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Tuberculosis and the Tubercle Bacillus (ASM Books #37)
by Jr. Et Al. Helen McShane William R. Jacobs Valerie MizrahiCan today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Tuberculosis and Nontuberculous Mycobacterial Infections: And Non Tuberculous Myobacterial Infections (ASM Books #36)
by David SchlossbergFor Tuberculosis and Nontuberculous Mycobacterial Infections, Dr. Schlossberg assembled an international team of experts to write about nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, four new chapters cover topics of critical importance: The role of therapeutic drug monitoring in mycobacterial infections The public health issues of refugees and migrants, and their exposure and transmission of tuberculosis resulting from humanitarian crises Diabetes mellitus as a significant risk factor for tuberculosis The increased risk of tuberculosis reactivation in people taking tumor necrosis factor alpha inhibitors and other biopharmaceuticals Other chapters provide detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis, including: The many presentations of tuberculosis, from pulmonary to ocular and cardiovascular to urogenital The complications that tuberculosis and antituberculosis therapy cause to the hematologic and endocrine systems Tuberculosis during pregnancy and in infants and children Treatment of multidrug-resistant tuberculosis and extensively drugresistant tuberculosis Development of new vaccines Nontuberculous infections caused by mycobacteria found throughout our environment The seventh edition of Tuberculosis and Nontuberculous Mycobacterial Infections is an essential resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists to scientists, policymakers, and epidemiologists.
Tuberculosis and Irish Fiction, 1800–2022: A Lingering Condition (New Directions in Irish and Irish American Literature)
by Rachael Sealy LynchThis book focuses on Ireland’s lived experience of tuberculosis as represented in the nation’s fiction; not surprisingly, the disease both manifests and conceals itself with devastating frequency in literature as it did in life. It seeks to place the history of tuberculosis in Ireland, from 1800 until after its virtual eradication in the mid-Twentieth Century, in conversation with fictional representations or repressions of a condition so fearsome that until very recently it was usually referred to by code words and euphemisms rather than by its name.
Tuberculosis and Disabled Identity in Nineteenth Century Literature: Invalid Lives (Literary Disability Studies)
by Alex TankardUntil the nineteenth century, consumptives were depicted as sensitive, angelic beings whose purpose was to die beautifully and set an example of pious suffering – while, in reality, many people with tuberculosis faced unemployment, destitution, and an unlovely death in the workhouse. Focusing on the period 1821-1912, in which modern ideas about disease, disability, and eugenics emerged to challenge Romanticism and sentimentality, Invalid Lives examines representations of nineteenth-century consumptives as disabled people. Letters, self-help books, eugenic propaganda, and press interviews with consumptive artists suggest that people with tuberculosis were disabled as much by oppressive social structures and cultural stereotypes as by the illness itself. Invalid Lives asks whether disruptive consumptive characters in Wuthering Heights, Jude the Obscure, The Idiot, and Beatrice Harraden’s 1893 New Woman novel Ships That Pass in the Night represented critical, politicised models of disabled identity (and disabled masculinity) decades before the modern disability movement.
Tuberculosis
by Mark L. LewisFor many years, patients with tuberculosis had to live in sanitoriums to stop the spread of infection. Treatments included removing ribs and lungs. Read this book to learn more about the history of the infectious disease known as the white death.
Tuberculosis: Laboratory Diagnosis and Treatment Strategies (Advances in Molecular and Cellular Microbiology)
by Andrew Ramsay Clare Ling Leonor Amaral Leonid Heifits Ajit Lalvani Marc Lipman Pablo Bifani Ruth McNerney Dick Van Soolingen Mike Barer Isobel Honeyborne Simon Waddell Gerry Davies Paul Van Helden Stephen Gillespie Helen McShane Michael Hoelscher M Boeree Geoff CoxonTuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.
Tuberculosis: The Essentials, Fourth Edition (Lung Biology in Health and Disease)
by Mario C. RaviglioneEvery second a new person is exposed to tuberculosis (TB). Each untreated TB-infected person will infect 10-15 people every year. Following the success of its predecessor, this new edition of Tuberculosis: The Essentials scrutinizes the new discoveries and observations of the key aspects of the disease. Recognized world experts provide a concise, state-of-the-art review of the 15 essential elements of TBsupply an international, current view of the epidemiology, pathophysiology, diagnosis, and treatment methodsdiscuss the emerging threat of XDR-TB and the HIV/AIDS factorassess advances in TB research such as new drugs and vaccinesreflect on the progress of the "Stop TB" strategy.
