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Immune Infertility
by Walter K.H. Krause Rajesh K. NazThis comprehensive overview of immune reactions inducing fertility disorders in both sexes first describes the nature and the function of sperm antigens which are capable to induce immune infertility as well as the methods to analyse and characterize these antigens. Secondly, the nature, the origin and induction of antisperm antibodies (ASA) in both sexes and the role of reproductive organs and their interaction with the immune system will be discussed. A large section of the book, which is most important for clinicians working in reproductive medicine, deals with the clinical impact of the immune reaction in reproductive medicine, including the methods of determination and the treatment in immune infertility. Closely related to immune infertility is the development of immune contraceptives which is also discussed.
Molecular Networks
by Mir Wais HosseiniFrom the reviews: “This book gives an overview of some recent developments in crystal engineering of molecular and metalloorganic solids in five, essentially independent chapters written by different authors. … All in all, this book makes good reading material that can appeal to nonexperts by showcasing some recent developments in the field of crystal engineering, as well as to … experts seeking a detailed overview of a specific subfield, such as a comprehensive account of all possible assemblies of bipyridine-dioxide … .” (Dmitrii F. Perepichka, Journal of the American Chemical Society, Vol. 132 (11), 2010)
Innovation performance accounting
by Matthias Hartmann Hermann Mohnkopf Gerhard Metze Wilhelm SchmeisserFor successful innovation in business the responsible managers need a consistent view of the individual processes as well as an assessment of key projects in all phases of the development. Generating new ideas, fast examination of its feasibility requires skilled methods for evaluation of these ideas, plans and especially costs and revenues. Business models, calculation methods and some assessments of certain options are presented by the authors. The ability to identify risks and appropriate responses to misperceptions are important milestones in the innovation process. From analysis of problems to the introduction of market-ready solutions, legal requirements, business demands and risk management systems are discussed. Concepts promoting uniform, binding rules for ratings in the innovation process are treated. The identification of target pricing, target costing and litigation, the evaluation of the solution to calculate risk aspects as tasks in financial management and innovation controlling are part of the content. The authors demonstrate that any innovation in different industries requires a strategic and financial project management. Monetary assessment of the individual processes, a detailed patent portfolio and accounts management for innovation processes are of enormous importance. The book is completed by applications of the Berlin Balanced Scorecard Concept with practical examples from the innovation projects in pharmaceutical and technical business.
Sensor Networks
by Gianluigi FerrariThis book collects very recent results in the realm of sensor networking. In particular, it links the theory of sensor networking with practical and implementation aspects. Such, it highlights how sensor networking represents a very interesting research/application area, allowing a researcher to apply his theories and a practitioner to "see" the theories behind his/her used technologies.
Characterization of Partially Polarized Light Fields (Springer Series in Optical Sciences #147)
by Gemma Piquero Pedro M. Mejías Rosario Martínez-HerreroPolarization involves the vectorial nature of light fields. In current applications of optical science, the electromagnetic description of light with its vector features has been shown to be essential: In practice, optical radiation also exhibits randomness and spatial non-uniformity of the polarization state. Moreover, propagation through photonic devices can alter the correlation properties of the light field, resulting in changes in polarization. All these vectorial properties have been gaining importance in recent years, and they are attracting increasing attention in the literature. This is the framework and the scope of the present book, which includes the authors' own contributions to these issues.
Glycoscience and Microbial Adhesion
by Stefan Oscarson Thisbe K. LindhorstMumtaz Virji: Ins and Outs of Microbial Adhesion. - Martina Lahmann: Architectures of multivalent glycomimetics for probing carbohydrate-lectin interactions. - Stefan D. Knight and Julie Bouckaert: Structure, Function, and Assembly of Type 1 Fimbriae. - Knut Ohlsen, Tobias A. Oelschlaeger, Jörg Hacker, A. Salam Khan: Carbohydrate receptors of bacterial adhesins: Implications and reflections. - Susann Teneberg: The multiple carbohydrate binding specificities of Helicobacter pylori. - Andrea Kristina Horst and Christoph Wagener: Bitter sweetness of complexity. - Dietrich Mack, Angharad P. Davies, Llinos G. Harris, Johannes K. M. Knobloch and Holger Rohde: Staphylococcus epidermidis biofilms: functional molecules, relation to virulence, and vaccine potential. -
Submarine Power Cables
by Thomas WorzykThe demand for high-performance submarine power cables is increasing as more and more offshore wind parks are installed, and the national electric grids are interconnected. Submarine power cables are installed for the highest voltages and power to transport electric energy under the sea between islands, countries and even continents. The installation and operation of submarine power cables is much different from land cables. Still, in most textbooks on electrical power systems, information on submarine cables is scarce. This book is closing the gap. Different species of submarine power cables and their application are explained. Students and electric engineers learn on the electric and mechanic properties of submarine cables. Project developers and utility managers will gain useful information on the necessary marine activities such as pre-laying survey, cable lay vessels, guard boats etc., for the submarine cable installation and repair. Investors and decision makers will find an overview on environmental aspects of submarine power cables. A comprehensive reference list is given for those who want further reading.
