crime Writers' Association Gold Dagger 2021 Dead Ground longlisted for the Theakston Old Peculiar Crime Novel of the Year 2022 & longlisted for the Crime Writers' Association Ian Fleming Steel Dagger 2022'Heart-pounding, hilarious, sharp and shocking, Dead Ground is further proof that M.W. Craven never disappoints. Miss this series at your peril.' Chris Whitaker'Dark and entertaining, this is top rank crime fiction.' Vaseem Khan, Author of the Malabar House series and the Baby Ganesh Agency series'Fantastic' Martina Cole'Dark, sharp and compelling' Peter James'A brutal and thrilling page turner' The Sun'A thrilling curtain raiser for what looks set to be a great new series' Mick Herron'A powerful thriller from an explosive new talent. Tightly plotted, and not for the faint hearted!'David Mark'A gripping start to a much anticipated new series' Vaseem Khan
Frank and Red: The heart-warming story of an unlikely friendship
by Matt CoyneSometimes, the friend you need is the one you never saw coming.'A lovely feel-good treat' The Times | 'Heart-warming, perceptive and empathetic' CultureFlyFrank and Red are a mess.Frank is a grumpy old curmudgeon. A recluse whose only company is the 'ghost' of his dead wife, Marcie. He is estranged from his friends, his son, and the ever-changing world beyond his front gate. And then Red moves in next door.Red is six. A boy struggling to adjust to the separation of his mum and dad, a new school, and the demonic school bully. Red is curious, smart, he never stops talking, and he's got a trampoline. From the moment Red's blonde mop appears over the top of the fence that divides their two gardens, the unlikeliest of friendships is born. . . . And it is a friendship that will change both of their lives forever.Early readers can't get enough:'Best book of the year!' ⭐ ⭐ ⭐ ⭐ ⭐'A fantastic debut' ⭐ ⭐ ⭐ ⭐ ⭐'Stunningly well-written, warm hearted, incredibly funny and moving story' ⭐ ⭐ ⭐ ⭐ ⭐'A beautifully written, warm and empathic read' ⭐ ⭐ ⭐ ⭐ ⭐
Flipping Schools: Why it's time to turn your school and community inside out
by John West Burnham Malcolm GrovesThis brilliant book, focused on the education of the most vulnerable and disadvantaged children, offers a radical critique of traditional approaches to school improvement. The text argues for a movement away from the focus on social mobility to placing equity at the heart of school leadership. It suggests moving from improvement to social justice through a re-examination of the school's role in relation to its communities. The book is evidence-based and combines a focus on moral leadership with strategies to turn principle into practice.
Confessions of a Traveloholic: To Travel Is To Evolve
by Ashish Raisinghani"Confessions of a Traveloholic" by Col. Ashish Raisinghani offers a captivating insight into the world of travel through the eyes of an experienced Indian Army Officer. Spanning over two decades of exploration, Raisinghani shares thirteen compelling travelogues, ranging from solo backpacking adventures to heartwarming family trips with his wife and daughter. With a keen eye for detail and a philosophical approach, Raisinghani delves into the essence of travel, distinguishing between mere tourists and true travelers who seek immersive experiences and continuous growth. Through vivid storytelling and practical insights, this book inspires readers to embark on their own journeys of self-discovery, embracing the joy of exploration and the transformative power of travel.
Cultural Activism around Gender and Sexualities in Colombia and Mexico: De un Mundo Raro (Global Queer Politics)
by César Sánchez-AvellaThis book focuses on an underestimated alternative to the mainstream liberal rights-based approach: cultural activism. This political strategy deploys art and other creative techniques to support the quest for social justice. This work explores this approach's dynamics, strategies, and potential, presenting a qualitative case study of three cultural activists in Colombia and Mexico -Lia García, Felipe Osornio, and Manuel Parra-, including in-depth interviews and ethnographic observation of their artistic/activist work.Through their intervention in the realm of ordinary affects, these cultural producers create new affective climates for the experience of sexual and gender difference and develop new repertoires of affective response concerning identities usually seen as abject or worthy of social punishment. Strategies of cultural activism aim to subvert dominant representations and performances of marginalized subjectivities, to critique and subvert gender norms, to give visibility to non-hegemonic identities, to resist different forms of oppression and marginalization, and to prompt collective healing of wounds left by violence and discrimination.
Proceedings of the 3rd International Conference on Advanced Surface Enhancement: Surface Engineering for Sustainability (Lecture Notes in Mechanical Engineering)
by Niroj Maharjan Wei HeThis book presents the proceedings of the ‘3rd International Conference on Advanced Surface Enhancement’, INCASE 2023. It compiles the papers presented by researchers in surface engineering field at INCASE 2023 conference. The book presents a comprehensive review of the state of the art in surface engineering-related techniques and strategies, with a focus towards sustainability. The main topics include ‘Advanced techniques for surface engineering towards enhanced performance’, ‘Surface and sub-surface characterisation’, ‘Simulation and modelling of surface integrity’, ‘Advanced coating materials design synthesis and industry applications’, and ‘Emerging trends in surface engineering’. The book identifies the gaps between research and manufacturing and promotes sustainable approaches towards development of surface engineering solutions for adoption by industry. The book is useful for researchers, scientists, students, and engineers working in the field of surface engineering.
