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Patenting of Pharmaceuticals and Development in Sub-Saharan Africa
by Poku AduseiThis book critically investigates the patent protection of medication in light of the threats posed by HIV/AIDS, malaria and tuberculosis epidemics to the citizens of countries in Sub-Saharan Africa (hereinafter "SSA" or "Africa"). The book outlines the systemic problems associated with the prevailing globalized patent regime and the regime's inability to promote access to life-saving medication at affordable prices in SSA. It argues that for pharmaceutical patents to retain their relevance in SSA countries, human development concepts must be integrated into global patent law- and policy-making. An integrative approach implies developing additional public health and human development exceptions/limitations to the exercise of patent rights with the goal of scaling up access to medication that can treat epidemics in SSA. By drawing on multiple perspectives of laws, institutions, practices, and politics, the book suggests that SSA countries adopt an evidence-based approach to implementing global patent standards in domestic jurisdictions. This evidence-based approach would include mechanisms like local need assessments and the use of empirical data to shape domestic patent law-making endeavors. The approach also implies revising patent rules and policies with a pro-poor and pro-health emphasis, so that medication will be more affordable and accessible to the citizens of SSA countries. It also suggests considering the opinions of individuals and pro-access institutions in enacting crucial pieces of health-related statutes in SSA countries. The approach in this book is sensitive to the public health needs of the citizens affected by epidemics and to the imperative of building local manufacturing facilities for pharmaceutical research and development in SSA.
Cybernetic Approach to Project Management
by Bogdan LentThis book attempts to reflect the project reality as closely as possible, covering the ISO 21500:2012 standard that has just been introduced and the benefits from the best contributions worldwide and also providing the concise yet powerful tool box. It shall be easy to use and intuitively supportive of project managers. So far, evidence indicates that these targets are successfully met. One of its key recognitions, and in consequence a distinctive feature of this book, is the impact that the project manager's personality has on the fate of the project. The project manager's successful self-management in work & life and in leadership processes should be considered as important in any endeavor as all other project management processes, covered by the new standards and guidelines.
Humanity’s Children
by Sonja C. GroverThis book addresses the phenomenon of children as the particular targets of extreme cruelty and genocide during armed conflict. Selected International Criminal Court cases are analyzed to illustrate the ICC's failure to address the genocidal forcible transfer of children to armed State and/or non-State groups or forces perpetrating mass atrocities and/or genocide. An original legal interpretation of children as a protected group in the context of the genocide provision of the Rome Statute is provided. The work also examines certain examples of the various modes in which armed State and/or non-State groups or forces perpetrating mass atrocities and/or genocide appropriate children and accomplish the genocidal forcible transfer of children to the perpetrator group. It is argued that the failure to prosecute the genocidal forcible transfer of children through the ICC mechanisms (where the Court has jurisdiction and the State has failed to meet its obligations in this regard) undermines the perceived gravity of this heinous international crime within the international community. Furthermore, this ICC failure to prosecute conflicts with the interests of justice and ultimately results in an erosion of the respect for the personhood and human dignity of children.
Dispersion Forces I
by Stefan Yoshi BuhmannDispersion forces acting on both atoms and bodies play a key role in modern nanotechnology. As demonstrated in this book, macroscopic quantum electrodynamics provides a powerful method for understanding and quantifying dispersion forces in a vast range of realistic scenarios. The basic physical concepts and theoretical steps allow for the derivation of outlined general expressions for dispersion forces. As illustrated by a number of examples, these expressions can easily be used to study forces between objects of various shapes and materials, including effects like material absorption, nontrivial magnetic properties and dynamical forces asssociated with excited systems.
Johan Galtung
by Dietrich Fischer Johan GaltungThis is the first ever anthology of key articles by Johan Galtung, widely regarded as the founder of the academic discipline of peace studies. It covers such concepts as direct, structural and cultural violence; theories of conflict, development, civilization and peace; peaceful conflict transformation; peace education; mediation; reconciliation; a life-sustaining economy; macro-history; deep culture and deep structure; and social science methodology. Galtung has contributed original research, concepts and theories to more than 20 social science disciplines, including sociology, international relations and future studies, and has also applied his new insights in practice. The book is a valuable resource for researchers and practitioners, and can serve as a supplemental textbook for graduate and upper undergraduate courses in peace studies and related fields.
