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Behavioral Neurobiology of Eating Disorders (Current Topics in Behavioral Neurosciences #6)
by Roger A.H. Adan Walter H. KayeThe intention of this book was to have investigators describe an expert opinion on their field of research and cutting-edge work in their laboratory on the neurobiology and treatment of eating disorders.
Behavioral Neurobiology of GABAB Receptor Function (Current Topics in Behavioral Neurosciences #52)
by Styliani Vlachou Kevin WickmanIt has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors.The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives.The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Current Topics in Behavioral Neurosciences #22)
by Hoa Huu Phuc Nguyen M. Angela CenciMotor dysfunction and cognitive impairment are major symptoms in both Huntington's Disease (HD) and Parkinson's Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e. g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Behavioral Neurobiology of Psychedelic Drugs (Current Topics In Behavioral Neurosciences Ser. #36)
by David E. Nichols Franz X. Vollenweider Adam L. HalberstadtThis volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.
Behavioral Neurobiology of PTSD (Current Topics in Behavioral Neurosciences #38)
by Eric Vermetten Dewleen G. Baker Victoria B. RisbroughThis volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders, (2) the biological and psychological constructs that support risk and resiliency for trauma disorders, and (3), novel treatment strategies and therapeutics on the horizon.
Behavioral Neurobiology of Schizophrenia and Its Treatment (Current Topics in Behavioral Neurosciences #4)
by Neal R. SwerdlowThis book describes the state-of-the-art of treatment of schizophrenia and reflects its development in 22 chapters written by leading authorities in the field
Behavioral Neurobiology of Stress-related Disorders (Current Topics in Behavioral Neurosciences #18)
by Carmine M. Pariante M. Danet Lapiz-BluhmStress is such an over-used word that it is at time difficult to define its core features. When is an environment stressful? What does a stressful environment do to the brain and to the body? What are the biological mechanisms by which a stressor affects us? How does stress contributes to the onset and the progression of mental disorders? How do the effects of stress change over the life-time of an individual? These are just some of the overarching questions addressed by this book, thanks to the contribution of some of the world leading experts on the neurobiology of stress at the pre-clinical and clinical levels. Topics include current advances on the neurobiology of stress on various neurobiological systems such as immune, hypothalamic-pituitary-adrenal (HPA) axis, neurogenesis and neuroplasticity, neurotransmitter (glutamate, noradrenaline, dopamine, serotonin and endocannabinoid), neuropeptides, cognition and emotional processing as well as in utero and early postnatal effects. The clinical chapters deal with the relationship of stress and mental disorders such as depression, posttraumatic stress disorder (PTSD), anxiety disorders, schizophrenia, bipolar disorder, substance abuse and addiction, dementia and age-related cognitive decline as well as resilience to stress. Thus, this book brings together some of the most updated and authoritative views on the effects of stress of brain and behavior.
Behavioral Neurobiology of Suicide and Self Harm (Current Topics in Behavioral Neurosciences #46)
by Enrique Baca-GarciaThis book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.
Behavioral Neurobiology of the Endocannabinoid System (Current Topics in Behavioral Neurosciences #1)
by Stephen Alexander Dave KendallThe endocannabinoid signaling system is one of the key modulators of central nervous function. This volume provides timely and in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior. It is essential reading for any researcher with a background in neuroscience wanting to know more about the endocannabinoids.
Behavioral Neuroendocrinology
by Barry R. Komisaruk Gabriela González-MariscalInspired by Carlos Beyer’s 50 years of pioneering research and influence on his students and colleagues, Behavioral Neuroendocrinology builds upon Beyer’s fundamental discoveries and concepts as well as their widespread implications. It presents original research and reviews on mechanisms — genomic and non-genomic — of steroid and protein hormone action; the role of steroid metabolism, especially aromatization, protein phosphorylation, and neurotransmitter action in mediating reproductive behavior and sexual differentiation; and brain and spinal cord mechanisms in sexual behavior and analgesia. This book presents a rich diversity of topics — lactation, maternal behavior, pheromone action, chronobiology, allodynia, angiogenesis, prostate physiology, sexual motivation, and specific brain systems, including vomeronasal system, cerebellum, preoptic area, hypothalamus, and spinal cord. This book brings together, in one source, an international "family" of researchers whose work has evolved in diverse but related ways from a seminal set of discoveries and concepts in behavioral neuroendocrinology.
Behavioral Neurogenetics (Current Topics in Behavioral Neurosciences #12)
by Andreas Reif John F. CryanThis book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
Behavioral Neurogenetics (Neuromethods #181)
by Daisuke YamamotoThis volume looks at the framework in which different scientific disciplines are integrated into the latest studies in behavioral neurogenetics, and covers new approaches toward understanding the system that controls behavior across the animal kingdom. Chapters in this book cover topics such as mapping brain-wide mesoscale connectome from single animals with BRICseq; gut microbes and Drosophila behavior; bioassaying the function of pheromones in Drosophila melanogaster’s social behavior; automated behavior analysis using a YOLO-based object detection system; and proteomic analysis of C. elegans neurons using TurboID-based proximity labeling. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Behavioral Neurogenetics is a valuable resource for experienced and novice researchers interested in learning more about this field and its future developments.
