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Bioinformatics Programming in Python: A Practical Course for Beginners
by Ruediger-Marcus FlaigThis first introductory book designed to train novice programmers is based on a student course taught by the author, and has been optimized for biology students without previous experience in programming. By interspersing theory chapters with numerous small and large programming exercises, the author quickly shows readers how to do their own programming, and throughout uses anecdotes and real-life examples from the biosciences to 'spice up' the text. This practical book thus teaches essential programming skills for life scientists who want -- or need -- to write their own bioinformatics software tools.
Yeast: Molecular and Cell Biology
by Horst FeldmannYeast is one of the oldest domesticated organisms and has both industrial and domestic applications. In addition, it is very widely used as a eukaryotic model organism in biological research and has offered valuable knowledge of genetics and basic cellular processes. In fact, studies in yeast have offered insight in mechanisms underlying ageing and diseases such as Alzheimers, Parkinsons and cancer. Yeast is also widely used in the lab as a tool for many technologies such as two-hybrid analysis, high throughput protein purification and localization and gene expression profiling. The broad range of uses and applications of this organism undoubtedly shows that it is invalubale in research, technology and industry. Written by one of the world's experts in yeast, this book offers insight in yeast biology and its use in studying cellular mechanisms.
Industry Immersion Learning: Real-Life Industry Case-Studies in Biotechnology and Business
by William Barrett Lucia Clontz Cedric Pearce Alan Woodall John Shaeffer Lisbeth Borbye Amy Peterson Elaine Sale Michael StocumHow to Create and Conduct Real-Life Reusable Case Studies with Industry Employer Alliances and Projects Written and Endorsed by Science and Business Professionals in the Research Triangle Park in North Carolina, USA. Many students and university teachers are unfamiliar with the industry environment. Case studies developed in collaboration with working professionals can help students and professors bridge the gap between universities and industry. This book provides guidance on how to approach industry professionals and create educational alliances. The strategy of establishing contact with industry employers and the process of developing and teaching case-studies are described. Among the case-studies are examples of how to identify biomarkers and new drugs simultaneously, prioritize and develop products in compliance with rules and regulations, commercialize products and protect and manage the intellectual property, optimize processes and technologies for manufacturing, and minimize human errors in production.
Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives
by Roland KontermannFor this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
Epigenetics and Human Health: Linking Hereditary, Environmental and Nutritional Aspects
by Alexander G. Haslberger Sabine GresslerAfter first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.
Next-Generation Genome Sequencing: Towards Personalized Medicine
by Michal JanitzWritten by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.
Medical Product Regulatory Affairs: Pharmaceuticals, Diagnostics, Medical Devices
by Gary Walsh John J. TobinWritten in a clear and concise style by an experienced author, this attractively-priced book covers regulatory affairs in all major global markets for pharmaceuticals and medical devices, making it the most comprehensive in its field. Following a look at drug development, complete sections are devoted to national and EU regulatory issues, manufacturing license application and retention, and regulation in the USA. Other topics dealt with include CDER, CBER and marketing and manufacturing licenses, the ICH process and Good Laboratory/Clinical/Manufacturing Practices. Everything pharmacologists, bioengineers, pharma engineers, students in pharmacy and those working in the pharmaceutical industry need to know about medical regulatory affairs.
Proteomics Sample Preparation
by Jörg Von HagenThis long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics (Developmental Perspectives In Psychiatry Ser.)
by Elizabeth A. Thiele David J. Kwiatkowski Vicky Holets WhittemoreThe only comprehensive overview of the molecular basis and clinical features of the genetic disorder tuberous sclerosis, which affects approximately 50,000 people in the US alone. Special focus is placed on novel insights into the signal transduction pathways affected by the disease as well as genotype phenotype correlations, while existing and potential therapies are also discussed in depth. The editors are leading experts in research and treatment of the disease as well as the Vice President of the Tuberous Sclerosis Alliance, the only voluntary health organization for TSC in the US.
Lithium Ion Rechargeable Batteries: Materials, Technology, and New Applications
by Kazunori OzawaStarting out with an introduction to the fundamentals of lithium ion batteries, this book begins by describing in detail the new materials for all four major uses as cathodes, anodes, separators, and electrolytes. It then goes on to address such critical issues as self-discharge and passivation effects, highlighting lithium ion diffusion and its profound effect on a battery's power density, life cycle and safety issues. The monograph concludes with a detailed chapter on lithium ion battery use in hybrid electric vehicles. Invaluable reading for materials scientists, electrochemists, physicists, and those working in the automobile and electrotechnical industries, as well as those working in computer hardware and the semiconductor industry.