Tuberculosis: Integrated Studies for a Complex Disease (Integrated Science #11)
by Nima RezaeiTuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
Tuberculosis: The Microbe Host Interface
by Larry S. Schlesinger Lucy E. DesJardinM. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies.
Tuberculosis
by Dick Van Soolingen Leonid Heifits Michael Hoelscher Ajit Lalvani Simon Waddell Timothy Mchugh Mike Barer Leonor Amaral Helen Mcshane Isobel Honeyborne Pablo Bifani M Boeree Gerry Davies Andrew Ramsay Paul Van Helden Clare Ling Ruth Mcnerney Stephen Gillespie Geoff Coxon Marc LipmanTuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.
Tubercular Drug Delivery Systems: Advances in Treatment of Infectious Diseases
by Yashwant Pathak Ranjita ShegokarThe book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies and drug delivery platforms in the understanding of host-pathogens relationship for providing better therapy. A wide variety of novel and nano-formulations using promising technologies are being explored to deliver the drug via different administration routes. This book It addresses the gap between new approaches and old treatment modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and current research advances in the field of tuberculosis research..
Tubercular Capital: Illness and the Conditions of Modern Jewish Writing (Stanford Studies in Jewish History and Culture)
by Sunny S. YudkoffAt the turn of the twentieth century, tuberculosis was a leading cause of death across America, Europe, and the Russian Empire. The incurable disease gave rise to a culture of convalescence, creating new opportunities for travel and literary reflection. Tubercular Capital tells the story of Yiddish and Hebrew writers whose lives and work were transformed by a tubercular diagnosis. Moving from eastern Europe to the Italian Peninsula, and from Mandate Palestine to the Rocky Mountains, Sunny S. Yudkoff follows writers including Sholem Aleichem, Raḥel Bluvshtein, David Vogel, and others as they sought "the cure" and drew on their experiences of illness to hone their literary craft. Combining archival research with literary analysis, Yudkoff uncovers how tuberculosis came to function as an agent of modern Jewish literature. The illness would provide the means for these suffering writers to grow their reputations and find financial backing. It served a central role in the public fashioning of their literary personas and ushered Jewish writers into a variety of intersecting English, German, and Russian literary traditions. Tracing the paths of these writers, Tubercular Capital reconsiders the foundational relationship between disease, biography, and literature.
Tube Ritual: Jumpstart Your Journey to 5000 YouTube Subscribers
by Brian G. JohnsonEverybody begins their YouTube journey from zero.You have to start with no videos, views, or subscribers. Furthermore, more than 400 minutes of content is uploaded to YouTube each minute. To say that it&’s challenging to grow a channel is an understatement! In fact, less than 3% of YouTube channels ever gain more than 10,000 subscribers. Yet, in a one-year period, Brian G Johnson gained 10,623 subscribers and drove over half a million video views. Truly beginning from zero. Brian had no previous YouTube success to draw from and had to learn the myriad of camera settings, editing options, and technical details that often become a roadblock. Furthermore, he did it in a small and competitive niche, the YouTube video marketing niche.How, you ask?By researching, testing, and tweaking various video growth methods over a one-year period in order to identify why the YouTube algorithm promotes one video over another. Ultimately, this led to the creation of a video ritual based on his findings—a series of actions according to a prescribed order. More than a mere guide, Tube Ritual is a one-year case study with the goal being to drive more views and convert more viewers into subscribers. For those already creating videos or who want to in the future, Tube Ritual contains detailed, step-by-step information that plain works. From Branding to thumbnails, video structure, YouTube SEO, video calls to action, playlist strategies, channel strategies and more, Tube Ritual leaves no stone unturned.
Tube Life: London’s Underground in Photographs
by MirrorpixThe London Underground has always been key to the lives of Londoners, from when its stations and stairwells offered refuge from the barrage of the Blitz through to its unique ability across the years to transport people safely all around the capital. It has remained strong in the face of devastation, surviving horrors like the Moorgate Tube crash and the 7/7 bombings. An icon throughout the world, the Tube is as resilient as any Londoner, and is the thread that holds the capital together. These stunning photographs from the Mirrorpix archives present its changing face over time.
