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Introduction to Biologic and Biosimilar Product Development and Analysis (AAPS Introductions in the Pharmaceutical Sciences)
by Karen M. NagelThe purpose of this book is to give a concise introduction to development and analysis of pharmaceutical biologics for those in the pharmaceutical industry who are switching focus from small molecules to biologics processing, analysis, and delivery. In order to maintain a limited focus, Introduction to Biologic and Biosimilar Product Development and Analysis, will deal only with peptides, proteins and monoclonal antibodies.
A Life of Experimental Economics, Volume II: The Next Fifty Years
by Vernon L. SmithThis sequel to A Life of Experimental Economics, Volume I, continues the intimate history of Vernon Smith’s personal and professional maturation after a dozen years at Purdue. The scene now shifts to twenty-six transformative years at the University of Arizona, then to George Mason University, and his recognition by the Nobel Prize Committee in 2002. The book ends with his most recent decade at Chapman University. At Arizona Vernon and his students studied asset trading markets and learned how wrong it had been to suppose that price bubbles could not occur where markets were full-information transparent. Their work in computerization of the lab facilitated very complex supply and demand experiments in natural gas pipeline, communication and electricity markets that paved the way for implementing, through decentralized market processes, the liberalization of industries traditionally believed to be “natural” monopolies. The “Smart Computer Assisted Market” was born. Smith’s move to George Mason University greatly facilitated government and industry work in tandem with various public and private entities, whereas his relocation to Chapman University coincided with the Great Recession, whose similarity with the Depression was evident in his research. There he integrated two fundamental kinds of markets with laboratory experiments: Consumer non-durables, the supply and demand for which was stable in the lab and in the economy, and durable assets whose bubble tendencies made them unstable in the lab as well as in the economy—witness the great housing-mortgage market bubble run-up of 1997-2007. This book’s conversational style and emphasis on the backstory of published research accomplishments allows readers an exclusive peak into how and why economists pursue their work. It’s a must-read for those interested in experimental economics, the housing crisis, and economic history.
Spinal Tumor Surgery: A Case-based Approach
by Daniel M. SciubbaThis practical, step-wise text covers the surgical approaches, resection strategies and reconstruction techniques used for each type of presenting tumor of the spine. Demonstrating the variety of anterior, posterior and intradural approaches and stabilization techniques, and spanning from pathologies of the craniocervical region to sacral and intradural pathologies, each chapter is generously illustrated with figures, radiographs and intraoperative photos. The chapters themselves follow a consistent and user-friendly format: the anatomy and biomechanics of a specific region, patient evaluation, essential oncologic principles, the decision-making process, and technical steps of surgery. A representative case illustration is provided at the conclusion of each chapter, exemplifying pertinent concepts described. Additionally, video segments accompany selected chapters, providing real-time illustration of surgical techniques. <p><p> Technical and in-depth, yet highly accessible, Spinal Tumor Surgery: A Case-Based Approach is an essential resource for orthopedic spine surgeons, neurosurgeons, and surgical oncologists operating on tumors of the spine.
Literatures of Liberalization: Global Circulation And The Long Nineteenth Century (New Comparisons In World Literature Series)
by Regenia GagnierThis book traces the global circulation of cultures and ideologies from the technological and democratic revolutions of the long nineteenth century to liberal and neoliberal modernity. Focussing on moments of coerced (colonial and postcolonial) and voluntary contact rather than national boundaries, the author draws attention to the global scope of literatures and geopolitical commodities as actants in world affairs, as in processes of liberalization, democratization, and trade, but also to the distinctiveness of each local environment at its moments of transculturation. Based in extensive experience in collaborative, multilingual, interdisciplinary networks, the book synthesizes existing theoretical scholarship, provides original case studies of world-historical Victorian and modern writers, and articulates a new interdisciplinary methodology for literary studies in a global context. It will be of interest to Victorianists, modernists, comparatists, political theorists, translators, and scholars of world literatures, world ecology, and globalization.
Personal Financial Planning for Executives and Entrepreneurs: The Path to Financial Peace of Mind
by Michael J. Nathanson Jeffrey T. Craig Jennifer A. Geoghegan Nadine Gordon Lee Michael A. Haber Seth P. Hieken Matthew C. Ilteris D. Scott McDonald Joseph A. Salvati Stephen R. StelljesEffective financial planning for executives and entrepreneurs is complex, dense, and impossible to reduce to a single, easy-to-understand formula. Designed to emphasize the importance of effective, targeted financial planning, this book begins by telling a story about a fictional, but plausible, power couple and their family who (spoiler alert!) do pretty much everything wrong in securing their financial future. In most cases, they don’t do the things needed because they don’t know what they are. Using this story as a case study of executives and entrepreneurs, the book breaks down the case into chapters and offers practical discussions of all the key financial planning pillars—investment planning, tax planning, estate planning, philanthropic planning, risk management, and equity-based compensation to name a few—with the tools needed to tailor a plan for virtually every circumstance and need. While there is no single plan that works for everybody, this book will provide a guide with complicated, technical information alongside specific guidance on how to build an effective financial plan.
