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The Role of Experimentation Campaigns in the Air Force Innovation Life Cycle

by Medicine Engineering National Academies of Sciences

The Air Force (USAF) has continuously sought to improve the speed with which it develops new capabilities to accomplish its various missions in air, space, and cyberspace. Historically, innovation has been a key part of USAF strategy, and operating within an adversary’s OODA loop (observe, orient, decide, act) is part of Air Force DNA. This includes the ability to deploy technological innovations faster than do our adversaries. The Air Force faces adversaries with the potential to operate within the USAF’s OODA loop, and some of these adversaries are already deploying innovations faster than the USAF. The Role of Experimentation Campaigns in the Air Force Innovation Life Cycle examines the current state of innovation and experimentation in the Air Force and best practices in innovation and experimentation in industry and other government agencies. This report also explores organizational changes needed to eliminate the barriers that deter innovation and experimentation and makes recommendations for the successful implementation of robust innovation and experimentation by the Air Force.

A Threat to America’s Global Vigilance, Reach, and Power–High-Speed, Maneuvering Weapons: Unclassified Summary

by Medicine Engineering National Academies of Sciences

The National Academies of Sciences, Engineering, and Medicine was asked by the Assistant Secretary of the Air Force for Science, Technology and Engineering to assess the threat of high-speed weapons and recommendations to counter the threat. This report reviews the current and evolving threats, and the current and planned U.S. efforts and capabilities to counter these threats, identifies current gaps and future opportunities where the United States Air Force (USAF) could provide significant contribution to the U.S. effort to counter high-speed threats, and recommends actions the USAF could take in terms of materiel, non-materiel, and technology development to address the identified opportunities and gaps in U.S. efforts to address these threats.

Big Data and Analytics for Infectious Disease Research, Operations, and Policy: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

With the amount of data in the world exploding, big data could generate significant value in the field of infectious disease. The increased use of social media provides an opportunity to improve public health surveillance systems and to develop predictive models. Advances in machine learning and crowdsourcing may also offer the possibility to gather information about disease dynamics, such as contact patterns and the impact of the social environment. New, rapid, point-of-care diagnostics may make it possible to capture not only diagnostic information but also other potentially epidemiologically relevant information in real time. With a wide range of data available for analysis, decision-making and policy-making processes could be improved. While there are many opportunities for big data to be used for infectious disease research, operations, and policy, many challenges remain before it is possible to capture the full potential of big data. In order to explore some of the opportunities and issues associated with the scientific, policy, and operational aspects of big data in relation to microbial threats and public health, the National Academies of Sciences, Engineering, and Medicine convened a workshop in May 2016. Participants discussed a range of topics including preventing, detecting, and responding to infectious disease threats using big data and related analytics; varieties of data (including demographic, geospatial, behavioral, syndromic, and laboratory) and their broader applications; means to improve their collection, processing, utility, and validation; and approaches that can be learned from other sectors to inform big data strategies for infectious disease research, operations, and policy. This publication summarizes the presentations and discussions from the workshop.

The Ebola Epidemic in West Africa: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

Predictive Theoretical and Computational Approaches for Additive Manufacturing: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

Additive manufacturing (AM) methods have great potential for promoting transformative research in many fields across the vast spectrum of engineering and materials science. AM is one of the leading forms of advanced manufacturing which enables direct computer-aided design (CAD) to part production without part-specific tooling. In October 2015 the National Academies of Sciences, Engineering, and Medicine convened a workshop of experts from diverse communities to examine predictive theoretical and computational approaches for various AM technologies. While experimental workshops in AM have been held in the past, this workshop uniquely focused on theoretical and computational approaches and involved areas such as simulation-based engineering and science, integrated computational materials engineering, mechanics, materials science, manufacturing processes, and other specialized areas. This publication summarizes the presentations and discussions from the workshop.

