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Heteroaromatic Lipoxin A4 Analogues
by Colm DuffyIn this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Homogeneous Catalysis with Metal Complexes
by Gheorghe DucaThe book about homogeneous catalysis with metal complexes deals with the description of the reductive-oxidative, metal complexes in a liquid phase (in polar solvents, mainly in water, and less in nonpolar solvents). The exceptional importance of the redox processes in chemical systems, in the reactions occuring in living organisms, the environmental processes, atmosphere, water, soil, and in industrial technologies (especially in food-processing industries) is discussed. The detailed practical aspects of the established regularities are explained for solving the specific practical tasks in various fields of industrial chemistry, biochemistry, medicine, analytical chemistry and ecological chemistry. The main scope of the book is the survey and systematization of the latest advances in homogeneous catalysis with metal complexes. It gives an overview of the research results and practical experience accumulated by the author during the last decade.
Non-Centrosymmetric Superconductors
by Ernst Bauer Manfred SigristSuperconductivity in materials without inversion symmetry in the respective crystal structures occurs in the presence of antisymmetric spin-orbit coupling as a consequence of an emerging electric field gradient. The superconducting condensate is then a superposition of spin-singlet and spin-triplet Cooper pairs. This scenario accounts for various experimental findings such as nodes in the superconducting gap or extremely large upper critical magnetic fields. Spin-triplet pairing can occur in non-centrosymmetric superconductors in spite of Anderson's theorem that spin-triplet pairing requires a crystal structure that exhibits inversion symmetry. This book, authored and edited by leading researchers in the field, is both an introduction to and overview on this exciting branch of novel superconductors. Its self-contained and tutorial style makes it particularly suitable for self-study and as source of teaching material for special seminars and courses. At the same time it constitutes an up-to-date and authoritative reference for anyone working in this exciting field.
Patient-Specific Modeling in Tomorrow's Medicine
by Amit GefenThis book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field. The book is useful for medical physicists, biomedical engineers and other engineers who are interested in the science and technology aspects of Patient Specific Modeling, as well as for radiologists and other medical specialists who wish to be updated about the state of implementation.
Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder and Its Treatment (Current Topics in Behavioral Neurosciences #9)
by Rosemary Tannock Clare StanfordIn this volume there is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long-term use.
Dijet Angular Distributions in Proton-Proton Collisions
by Nele BoelaertThis thesis is based on the first data from the Large Hadron Collider (LHC) at CERN. Its theme can be described as the classical Rutherford scattering experiment adapted to the LHC: measurement of scattering angles to search for new physics and substructure. At the LHC, colliding quarks and gluons exit the proton collisions as collimated particle showers, or jets. The thesis presents studies of the scattering angles of these jets. It includes a phenomenological study at the LHC design energy of 14 TeV, where a model of so-called large extra dimensions is used as a benchmark process for the sensitivity to new physics. The experimental result is the first measurement, made in 2010, by ATLAS, operating at the LHC start-up energy of 7 TeV. The result is compatible with the Standard Model and demonstrates how well the physics and the apparatus are understood. The first data is a tiny fraction of what will be accumulated in the coming years, and this study has set the stage for performing these measurements with confidence as the LHC accumulates luminosity and increases its energy, thereby probing smaller length scales.
Evidence-Based Practice in Complementary and Alternative Medicine: Perspectives, Protocols, Problems and Potential in Ayurveda
by Francesco Chiappelli Manisha Harish Ramchandani Sanjeev Rastogi Ram Harsh SinghThis book investigates the ways in which the evidence base is influencing complementary and alternative medicine in general and Ayurveda and allied health practices in particular. The latter have traditionally been prevalent in Asia and are now increasingly attracting interest worldwide. The book is divided into four sections, the first of which examines issues related to acquisition and evaluation of the evidence base. Evidence-based approaches to Ayurvedic diagnosis and therapy are then examined, with a special focus on management of cardiovascular and rheumatological diseases, dental care, and rejuvenating treatments. The final section explores further the challenges of applying evidence-based practice in contemporary and alternative medicine and Ayurveda with a focus upon the issues requiring urgent attention in ongoing decade. The same involves encompassing areas such as Ayurvedic pharmaceutics, practice, education and research within an evidence-based perspective.