Automotive Development Processes: Processes for Successful Customer Oriented Vehicle Development
by Julian WeberThe book - based on the corresponding graduate course the author held at Clemson University, South Carolina - is a comprehensive, practically oriented presentation of the vehicle development processes. Based on the key question of the product strategy ("Which factors guarantee the product development's success?") it characterizes the contents of the different stages, roles and activities during the product development process, the application of project management methods and the networking with suppliers - enriched with the author's professional expertise. In contrast to the already available textbooks on vehicle development this publication is focused on the integration processes of the overall vehicle development, which means the "orchestration" of the single components for the strategic implementation of customer relevant characteristics of the completed product and to a lesser extent on the optimization of the vehicle components. Furthermore the construction and testing of virtual vehicles concentrating on the geometry-, function- and product-production-integration is broadly discussed.
Tailored Light 1: High Power Lasers For Production (Rwthedition Ser.)
by Reinhart Poprawe Konstantin Boucke Dieter HoffmanThe Laser world consists basically of two areas, which are necessary and in many cases also sufficient for effective innovation: The right laser for the right application. For the individual application that means the determination of optimized process parameters in terms of laser power, peak power/ intensity, focus geometry and dimension, pulse length, pulse repetition rate and wavelength to name only the six most important ones. Once these parameters are identified, the corresponding Laser has to be selected on the basis of commercial availability. Obviously there is no such thing than "One Laser for all". The situation is rather comparable with electrical power, were depending on the demand of the application in terms of voltage, current and time corresponding power supplies need to be tailored, however, with the difference that in the case of the Laser the variety of parameters is even higher, thus the technology is more complex but on the other hand much more flexible in terms optimizing the source to the application. As a consequence it is suggested to generate two volumes on Lasers and Applications named "Tailored Light".
Scanning Force Microscopy of Polymers
by Holger Schönherr G. Julius VancsoThis lab manual introduces the reader to scanning force microscopy of polymers based on a practice-oriented approach. It begins with a broad introduction to the necessary background of SFM, including intermolecular forces and various SFM imaging modes. "Scanning Force Microscopy of Polymers" is developed in a didactically clear and easily understandable style. The application of SFM to visualize and study polymers is exemplified by numerous case studies, including experimental protocols. In addition, the book helps the reader to develop a conscious and critical understanding of SFM data. This approach enables the reader to acquire the knowledge and experimental skills that are necessary to understand and obtain good and reliable SFM results within the shortest time possible.
Molecular and Cellular Enzymology
by Jeannine Yon-Kahn G. HervéMolecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists' and students' understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.
Pediatric and Neonatal Mechanical Ventilation
by Peter C. RimensbergerWritten by outstanding authorities from all over the world, this comprehensive new textbook on pediatric and neonatal ventilation puts the focus on the effective delivery of respiratory support to children, infants and newborns. In the early chapters, developmental issues concerning the respiratory system are considered, physiological and mechanical principles are introduced and airway management and conventional and alternative ventilation techniques are discussed. Thereafter, the rational use of mechanical ventilation in various pediatric and neonatal pathologies is explained, with the emphasis on a practical step-by-step approach. Respiratory monitoring and safety issues in ventilated patients are considered in detail, and many other topics of interest to the bedside clinician are covered, including the ethics of withdrawal of respiratory support and educational issues. Throughout, the text is complemented by numerous illustrations and key information is clearly summarized in tables and lists.
A Systems Approach to Leadership: How to Create Sustained High Performance in a Complex and Uncertain Environment
by Geoffrey Coffey"A Systems Approach to Leadership" (SAL) is a methodology for creating sustained high performance in conditions of high complexity and uncertainty. SAL places the latest developments in Systems Science into an actionable method for use by everyday leaders. It enables leaders to develop themselves and their organisation (or part of it) quickly and effectively to achieve a competitive advantage in a complex and uncertain world. SAL consists of an integrated framework with an overall strategy of whole system development. Central to the framework is a practical method which can be used by any leader at any organisational level. Supporting the framework are a range of systems approaches and a set of foundational assumptions. SAL has been carefully researched and refined in extensive field tests where it typically delivers outcomes well above expectations.