Computational Methods for Physicists: Compendium for Students (Graduate Texts in Physics)
by Simon Sirca Martin HorvatThis book helps advanced undergraduate, graduate and postdoctoral students in their daily work by offering them a compendium of numerical methods. The choice of methods pays significant attention to error estimates, stability and convergence issues as well as to the ways to optimize program execution speeds. Many examples are given throughout the chapters, and each chapter is followed by at least a handful of more comprehensive problems which may be dealt with, for example, on a weekly basis in a one- or two-semester course. In these end-of-chapter problems the physics background is pronounced, and the main text preceding them is intended as an introduction or as a later reference. Less stress is given to the explanation of individual algorithms. It is tried to induce in the reader an own independent thinking and a certain amount of scepticism and scrutiny instead of blindly following readily available commercial tools.
Amorphous Nanophotonics (Nano-Optics and Nanophotonics)
by Carsten Rockstuhl Toralf ScharfThis book represents the first comprehensive overview over amorphous nano-optical and nano-photonic systems. Nanophotonics is a burgeoning branch of optics that enables many applications by steering the mould of light on length scales smaller than the wavelength with devoted nanostructures. Amorphous nanophotonics exploits self-organization mechanisms based on bottom-up approaches to fabricate nanooptical systems. The resulting structures presented in the book are characterized by a deterministic unit cell with tailored geometries; but their spatial arrangement is not controlled. Instead of periodic, the structures appear either amorphous or random. The aim of this book is to discuss all aspects related to observable effects in amorphous nanophotonic material and aspects related to their design, fabrication, characterization and integration into applications. The book has an interdisciplinary nature with contributions from scientists in physics, chemistry and materials sciences and sheds light on the topic from many directions.
Photoemission Spectroscopy on High Temperature Superconductor
by Wentao ZhangThis book mainly focuses on the study of the high-temperature superconductor Bi2Sr2CaCu2O8 by vacuum, ultra-violet, laser-based, angle-resolved photoemission spectroscopy (ARPES). A new form of electron coupling has been identified in Bi2212, which occurs in the superconducting state. For the first time, the Bogoliubov quasiparticle dispersion with a clear band back-bending has been observed with two peaks in the momentum distribution curve in the superconducting state at a low temperature. Readers will find useful information about the technique of angle-resolved photoemission and the study of high-temperature superconductors using this technique. Dr. Wentao Zhang received his PhD from the Institute of Physics at the Chinese Academy of Sciences.
Dispersion Forces II
by Stefan BuhmannIn this book, a modern unified theory of dispersion forces on atoms and bodies is presented which covers a broad range of different aspects and scenarios. Macroscopic quantum electrodynamics is applied within the context of dispersion forces. In contrast to the normal-mode quantum electrodynamics traditionally used to study dispersion forces, the new approach allows to consider realistic material properties including absorption and is flexible enough to be applied to a broad range of geometries. Thus general properties of dispersion forces like their non-additivity and the relation between microscopic and macroscopic dispersion forces are discussed. It is demonstrated how the general results can be used to obtain dispersion forces on atoms in the presence of bodies of various shapes and materials. In particular, nontrivial magnetic properties of the bodies, bodies of irregular shapes, the role of material absorption, and dynamical forces for excited atoms are discussed. This volume 2 deals especially with quantum electrodynamics, dispersion forces, Casimir forces, asymptotic power laws, quantum friction and universal scaling laws. The book gives both the specialist and those new to the field a thorough overview over recent results in the context of dispersion forces. It provides a toolbox for studying dispersion forces in various contexts.
Endocytosis in Plants
by Jozef ŠamajEndocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
Traffic Flow Dynamics: Data, Models and Simulation
by Martin Treiber Arne Kesting Christian ThiemannThis textbook provides a comprehensive and instructive coverage of vehicular traffic flow dynamics and modeling. It makes this fascinating interdisciplinary topic, which to date was only documented in parts by specialized monographs, accessible to a broad readership. Numerous figures and problems with solutions help the reader to quickly understand and practice the presented concepts. This book is targeted at students of physics and traffic engineering and, more generally, also at students and professionals in computer science, mathematics, and interdisciplinary topics. It also offers material for project work in programming and simulation at college and university level. The main part, after presenting different categories of traffic data, is devoted to a mathematical description of the dynamics of traffic flow, covering macroscopic models which describe traffic in terms of density, as well as microscopic many-particle models in which each particle corresponds to a vehicle and its driver. Focus chapters on traffic instabilities and model calibration/validation present these topics in a novel and systematic way. Finally, the theoretical framework is shown at work in selected applications such as traffic-state and travel-time estimation, intelligent transportation systems, traffic operations management, and a detailed physics-based model for fuel consumption and emissions.