Sleep in Children with Neurodevelopmental Disabilities: An Evidence-Based Guide
by Jennifer A. AccardoThis practical guide presents approaches to working with children and adolescents with neurodevelopmental disabilities who have sleep problems. Divided into four sections, the book begins with the impact of sleep problems in children with disabilities and the evaluation of sleep complaints. The next two sections cover the major categories of sleep disorders as they apply in children with disabilities, and specific neurodevelopmental disabilities with their characteristic sleep manifestations. The last section details options for treatment, which include behavioral and environmental strategies, occupational therapy, exercise, and medications. Chapters feature case studies that introduce and reinforce diagnostic and therapeutic approaches. Those engaged in the care of children with neurodevelopmental disabilities and sleep problems will find this text to be an invaluable guide when assessing and treating sleep disorders.
Mechanical Ventilation in Emergency Medicine
by Susan R. Wilcox Ani Aydin Evie G. MarcoliniThis book discusses mechanical ventilation in emergency settings, covering the management of patients from the time of intubation until transfer to the ICU. It provides an introduction to key concepts of physiology pertinent to mechanical ventilation as well as a review of the core evidence-based principles of ventilation. The text highlights the management of mechanical ventilation for critically ill patients with several conditions commonly encountered in EM practice, including acute respiratory distress syndrome, asthma, chronic obstructive pulmonary disease, and traumatic brain injury. It begins by reviewing terminology and definitions as well as pathophysiology and physiology. It then addresses the use of ventilators including modes of ventilation, pressures on the ventilators, understanding the screens, the variety of settings, and troubleshooting. It concludes with a series of case studies from emergency settings and a review of key concepts. Mechanical Ventilation in Emergency Medicine is an essential resource for emergency medicine clinicians including experienced physicians, EM residents, physician assistants, nurse practitioners, nurses, and medical students rotating in the ED as well as professionals who provide emergency care for ventilated patients outside the emergency department, including paramedics, critical care transport nurses, and hospitalists.
Symmetrization and Stabilization of Solutions of Nonlinear Elliptic Equations (Fields Institute Monographs #36)
by Messoud EfendievThis book deals with a systematic study of a dynamical system approach to investigate the symmetrization and stabilization properties of nonnegative solutions of nonlinear elliptic problems in asymptotically symmetric unbounded domains. The usage of infinite dimensional dynamical systems methods for elliptic problems in unbounded domains as well as finite dimensional reduction of their dynamics requires new ideas and tools. To this end, both a trajectory dynamical systems approach and new Liouville type results for the solutions of some class of elliptic equations are used. The work also uses symmetry and monotonicity results for nonnegative solutions in order to characterize an asymptotic profile of solutions and compares a pure elliptic partial differential equations approach and a dynamical systems approach. The new results obtained will be particularly useful for mathematical biologists.
A Life of Experimental Economics, Volume I: Forty Years of Discovery
by Vernon L. SmithThis book provides an intimate history of Nobel Laureate Vernon Smith’s early life, combining elements of biography, history, economics and philosophy to show how crucial incidents early in his life provided the necessary framework for his research into experimental economics. Smith takes the reader from his family roots on the railroads and oil fields of Middle America to his early life on a farm in Depression-wracked Kansas. A mediocre student in high school, Smith attended Friends University, on Wichita’s west side, where an intense study of mathematics, physics, chemistry, and astronomy enabled him to pass the examinations to enter Caltech and study under luminary scientists like Linus Pauling. Eventually Smith discovered economics and pursued graduate study in the field at University of Kansas and Harvard. This volume ends with his Camelot years at Purdue, where he began his famous work in experimental economics, nurturing his research into an unlikely new field of economics.
Quantum Photonics: Pioneering Advances and Emerging Applications
by Robert W. Boyd Svetlana G. Lukishova Victor N. ZadkovThis book brings together reviews by internationally renowed experts on quantum optics and photonics. It describes novel experiments at the limit of single photons, and presents advances in this emerging research area. It also includes reprints and historical descriptions of some of the first pioneering experiments at a single-photon level and nonlinear optics, performed before the inception of lasers and modern light detectors, often with the human eye serving as a single-photon detector. The book comprises 19 chapters, 10 of which describe modern quantum photonics results, including single-photon sources, direct measurement of the photon's spatial wave function, nonlinear interactions and non-classical light, nanophotonics for room-temperature single-photon sources, time-multiplexed methods for optical quantum information processing, the role of photon statistics in visual perception, light-by-light coherent control using metamaterials, nonlinear nanoplasmonics, nonlinear polarization optics, and ultrafast nonlinear optics in the mid-infrared.