Owning the Technical Baseline for Acquisition Programs in the U.S. Air Force

by Medicine Engineering National Academies of Sciences

While there are examples of successful weapon systems acquisition programs within the U.S. Air Force (USAF), many of the programs are still incurring cost growth, schedule delays, and performance problems. The USAF now faces serious challenges in acquiring and maintaining its weapons systems as it strives to maintain its current programs; add new capabilities to counter evolving threats; and reduce its overall program expenditures. Owning the technical baseline is a critical component of the Air Force’s ability to regain and maintain acquisition excellence. Owning the technical baseline allows the government acquisition team to manage and respond knowledgeably and effectively to systems development, operations, and execution, thereby avoiding technical and other programmatic barriers to mission success. Additionally, owning the technical baseline ensures that government personnel understand the user requirements, why a particular design and its various features have been selected over competing designs, and what the options are to pursue alternative paths to the final product given unanticipated cost, schedule, and performance challenges. Owning the Technical Baseline for Acquisition Programs in the U.S. Air Force discusses the strategic value to the Air Force of owning the technical baseline and the risk of not owning it and highlights key aspects of how agencies other than the Air Force own the technical baseline for their acquisition programs. This report identifies specific barriers to owning the technical baseline for the Air Force and makes recommendations to help guide the Air Force in overcoming those barriers.

Families Caring for an Aging America

by Medicine Engineering National Academies of Sciences

Family caregiving affects millions of Americans every day, in all walks of life. At least 17.7 million individuals in the United States are caregivers of an older adult with a health or functional limitation. The nation’s family caregivers provide the lion’s share of long-term care for our older adult population. They are also central to older adults’ access to and receipt of health care and community-based social services. Yet the need to recognize and support caregivers is among the least appreciated challenges facing the aging U.S. population. Families Caring for an Aging America examines the prevalence and nature of family caregiving of older adults and the available evidence on the effectiveness of programs, supports, and other interventions designed to support family caregivers. This report also assesses and recommends policies to address the needs of family caregivers and to minimize the barriers that they encounter in trying to meet the needs of older adults.

The Role of Experimentation Campaigns in the Air Force Innovation Life Cycle: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

The Workshop on the Role of Experimentation Campaigns in the Innovation Cycle was held in January 2016 to define and assess the current use of experimentation campaigns within the Air Force, evaluate barriers to their use, and make recommendations to increase their use. Participants at the workshop presented a broad range of issues, experiences, and insights related to experimentation, experimentation campaigns, and innovation. This publication summarizes the presentations and discussions from the workshop.

NASA Space Technology Roadmaps and Priorities Revisited

by Medicine Engineering National Academies of Sciences

Historically, the United States has been a world leader in aerospace endeavors in both the government and commercial sectors. A key factor in aerospace leadership is continuous development of advanced technology, which is critical to U.S. ambitions in space, including a human mission to Mars. To continue to achieve progress, NASA is currently executing a series of aeronautics and space technology programs using a roadmapping process to identify technology needs and improve the management of its technology development portfolio. NASA created a set of 14 draft technology roadmaps in 2010 to guide the development of space technologies. In 2015, NASA issued a revised set of roadmaps. A significant new aspect of the update has been the effort to assess the relevance of the technologies by listing the enabling and enhancing technologies for specific design reference missions (DRMs) from the Human Exploration and Operations Mission Directorate and the Science Mission Directorate. NASA Space Technology Roadmaps and Priorities Revisited prioritizes new technologies in the 2015 roadmaps and recommends a methodology for conducting independent reviews of future updates to NASA’s space technology roadmaps, which are expected to occur every 4 years.

Molybdenum-99 for Medical Imaging

by Medicine Engineering National Academies of Sciences

The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world’s supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.

New Worlds, New Horizons: A Midterm Assessment

by Medicine Engineering National Academies of Sciences

New Worlds, New Horizons in Astronomy and Astrophysics (NWNH), the report of the 2010 decadal survey of astronomy and astrophysics, put forward a vision for a decade of transformative exploration at the frontiers of astrophysics. This vision included mapping the first stars and galaxies as they emerge from the collapse of dark matter and cold clumps of hydrogen, finding new worlds in a startlingly diverse population of extrasolar planets, and exploiting the vastness and extreme conditions of the universe to reveal new information about the fundamental laws of nature. NWNH outlined a compelling program for understanding the cosmic order and for opening new fields of inquiry through the discovery areas of gravitational waves, time-domain astronomy, and habitable planets. Many of these discoveries are likely to be enabled by cyber-discovery and the power of mathematics, physics, and imagination. To help realize this vision, NWNH recommended a suite of innovative and powerful facilities, along with balanced, strong support for the scientific community engaged in theory, data analysis, technology development, and measurements with existing and new instrumentation. Already in the first half of the decade, scientists and teams of scientists working with these cutting-edge instruments and with new capabilities in data collection and analysis have made spectacular discoveries that advance the NWNH vision. New Worlds, New Horizons: A Midterm Assessment reviews the responses of NASA’s Astrophysics program, NSF’s Astronomy program, and DOE’s Cosmic Frontiers program to NWNH. This report describes the most significant scientific discoveries, technical advances, and relevant programmatic changes in astronomy and astrophysics over the years since the publication of the decadal survey, and assesses how well the Agencies’ programs address the strategies, goals, and priorities outlined in the 2010 decadal survey.