Taxation of Hybrid Financial Instruments and the Remuneration Derived Therefrom in an International and Cross-border Context: Issues and Options for Reform
by Sven-Eric BärschDespite the enormous diversity and complexity of financial instruments, the current taxation of hybrid financial instruments and the remuneration derived therefrom are characterized by a neat division into dividend-generating equity and interest-generating debt as well as by a coexistence of source- and residence-based taxation. This book provides a comparative analysis of the classification of hybrid financial instruments in the national tax rules currently applied by Australia, Germany, Italy and the Netherlands as well as in the relevant tax treaties and EU Directives. Moreover, based on selected hybrid financial instruments, mismatches in these tax classifications, which lead to tax planning opportunities and risks and thus are in conflict with the single tax principle, are identified. To address these issues, the author provides reform options that are in line with the dichotomous debt-equity framework, as he/she suggests the coordination of either tax classifications or tax treatments.
Sustained Simulation Performance 2012
by Xin Wang Michael M. Resch Wolfgang Bez Erich Focht Hiroaki KobayashiThe book presents the state of the art in high performance computing and simulation on modern supercomputer architectures. It covers trends in hardware and software development in general and specifically the future of high performance systems and heterogeneous architectures. The application contributions cover computational fluid dynamics, material science, medical applications and climate research. Innovative fields like coupled multi-physics or multi-scale simulations are presented. All papers were chosen from presentations given at the 14th Teraflop Workshop held in December 2011 at HLRS, University of Stuttgart, Germany and the Workshop on Sustained Simulation Performance at Tohoku University in March 2012.
Unsupervised Classification
by Sanghamitra Bandyopadhyay Sriparna SahaClustering is an important unsupervised classification technique where data points are grouped such that points that are similar in some sense belong to the same cluster. Cluster analysis is a complex problem as a variety of similarity and dissimilarity measures exist in the literature. This is the first book focused on clustering with a particular emphasis on symmetry-based measures of similarity and metaheuristic approaches. The aim is to find a suitable grouping of the input data set so that some criteria are optimized, and using this the authors frame the clustering problem as an optimization one where the objectives to be optimized may represent different characteristics such as compactness, symmetrical compactness, separation between clusters, or connectivity within a cluster. They explain the techniques in detail and outline many detailed applications in data mining, remote sensing and brain imaging, gene expression data analysis, and face detection. The book will be useful to graduate students and researchers in computer science, electrical engineering, system science, and information technology, both as a text and as a reference book. It will also be useful to researchers and practitioners in industry working on pattern recognition, data mining, soft computing, metaheuristics, bioinformatics, remote sensing, and brain imaging.
Leadership through the Classics: Learning Management and Leadership from Ancient East and West Philosophy
by Gregory P Prastacos Klas Eric Soderquist Fuming WangThe unforeseeably complex socio-economic and environmental challenges of the 21st century must be tackled by placing faith in the power of mankind to integrate established wisdom and new knowledge, and in our ability to collaborate for a sustainable future. Departing from this, a global 2011 conference debating papers devoted to the impact of ancient philosophy, focusing on Confucius and Aristotle, in modern leadership and management was organized by Hanban, the Athens University of Economics & Business, and the University of International Economics & Business, Beijing, China. A rich sourcebook for a broad audience, this unique volume presents the wide array of conference contributions by international thought-leaders. Departing from a foundation of general concepts of ethics and leadership the book then delves into questions about how philosophy shape emerging economic and business systems, to end with direct lessons from ancient philosophy for contemporary business challenges.
Insuring the Air Transport Industry Against Aviation War and Terrorism Risks and Allied Perils
by Yaw Otu NyampongThis book explores the central problems underlying the insurance of aviation war and terrorism risks and associated perils. It critically analyses the reasons why conventional insurance markets are unwilling or unable to provide sustainable insurance coverage for aviation war and terrorism risks in the aftermath of catastrophic events such as the terrorist events of September 11, 2001. It also examines some of the prominent concepts proposed and/or implemented after 9/11 to determine whether and to what extent these concepts avoid identified pitfalls. Like many of life's essentials, the importance of insurance is most evident when it is not available. The sheer scale and magnitude of the insurance losses that followed 9/11 caused conventional insurance markets (which hitherto had been offering generous insurance coverage for aviation war and terrorism risks to air transport operators for little or no premium) to withdraw coverage forthwith. The ensuing absence or insufficiency of commercial insurance coverage for aviation war and terrorism risks has sparked a global search for viable and sustainable alternatives. Ten years have since elapsed, and despite numerous efforts, the fundamental problems remain unresolved. The book proceeds on the premise that the underlying issues are not entirely legal in nature; they have immense economic, psychological and policy implications that cannot be underestimated. A multidisciplinary approach is therefore used in examining the issues, drawing heavily upon analytical principles adapted from law and economics and behavioural law and economics. It is hoped that the resulting study will be beneficial not only to lawyers and those interested in aviation insurance but also to economists, air transport insurance program managers, capital market investors and governmental policymakers, both at the national and international levels.
