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Synthesis of Heterocycles via Multicomponent Reactions II
by Romano V. Orru Eelco RuijterGéraldine Masson, Luc Neuville Carine Bughin Aude Fayol Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar Eelco Ruijter Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal Jalpa C. Trivedi Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery
Advances in 3D Geo-Information Sciences (Lecture Notes in Geoinformation and Cartography)
by Claus Nagel Gerhard König Thomas H. KolbeDuring the last decade developments in 3D Geoinformation have made substantial progress. We are about to have a more complete spatial model and understanding of our planet in different scales. Hence, various communities and cities offer 3D landscape and city models as valuable source and instrument for sustainable management of rural and urban resources. Also municipal utilities, real estate companies etc. benefit from recent developments related to 3D applications. To meet the challenges due to the newest changes academics and practitioners met at the 5th International Workshop on 3D Geoinformation in order to present recent developments and to discuss future trends. This book comprises a selection of evaluated, high quality papers that were presented at this workshop in November 2010. The topics focus explicitly on the last achievements (methods, algorithms, models, systems) with respect to 3D geo-information requirements. The book is aimed at decision makers and experts as well at students interested in the 3D component of geographical information science including GI engineers, computer scientists, photogrammetrists, land surveyors, urban planners, and mapping specialists.
Materials with Complex Behaviour
by Lucas F. Silva Holm AltenbachThe increasing demand for materials with superb properties in all types of technical applications requires the development of advanced materials and respective tools to characterise and predict the material properties and behaviour. This monograph highlights the latest developments and trends in advanced materials and their properties, the modelling and simulation of non-classical materials and structures, and new technologies for joining materials.
The Chemokine System in Experimental and Clinical Hematology
by Oystein BruserudThe aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.
Biocatalysis Based on Heme Peroxidases: Peroxidases as Potential Industrial Biocatalysts
by Eduardo Torres Marcela AyalaThis monograph describes many applications of peroxidase-based biocatalysis in the biotechnology industry. The need for such a book emerges from the considerable amount of new data regarding the phylogeny, reaction mechanisms, thermodynamic characterization and structural features of fungal and plant heme peroxidases that has been generated in the past 10 years, since the last specialized book on peroxidases was published. The aim of this book is to present recent advances on such basic aspects as evolution, structure-function relation and catalytic mechanism as well as applied aspects, such as bioreactor and protein engineering, to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes.
Angewandte Psychologie für die Personalentwicklung. Konzepte und Methoden für Bildungsmanagement, betriebliche Aus- und Weiterbildung: Konzepte Und Methoden Für Bildungsmanagement, Betriebliche Aus- Und Weiterbildung
by Christoph NegriIn Zeiten rasanter Veränderungen in Organisationen und der Wirtschaft insgesamt sind auch Bildungsfachleute und Personalentwickler gefordert, ihre Kernaufgaben neu zu definieren. Dazu bietet die angewandte Psychologie einen Orientierungsrahmen. In dem Band vermitteln Praktiker die psychologischen Grundlagen für eine moderne, nachhaltige betriebliche Bildungsarbeit und Personalentwicklung. Dabei greifen sie auch aktuelle Themen wie E-Learning, erlebnisorientiertes Lernen, Bildungsmarketing, Performance Management oder Corporate Learning auf.
Extracellular Nucleic Acids
by Elena Y. Rykova Yo KikuchiExtracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In the last several years, extracellular nucleic acids have been shown to be involved in not only microbial evolution as genetic elements but also to have structural roles in bacterial communities, such as biofilms. Circulating DNA and RNA have been found in human blood and expected to be useful as non-invasive markers for the diagnosis of several diseases. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans. This book covers nearly all of the newly developing fields related to extracellular nucleic acids, including those of basic biology, ecology and the medical sciences, and provides readers with the latest knowledge on them.
Population Ageing - A Threat to the Welfare State?: The Case of Sweden
by Tommy BengtssonThis book is the first to take a comprehensive view of the challenges that population ageing present in the near future taking Sweden as the case. Can the increasing number of retirees per worker be stopped by immigration or increasing fertility or will we need to increase pension age instead? Cost for the social-care system is readily increasing; even more is the costs for health care. Can the galloping costs be funded by an increase in taxes or do we need to make reforms, similar to the ones already made in the pension system, which has been used as a model for many other countries. The fact that it is difficult to make health care dependent on personal contributions, as is the case of the pension system, funding of health care is a true test of solidarity across generations. The book ends with a discussion on whether the demographic challenge to the welfare system is also a threat to the welfare state as such.