Work, Inheritance, and Deserts in Joseph Conrad’s Fiction
by Evelyn Tsz ChanThis book focuses on the complex relationships between inheritance, work, and desert in literature. It shows how, from its manifestation in the trope of material inheritance and legacy in Victorian fiction, “inheritance” gradually took on additional, more modern meanings in Joseph Conrad’s fiction on work and self-making. In effect, the emphasis on inheritance as referring to social rank and wealth acquired through birth shifted to a focus on talent, ability, and merit, often expressed through work.The book explores how Conrad’s fiction engaged with these changing modes of inheritance and work, and the resulting claims of desert they led to. Uniquely, it argues that Conrad’s fiction critiques claims of desert arising from both work and inheritance, while also vividly portraying the emotional costs and existential angst that these beliefs in desert entailed. The argument speaks to and illuminates today’s debates on moral desert arising from work and inheritance, in particular from meritocratic ideals. Its new approach to Conrad’s works will appeal to students and scholars of Conrad and literary modernism, as well as a wider audience interested in philosophical and social debates on desert deriving from inheritance and work.
Deep-Sea Minerals Developments in the 20th Century
by David S. CronanThe book is an historical monograph on deep-sea mineral-related activities and attitudes towards deep-sea mining in the 20th Century which makes comparisons with the current situation in regard to those activities and attitudes. It reviews developments in the study of, and prospects and plans for mining deep-sea manganese nodules, cobalt-rich crusts, hydrothermal deposits, and phosphorites, and discusses associated environmental, technological, and economic issues. It is based on several sources. First, the author’s experience gleaned from around 50 years of attending conferences on the subject (the most important of which was the annual Underwater Mining Institutes held from 1970 onwards at which much of the material in the book was first exposed), second, discussions with and advice from the author's colleagues on the subject, all attributed, and third, the published literature. The target audiences are marine mining companies and their associates, marine environmentalists, UN and Government administrators responsible for seabed activities, undergraduate students of marine affairs and history, and interested lay persons. Unique features include the widespread sources used including unpublished conference proceedings and reports, personal insights gleaned from more than 50 years of working in the field, the author’s publications dating from 1967-2022, and attributed personal communications from the author’s colleagues.
A History of Macedonian Sociology: In Quest for Identity (Sociology Transformed)
by Naum TrajanovskiThis book is the first English-language monograph about the institutional development of sociology in (North) Macedonia. It maps and discusses the contexts, goals, and merits of the pioneering attempts for sociological research in the interwar period, early post-war educational and publishing politics, the institutionalization of sociology in socialist Macedonia in the course of the 1960s, its cross-national exchanges, as well as its major trajectories and debates up until the present days. Against the backgrounds of the political and intellectual histories of Yugoslav and post-Yugoslav Macedonia, it argues that the development of the sociological activities, themes, and arguments is entwined with the Macedonian nation- and state-building.
Agile Audits im Krankenhaus: DIN trifft AGILE - Sprint, Scrum und Kaizen erfolgreich in Audits einbinden
by Kirstin BörchersAudits im Krankenhaus werden oft noch sehr dokumentenlastig und auf ISO-Konformitätsprüfung ausgerichtet durchgeführt. Dabei geht es in Zeiten von E-Health, Digitalisierung und künstlicher Intelligenz (KI) im Krankenhaus längst um mehr und es ist vor allem eine flexiblere Herangehensweise gefordert. Die aktuellen Transformationsprozesse benötigen schnellere und dynamischere Anpassungen in der Organisation und bei den Abläufen. Mit Hilfe von agilen Audit-Instrumenten wie Scrum, Kaizen und Kanban können diese Herausforderungen gemeistert werden.Dieses Buch stellt nach einer Einführung in die Grundlagen von Audits die wichtigsten agilen Werte, Praktiken und Methoden vor, erläutert ihren möglichen Einsatz im Rahmen des allgemeinen Auditprozesses wie auch in den sogenannten „Audits im Sprint“. Agilität im Qualitätsmanagement und in der Durchführung interner Audits steht nicht im Widerspruch zum Leitfaden ISO 19011 „Auditierung von Managementsystemen“, in dem es um dieWirksamkeit und Eignung des QM-Systems sowie dessen Chancen zur Weiterentwicklung geht – sie ist vielmehr eine konsequente Weiterentwicklung. Best-Practice-Beispiele veranschaulichen, wie eine konkrete Umsetzung im Krankenhausumfeld aussehen kann.