The Tube
by Oliver GreenFrom Norman Foster's remarkable station at Canary Wharf to the Yellow-brick vaults of Baker street to the Art Deco exuberance of Arnos Grove, London's tube stations are among its most distinctive and iconic buildings. This beautiful hardback edition is a fantastic gift-book, publishing in the run up to Christmas, and sales will be boosted even further by the much-loved network's 150th anniversary in 2013.
Tuareg (Tuareg #Volumen 1)
by Alberto Vázquez-FigueroaUna apasionante epopeya que es a la vez un canto a uno de los pueblos más singulares del mundo. Los tuareg constituyen un pueblo altivo cuyo código moral difiere del de los árabes. Auténticos hijos del desierto, los tuareg no tienen rival en cuanto a sobrevivir en las condiciones más adversas. El noble inmouchar Gacel Sayah, protagonista de esta novela, es amo absoluto de una infinita extensión de desierto. Cierto día llegan al campamento dos fugitivos procedentes del norte, y el inmouchar, fiel a las multiseculares y sagradas leyes de la hospitalidad, los acoge. Sin embargo, Gacel ignora que esas mismas leyes le arrastrarán a una aventura mortal...
Tuareg
by Alberto Vázquez-FigueroaLos tuareg constituyen un pueblo altivo cuyo código moral difiere del de los árabes. Auténticos hijos del desierto, los tuareg no tienen rival en cuanto a sobrevivir en las condiciones más adversas. El noble inmouchar Gacel Sayah, protagonista de esta novela, es amo absoluto de una infinita extensión de desierto. Cierto día llegan al campamento dos fugitivos procedentes del norte, y el inmouchar, fiel a las multiseculares y sagradas leyes de la hospitalidad, los acoge. Sin embargo, Gacel ignora que esas mismas leyes le arrastrarán a una aventura mortal... Una apasionante epopeya que es a la vez un canto a uno de los pueblos más singulares del mundo.
A tua segunda vida começa quando percebes que não terás outra
by Raphäelle GiordanoUm romance enternecedor e autêntico sobre a capacidade de nos reinventarmos. Mais de 500 000 exemplares vendidos. Camille, trinta e oito anos e um quarto, tem tudo e parece estar feliz. Então, porque sente a felicidade escorregar-lhe por entre os dedos? Tudo o que quer é encontrar o caminho para a felicidade e a realização. Quando Claude, rotinólogo, lhe oferece um acompanhamento original para a ajudar, ela não hesita. Através de experiências surpreendentes e incríveis, Camille vai, passo a passo, transformando a sua vida e começa a conquistar os seus sonhos. - Parece-me que sofre, provavelmente, de uma forma de rotinite aguda. - Uma quê? - Rotinite aguda. É uma condição da alma que está a afectar cada vez mais pessoas no mundo, especialmente no Ocidente. Os sintomas são quase sempre os mesmos: falta de motivação, lentidão crónica, perda de direcção e sentido, dificuldade em ser feliz, apesar de uma riqueza de bens materiais, desencanto, fadiga... - Mas... Como é que sabe tudo isso? - Sou rotinólogo. - Roti... quê?
Tua and the Elephant
by R.P. HarrisTen-year-old Tua—Thai for "peanut"—has everything she needs at home in Chiang Mai, Thailand, except for one thing she's always wanted: a sister. In the market one day, Tua makes an accidental acquaintance—one with wise, loving eyes, remarkable strength, and a very curious trunk. And when Tua meets Pohn-Pohn, it's clear this elephant needs her help. Together, the unusual team sets off on a remarkable journey to escape from Pohn-Pohn's vile captors. From the bustling night market to the hallowed halls of a Buddhist temple and finally, to the sanctuary of an elephant refuge, this clever girl and her beloved companion find that right under their noses is exactly what each has been searching for: a friend.