Extracting Knowledge From Time Series: An Introduction to Nonlinear Empirical Modeling
by Boris P. Bezruchko Dmitry A. SmirnovThis book addresses the fundamental question of how to construct mathematical models for the evolution of dynamical systems from experimentally-obtained time series. It places emphasis on chaotic signals and nonlinear modeling and discusses different approaches to the forecast of future system evolution. In particular, it teaches readers how to construct difference and differential model equations depending on the amount of a priori information that is available on the system in addition to the experimental data sets. This book will benefit graduate students and researchers from all natural sciences who seek a self-contained and thorough introduction to this subject.
Innovation Policy and Governance in High-Tech Industries: The Complexity of Coordination
by Johannes Bauer Achim Lang Volker SchneiderThe book examines the conditions for successful high-technology policy from theoretical and empirical perspectives. It enhances the predominant national systems of innovation approach to innovation policy with concepts based on new developments in the governance of complex systems and processes. The conceptual framework of complex networks and systems is used to examine national policy approaches in countries that have created environments conducive to high-technology industries as well as individual high-technology sectors, such as biotechnology, alternative energy, and aerospace. Theoretical and empirical contributions are synthesised into lessons for high-tech policy and further research.
Structures for Nuclear Facilities
by M.Y.H. BangashThis book provides a general introduction to the topic of buildings for resistance to the effects of abnormal loadings. The structural design requirements for nuclear facilities are very unique. In no other structural system are extreme loads such as tornadoes, missile and loud interaction, earthquake effects typical in excess of any recorded historical data at a site, and postulated system accident at very low probability range explicitly, considered in design. It covers the whole spectrum of extreme load which has to be considered in the structural design of nuclear facilities and reactor buildings, the safety criteria, the structural design, the analysis of containment. Test case studies are given in a comprehensive treatment. Each major section contains a full explanation which allows the book to be used by students and practicing engineers, particularly those facing formidable task of having to design complicated building structures with unusual boundary conditions.
Procedural Autonomy of EU Member States: Paradise Lost?
by Diana-Urania GalettaIs the procedural autonomy of EU Member State a myth or a reality? What should this concept be taken to mean? Starting from the analysis of requirements and principles regulating, generally speaking, the relationships between Member States' and EU law, this book provides a definition of procedural autonomy able to account for the concept's inherent limits. Out of an analysis of the more relevant EU jurisprudence, the author identifies the rationale underlying the interventions of the ECJ on issues of procedural autonomy and the common logic that emerges from it; and reveals how, in an unchanged context of 'procedural autonomy' of the Member States, national procedural law becomes more and more 'functionalized' to the requirements of effectiveness of substantive EU law. As such, we should speak of a 'functionalized procedural competence' rather than of procedural autonomy. But this is by no means a case of "Paradise Lost." The book includes a foreword by Prof. Jürgen Schwarze, one of the founding fathers of European Administrative Law.
Intentional Perspectives on Information Systems Engineering
by Selmin Nurcan Jolita Ralyté Carine Souveyet Camille SalinesiRequirements engineering has since long acknowledged the importance of the notion that system requirements are stakeholder goals--rather than system functions--and ought to be elicited, modeled and analyzed accordingly. In this book, Nurcan and her co-editors collected twenty contributions from leading researchers in requirements engineering with the intention to comprehensively present an overview of the different perspectives that exist today, in 2010, on the concept of intention in the information systems community. These original papers honor Colette Rolland for her contributions to this field, as she was probably the first to emphasize that 'intention' has to be considered as a first-class concept in information systems engineering. Written by long-term collaborators (and most often friends) of Colette Rolland, this volume covers topics like goal-oriented requirements engineering, model-driven development, method engineering, and enterprise modeling. As such, it is a tour d'horizon of Colette Rolland's lifework, and is presented to her on the occasion of her retirement at CaISE 2010 in Hammamet, the conference she once cofounded and which she helped to grow and prosper for more than 20 years.
A Concise Guide to Market Research: The Process, Data, and Methods Using IBM SPSS Statistics (Springer Texts in Business and Economics)
by Erik Mooi Marko SarstedtThis accessible, practice-oriented and compact text provides a hands-on introduction to the principles of market research. Using the market research process as a framework, the authors explain how to collect and describe the necessary data and present the most important and frequently used quantitative analysis techniques, such as ANOVA, regression analysis, factor analysis, and cluster analysis. An explanation is provided of the theoretical choices a market researcher has to make with regard to each technique, as well as how these are translated into actions in IBM SPSS Statistics. This includes a discussion of what the outputs mean and how they should be interpreted from a market research perspective. Each chapter concludes with a case study that illustrates the process based on real-world data. A comprehensive web appendix includes additional analysis techniques, datasets, video files and case studies. Several mobile tags in the text allow readers to quickly browse related web content using a mobile device.