Globalization 2.0
by Raschid Ijioui Michael Ceyp Jochen Hagen Heike EmmerichThe recent near-collapse of the global financial sector and the resulting economic problems have caused a great deal of re-examining of the fundamental principles of globalization. This book showcases how leading managers perceive the current crises and the future of globalization. It offers trendsetting answers, solutions and a roadmap for the roadblocks facing future economic growth which are proposed by leading minds from world-leading companies such as CISCO Systems, British Telecom, Lufthansa Technik, Henkel, A.T. Kearney, Roland Berger, Arthur D. Little, Kienbaum, T-Systems, Mercedes-Benz technology, Landis and Gyr, Conergy.
Handbook of Adhesion Technology
by Andreas Öchsner Robert D. Adams Lucas F. SilvaAdhesives have been used for thousands of years, but until 100 years ago, the vast majority was from natural products such as bones, skins, fish, milk, and plants. Since about 1900, adhesives based on synthetic polymers have been introduced, and today, there are many industrial uses of adhesives and sealants. It is difficult to imagine a product--in the home, in industry, in transportation, or anywhere else for that matter--that does not use adhesives or sealants in some manner. The Handbook of Adhesion Technology is intended to be the definitive reference in the field of adhesion. Essential information is provided for all those concerned with the adhesion phenomenon. Adhesion is a phenomenon of interest in diverse scientific disciplines and of importance in a wide range of technologies. Therefore, this handbook includes the background science (physics, chemistry and materials science), engineering aspects of adhesion and industry specific applications. It is arranged in a user-friendly format with ten main sections: theory of adhesion, surface treatments, adhesive and sealant materials, testing of adhesive properties, joint design, durability, manufacture, quality control, applications and emerging areas. Each section contains about five chapters written by internationally renowned authors who are authorities in their fields. This book is intended to be a reference for people needing a quick, but authoritative, description of topics in the field of adhesion and the practical use of adhesives and sealants. Scientists and engineers of many different backgrounds who need to have an understanding of various aspects of adhesion technology will find it highly valuable. These will include those working in research or design, as well as others involved with marketing services. Graduate students in materials, processes and manufacturing will also want to consult it.
The Dawn Angiosperms
by Xin WangThis book is about fossil plants of so-called "pre-historic" angiosperms. It reflects the newest progress in research on the origin of angiosperms, and will definitely trigger many new ideas in research. It emphasizes the early Cretaceous and Jurassic materials, rather than later ones, as they are the key periods for the origin of angiosperms. The author integrates multiple techniques, including SEM, TEM, light microscopy, peeling and cladistics, to study the morphology, anatomy and phylogeny of the fossils. Several Jurassic materials of angiosperms that have never been reported before are included, these used to be thought as pre-historic for flowering plants. Two more fossils angiosperms from the Yixian Formation, where Archaefructus was excavated, are reported. Newer and stricter criterion for identifying fossil angiosperms is proposed.
Seawater Desalination
by Andrea Cipollina Giorgio Micale Lucio RizzutiA growing proportion of the world's population is dependent on Seawater Desalination as a source of fresh water for both potable and civil use. One of the main drawbacks of conventional desalination technologies is the substantial energy requirement, which is facing cost increases in the global energy market. "Seawater Desalination" presents an overview of conventional and non-conventional technologies, with a particular focus on the coupling of renewable energies with desalination processes. The first section of this book presents, in a technical but reader-friendly way, an overview of currently-used desalination processes, from thermal to membrane processes, highlighting the relevant technical features, advantages and disadvantages, and development potential. It also gives a rapid insight into the economic aspects of fresh water production from seawater. The second section of the book presents novel processes which use Renewable Energies for fresh water production. From the first solar still evaporators, which artificially reproduced the natural cycle of water, technology has progressed to develop complex systems to harness energy from the sun, wind, tides, waves, etc. and then to use this energy to power conventional or novel desalination processes. Most of these processes are still at a preliminary stage of development, but some are already being cited as examples in remote areas, where they are proving to be valuable in solving the problems of water scarcity. A rapid growth in these technologies is foreseen in the coming years. This book provides a unique foundation, within the context of present and future sustainability, for professionals, technicians, managers, and private and public institutions operating in the area of fresh water supply.
Antibody Engineering Volume 1 (Springer Laboratory Manual Ser.)
by Roland E. Kontermann Stefan DübelAntibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
PET-CT and PET-MRI in Oncology
by Patrick Peller Rathan Subramaniam Ali GuermaziOver the past decade, PET-CT has achieved great success owing to its ability to simultaneously image structure and function, and show how the two are related. More recently, PET-MRI has also been developed, and it represents an exciting novel option that promises to have applications in oncology as well as neurology. The first part of this book discusses the basics of these dual-modality techniques, including the scanners themselves, radiotracers, scan performance, quantitation, and scan interpretation. As a result, the reader will learn how to perform the techniques to maximum benefit. The second part of the book then presents in detail the PET-CT and PET-MRI findings in cancers of the different body systems. The final two chapters address the use of PET/CT in radiotherapy planning and examine areas of controversy. The authors are world-renowned experts from North America, Europe, and Australia, and the lucid text is complemented by numerous high-quality illustrations.