Tú, yo y el karma
by Lola Llatas«Amaya se ha esforzado muchísimo en conseguir tener una vida perfecta. Menos mal que, durante un viaje a India, la magia y la causalidad se encargará de volvérsela del revés.» Amaya ha cumplido los treinta y se siente más que satisfecha con su vida. Vive en un ático muy chic en el centro de Madrid, su carrera como publicista está en lo más alto y con Nicolás, su novio y jefe inmediato, se entiende a la perfección. Los dos comparten la misma pasión por el trabajo, y los dos huyen de todo aquello que implique compromiso. Bueno, para ser exactos, más él que ella. Un día descubren que su cliente más importante está pensando en contratar a la competencia. Si pierden la cuenta, perderán los bonos a final de año y puede que hasta el empleo. ¡Tienen que impedirlo como sea! Aunque eso implique viajar al sur de India para hacerle cambiar de opinión personalmente. Pero, ¿qué sucede si al aterrizar en Kerala resulta que la competencia ha tenido la misma idea que ellos? Mateo Serrano, un lince en el sector, no está dispuesto a dejar pasar la oportunidad. ¡Es la guerra! Ambos equipos no dudarán en usar los trucos más sucios y rastreros para hacerse con la victoria, sin saber que el karma les depara una inesperada sorpresa: un extraño incidente hará que Amaya y Mateo se pierdan en la selva y, en su odisea para volver a reunirse con el resto, descubran una India como nunca pensaron que pudiera existir, y algo más...
Tú, yo... y él (Viaje hacia el amor #1)
by Annie LavigneDe París hasta Venecia, de Viena hasta Nueva York, Morgana descubre el amor, la sexualidad, los escalofríos... Antes de que se vaya para Italia, Morgana se enamora de su mejor amigo Julián. Los dos amantes juran que se esperaran uno al otro. ¿Pero Morgana podrá resistir a Alejandro, el chico más guapo de la secundaria que trata de seducirla? Siente que se ahoga en su vida cotidiana de estudiante, en cuanto terminen las clases, Morgana se ira con su mochila, para un viaje sin itinerario, que empezara en Italia donde se encontrará con Julián. Y eso, solo será el principio del largo viaje de Morgana... Este "viaje hacia el amor" es un viaje en búsqueda de identidad tanto como geográfico, que nos lleva por las profundidades del corazón humano que solo quiere una cosa: ser amado. Una serie Young Adult que entra en la intimidad de la joven mujer de 18 años para hacernos compartir de sus cuestionamientos, sus sueños y sus esperanzas. Una novela que trata de los temas de amistad, de pasión y del amor, mientras Morgana debe disecar sus sentimientos para saber lo que realmente siente para los dos chicos: Julián y Alejandro. ¿Amistad, pasión efímera o un gran amor? Una novela que les llenara el corazón por su sinceridad, su originalidad y su toque de poesía.
Tú, yo, todo
by Catherine IsaacUna conmovedora novela sobre lo lejos que podemos llegar para defender aquello que amamos. Cansada de que su novio Adam no dejara de mentirle, engañarle y de que no mostrara ningún tipo de interés en ser padre, Jess le echó de casa apenas unos meses después de haber dado a luz a su hijo William. Su madre le ayuda a cuidarlo, mientras Adam se traslada a Francia persiguiendo sus sueños y liberándose de cualquier compromiso con el niño que nunca quiso.Diez años después, la madre de Jess se encuentra ingresada en una residencia, luchando contra una enfermedad que la está matando a sus cincuenta y tres años. Allí es donde esta obliga a su hija a reconocer algo que nunca ha querido admitir: William necesita un padre en su vida. Así, en su primer viaje al extranjero en años, Jess y William, ahora con diez años, se disponen a pasar el verano en Château de Roussignol, en las ricas y soleadas colinas de la Dordoña. Allí se reencontrarán con Adam, y Jess deberá conseguir que este acepte y empiece a querer a su propio hijo. Sin embargo, lo peor no es que Adam esté lejos de implicarse en este juego, sino que Jess vive atormentada por un secreto terrible que nadie, y especialmente William, deberá descubrir. Reseñas:«Todo lo que necesitas de una lectura conmovedora, divertida y tierna. Una historia para celebrar el poder del amor y para sobreponerse a cualquier miedo.»Susan Wiggs «Qué lectura tan bella; te desgarrará el corazón.»Rea's Book Reviews «Estoy hecha