Technologiemanagement
by Günther Schuh Sascha KlappertDer 2. Band der Buchreihe "Produktion und Management" konzentriert sich auf den Umgang mit Technologien. Die Autoren nehmen Technologiestrategien zum Ausgangspunkt und führen in die grundlegenden Zusammenhänge, Vorgehensweisen und Methoden des Technologiemanagements ein: von der Technologiefrüherkennung über die Technologieplanung, Technologieentwicklung und Technologieverwertung bis zur Technologiebewertung. Leser können sich einen Überblick zum Thema Technologiemanagement verschaffen und den Stoff anhand realer Fallbeispiele nachvollziehen.
Thermal Separation Technology
by Matthias Kind Alfons Mersmann Johann StichlmairThermal Separation Technology is a key discipline for many industries and lays the engineering foundations for the sustainable and economic production of high-quality materials. This book provides fundamental knowledge on this field and may be used both in university teaching and in industrial research and development. Furthermore, it is intended to support professional engineers in their daily efforts to improve plant efficiency and reliability. Previous German editions of this book have gained widespread recognition. This first English edition will now make its content available to the international community of students and professionals. In the first chapters of the book the fundamentals of thermodynamics, heat and mass transfer, and multiphase flow are addressed. Further chapters examine in depth the different unit operations distillation and absorption, extraction, evaporation and condensation, crystallization, adsorption and chromatography, and drying, while the closing chapter provides valuable guidelines for a conceptual process development.
Five Years of an Enlarged EU
by Filip Keereman Istvan SzekelyThis book analyzes the economic performance of the EU in the first five years after its largest expansion in 2004. Accession and integration were expected to foster growth and convergence among the new Member States through intensified trade, foreign direct investment, financial deepening and the adoption of the EU's institutional framework. With the benefit of five years experience, this book brings together experts from academia and think-tanks to assess the driving forces of economic growth and real convergence. The question whether the EU has made a difference in terms of growth is studied thoroughly from various angles, including that of country-specific and sector-specific analysis. It is shown that while the enlargement has been a success story overall, growth and catching-up cannot be taken for granted and the importance of economic policy remains undiminished.
Diffraction Radiation from Relativistic Particles
by Alexander Potylitsyn Alexey Alexandrovich Tishchenko Mikhail Nikolaevich Strikhanov Mikhail Ivanovich RyazanovThis book deals with diffraction radiation, which implies the boundary problems of electromagnetic radiation theory. Diffraction radiation is generated when a charged particle moves near a target edge at a distance ( - Lorentz factor, - wave length). Diffraction radiation of non-relativistic particles is widely used to design intense emitters in the cm wavelength range. Diffraction radiation from relativistic charged particles is important for noninvasive beam diagnostics and design of free electron lasers based on Smith-Purcell radiation which is diffraction radiation from periodic structures. Different analytical models of diffraction radiation and results of recent experimental studies are presented in this book. The book may also serve as guide to classical electrodynamics applications in beam physics and electrodynamics. It can be of great use for young researchers to develop skills and for experienced scientists to obtain new results.
Social Web im Tourismus
by Roman Egger Florian Bauhuber Jens Oellrich Daniel AmersdorfferZiel der Autoren ist es, Mechanismen und Prinzipien des Social Webs im Tourismus aufzuzeigen. Neben den theoretischen Grundlagen erläutern sie die praktischen Anwendungen und illustrieren das Thema anhand vieler Best-Practice-Beispiele. Leser erfahren, welche Bedeutung das Social Web und seine grundlegenden Mechanismen haben, so dass Internet-Aktivitäten besser geplant und an neue Entwicklungen angepasst werden können. Für Akteure in der Tourismusbranche, aber auch Wissenschaftler, die einen Einstieg in die touristische Praxis des Social Web suchen.