The Greenhouse Gas Balance of Italy
by Riccardo Valentini Franco MigliettaThe book addresses in a comprehensive way the full greenhouse gases budget of the Italian landscape, focusing on land use and terrestrial ecosystems. In recent years there has been a growing interest in the role of terrestrial ecosystems with regard to the carbon cycle and only recently a regional approach has been considered for its specificity in terms of new methodologies for observations and models and its relevance for national policies on mitigation and adaptation to climate changes. In terms of methods this book describes the role of flux networks and data-driven models, airborne regional measurements of fluxes and specific sectoral approaches related to important components of the human and natural landscapes. There is also a growing need on the part of institutions, agencies and policy stakeholders for new data and analyses enabling them to improve their national inventories of greenhouse gases and their compliance with the UNFCCC process. In this respect the data presented is a basis for a full carbon accounting and available to relevant stakeholders for improvements and/or verification of national inventories. The wealth of research information is the result of a national project, CARBOITALY, which involved 15 Italian institutions and several researchers to provide new data and analyses in the framework of climate policies.
Recent Developments in Modeling and Applications in Statistics
by Maurizio Vichi Paulo Eduardo Oliveira Maria da Graça Temido Carla HenriquesStatistics has been a main tool in almost every field of activity and an essential part of applied scientific work, supporting conclusions and offering insights into new uses for established methodologies, thus making it a valuable resource in looking for faceless facts. Model construction describing populations or phenomena subject to randomness use a wide range of methods. Data collection provides the basis for modelling and assumption verification. Modelling must be conducted using suitable techniques that give researchers the means to search for hidden facts or behaviours. This may be addressed by fitting pre-defined shapes and distributions to the data or by allowing the data to reveal its intrinsic properties by using nonparametric methods. This volume contains a selection of contributions presented at the XVIII Annual Congress of the Portuguese Statistical Society.
Global Power Europe - Vol. 2
by Aukje Van Loon Jan-Frederik Kremer Astrid BoeningThis two-volume project provides a multi-sectoral perspective over the EU's external projections from traditional as well as critical theoretical and institutional perspectives, and is supported by numerous case studies covering the whole extent of the EU's external relations. The aim is to strive to present new approaches as well as detailed background studies in analyzing the EU as a global actor.<P><P> Volume 1: The first volume "Theoretical and Institutional Approaches to the EU's External Relations" addresses the EU's overall external post-Lisbon Treaty presence both globally and regionally (e.g. in its "neighborhood"), with a special emphasis on the EU's institutional framework. It also offers fresh and innovative theoretical approaches to understanding the EU's international position. - With a preface by Alvaro de Vasoncelos (former Director European Union Institute for Security Studies)<P> Volume 2: The second volume "Policies, Actions and Influence of the EU's External Relations", examines in both quantitative and qualitative contributions the EU's international efficacy from a political, economic and social perspective based on a plethora of its engagements.
Global Power Europe - Vol. 1
by Aukje Van Loon Jan-Frederik Kremer Astrid BoeningThis two-volume project provides a multi-sectoral perspective over the EU's external projections from traditional as well as critical theoretical and institutional perspectives, and is supported by numerous case studies covering the whole extent of the EU's external relations. The aim is to strive to present new approaches as well as detailed background studies in analyzing the EU as a global actor.<P><P> Volume 1: The first volume "Theoretical and Institutional Approaches to the EU's External Relations" addresses the EU's overall external post-Lisbon Treaty presence both globally and regionally (e.g. in its "neighborhood"), with a special emphasis on the EU's institutional framework. It also offers fresh and innovative theoretical approaches to understanding the EU's international position. - With a preface by Alvaro de Vasoncelos (former Director European Union Institute for Security Studies)<P> Volume 2: The second volume "Policies, Actions and Influence of the EU's External Relations", examines in both quantitative and qualitative contributions the EU's international efficacy from a political, economic and social perspective based on a plethora of its engagements.