The Changing Landscape of Hydrocarbon Feedstocks for Chemical Production: Implications for Catalysis: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

A decade ago, the U.S. chemical industry was in decline. Of the more than 40 chemical manufacturing plants being built worldwide in the mid-2000s with more than 1$ billion in capitalization, none were under construction in the United States. Today, as a result of abundant domestic supplies of affordable natural gas and natural gas liquids resulting from the dramatic rise in shale gas production, the U.S. chemical industry has gone from the world’s highest-cost producer in 2005 to among the lowest-cost producers today. The low cost and increased supply of natural gas and natural gas liquids provides an opportunity to discover and develop new catalysts and processes to enable the direct conversion of natural gas and natural gas liquids into value-added chemicals with a lower carbon footprint. The economic implications of developing advanced technologies to utilize and process natural gas and natural gas liquids for chemical production could be significant, as commodity, intermediate, and fine chemicals represent a higher-economic-value use of shale gas compared with its use as a fuel. To better understand the opportunities for catalysis research in an era of shifting feedstocks for chemical production and to identify the gaps in the current research portfolio, the National Academies of Sciences, Engineering, and Medicine conducted an interactive, multidisciplinary workshop in March 2016. The goal of this workshop was to identify advances in catalysis that can enable the United States to fully realize the potential of the shale gas revolution for the U.S. chemical industry and, as a result, to help target the efforts of U.S. researchers and funding agencies on those areas of science and technology development that are most critical to achieving these advances. This publication summarizes the presentations and discussions from the workshop.

Pathways to Urban Sustainability: Challenges and Opportunities for the United States

by Medicine Engineering National Academies of Sciences

Cities have experienced an unprecedented rate of growth in the last decade. More than half the world’s population lives in urban areas, with the U.S. percentage at 80 percent. Cities have captured more than 80 percent of the globe’s economic activity and offered social mobility and economic prosperity to millions by clustering creative, innovative, and educated individuals and organizations. Clustering populations, however, can compound both positive and negative conditions, with many modern urban areas experiencing growing inequality, debility, and environmental degradation. The spread and continued growth of urban areas presents a number of concerns for a sustainable future, particularly if cities cannot adequately address the rise of poverty, hunger, resource consumption, and biodiversity loss in their borders. Intended as a comparative illustration of the types of urban sustainability pathways and subsequent lessons learned existing in urban areas, this study examines specific examples that cut across geographies and scales and that feature a range of urban sustainability challenges and opportunities for collaborative learning across metropolitan regions. It focuses on nine cities across the United States and Canada (Los Angeles, CA, New York City, NY, Philadelphia, PA, Pittsburgh, PA, Grand Rapids, MI, Flint, MI, Cedar Rapids, IA, Chattanooga, TN, and Vancouver, Canada), chosen to represent a variety of metropolitan regions, with consideration given to city size, proximity to coastal and other waterways, susceptibility to hazards, primary industry, and several other factors.

A National Trauma Care System: Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths After Injury

by Medicine Engineering National Academies of Sciences

Advances in trauma care have accelerated over the past decade, spurred by the significant burden of injury from the wars in Afghanistan and Iraq. Between 2005 and 2013, the case fatality rate for United States service members injured in Afghanistan decreased by nearly 50 percent, despite an increase in the severity of injury among U.S. troops during the same period of time. But as the war in Afghanistan ends, knowledge and advances in trauma care developed by the Department of Defense (DoD) over the past decade from experiences in Afghanistan and Iraq may be lost. This would have implications for the quality of trauma care both within the DoD and in the civilian setting, where adoption of military advances in trauma care has become increasingly common and necessary to improve the response to multiple civilian casualty events. Intentional steps to codify and harvest the lessons learned within the military’s trauma system are needed to ensure a ready military medical force for future combat and to prevent death from survivable injuries in both military and civilian systems. This will require partnership across military and civilian sectors and a sustained commitment from trauma system leaders at all levels to assure that the necessary knowledge and tools are not lost. A National Trauma Care System defines the components of a learning health system necessary to enable continued improvement in trauma care in both the civilian and the military sectors. This report provides recommendations to ensure that lessons learned over the past decade from the military’s experiences in Afghanistan and Iraq are sustained and built upon for future combat operations and translated into the U.S. civilian system.

Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment: Proceedings of a Workshop

by Medicine Engineering National Academies of Sciences

Immunotherapy is a form of cancer therapy that harnesses the body’s immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.

An Assessment of the National Institute of Standards and Technology Physical Measurement Laboratory: Fiscal Year 2015

by Medicine Engineering National Academies of Sciences

The Physical Measurement Laboratory (PML) at the National Institute of Standards and Technology (NIST) is dedicated to three fundamental and complementary tasks: (1) increase the accuracy of our knowledge of the physical parameters that are the foundation of our technology-driven society; (2) disseminate technologies by which these physical parameters can be accessed in a standardized way by the stakeholders; and (3) conduct research at both fundamental and applied levels to provide knowledge that may eventually lead to advances in measurement approaches and standards. This report assesses the scientific and technical work performed by the PML and identifies salient examples of accomplishments, challenges, and opportunities for improvement for each of its nine divisions.

Reducing the Use of Highly Enriched Uranium in Civilian Research Reactors

by Medicine Engineering National Academies of Sciences

The continued presence of highly enriched uranium (HEU) in civilian installations such as research reactors poses a threat to national and international security. Minimization, and ultimately elimination, of HEU in civilian research reactors worldwide has been a goal of U.S. policy and programs since 1978. Today, 74 civilian research reactors around the world, including 8 in the United States, use or are planning to use HEU fuel. Since the last National Academies of Sciences, Engineering, and Medicine report on this topic in 2009, 28 reactors have been either shut down or converted from HEU to low enriched uranium fuel. Despite this progress, the large number of remaining HEU-fueled reactors demonstrates that an HEU minimization program continues to be needed on a worldwide scale. Reducing the Use of Highly Enriched Uranium in Civilian Research Reactors assesses the status of and progress toward eliminating the worldwide use of HEU fuel in civilian research and test reactors.

Carve the Mark

by Veronica Roth

Fans of Star Wars and Divergent will revel in internationally bestselling author Veronica Roth’s stunning new science-fiction fantasy series.On a planet where violence and vengeance rule, in a galaxy where some are favored by fate, everyone develops a currentgift, a unique power meant to shape the future. While most benefit from their currentgifts, Akos and Cyra do not—their gifts make them vulnerable to others’ control. Can they reclaim their gifts, their fates, and their lives, and reset the balance of power in this world?Cyra is the sister of the brutal tyrant who rules the Shotet people. Cyra’s currentgift gives her pain and power—something her brother exploits, using her to torture his enemies. But Cyra is much more than just a blade in her brother’s hand: she is resilient, quick on her feet, and smarter than he knows.Akos is from the peace-loving nation of Thuvhe, and his loyalty to his family is limitless. Though protected by his unusual currentgift, once Akos and his brother are captured by enemy Shotet soldiers, Akos is desperate to get his brother out alive—no matter what the cost. When Akos is thrust into Cyra’s world, the enmity between their countries and families seems insurmountable. They must decide to help each other to survive—or to destroy one another.

GED Test For Dummies

by Murray Shukyn Jane R. Burstein

Score high on the GED Test In today's job environment, it's usually the better-educated person who gets the position, promotion, or raise. Scoring high on the GED Test can give you an edge over the competition—whether it's to get a brand-new job or advance in the one you already have. If you're preparing for the exam and want to increase your odds of scoring higher, GED Test For Dummies gets you up and running with everything you need to know for test day. Inside, you'll find valuable, easy-to-digest information for navigating your way through tests on Language Arts, Social Studies, Mathematical Reasoning, and Science. Whether you're looking to perfect your grammar and punctuation skills, put the social in your studies, take the fear out of math and science, get familiar with different types of fiction and nonfiction passages, or answer every multiple-choice question with confidence, GED Test For Dummies makes it not only possible, but easy for you to score high on this life-changing exam. Fully updated to reflect the latest version of the GED test Includes two full-length practice tests with answers and detailed explanations Provides vital information and test-taking tips to help maximize your score Includes special considerations for those whose first language isn't English Feel good about yourself knowing that you accomplished something amazing. Get GED Test For Dummies and put yourself on the road to greater success.

