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Small Molecules for Cancer Treatment
by Asim K. Duttaroy Surajit Pathak Antara BanerjeeThe book explores role of small molecules and peptides in cancer therapy, with a focus on (Aptamer-drug conjugates, Androgen Receptor and Tyrosine Kinase inhibitors, and Glycosylation inhibitors. Small molecule inhibitors targeting oncogenic pathways such as EGFR and PI3K inhibitors, Peptides in oral cancer such as Antimicrobial peptides, Cell Penetrating Peptides, Tumour targeting peptides, Natural small molecules with anti-cancer effects such as phenolic compounds, alkaloids, terpenoids and steroids, Phthalides and lectins, Peptides targeting the tumor microenvironment such as GM-CSF's, LAG3, PD 1, CCL2, CCR-5, CXCR4 inhibitors). An introductory chapter covers the foundation for understanding their significance in cancer treatment. The book delves into the versatility and precision of small molecules, highlighting their advantages in drug delivery and formulation strategies. It emphasizes the expansion of therapeutic horizons through small molecule peptides, shedding light on their potential in targeting tumor microenvironments and advancing cancer therapeutics. Additionally, the book discusses combination therapies and synergistic effects, offering a deeper understanding of integrating different therapeutic approaches. Furthermore, it addresses emerging trends, challenges, safety considerations, and the relevance of small-molecule inhibitors. This book provides a crucial update on the latest advancements and serves as a valuable resource for researchers, clinicians, and students interested in the rapidly evolving landscape of cancer treatment, offering an overview of the potential and complexities associated with these compounds in the fight against cancer.
Status of Decline and Conservation of Amphibians of the Middle East: Amphibian Biology, Volume 11, Part 8 Status of Conservation and Decline of Amphibians: Eastern Hemisphere
by Susan King Indraneil Das Harold HeatwoleAmphibians by virtue of their thin, moist, permeable skins are poorly protected from harsh environments and are especially susceptible to chemical changes, desiccation, and alteration of their habitat. Accordingly, it is not surprising that they manifest exceptionally high rates of extinction and suffer more severe declines than do most other taxa in an environment undergoing unprecedented anthropogenic change. They are especially important to study as they serve as an early-warning system portending changes that are beginning to engulf more resistant species, including our own.The current volume covers the 14 countries of the Middle East, each written by a specialist, and is part of the Amphibian Biology series.
Probing Human Dignity: Exploring Thresholds from an Interdisciplinary Perspective
by Stephanie N. Arel Levi Cooper Vanessa HellmannProbing Human Dignity from multiple disciplinary backgrounds by scholars from a variety of countries and different cultures is an intense intellectual and emotional venture. The intensity emerges from an encounter with Human dignity that challenges individuals, communities, and society at large to navigate different spheres of human action, including ethical, moral, religious, and legal realms. Difficulties arise in the attempt to bridge the conversation about Human Dignity across cultures and traditions. This volume addresses such difficulties, exploring new horizons of the discourse and offering a mosaic of the quest for Human Dignity. Alas, the denial of a person’s dignity continues to manifest in contemporary life, through injustices often related to personal hardship, crisis, unrest, or upheaval. This collection confronts such injustices with sensitive, complex, nuanced, and academically rigorous engagement. Each chapter begins from the understanding that recognizing and investigating Human Dignity often occurs “at the threshold”, where in times of societal crisis or individual hardship questions of Human Dignity turn into ethical, moral, and legal dilemmas. The objective of this volume is to draw on theoretical and conceptual distinctions of Human Dignity in order to inform new perspectives that probe its ambiguity. The contributors offer greater clarity and push beyond existing thresholds to develop new paradigms that cross disciplinary lines while speaking to the goals and needs of post-modern societies and individuals. Each contributor crosses into new territory to examine a pressing legal or societal issue with a new lens. The authors worked together as an international and interdisciplinary research group within the framework of the 2nd Intercontinental Academia of the UBIAS network (University-Based Institutes for Advanced Studies). This volume reflects their journey, their fruitful collaboration, and their scholarly endeavors. The result is a collection that serves as a fresh and exciting contribution to the contemporary Human Dignity discourse.
Connecticut Vanguards: Historic Trailblazers & Their Legacies
by Eric D. LehmanAuthor Eric D. Lehman chronicles the lives of two dozen men and women who left their marks on Connecticut and the world as a whole.Noah Webster, Charles Goodyear, P.T. Barnum and Katharine Hepburn all have Connecticut in common. Like so many other residents, they had an inventive spirit and drive that changed the course of history for the rest of the state. Some of the state's natives, like Eli Whitney and Henry C. Lee, pioneered new methods. Prudence Crandall and Helen Keller championed the rights of the underprivileged. Some, like Frederick Law Olmsted and Sol LeWitt, changed our perception of the world.