Study of the Inclusive Beauty Production at CMS and Construction and Commissioning of the CMS Pixel Barrel Detector
by Lea CaminadaThis thesis describes one of the first measurements made at CERN's Large Hadron Collider, the world's largest and highest-energy particle collider. The method of analysis described in the first part is applied to the first CMS collision data collected after the LHC startup in 2010 and leads to the first experimental result for the inclusive b cross section using semileptonic decays at a center of mass energy of 7 TeV. The second part of the thesis describes the building and testing of the barrel pixel detector; the author herself played an important role in its construction, commissioning and first exploitation. The CMS collaboration Thesis Award Committee selected this work as the best thesis of the year 2010
Complexity Theories of Cities Have Come of Age: An Overview with Implications to Urban Planning and Design
by Juval Portugali Egbert Stolk Ekim Tan Han MeyerToday, our cities are an embodiment of the complex, historical evolution of knowledge, desires and technology. Our planned and designed activities co-evolve with our aspirations, mediated by the existing technologies and social structures. The city represents the accretion and accumulation of successive layers of collective activity, structuring and being structured by other, increasingly distant cities, reaching now right around the globe. This historical and structural development cannot therefore be understood or captured by any set of fixed quantitative relations. Structural changes imply that the patterns of growth, and their underlying reasons change over time, and therefore that any attempt to control the morphology of cities and their patterns of flow by means of planning and design, must be dynamical, based on the mechanisms that drive the changes occurring at a given moment. This carefully edited post-proceedings volume gathers a snapshot view by leading researchers in field, of current complexity theories of cities. In it, the achievements, criticisms and potentials yet to be realized are reviewed and the implications to planning and urban design are assessed.
GaN-Based Laser Diodes
by Wolfgang G. ScheibenzuberThe emergence of highly efficient short-wavelength laser diodes based on the III-V compound semiconductor GaN has not only enabled high-density optical data storage, but is also expected to revolutionize display applications. Moreover, a variety of scientific applications in biophotonics, materials research and quantum optics can benefit from these versatile and cost-efficient laser light sources in the near-UV to green spectral range. This thesis describes the device physics of GaN-based laser diodes, together with recent efforts to achieve longer emission wavelengths and short-pulse emission. Experimental and theoretical approaches are employed to address the individual device properties and optimize the laser diodes toward the requirements of specific applications.
Radiation Dose from Multidetector CT
by Pierre Alain Gevenois Denis Tack Mannudeep K. KalraComputed tomography (CT) is a powerful technique providing precise and confident diagnoses. The burgeoning use of CT has resulted in an exponential increase in collective radiation dose to the population. Despite investigations supporting the use of lower radiation doses, surveys highlight the lack of proper understanding of CT parameters that affect radiation dose. Dynamic advances in CT technology also make it important to explain the latest dose-saving strategies in an easy-to-comprehend manner. This book aims to review all aspects of the radiation dose from CT and to provide simple rules and tricks for radiologists and radiographers that will assist in the appropriate use of CT technique. The second edition includes a number of new chapters on the most up-to-date strategies and technologies for radiation dose reduction while updating the outstanding contents of the first edition. Vendor perspectives are included, and an online image gallery will also be available to readers.
Application of Bacterial Pigments as Colorant: The Malaysian Perspective (SpringerBriefs in Molecular Science)
by Wan Yunus Wan Ahmad Wan Azlina Ahmad Zainul Akmar Zakaria Nur Zulaikha YusofEnvironmental concerns regarding continuous use of synthetic dyes saw a revival in the demand for natural dyes as natural dyes exhibit better biodegradability and generally have a higher compatibility with the environment. However, one of the limitations on the use of natural dyes or pigments is the low extraction yield factors (a few grams of pigment per kg of dried raw material). Therefore, the exploitation of other biological sources such as fungi, bacteria and cell cultures offers interesting alternative. Microbial pigments such as from bacterial origins offer the advantage in terms of production compared to pigments extracted from vegetables or animals, due to its simple cell and fast culturing technique. This book offers interesting insight into initial works carried out to demonstrate the potential use of bacterial pigment as colorant for various applications.
Mathematics and Modern Art
by Claude BruterThe link between mathematics and art remains as strong today as it was in the earliest instances of decorative and ritual art. Arts, architecture, music and painting have for a long time been sources of new developments in mathematics, and vice versa. Many great painters have seen no contradiction between artistic and mathematical endeavors, contributing to the progress of both, using mathematical principles to guide their visual creativity, enriching their visual environment with the new objects created by the mathematical science. Owing to the recent development of the so nice techniques for visualization, while mathematicians can better explore these new mathematical objects, artists can use them to emphasize their intrinsic beauty, and create quite new sceneries. This volume, the content of the first conference of the European Society for Mathematics and the Arts (ESMA), held in Paris in 2010, gives an overview on some significant and beautiful recent works where maths and art, including architecture and music, are interwoven. The book includes a wealth of mathematical illustrations from several basic mathematical fields including classical geometry, topology, differential geometry, dynamical systems. Here, artists and mathematicians alike elucidate the thought processes and the tools used to create their work
Future Trends in Production Engineering
by Günther Schuh Eckart Uhlmann Reimund NeugebauerTo meet and adapt to the current and future trends and issues in technology and society, the science committee of The German Academic Society for Production Engineering (WGP) continues to define future topics for production technology. These themes represent not only the key focus for the scientific work of the WGP, but also the central themes of the first annual conference in June 2011, whose paper is publically available in this volume. Such themes, including electric mobility, medical technology, lightweight construction, and resource efficiency, as well as mass production ability have all been identified as future, large-scale, and long-term drivers of change. Future trends influence changes sustainably and fundamentally; they permeate society, technology, economics, and value systems and have an effect in virtually all areas of life. The WGP has, as part of its research, established for itself the goal of not only observing these emerging changes, but also of supervising and influencing their development in order to ensure steady progress, secure sustainability, and shape the future.