Beyond Oil and Gas
by George A. Olah G. K. Prakash Alain GoeppertThe world is currently consuming about 85 million barrels of oil a day, and about two-thirds as much natural gas equivalent, both derived from non-renewable natural sources. In the foreseeable future, our energy needs will come from any available alternate source. Methanol is one such viable alternative, and also offers a convenient solution for efficient energy storage on a large scale.In this updated and enlarged edition, renowned chemists discuss in a clear and readily accessible manner the pros and cons of humankind's current main energy sources, while providing new ways to overcome obstacles.Following an introduction, the authors look at the interrelationship of fuels and energy, and at the extent of our non-renewable fossil fuels. They also discuss the hydrogen economy and its significant shortcomings. The main focus is on the conversion of CO2 from industrial as well as natural sources into liquid methanol and related DME, a diesel fuel substitute that can replace LNG and LPG. The book is rounded off with an optimistic look at future possibilities. A forward-looking and inspiring work that vividly illustrates potential solutions to our energy and environmental problems.
Beyond Oil and Gas: The Methanol Economy
by George A. Olah Alain Goeppert G. K. PrakashThe world is currently consuming about 85 million barrels of oil a day, and about two-thirds as much natural gas equivalent, both derived from non-renewable natural sources. In the foreseeable future, our energy needs will come from any available alternate source. Methanol is one such viable alternative, and also offers a convenient solution for efficient energy storage on a large scale.In this updated and enlarged edition, renowned chemists discuss in a clear and readily accessible manner the pros and cons of humankind's current main energy sources, while providing new ways to overcome obstacles.Following an introduction, the authors look at the interrelationship of fuels and energy, and at the extent of our non-renewable fossil fuels. They also discuss the hydrogen economy and its significant shortcomings. The main focus is on the conversion of CO2 from industrial as well as natural sources into liquid methanol and related DME, a diesel fuel substitute that can replace LNG and LPG. The book is rounded off with an optimistic look at future possibilities. A forward-looking and inspiring work that vividly illustrates potential solutions to our energy and environmental problems.
Geothermal Energy Systems: Exploration, Development, and Utilization
by Ernst HuengesPresenting boundary conditions for the economic and environmental utilization of geothermal technology, this is the first book to provide basic knowledge on the topic in such detail. The editor is the coordinator of the European Geothermic Research Initiative, while the authors are experts for the various geological situations in Europe with high temperature reservoirs in shallow and deep horizons. With its perspectives for R&D in geothermic technology concluding each chapter, this ready reference will be of great value to scientists and decision-makers in research and politics, as well as those giving courses in petroleum engineering, for example.
Energy Demand and Climate Change: Issues and Resolutions
by Franklin Hadley CocksThis scientifically sound, yet easily readable book provides the fundamentals necessary to understand today's energy and climate problems and provides possible answers based on current technology such as solar, water and geothermal power. Moreover, it introduces the reader to new concepts that are already or may soon be realized, such as nuclear fusion or a hydrogen-based economy. Aimed at a wide readership ranging from educated laypeople and students to practitioners in engineering and environmental science.
Tag-based Next Generation Sequencing (Molecular Plant Biology Ser.)
by Matthias Harbers Günter KahlTag-based approaches were originally designed to increase the throughput of capillary sequencing, where concatemers of short sequences were first used in expression profiling. New Next Generation Sequencing methods largely extended the use of tag-based approaches as the tag lengths perfectly match with the short read length of highly parallel sequencing reactions. Tag-based approaches will maintain their important role in life and biomedical science, because longer read lengths are often not required to obtain meaningful data for many applications. Whereas genome re-sequencing and de novo sequencing will benefit from ever more powerful sequencing methods, analytical applications can be performed by tag-based approaches, where the focus shifts from 'sequencing power' to better means of data analysis and visualization for common users. Today Next Generation Sequence data require powerful bioinformatics expertise that has to be converted into easy-to-use data analysis tools. The book's intention is to give an overview on recently developed tag-based approaches along with means of their data analysis together with introductions to Next-Generation Sequencing Methods, protocols and user guides to be an entry for scientists to tag-based approaches for Next Generation Sequencing.