pedazos; qué novela más maravillosa. Este será el libro del que todo el mundo hablará este año.»Penny Parkes«Emotiva y llena de fuerza, y además una lectura muy placentera. Una historia de amor en toda la extensión de la palabra.»Claire Frost «Espectacular, maravillosa. Si tegustó Yo antes de tí, Tú, yo, todo te encantará. Una conmovedora historia que te romperá el corazón.»Clare Mackintosh «Todo lo que necesitas de una lectura conmovedora, divertida y tierna. Situada en uno de los sitios con más magia del mundo entero. Una historia para celebrar el poder del amor y para sobreponerse a cualquier miedo.»Susan Wiggs «Es una bonita y emotiva novela que habla y pone en alza los valores de los lazos familiares y la amistad. Es una novela dura y a la vez esperanzadora.»Adivina quién lee «Bonito, sencillo y desgarrador.»En el mundo de la fantasía «La positividad que transmite es contagiosa, pero, sin duda, el gran acierto es su elenco. Todos los personajes tienen carisma.»Revista Krítica«Es una historia aparentemente sencilla que nos demuestra, de forma tierna y a veces divertida, lo maravillosa y desgarradora que puede ser la vida.»Mil libros en mi biblioteca «Una auténtica montaña rusa de emociones. Una vez empecéis a leer el libro no vais a tener ganas de soltarlo hasta que lleguéis al final. Porque la historia atrapa.»The somewhere library«Tú, yo, todo es una novela tierna, conmovedora y que nos erizará la piel. Una novela llena de esperanza que nos enseñará que, a pesar de las adversidades, todo saldrá bien.»Pequeño águila
Tú & yo, aquí, ahora
by Carolyn Mackler Jay AsherTú y yo, aquí, ahora es una historia sobre las barreras invisibles entre la amistad y el amor, y la importancia de vivir aquí y ahora. A veces es necesario perderse para volver a encontrar el camino... Emma y Josh han sido vecinos y amigos íntimos desde siempre, pero últimamente su relación no pasa por un buen momento. Todo porque un día Josh malinterpretó a Emma e intentó besarla... Desde entonces, ambos mantienen las distancias y ya no se ven fuera del instituto. Pero a raíz de una página web extraña que aparecerá en el ordenador de Emma con información acerca de su futuro, su camino y el de Josh volverán a unirse de forma inesperada...
Tú y yo somos seis
by Antoni BolinchesTú y yo somos seis nos propone un viaje hacia la madurez y la realización personal, a fin de convertirnos en la mejor versión de nosotros mismos.El periplo se articula a partir de cien reflexiones que introducirán al lector progresivamente en el conocimiento de las cuatro facultades que posibilitan el mejoramiento humano: la actitud positiva, la inteligencia, la bondad y la voluntad. Estas son las cualidades que la Terapia Vital enseña a potenciar para que cada persona logre convertirse en quien quiere ser y sepa orientarse hacia donde quiere ir.Se trata por tanto de un libro de gran utilidad práctica que hace fácilmente entendibles los mecanismos psicológicos que determinan el comportamiento, enseña la manera de convertir las vivencias en experiencias y las experiencias en madurez personal.Quien desee profundizar en su autoconocimiento encontrará en este libro un método fácil de aprender y de aplicar, que no sólo aumentará su bienestar emocional, sino que mejorará de forma espectacular su capacidad de relación interpersonal.«Cuando comprendas que Tú y yo somos seis podremos entendernos mejor los dos.»Antoni Bolinches
Tú y yo nunca fuimos nosotros
by Selam WearingSelam Wearing se revela con su primer poemario como uno de los grandes talentos literarios de su generación. Su poética está llena de ternura, sensualidad, humor, imágenes muy certeras y comunicativas que rozan la anécdota y que hacen evidente la influencia de la poesía de la experiencia, el realismo sucio o el neorrealismo en su imaginario. Esto no es otro libro de poemas, soy yo pidiendo auxilio, pero nadie me socorre. He asumido que nunca nos olvidaremos. Cada vez que nos cruzamos sus ojos se revelan ante mí, nostálgicos de todo aquello que no hemos sido, preguntándose acaso si aún no es demasiado tarde. Pero ninguno hace nada. Ella se muerde el labio y mira a cualquier otra parte con los pensamientos clavados en mí. Yo acelero el paso, como si llegara tarde a donde nadie me está esperando. Prologado por Roger Wolfe.