Challenges at the Interface of Data Analysis, Computer Science, and Optimization: Proceedings of the 34th Annual Conference of the Gesellschaft für Klassifikation e. V., Karlsruhe, July 21 - 23, 2010 (Studies in Classification, Data Analysis, and Knowledge Organization)
by Andreas Geyer-Schulz Lars Schmidt-Thieme Jonas Kunze Wolfgang A. GaulThis volume provides approaches and solutions to challenges occurring at the interface of research fields such as data analysis, computer science, operations research, and statistics. It includes theoretically oriented contributions as well as papers from various application areas, where knowledge from different research directions is needed to find the best possible interpretation of data for the underlying problem situations. Beside traditional classification research, the book focuses on current interests in fields such as the analysis of social relationships as well as statistical musicology.
Handbook of Manufacturing Control: Fundamentals, description, configuration
by Hermann Lödding Rett RossiUnternehmen mit kurzen Lieferzeiten, hoher Liefertreue und niedrigen Beständen wachsen schnell und erzielen hohe Gewinne. Wie Unternehmen diese logistische Herausforderung meistern können, zeigt das Buch anhand von aktuellen Forschungsergebnissen der Leibniz Universität Hannover. Der Band gibt einen umfassenden Überblick über die Aufgaben und Verfahren der Fertigungssteuerung und befähigt Leser dazu, Schwächen in diesem Bereich zu erkennen und zu korrigieren. Ein fundiertes Nachschlagewerk für Studierende, Dozenten, Ingenieure und Wissenschaftler.
Quantum Triangulations
by Annalisa Marzuoli Mauro CarforaResearch on polyhedral manifolds often points to unexpected connections between very distinct aspects of Mathematics and Physics. In particular triangulated manifolds play quite a distinguished role in such settings as Riemann moduli space theory, strings and quantum gravity, topological quantum field theory, condensed matter physics, and critical phenomena. Not only do they provide a natural discrete analogue to the smooth manifolds on which physical theories are typically formulated, but their appearance is rather often a consequence of an underlying structure which naturally calls into play non-trivial aspects of representation theory, of complex analysis and topology in a way which makes manifest the basic geometric structures of the physical interactions involved. Yet, in most of the existing literature, triangulated manifolds are still merely viewed as a convenient discretization of a given physical theory to make it more amenable for numerical treatment. The motivation for these lectures notes is thus to provide an approachable introduction to this topic, emphasizing the conceptual aspects, and probing, through a set of cases studies, the connection between triangulated manifolds and quantum physics to the deepest. This volume addresses applied mathematicians and theoretical physicists working in the field of quantum geometry and its applications.
Nano-Antimicrobials
by Mahendra Rai Nicola CioffiThere is a high demand for antimicrobials for the treatment of new and emerging microbial diseases. In particular, microbes developing multidrug resistance have created a pressing need to search for a new generation of antimicrobial agents, which are effective, safe and can be used for the cure of multidrug-resistant microbial infections. Nano-antimicrobials offer effective solutions for these challenges; the details of these new technologies are presented here. The book includes chapters by an international team of experts. Chemical, physical, electrochemical, photochemical and mechanical methods of synthesis are covered. Moreover, biological synthesis using microbes, an option that is both eco-friendly and economically viable, is presented. The antimicrobial potential of different nanoparticles is also covered, bioactivity mechanisms are elaborated on, and several applications are reviewed in separate sections. Lastly, the toxicology of nano-antimicrobials is briefly assessed.
Technologie von Unternehmenssoftware
by Rainer WeberUnternehmenssoftware - das sind operative Anwendungssysteme, analytische Systeme wie Data-Warehouse-Systeme und Planungssysteme, z. B. für das Supply-Chain-Management. In dem Buch werden die zugrunde liegende Technologie und die Modellierungskonzepte beschrieben. Behandelt werden auch Integrationstechniken zur Verbindung mehrerer Systeme, Methoden im Lebenszyklus von Unternehmenssoftware sowie Client-Server-Technologie und Geschäftsobjekte, aber auch neue Entwicklungen wie Cloud-Computing. Mit vielen Beispielen und Übungen mit Lösungsvorschlägen.