Melanins and Melanosomes: Biosynthesis, Structure, Physiological and Pathological Functions
by Jan Borovansky Patrick A. RileyThe surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.
NMR of Biomolecules: Towards Mechanistic Systems Biology
by Ivano Bertini Giacomo Parigi Kathleen S. McGreevyNMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.
Zooming in: The Cosmos at High Resolution (Reviews in Modern Astronomy #23)
by Regina Von BerlepschHigh resolution is a key element in research in astronomy and cosmology. Advances in instrumentation and new methods are enabling us to constantly make new exciting discoveries, and progress in theoretical modelling allows us to gain a deeper understanding of cosmic physics. One example of this progress in instrumentation and observing strategy have made possible the discovery of a rich population of low-mass planets orbiting solar-type stars (Michel Mayor et al., Karl Schwarzschild Lecture 2010). This 23rd volume in the series Reviews of Modern Astronomy contains 14 invited reviews and highlight contributions presented during the 2010 annual meeting of the Astronomical Society on the topic "Zooming in: The cosmos at high resolution", held in Bonn, Germany, in September 2010.
Modeling and Prediction of Polymer Nanocomposite Properties (Polymer Nano-, Micro- and Macrocomposites)
by Vikas MittalThe book series 'Polymer Nano-, Micro- and Macrocomposites' provides complete and comprehensive information on all important aspects of polymer composite research and development, including, but not limited to synthesis, filler modification, modeling, characterization as well as application and commercialization issues. Each book focuses on a particular topic and gives a balanced in-depth overview of the respective subfi eld of polymer composite science and its relation to industrial applications. With the books the readers obtain dedicated resources with information relevant to their research, thereby helping to save time and money. This book lays the theoretical foundations and emphasizes the close connection between theory and experiment to optimize models and real-life procedures for the various stages of polymer composite development. As such, it covers quantum-mechanical approaches to understand the chemical processes on an atomistic level, molecular mechanics simulations to predict the filler surface dynamics, finite element methods to investigate the macro-mechanical behavior, and thermodynamic models to assess the temperature stability. The whole is rounded off by a look at multiscale models that can simulate properties at various length and time scales in one go - and with predictive accuracy.
Materials for High-Temperature Fuel Cells
by San Ping Jiang Max Lu Yushan YanThe world's ever-growing demand for power has created an urgent need for new efficient and sustainable sources of energy and electricity. Today's consumers of portable electronics also demand devices that not only deliver more power but are also environmentally friendly. Fuel cells are an important alternative energy source, with promise in military, commercial and industrial applications, for example power vehicles and portable devices.A fuel cell is an electrochemical device that directly converts the chemical energy of a fuel into electrical energy. Fuel cells represent the most efficient energy conversion technologies to-date and are an integral part in the new and renewable energy chain (e.g., solar, wind and hydropower). Fuel cells can be classified as either high-temperature or lowtemperature, depending on their operating temperature, and have different materials requirements. This book is dedicated to the study of high temperature fuel cells. In hightemperature fuel cells, the electrolyte materials are ceramic or molten carbonate, while the electrode materials are ceramic or metal (but not precious metal). High operation temperature fuel cells allow internal reforming, promote rapid kinetics with non-precious materials and offer high flexibilities in fuel choice, and are potential and viable candidate to moderate the fast increase in power requirements and to minimize the impact of theincreased power consumption on the environment.'Materials for High Temperature Fuel Cells' is part of the series on Materials for Sustainable Energy and Development edited by Prof. Max Q. Lu. The series covers advances in materials science and innovation for renewable energy, clean use of fossil energy, and greenhouse gas mitigation and associated environmental technologies.
Handbook of Wafer Bonding
by Maaike M. Taklo James Jian-Qiang Lu Peter RammThe focus behind this book on wafer bonding is the fast paced changes in the research and development in three-dimensional (3D) integration, temporary bonding and micro-electro-mechanical systems (MEMS) with new functional layers. Written by authors and edited by a team from microsystems companies and industry-near research organizations, this handbook and reference presents dependable, first-hand information on bonding technologies. Part I sorts the wafer bonding technologies into four categories: Adhesive and Anodic Bonding; Direct Wafer Bonding; Metal Bonding; and Hybrid Metal/Dielectric Bonding. Part II summarizes the key wafer bonding applications developed recently, that is, 3D integration, MEMS, and temporary bonding, to give readers a taste of the significant applications of wafer bonding technologies.This book is aimed at materials scientists, semiconductor physicists, the semiconductor industry, IT engineers, electrical engineers, and libraries.