Technology Fears and Scapegoats: 40 Myths About Privacy, Jobs, AI, and Today’s Innovation Economy
by Robert D. Atkinson David MoschellaTechnologies and tech companies are routinely accused of creating many societal problems. This book exposes these charges as mostly myths, falsehoods, and exaggerations. Technology Fears and Scapegoats debunks 40 widespread myths about Big Tech, Big Data, AI, privacy, trust, polarization, automation, and similar fears, while exposing the scapegoating behind these complaints. The result is a balanced and positive view of the societal impact of technology thus far. The book takes readers through the steps and mindset necessary to restore the West’s belief in technological progress. Each individual chapter provides a cogent and often controversial rebuttal to a common tech accusation. The resulting text will inspire conversations among tech insiders, policymakers, and the general public alike.
Von den Molukken zu Molekülen: Wie Naturstoffe Geschichte schreiben
by Oliver KayserNaturstoffe sind ein Wunderwerk der Evolution. Pflanzen sind chemische Fabriken und haben mit ihren außergewöhnlichen Eigenschaften eine riesige Anzahl sehr vielfältiger interessanter Naturstoffe hervorgebracht, die wir Menschen seit Jahrhunderten zur Linderung und Heilung von Krankheiten nutzen. Spätestens seit der Entdeckung des Penicillins sind Naturstoffe zu einer wichtigen Quelle für Medikamente geworden, aber wir kennen nur sehr wenige der vermutlich vielen Millionen, die auf ihre Entdeckung warten. Zu den Naturstoffen gehören wichtige Antibiotika, Immunsuppressiva, Antikrebsmittel, Hormone und auch antivirale Wirkstoffe. Aber haben Naturstoffe im Zeitalter der Bio- und Gentechnologie überhaupt noch eine Bedeutung? Ja, mehr denn je, denn Medizinalchemiker holen sich kreative Anregungen für ihre Synthesen aus der Natur, um den nächsten Blockbuster in der Medizin zu entwickeln. Oliver Kayser erzählt in diesem Buch die Geschichte der Naturstoffe und Medizinpflanzen auf höchst informative und amüsante Weise aus einem neuen Blickwinkel. Er geht der Frage nach, wie Naturstoffe aus der Naturheilkunde die pharmazeutische Industrie ins Leben riefen, wie sie als Arznei- und Heilmittel unsere Gesellschaft prägten, wie sie Kriege ermöglichten und den Weg zu Nobelpreisen ebneten. Der Autor zeichnet ein faszinierendes Panorama der Naturstoffchemie in Pflanzen, Mikroorganismen und Tieren. Beginnend mit den ersten Isolierungen zu Anfang der industriellen Revolution führt er uns mit den Ideen und der Begeisterung vieler Wissenschaftlerinnen und Wissenschaftler in die Moderne der Wirkstofftests, der Computerchemie und der höchst erfolgreichen Zufallsentdeckungen von Wirkstoffen. Die Naturstoffforschung im Labor hat einen enormen Einfluss auf unser heutiges Leben. Der Autor lässt sich über die Schulter schauen, wie heute die Suche nach den neuen Medikamenten von morgen funktioniert. Das Buch ist das ultimative Buch aus der Feder eines Wissenschaftlers, der tief in der Forschung verwurzelt ist und dem Leser einen erhellenden und zugleich kurzweiligen Einblick gibt, wie Wissenschaftler ticken und wie mühsam Forschung sein kann.
Drug Resistance in Cancer: Mechanisms and Strategies
by Sameer Ullah Khan Fayaz MalikThis book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
Research on the Characteristics and Effects of Climate Extremes on Multi-spatial-temporal Scales in the Mongolian Plateau (Climate Change Management)
by Chunlan LiCompared with average climate changes, climate extremes which are considered as low-probability events have greater impacts on natural and social systems due to their suddenness, unpredictability and strong destructiveness. Located in the typical arid–semiarid climate transition zone, the Mongolian Plateau, dominated by herbage animal husbandry, is greatly affected by climate extremes, and its ecosystem is extremely fragile. In the context of global warming, the spatial-temporal variation research about climate extremes and their impacts on vegetation is not only beneficial to the protection of the grassland ecological environment in the Mongolian Plateau, but also of great significance to formulate an effective meteorological disaster risk management.Based on daily highest temperature, daily minimum temperature and daily precipitation dataset of 111 meteorological stations over Mongolian Plateau from 1961 to 2014. Firstly, sixteen extreme temperature indices and eleven extreme precipitation indices were calculated. Then, multi-spatial-temporal characteristics of climate extremes in the scope of intensity, duration and frequency were analyzed. At the same time, the vegetation variations were analyzed based on GIMMS NDVI3g data. Thirdly, correlation analysis and multiple stepwise regression analysis were used to analyze the relationships between extreme climate indices and NDVI in different spatial scales from the perspective of single factor and multiple factors, respectively. Finally, the future change of climate extremes in duration were explored based on the climate model data. At the same time, the vulnerable areas of grassland and forest were also identified, and adaptive options of different scales were proposed.Researchers engaged in extreme climate change and managers of government departments are the readership/primary audience for the work.