Bedlam on the West Virginia Rails: The Last Train Bandit Tells His True Tale (True Crime)
by Wilson CaseyIn 1949, two bandits from Youngstown, Ohio, boarded a B&O passenger train from Washington, D.C., to Detroit. In the West Virginia mountains near Martinsburg, Luman "Lu" Ramsdell and his gang stopped the train to rob and terrorize nearly 150 people on board. They pistol-whipped several and shot at others before exiting the train to next rob a tavern and hijack getaway cars. National headlines likened the event to the exploits of Jesse James and the infamous days of the Wild West. Lu and the gang led authorities on a chase that ended with a harrowing shootout five blocks from the White House. Climb aboard with author Wilson Casey for a firsthand account from the head bandit himself in this true tale of America's last moving train robbery.
North Platte's Keith Blackledge: Lessons from a Community Journalist
by Carol LomickyPopular culture glorified newspapers in the 1970s, creating a kind of mythical community newspaperman--like Keith Blackledge, longtime editor of the North Platte Telegraph. In his editorials and columns, he praised, scolded, cajoled, teased and encouraged readers. He provided a civic connection while also, mostly behind the scenes, working to make the town better. Blackledge's story resonates today because it's also about the evolution of newspapers. The editor's career spanned a time when the industry was hit by a tsunami of change, including shrinking circulations and advertising revenues, as well as new technologies altering forever the way news is produced, delivered and consumed. Author Carol Lomicky chronicles the life of this remarkable newspaperman.
Signal Processing for Mobile Communications Handbook
by Mohamed IbnkahlaThis internationally contributed handbook covers all aspects of signal processing as applied to digital communications, including adaptive coded modulation, channel modeling, estimation and identification, diversity combining and adaptive equalization, OFDM, cross-layer design, power control, neural networks, MCMC methods, and chaos. The editor puts a special focus on future 4-G mobile communication systems, including voice over IP, satellite mobile communications, and GPS receivers. Presented in a tutorial format, the reader will find a comprehensive survey of signal processing techniques used in mobile communications that concern the transmitter, the receiver, and the propagation channel.
Chromatography of Natural, Treated and Waste Waters
by T.R CromptonChromatography of Natural, Treated and Waste Waters is the first book to bring together information of a range of chromatographic techniques in all types of water, precipitation to sewage effluents. Organic and inorganic compounds, cations, anions and elements are all discussed. Particular attention is paid to multi compound analysis of water, and
Handbook of Photochemistry
by Marco Montalti Alberto Credi Luca Prodi M. Teresa GandolfiSince the publication of the second edition of this handbook in 1993, the field of photochemical sciences has continued to expand across several disciplines including organic, inorganic, physical, analytical, and biological chemistries, and, most recently, nanosciences. Emphasizing the important role light-induced processes play in all of these fie
Municipal Stormwater Management
by Thomas N. Debo Andrew ReeseDesigned to be a stand alone desktop reference for the Stormwater manager, designer, and planner, the bestselling Municipal Stormwater Management has been expanded and updated. Here is what's new in the second edition: New material on complying with the NPDES program for Phase II and in running a stormwater quality programThe latest information on
Chemical, Biological, and Functional Aspects of Food Lipids
by Zdzislaw E. Sikorski Anna KolakowskaBased on years of academic and industrial research by an international panel of experts, Chemical, Biological, and Functional Properties of Food Lipids, Second Edition provides a concise, yet well-documented presentation of the current state of knowledge on lipids. Under the editorial guidance of globally recognized food scientists Zdzislaw E. Siko
Male Reproductive Dysfunction: Pathophysiology and Treatment
by Fouad R. Kandeel Ronald S. Swerdloff Jon L. PryorThe successful practice of reproductive medicine requires the coordinated efforts of many medical professionals. Male Reproductive Dysfunction: Pathophysiology and Treatment describes the most significant advances towards the improved overall understanding of male reproductive dysfunction and provides practical strategies for the assessment and man
Diseases of the Colon
by Steven D. WexnerThis first reference to comprehensively address both the medical and surgical management of diseases affecting the colon, this source spans the wide array of colorectal disorders including rectal prolapse, irritable bowel syndrome, benign and malignant colonic tumors, fissures and ulcers, and Crohn's colitis, among other ailments. With chapters by
Hepatobiliary Surgery
by Ronald S. ChamberlainThis book is written as a reference and guidebook for practicing surgeons, gastroenterologists, and interventional radiologists with an interest in hepatobiliary diseases. It presents a strategy to enhance surgeons practice and the care of patients.
Powder Technology: Handling and Operations, Process Instrumentation, and Working Hazards
by Ko Higashitani Hiroaki Masuda Hideto YoshidaDrawing from the third edition of the bestselling Powder Technology Handbook, this book concentrates on handling methods and unit operations for powder and particle processing techniques. Itexamines the purpose and factors involved in each process-including planning, equipment, measurements, and other necessary considerations.This book c
Physical-Chemical Treatment of Water and Wastewater
by Arcadio P. Sincero Gregoria A. SinceroThe books currently available on this subject contain some elements of physical-chemical treatment of water and wastewater but fall short of giving comprehensive and authoritative coverage. They contain some equations that are not substantiated, offering empirical data based on assumptions that are therefore difficult to comprehend. This text bring
New England Coast Guard Stories: Remarkable Mariners (American Heritage)
by Dyke HendricksonIn 1790, Treasury Secretary Alexander Hamilton asked President George Washington to fund a fleet of "revenue cutters" that could halt smuggling and collect taxes in U.S. waters. Today, from northern Maine to southern Connecticut, the Coast Guard provides the might and the oversight to ensure that the coastlines are safe and navigable. From icebreaking and harrowing rescues to the global war on terror, the service plays a unique role in the region. Author Dyke Hendrickson profiles the varied careers and contributions of the brave men and women throughout New England who ensure the service remains Semper Paratus-Always Ready.