Corneal Surgery: Essential Techniques
by Bruno Zuberbuhler David Gartry David Spokes Stephen TuftThis book is an informative and comprehensive guide to the essential techniques currently employed in corneal surgery. It focuses in particular on two principal areas: the treatment of corneal disorders by means of different forms of corneal transplantation and the use of the Excimer laser to treat refractive disorders. In order to facilitate learning and later deployment of the techniques a multimedia approach is used. Surgical steps are described clearly within the book and can then be observed in detail on the accompanying high-quality DVD. A further feature is the inclusion of a chapter devoted to wet lab training, which presents practical preparatory exercises. This book will be of special value as a handy reference for ophthalmologists who are just embarking upon their surgical training. However, it will also be informative for trained eye surgeons, who will be able to compare their own practice with the presented procedures and to assimilate the latest techniques.
Dyke Swarms: Keys for Geodynamic Interpretation
by Rajesh SrivastavaDykes occur in a wide variety of geological and tectonic settings and their detailed study through space and time is imperative for understanding several geological events. Dykes are believed to be an integral part of continental rifting and when they occur as spatially extensive swarms of adequate size, they can be of immense utility in continental reconstructions and also help to identify Large Igneous Provinces (LIPs). It is known that continental flood basalts and major dyke swarms have their origin related in some way to the up-rise of hot mantle plumes which may lead to rifting and eventual continental break-up. Dykes signify crustal extension and are important indicators of crustal stabilisation events, supercontinental assembly and dispersal, crust-mantle interaction and play a significant role in the delineation of crustal provinces as well as in deciphering crustal evolution events. Many economic mineral deposits of the world are also associated with a variety of dykes. The volume will provide state-of-the-art information on all aspects of dykes with emphasis on the origin, evolution and emplacement of dykes.
Manual of Pediatric Nephrology
by Kishore D. Phadke Paul Goodyer Martin BitzanThis manual will meet the everyday needs of the wide range of medical professionals who play a role in the treatment of children referred to hospital because of renal disease. It is an easy-to-use, portable guide that will assist pediatricians, residents, and trainees in making prompt first-level management decisions. It will also prove invaluable for the adult nephrologists who care for children in many developing countries, and will serve as a teaching guide for experts when training non-subspecialists. Individual sections are devoted to the evaluation of renal disease; fluid, electrolyte, and acid-base disorders; glomerular diseases; tubular disorders; congenital, inherited, and urological disorders; consequences of renal disease; and miscellaneous topics. The text is in a bulleted format with tables and algorithms wherever possible, making it straightforward and easy to read. An appendix includes further important information such as normal values, drug dosages, and drug nephrotoxicity.
Angewandte Psychologie für das Human Resource Management. Konzepte und Instrumente für ein wirkungsvolles Personalmanagement: Konzepte Und Instrumente Für Ein Wirkungsvolles Personalmanagement
by Birgit Werkmann-Karcher Jack RietikerAuch wenn Personalmanager keine Psychologen sein müssen, was sie tun, ist angewandte Psychologie: u. a. Menschen und ihre Rollen im Unternehmen verstehen und beeinflussen, Wandel in Organisationen gestalten. Dafür kann die Kenntnis psychologischer Instrumente und Theorien sehr hilfreich sein. Dieser Leitfaden basiert auf einer Weiterbildung für Personalmanager am Institut für Angewandte Psychologie (Zürich) und beleuchtet aktuelle Themen wie z. B. Talent-, Performance- und Demografie-Mangement - mit zahlreichen Tipps, Checklisten und Fallbeispielen.
Re-irradiation: New Frontiers
by Carsten Nieder Johannes LangendijkNew developments such as refined combined modality approaches and significant technical advances in radiation treatment planning and delivery are facilitating the re-irradiation of previously exposed volumes. As a consequence, both palliative and curative approaches can be pursued at various disease sites. Re-irradiation: New Frontiers is the first book to provide a comprehensive overview on current re-irradiation strategies. Re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance are all discussed in detail. In addition, disease-specific chapters document recent clinical results and future research directions. Professionals involved in radiation treatment planning and multimodal oncology treatment will find this book to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Scrotal Pathology
by Carlo Trombetta Michele BertolottoScrotal Pathology is a comprehensive practical guide to the management of patients who present with scrotal disorders. Introductory chapters consider imaging instrumentation, clinical evaluation, and clinical and imaging anatomy. The full range of disorders is then discussed in individual chapters organized according to clinical presentation. All clinical and imaging aspects are covered in depth, with full description of symptoms and explanation of the value of different clinical tests and imaging modalities. In addition, underlying histopathological features are presented and correlated with imaging features in order to clarify their pathological basis. For each disorder, therapeutic strategies are discussed and appraised. Adults and children are considered separately whenever necessary, bearing in mind that they often present essentially different scrotal pathology. The many images are all of high quality and were obtained using high-end equipment.