Behavioral Neurogenomics (Current Topics in Behavioral Neurosciences #42)
by Elisabeth B. Binder Torsten KlengelThis book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease. It focuses on our current understanding of genetic and epigenetic mechanisms of brain function and how they contribute to the complex formation of behavioral traits and psychiatric disorders. Readers experience diverse perspectives of the contributing authors starting from the genetic viewpoint and the effort to establish functional connection between genetic variants and behavioral phenotypes. Particular attention is given to the broad spectrum of epigenetic mechanisms and behavior.The chapter 'Role of MicoRNAs in Anxiety and Anxiety-Related Disorders' is available open access under a CC BY 4.0 license at link.springer.com
Behavioral Neurology in the Elderly
by Jose Leon-Carrion Margaret GianniniIt is important to understand the relationship between the brain, cognition and behavior when providing care to the elderly. Behavioral Neurology in the Elderly provides a comprehensive overview of this significant relationship, one of the most important topics concerning medical and behavioral gerontology today. It provides insight into how the ag
Behavioral Neurology & Neuropsychiatry
by David B. Arciniegas C. Alan Anderson Christopher M. Filley T. Angelita GarciaThe merger of behavioral neurology and neuropsychiatry into a single medical subspecialty, Behavioral Neurology & Neuropsychiatry, requires an understanding of brain-behavior relationships and a clinical approach that transcends the traditional perspectives of neurology and psychiatry. Designed as a primer of concepts and principles, and authored by a multidisciplinary group of internationally known clinical neuroscientists, this book divides into three sections: * Structural and Functional Neuroanatomy (Section I) addresses the neuroanatomy and phenomenology of cognition, emotion, and behavior * Clinical Assessment (Section II) describes neuropsychiatric history taking, neurological and mental status examinations, neuropsychological assessment, and neuroimaging, electrophysiologic, and laboratory methods * Treatment (Section III) discusses environmental, behavioral, rehabilitative, psychological, social, pharmacological, and procedural interventions for cognitive, emotional, and behavioral disorders. By emphasizing the principles of Behavioral Neurology & Neuropsychiatry, this book will improve your understanding of brain-behavior relationships and inform your care of patients and families affected by neurobehavioral disorders. David B. Arciniegas, MD is the Michael K. Cooper Professor of Neurocognitive Disease, Director of the Neurobehavioral Disorders Program, and Associate Professor of Psychiatry and Neurology at the University of Colorado School of Medicine. C. Alan Anderson, MD is Professor of Neurology, Emergency Medicine, and Psychiatry at the University of Colorado School of Medicine, and Staff Neurologist at the Denver Veterans Affairs Medical Center. Christopher M. Filley, MD is Professor of Neurology and Psychiatry, and Director of the Behavioral Neurology Section at the University of Colorado School of Medicine, and Neurology Service Chief at the Denver Veterans Affairs Medical Center.
The Behavioral Neurology of Dementia
by Miller Bruce L. Boeve Bradley F.The Behavioral Neurology of Dementia is a comprehensive textbook that offers a unique and modern approach to the diagnosis and treatment of patients with dementing conditions in the twenty-first century. The coverage is broad, ranging from common conditions such as Alzheimer's disease, Parkinsonian disorders, vascular and frontotemporal dementia, to the more obscure such as Jakob-Creutzfeldt disease. Subtypes of mild cognitive impairment are presented and the early prodromes of neurodegenerative diseases are explored. Simple approaches to bedside mental status testing, differential diagnosis and treatment, genetic testing, interpreting neuropsychological testing and neuroimaging findings, and assessing rapidly progressive dementias, paraneoplastic syndromes, and disorders of white matter give guidance to both the novice and expert in dementia. The basic science of dementia is outlined in introductory chapters on animal models of dementia, dementia epidemiology and dementia neuropathology.
Behavioral Neuroscience: Essentials and Beyond
by Stéphane GaskinBehavioral Neuroscience: Essentials and Beyond shows students the basics of biological psychology using a modern and research-based perspective. With fresh coverage of applied topics and complex phenomena, including social neuroscience and consciousness, author Stéphane Gaskin delivers the most current research and developments surrounding the brain′s functions through student-centered pedagogy. Carefully crafted features introduce students to challenging biological and neuroscience-based concepts through illustrations of real-life application, exploring myths and misconceptions, and addressing students′ assumptions head on.