The Ghostly Tales of Santa Fe (Spooky America)
by Lisha CauthenGhost stories from America's heart of the Southwest have never been so creepy, fun, and full of mystery! Welcome to the spooky streets of Santa Fe! Stay alert! Ghosts lurk around every corner. Even the most unexpected places might be haunted by wandering phantoms. Did you know a ghostly miner still roams the Sangre de Cristo Mountains looking for the treasure he lost? Or that the spirit of a Spanish solider wanders Santa Fe not realizing he's dead? Can you believe you may even spot the ghost of Billy the Kid playing cards in town? Pulled right from history, these ghostly tales will change the way you see Santa Fe, and have you sleeping with the light on!
The Stress Management Workbook: De-stress in 10 Minutes or Less
by Ruth C. WhiteReduce your stress in 10 minutes or less with the practical exercises and quick strategies in The Stress Management Workbook.Learning how to manage your stress shouldn't be stressful. With The Stress Management Workbook you'll get the relief you need in a time frame that works for you. With concrete exercises that require no more than 10 minutes each, The Stress Management Workbook will help you build sustainable stress management skills for significantly reducing stress—now and for the future.In The Stress Management Workbook, leading stress management and mental wellness expert Dr. Ruth White teaches you how to keep your brain sharp, improve your mind's response to stress, and develop strategies for minimizing stress. This fresh set of stress management skills will empower you to perform better at work, increase your energy, foster better relationships, and be healthier in both mind and body.Effective and easy-to-follow, The Stress Management Workbook will teach you to:Identify sources of stress through checklists, quizzes, and other informative activitiesSet personal stress management goals that will prepare you for the work you're about to doLearn to handle stress in the moment with interactive exercises that require no more than one, five, or ten minutesBuild long-term strategies that support your personal goals and foster positive lifestyle changes for a more fulfilling lifeA happier, stress-free life is within reach. Learn how to change the way you respond to stress in your daily life with the practical guidance in The Stress Management Workbook.
Warm Wishes from Sunny St. Pete: The Success Story of Promoting the Sunshine City
by Nevin SitlerSt. Petersburg was the first American city to hire a public relations director and the first to initiate a successful advertising program. More than almost any other Florida city, St. Petersburg relied on a constant message in postcards, newspaper editorials, print ads and broadcast commercials to market itself as the nation's playground. By the early 1900s, this sleepy fishing village had become the tourist destination of choice for thousands of winter-weary northerners. Early enthusiasts claimed the sun-filled peninsula was "the southern garden of perpetual well-being." Their methods ranged from serious academic papers to outrageous bathing suit inspections and "world record" schemes. Join" "historian Nevin D. Sitler as he presents an entertaining look at the men who crafted the promotion of paradise..
The Ghostly Tales of Galveston (Spooky America)
by Kathleen Shanahan MacaWelcome to the spooky streets of Galveston!Stay alert! Ghosts lurk around every corner. Even the most unexpected places might be haunted by wandering phantoms.Did you know that the worst natural disaster in American history happened here, leaving behind thousands of ghosts? Or that the spirit of the famous pirate Jean Lafitte still roams the Galveston coast? Can you believe that a tourist attraction that claims to be haunted (just for fun), is really haunted?Pulled right from history, these ghostly tales will change the way you see Galveston, and have you sleeping with the light on!??????????????????????????????????????????????????????????????
Ultrafiltration and Microfiltration Handbook
by Munir CheryanSoon after its publication in 1987, the first edition of Ultrafiltration Handbook became recognized as the leading handbook on ultrafiltration technology. Reviews in professional journals praised it as an authoritative and substantive information resource on this technology. Now a completely, updated and expanded edition is available under the titl
Transcendental Representations with Applications to Solids and Fluids (Mathematics and Physics for Science and Technology)
by Luis Manuel Braga da Costa CamposBuilding on the author's previous book in the series, Complex Analysis with Applications to Flows and Fields (CRC Press, 2010), Transcendental Representations with Applications to Solids and Fluids focuses on four infinite representations: series expansions, series of fractions for meromorphic functions, infinite products for functions with infinit
Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues
by Ronald J. Kendall Stephen B. CoxUpdating the extremely successful Wildlife Toxicology and Population Modeling (CRC Press, 1994), Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues brings together a distinguished group of international contributors, who provide a global assessment of a range of environmental stressors, including pesticides, environmental contaminant
The Immunological Basis of Asthma
by Zuzana Diamant Bart N. Lambrecht Henk C. HoogstedenThis text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and aller