Challenges in Molecular Structure Determination
by Jürgen Popp Manfred ReichenbächerTaking a problem-based approach, the authors provide a practice-oriented and systematic introduction to both organic and inorganic structure determination by spectroscopic methods. This includes mass spectrometry, vibrational spectroscopies, UV/VIS spectroscopy and NMR as well as applying combinations of these methods. The authors show how to elucidate chemical structures with a minimal number of spectroscopic techniques. Readers can train their skills by more than 400 problems with varying degree of sophistication. Interactive Powerpoint-Charts are available as Extra Materials to support self-study.
Soil-Subsurface Change
by Brian Berkowitz Bruno Yaron Ishai DrorThis book combines soil science, earth science, and environmental geochemistry, providing comprehensive background information for specialists interested in chemical-induced changes in the soil-subsurface system. Readers are introduced to the chemistry of contaminants that often disturb the natural soil-subsurface equilibrium as a result of human activity. While the soil-subsurface system has in many cases been affected by human impact, the effects of chemical contaminants on the actual matrix and properties have been largely neglected. The major focus of the book is on changes to the soil-subsurface matrix and properties caused by chemical pollution. By integrating results available in the literature, we observe that chemical pollutants may lead to the irreversible formation of a new soil-subsurface regime characterized by a matrix and properties different than those of the natural regime. In contrast to the geological time scales dictating natural changes to the matrix and properties of the soil-subsurface system, the time scale associated with chemical pollutant-induced changes is far shorter and extends over a "human lifetime scale." The numerous examples presented in the book confirm that chemical contamination should be considered as an additional factor in the formation of a contemporary soil-subsurface regime that is different than that of the pristine system.
Mapping of Parent Hamiltonians
by Martin GreiterThis monograph introduces an exact model for a critical spin chain with arbitrary spin S, which includes the Haldane--Shastry model as the special case S=1/2. While spinons in the Haldane-Shastry model obey abelian half-fermi statistics, the spinons in the general model introduced here obey non-abelian statistics. This manifests itself through topological choices for the fractional momentum spacings. The general model is derived by mapping exact models of quantized Hall states onto spin chains. The book begins with pedagogical review of all the relevant models including the non-abelian statistics in the Pfaffian Hall state, and is understandable to every student with a graduate course in quantum mechanics.
Mapping of Parent Hamiltonians: From Abelian and non-Abelian Quantum Hall States to Exact Models of Critical Spin Chains (Springer Tracts in Modern Physics #244)
by Martin GreiterThis monograph introduces an exact model for a critical spin chain with arbitrary spin S, which includes the Haldane--Shastry model as the special case S=1/2. While spinons in the Haldane-Shastry model obey abelian half-fermi statistics, the spinons in the general model introduced here obey non-abelian statistics. This manifests itself through topological choices for the fractional momentum spacings. The general model is derived by mapping exact models of quantized Hall states onto spin chains. The book begins with pedagogical review of all the relevant models including the non-abelian statistics in the Pfaffian Hall state, and is understandable to every student with a graduate course in quantum mechanics.
CFD-Modellierung: Grundlagen und Anwendungen bei Strömungsprozessen
by Rüdiger SchwarzeIn diesem kompakten Lehrbuch legt der Autor die Methodik der numerischen Simulation von Strömungsprozessen dar. Nach einer konzisen Erläuterung der Grundlagen lernen Leser das Potenzial der Methodik anhand von Anwendungsbeispielen kennen. Demonstriert werden sowohl einfache wie komplexe Probleme. Während Leser die einfachen Problemstellungen mithilfe von Open-Source-Softwarepaketen selbst bearbeitet können, sind die komplexen Beispiele aus aktuellen grundlagenorientierten und aus anwendungsnahen Forschungsprojekten des Autors abgeleitet.
From the Universe to the Elementary Particles
by Ulrich EllwangerIn this book, the author leads the reader, step by step and without any advanced mathematics, to a clear understanding of the foundations of modern elementary particle physics and cosmology. He also addresses current and controversial questions on topics such as string theory. The book contains gentle introductions to the theories of special and general relativity, and also classical and quantum field theory. The essential aspects of these concepts are understood with the help of simple calculations; for example, the force of gravity as a consequence of the curvature of the space-time. Also treated are the Big Bang, dark matter and dark energy, as well as the presently known interactions of elementary particles: electrodynamics, the strong and the weak interactions including the Higgs boson. Finally, the book sketches as yet speculative theories: Grand Unification theories, supersymmetry, string theory and the idea of additional dimensions of space-time. Since no higher mathematical or physics expertise is required, the book is also suitable for college and university students at the beginning of their studies. Hobby astronomers and other science enthusiasts seeking a deeper insight than can be found in popular treatments will also appreciate this unique book.