Metal-Fluorocarbon Based Energetic Materials
by Ernst-Christian KochMetal-Fluorocarbon Based Energetic Materials This exciting new book details all aspects of a major class of pyrolants and elucidates the progress that has been made in the field, covering both the chemistry and applications of these compounds. Written by a pre-eminent authority on the subject from the NATO Munitions Safety Information Analysis Center (MSIAC), it begins with a historical overview of the development of these materials, followed by a thorough discussion of their ignition, combustion and radiative properties. The next section explores the multiple facets of their military and civilian applications, as well as industrial synthetic techniques. The critical importance of the associated hazards, namely sensitivity, stability and aging, are discussed in detail, and the book is rounded off by an examination of the future of this vital and expanding field.The result is a complete guide to the chemistry, manufacture, applications and required safety precautions of pyrolants for both the military and chemical industries.From the preface:“... This book fills a void in the collection of pyrotechnic literature... it will make an excellent reference book that all researchers of pyrolants and energetics must have...” Dr. Bernard E. Douda, Dr. Sara Pliskin, NAVSEA Crane, IN, USA
Analytical Methods in Supramolecular Chemistry
by Christoph A. SchalleyThe second edition of "Analytical Methods in Supramolecular Chemistry" comes in two volumes and covers a broad range of modern methods and techniques now used for investigating supramolecular systems, e. g. NMR spectroscopy, mass spectrometry, extraction methods, crystallography, single molecule spectroscopy, electrochemisty, and many more. In this second edition, tutorial inserts have been introduced, making the book also suitable as supplementary reading for courses on supramolecular chemistry. All chapters have been revised and updated and four new chapters have been added.A must-have handbook for Organic and Analytical Chemists, Spectroscopists, Materials Scientists, and Ph.D. Students in Chemistry.From reviews of the first edition:"This timely book should have its place in laboratories dealing with supramolecular objects. It will be a source of reference for graduatestudents and more experienced researchers and could induce new ideas on the use of techniques other than those usually used in the laboratory."Journal of the American Chemical Society (2008) VOL. 130, NO. 1 doi: 10.1021/ja0769649"The book as a whole or single chapters will stimulate the reader to widen his horizon in chemistry and will help him to have new ideas in his research."Anal Bioanal Chem (2007) 389:2039-2040 DOI: 10.1007/s00216-007-1677-1
Synthesis of Polymers: New Structures and Methods (Materials Science and Technology: A Comprehensive Treatment)
by Junji Sakamoto Craig Hawker Uuml Ter Dieter A. SchlPolymers are huge macromolecules composed of repeating structural units. While polymer in popular usage suggests plastic, the term actually refers to a large class of natural and synthetic materials. Due to the extraordinary range of properties accessible, polymers have come to play an essential and ubiquitous role in everyday life - from plastics and elastomers on the one hand to natural biopolymers such as DNA and proteins on the other hand. The study of polymer science begins with understanding the methods in which these materials are synthesized. Polymer synthesis is a complex procedure and can take place in a variety of ways. This book brings together the "Who is who" of polymer science to give the readers an overview of the large field of polymer synthesis. It is a one-stop reference and a must-have for all Chemists, Polymer Chemists, Chemists in Industry, and Materials Scientists.
Polymers in Industry from A to Z: A Concise Encyclopedia
by Leno MasciaWe are surrounded by polymers: Whether it's to prepare a meal, use computer keyboards and mousepads, or step onto a new playground, you'll encounter a plastic product made of polymers.<P><P> Owing to the extraordinary range of properties accessible in polymeric materials, they play an essential and ubiquitous role in everyday life - from plastics and elastomers on the one hand to natural biopolymers such as DNA and proteins that are essential for life on the other. This desktop and library reference book provides a comprehensive yet concise overview of the materials, manufacture, structure and architecture, properties, processing, and applications of withing the field of polymers. The book offers a unique mix of theory and application, the essential personal reference for anyone studying or working within the field of polymers.