Behavioral Neuroscience: Essentials and Beyond
by Stéphane GaskinBehavioral Neuroscience: Essentials and Beyond shows students the basics of biological psychology using a modern and research-based perspective. With fresh coverage of applied topics and complex phenomena, including social neuroscience and consciousness, author Stéphane Gaskin delivers the most current research and developments surrounding the brain′s functions through student-centered pedagogy. Carefully crafted features introduce students to challenging biological and neuroscience-based concepts through illustrations of real-life application, exploring myths and misconceptions, and addressing students′ assumptions head on.
Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder and Its Treatment (Current Topics in Behavioral Neurosciences #9)
by Rosemary Tannock Clare StanfordIn this volume there is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long-term use.
Behavioral Neuroscience of Drug Addiction (Current Topics in Behavioral Neurosciences #3)
by Julie K. Staley Gottschalk David W. SelfThis volume highlights current state-of-the-art approaches and important findings on the behavioral neurobiology of drug addiction by prominent neuroscientists. Preclinical chapters span synaptic neuroplasticity associated with drug use, the neural systems underlying conditioned drug effects implicated in drug craving, and the role of sensitization and withdrawal processes in addictive behavior. Chapters on human studies emphasize neuroimaging of neurotransmitters and receptors, drug craving and other cognitive abnormalities in human drug abusers. Human studies also describe work on genetic vulnerability and the neuroeconomics of drug addiction, and novel pharmacological approaches to drug abuse treatment.
The Behavioral Neuroscience of Drug Discrimination (Current Topics in Behavioral Neurosciences #39)
by Joseph H. Porter Adam J. PrusThe goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has provided immense translational value for learning about the mechanisms responsible for drug effects in humans.
Behavioral Neuroscience of Learning and Memory (Current Topics In Behavioral Neurosciences Ser. #37)
by Stephen J. Martin Robert E. Clark‘Behavioral Neuroscience of Learning and Memory’ brings together the opinions and expertise of some of the world’s foremost neuroscientists in the field of learning and memory research. The volume provides a broad coverage of contemporary research and thinking in this field, focusing both on well established topics such as the medial temporal lobe memory system, as well as emerging areas of research such as the role of memory in decision making and the mechanisms of perceptual learning. Key intersecting themes include the molecular and cellular mechanisms of memory formation, the multiplicity of memory systems in the brain, and the way in which technological innovation is driving discovery. Unusually for a volume of this kind, this volume brings together research from both humans and animals—often relatively separate areas of discourse—to give a more comprehensive and integrated view of the field. The book will be of interest to both established researchers who wish to broaden their knowledge of topics outside of their specific areas of expertise, and for students who need a resource to help them make sense of the vast scientific literature on this subject.
Behavioral Neuroscience of Motivation (Current Topics in Behavioral Neurosciences #27)
by Eleanor H. Simpson Peter D. BalsamThis volume covers the current status of research in the neurobiology of motivated behaviors in humans and other animals in healthy condition. This includes consideration of the psychological processes that drive motivated behavior and the anatomical, electrophysiological and neurochemical mechanisms which drive these processes and regulate behavioural output. The volume also includes chapters on pathological disturbances in motivation including apathy, or motivational deficit as well as addictions, the pathological misdirection of motivated behavior. As with the chapters on healthy motivational processes, the chapters on disease provide a comprehensive up to date review of the neurobiological abnormalities that underlie motivation, as determined by studies of patient populations as well as animal models of disease. The book closes with a section on recent developments in treatments for motivational disorders.
Behavioral Neuroscience of Orexin/Hypocretin (Current Topics in Behavioral Neurosciences #33)
by Andrew J. Lawrence Luis De LeceaThis issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical perspective, genetic polymorphisms in hypocretin/orexin and orexin receptors are implicated in a number of psychiatric disorders. In addition, advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians.
The Behavioral Neuroscience of Tinnitus (Current Topics in Behavioral Neurosciences #51)
by Grant D. Searchfield Jinsheng ZhangThe origins of tinnitus and the development of effective treatments to treat tinnitus have puzzled scientists and clinicians for centuries. Now ground breaking research is beginning to unlock its secrets. The Behavioral Neuroscience of Tinnitus provides critical and comprehensive discussions of the most recent developments in behavioral neuroscience research of tinnitus. Each chapter represents the most important contemporary account of the subject, with an emphasis on preclinical and clinical trials for the development of new diagnostics and therapeutics. New and emerging innovative approaches are covered whenever possible. Six topics are discussed in detail in this volume, which provide new insights in the etiology and mechanisms of tinnitus, new biomarkers towards objective and reliable diagnosis of tinnitus, pharmacological approaches towards curing tinnitus, bioengineering advances towards developing effective medical devices, as well as the latest in psychotherapy methods. The reviews in the volume expose researchers and clinicians, both new and experienced, to exciting advancements and state-of-the-art developments from preeminent researchers in the field of tinnitus.