Handbook of Major Palm Pests: Biology and Management

by Victoria Soroker Stefano Colazza

Handbook of Major Palm Pests: Biology and Management contains the most comprehensive and up-to-date information on the red palm weevil and the palm borer moth, two newly emergent invasive palm pests which are adversely affecting palm trees around the world. It provides state-of-the-art scientific information on the ecology, biology, and management of palm pests from a global group of experts in the field.An essential compendium for anyone working with or studying palms, it is dedicated to the detection, eradication, and containment of these invasive species, which threaten the health and very existence of global palm crops.

The Architecture Student's Handbook of Professional Practice

by American Institute of Architects

Written by The American Institute of Architects, this is the definitive textbook on practice issues written specifically for architecture students. Specifically written for emerging architects, this is the first unabbreviated guide specifically for architecture students about to begin their careers. It is required reading in a professional practice course that architecture students must take within their final two years of school.

Ten Basic Responsibilities of Nonprofit Boards

by Richard T. Ingram

BoardSource's all-time bestseller, this book not only explores the board's 10 core responsibilities, it also puts them into the context of the governance challenges facing nonprofits today. The book clarifies and distinguishes the board's responsibilities from those of the chief executive and senior staff. In addition, it includes two appendixes, one covering the individual responsibilities of board members and the other providing a sample self-assessment for individual board members.

Back to School (Bone Chillers #3)

by Betsy Haynes

[from the back cover] "Fitzgerald Traflon III hates the food at Maple Grove Middle School--it's totally gross. The pizza tastes like cardboard, the spaghetti like glue, and the hot dogs like rubber. Fitz has even heard the hamburgers are made from horse meat! When Miss Buggy takes over the cafeteria, and things start to change. Fitz's friends love Miss Buggy's cooking, but Fitz still won't eat it. Soon his friends are acting really strange. They're even fighting for seconds. And the more they eat ... the weirder they get! So scary you'll lose your lunch!" This page turner for middle grade readers has 27 short chapters that will fly by. Fans of this book will love the author's other books in the Bookshare collection. The Bone Chillers series is so scary, your teeth will chatter! Look for #1 Beware the Shopping Mall, #2 Little Pet Shop of Horrors, #4 Frankenturkey, #5 Strange Brew #6 Teacher Creature, #7 Frankenturkey II, #8 Welcome to Alien Inn, #9 Attack of the Killer Ants, #10 Slime Time, #11 Toilet Terror, #12 Night of the Living Clay and #13 The Thing Under the Bed, with more to come. You'll also find over 20 more books by Betsy Haynes in Bookshare's library. There are individual books like The Great Mom Swap and many books from The Fabulous Five series.

Little Houses, Big Forests: Desire Is No Light Thing

by Siouxzi Mernagh

Little houses, big forests (desire is no light thing) is an anthology of essays, short fiction, novel extracts and film stills - the first containment in one place of the writing and visual work of Siouxzi Mernagh. The book is an invitation to get lost within varied landscapes of its pages: middle-of-nowhere Australia, the minds of Susan Sontag and W.G Sebald, and, most prominently, the proverbial forests of all of our childhoods. There are, however, a few thematic paths to trace through these landscapes. Coming-of-age desire, our uneasy sense of self when isolated in nature and female sexuality become the mile-markers. The invitation to get lost is an invitation to come out the other side with the sense that being lost is not necessarily a state to be avoided but one in which we can occasionally luxuriate in.

Buda's Wagon: A Brief History of the Car Bomb

by Mike Davis

On a September day in 1920, an angry Italian anarchist named Mario Budaexploded a horse-drawn wagon filled with dynamite and iron scrap nearNew York's Wall Street, killing 40 people. Since Buda's prototype thecar bomb has evolved into a "poor man's air force," a generic weapon ofmass destruction that now craters cities from Bombay to Oklahoma City.In this brilliant and disturbing history, Mike Davis traces itsworldwide use and development, in the process exposing the role ofstate intelligence agencies--particularly those of the United States,Israel, India, and Pakistan--in globalizing urban terrorist techniques.Davis argues that it is the incessant impact of car bombs, rather thanthe more apocalyptic threats of nuclear or bio-terrorism, that ischanging cities and urban lifestyles, as privileged centers of powerincreasingly surround themselves with "rings of steel" against a weaponthat nevertheless seems impossible to defeat.

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