Mathematics of Planet Earth
by Juan José Durán Eulogio Pardo-Igúzquiza Carolina Guardiola-Albert Javier Heredia Luis Moreno-Merino Jose Antonio Vargas-GuzmánIt is widely recognized that the degree of development of a science is given by the transition from a mainly descriptive stage to a more quantitative stage. In this transition, qualitative interpretations (conceptual models) are complemented with quantification (numerical models, both, deterministic and stochastic). This has been the main task of mathematical geoscientists during the last forty years - to establish new frontiers and new challenges in the study and understanding of the natural world. Mathematics of Planet Earth comprises the proceedings of the International Association for Mathematical Geosciences Conference (IAMG2013), held in Madrid from September 2-6, 2013. The Conference addresses researchers, professionals and students. The proceedings contain more than 150 original contributions and give a multidisciplinary vision of mathematical geosciences.
The Economics of Contemporary Art
by Alessia ZorloniThe book examines the contemporary art system with a broad and systematic approach, through the application of models of microeconomics and industrial organizations. By breaking down the traditional barriers between different academic disciplines such as art and economics, this book offers a unique opportunity to grasp the complexities of the contemporary art world and provides the tools to conduct a structural analysis of that market. The result is an in-depth analysis of the contemporary art market from an interdisciplinary perspective. While it is not a textbook in the strictest sense, the book offers a concise and effective overview of all actors in the art system, and provides supporting data and valuable information, both conceptual and practical. It is therefore a text that can be used by students wishing to better understand the complex dynamics that govern the contemporary art market, but also by cultural managers, collectors, potential art investors or simply art lovers who need a quick reference.
Subject-Oriented Business Process Management: Second International Conference, S-bpm One 2010, Karlsruhe, Germany, October 14, 2010 Selected Papers (Communications In Computer And Information Science #138)
by Werner Schmidt Albert Fleischmann Christian Stary Egon Börger Stefan ObermeierActivities performed in organizations are coordinated via communication between the people involved. The sentences used to communicate are naturally structured by subject, verb, and object. The subject describes the actor, the verb the action and the object what is affected by the action. Subject-oriented Business Process Management (S-BPM) as presented in this book is based on this simple structure which enables process-oriented thinking and process modeling. S-BPM puts the subject of a process at the center of attention and thus deals with business processes and their organizational environment from a new perspective, meeting organizational requirements in a much better way than traditional approaches. Subjects represent agents of an action in a process, which can be either technical or human (e.g. a thread in an IT system or a clerk). A process structures the actions of each subject and coordinates the required communication among the subjects. S-BPM provides a coherent procedural framework to model and analyze business processes: its focus is the cooperation of all stakeholders involved in the strategic, tactical, and operational issues, sharing their knowledge in a networked structure. The authors illustrate how each modeling activity through the whole development lifecycle can be supported through the use of appropriate software tools. The presentation style focuses on professionals in industry, and on students specializing in process management or organizational modeling. Each chapter begins with a summary of key findings and is full of examples, hints, and possible pitfalls. An interpreter model, a toolbox, and a glossary summarizing the main terms complete the book. The web site www.i2pm.net provides additional software tools and further material.
The Right to Be Punished
by Gabriel HallevyDoes an offender have the right to be punished? "The right to be punished" may sound like an oxymoron, but it is not necessarily so. With the emergence of modern criminal law, the offender gained the right to be punished by rational criminal law rather than being lynched by an angry mob. The present-day offender may have the right to be punished by doctrinal sentencing rather than being subjected to verdicts based on vague, unclear, and uncertain principles. In modern criminal law, the imposition of criminal liability follows accurate and strict rules, whereas there are no similar rules for the imposition of punishment. The process of sentencing is vague and obscure, as are the considerations used for the imposition of punishments. The objective of the present book is to propose a comprehensive, general, and legally sophisticated theory of modern doctrinal sentencing. The challenges of such a legal theory are plenty and complex. In addition to increasing clarity and certainty, modern doctrinal sentencing must deal with modern types of delinquency (e.g. organized crime, recidivism, corporate offenders, high-tech offenses, etc.) and modern principles of criminal law. Modern doctrinal sentencing must serve to ensure optimal sentencing.
Quantum Mechanics of Molecular Structures
by Kaoru YamanouchiAt a level accessible to advanced undergraduates, this textbook explains the fundamental role of quantum mechanics in determining the structure, dynamics, and other properties of molecules. Readers will come to understand the quantum-mechanical basis for harmonic oscillators, angular momenta and scattering processes. Exercises are provided to help readers deepen their grasp of the essential phenomena.