Übersetzerbau
by Sebastian Hack Helmut Seidl Reinhard WilhelmDas Buch behandelt die Analysephase von Übersetzern für Programmiersprachen. Die Autoren beschreiben die lexikalische, syntaktische und semantische Analyse sowie Spezifikationsmechanismen für diese Aufgaben aus der Theorie der formalen Sprachen und automatische Erzeugungsverfahren aus der Theorie der Automaten. Vorgestellt wird eine konzeptionelle Übersetzerstruktur, mit der ein Eingabe- in ein Maschinenprogramm transformiert wird. Das Buch enthält neben der notwendigen Theorie auch Hinweise zur Implementierung von Übersetzern.
Patentierung von Geschäftsprozessen
by Martin Moehrle Lothar WalterGeschäftsprozesse reichen von eBanking über Internetauktionen bis zur Buchung von Reisen. Sie sind ein wichtiges Feld für die Profilierung gegenüber Wettbewerbern. Die Autoren beschreiben die Grundlagen und Perspektiven der Patentierung von Geschäftsprozessen und zeigen dabei Gestaltungsoptionen für Unternehmen auf. Die Vorgehensweise - von der Patentrecherche über die Darstellung der Ergebnisse auf Patentlandkarten bis zur Ableitung von Handlungsempfehlungen für das strategische Management - wird beispielhaft auf zwei Geschäftsprozesse angewandt.
Mining, Society, and a Sustainable World
by Jeremy RichardsThis is the first book of peer-reviewed, edited papers that examines the broad subject of the minerals industry in relation to sustainable development. The book takes a proactive, positivist, and solution-oriented approach, while not shying away from identifying the real problems that mining raises in respect to social and economic development, environmental impact, and human development in general.
Lead-Seeking Approaches
by Matthew M. HaywardChristopher A. Lipinski: Overview of hit to lead: the medicinal chemistâ__s role from HTS retest to lead optimization hand offJeff W. Paslay â_¢ John E. Morin â_¢ Richard K. Harrison: High Throughput Screening in the 21st CenturyJack Andrew Bikker â_¢ Lakshmi S. Narasimhan: Lead Discovery Using Virtual Screening Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug DesignKevin D. Freeman-Cook â_¢ Daniel W. Kung: Hit Triage â__ Medicinal Chemistry Strategies to Improve the Odds of Success in DiscoveryJohn W. Ellingboe â_¢ Adam M. Gilbert: Lead Identification
Risikomanagement bei Public Private Partnerships
by Andreas Pfnür Christoph Schetter Henning SchöbenerDer Band beschäftigt sich mit dem Risikomangement bei öffentlichen Infrastrukturinvestitionen, insbesondere bei öffentlich-privaten Partnerschaften. Dabei legen die Autoren großen Wert auf Verständlichkeit und praktischen Nutzen: Leser sollen befähigt werden, Risikoidentifikation und -bewertung sowie das Risikomanagement selbst durchzuführen. Dabei wird der gesamte Lebenszyklus der Investition betrachtet, Verfahren der simulativen Risikoanalyse diskutiert sowie die Möglichkeiten und Grenzen des Handels mit Projektrisiken am Kapitalmarkt ausgelotet.
Architecture-Based Design of Multi-Agent Systems
by Danny WeynsMulti-agent systems are claimed to be especially suited to the development of software systems that are decentralized, can deal flexibly with dynamic conditions, and are open to system components that come and go. This is why they are used in domains such as manufacturing control, automated vehicles, and e-commerce markets. Danny Weyns' book is organized according to the postulate that "developing multi-agent systems is 95% software engineering and 5% multi-agent systems theory." He presents a software engineering approach for multi-agent systems that is heavily based on software architecture - with, for example, tailored patterns such as "situated agent", "virtual environment", and "selective perception" - and on middleware for distributed coordination - with programming abstractions such as "views" and "roles." Next he shows the feasibility and applicability of this approach with the development of an automated transportation system consisting of a number of automatic guided vehicles transporting loads in an industrial setting. Weyns puts the development of multi-agent systems into a larger perspective with traditional software engineering approaches. With this, he opens up opportunities to exploit the body of knowledge developed in the multi-agent systems community to tackle some of the difficult challenges of modern-day software systems, such as decentralized control, location-awareness, self-adaption, and large-scale. Thus his book is of interest for both researchers and industrial software engineers who develop applications in areas such as distributed control systems and mobile applications where such requirements are of crucial importance.