Advances in Databases and Information Systems: 22nd European Conference, ADBIS 2018, Budapest, Hungary, September 2–5, 2018, Proceedings (Lecture Notes in Computer Science #11019)
by András Benczúr Bernhard Thalheim Tomáš HorváthThis book constitutes the proceedings of the 22nd European Conference on Advances in Databases and Information Systems, ADBIS 2018, held in Budapest, Hungary, in September 2018.The 17 regular papers presented together with two invited papers were carefully selected and reviewed from numerous submissions. The papers are organized in topical sections such as information extraction and integration; data mining and knowledge discovery; indexing, query processing and optimization; data quality and data cleansing; distributed data platforms, including cloud data systems, key-value stores, and big data systems; and streaming data analysis; web, XML and semi-structured databases.
Trust, Institutions and Managing Entrepreneurial Relationships in Africa: An SME Perspective (Palgrave Studies of Entrepreneurship in Africa)
by Isaac Oduro AmoakoThis book highlights the importance of understanding how trust and indigenous African cultural institutions enhance the development of entrepreneurial networks and relationships in Africa. Drawing on institutional theories, the author re-examines the way that entrepreneurial behaviour can be shaped, with a focus on trust, networks and the development of relationships. Analysing a combination of existing literature and empirical data from 50 internationally trading SMEs in Africa, this book reflects the growing interests of entrepreneurs, investors and corporate executives to develop trust and relationships with customers in order to invest and grow. By addressing the need for a greater understanding of how social and cultural institutions in Africa affect the continent’s economy, this book not only offers theoretical frameworks, but also future implications for practice and policy, and will provide essential reading for those studying emerging markets and globalisation, African business, and entrepreneurship more generally.
Projected Capacitive Touch: A Practical Guide for Engineers
by Tony GrayThis book covers ALL aspects of projected capacitive touch sensors including basic principles, the physics of PCAP, capacitance measurements, touch sensor materials and construction, electrical noise, software drivers, and testing. It is targeted at working engineers who are implementing touch into their products as well as anyone else with an interest in how touch screens work.· Offers readers the first book on the use of projected capacitive (PCAP) touch technology for touch screens; · Explains not only how PCAP touch works, but also addresses the implementation details an engineer needs when incorporating PCAP into their product; · Includes explanations of different cover lens materials, cover lens coatings, software drivers, touch testing, and many other areas of general knowledge that would be useful to a design engineer.
Nomic Truth Approximation Revisited (Synthese Library #399)
by Theo A. KuipersThis monograph presents new ideas in nomic truth approximation. It features original and revised papers from a (formal) philosopher of science who has studied the concept for more than 35 years.Over the course of time, the author's initial ideas evolved. He discovered a way to generalize his first theory of nomic truth approximation, viz. by dropping an unnecessarily strong assumption. In particular, he first believed to have to assume that theories were maximally specific in the sense that they did not only exclude certain conceptual possibilities, but also that all non-excluded possibilities were in fact claimed to be nomically possible.Now, he argues that the exclusion claim alone, or for that matter the inclusion claim alone, is sufficient to motivate the formal definition of being closer to the nomic truth. The papers collected here detail this generalized view of nomic truthlikeness or verisimilitude.Besides this, the book presents, in adapted form, the relation with several other topics, such as, domain revision, aesthetic progress, abduction, inference to the best explanation, pragmatic aspects, probabilistic methods, belief revision and epistemological positions, notably constructive realism.Overall, the volume presents profound insight into nomic truth approximation. This idea seeks to determine how one theory can be closer to, or more similar to, the truth about what is nomically, e.g. physically, chemically, biologically, possible than another theory. As a result, it represents the ultimate goal of theory oriented empirical science.Theo Kuipers is the author of Studies in Inductive Probability and Rational Expectation (1978), From Instrumentalism to Constructive Realism (2000) and Structures in Science (2001). He is the volume-editor of the Handbook on General Philosophy of Science (2007).In 2005 there appeared two volumes of Essays in Debate with Theo Kuipers, entitled Confirmation, Empirical Progress, and Truth Approximation and Cognitive Structures in Scientific Inquiry.
Trust, Privacy and Security in Digital Business: 15th International Conference, TrustBus 2018, Regensburg, Germany, September 5–6, 2018, Proceedings (Lecture Notes in Computer Science #11033)
by Steven Furnell Haralambos Mouratidis Günther PernulThis book constitutes the refereed proceedings of the 15th International Conference on Trust, Privacy and Security in Digital Business, TrustBus 2018, held in Regensburg, Germany, in September 2018 in conjunction with DEXA 2018. The 15 revised full papers presented were carefully reviewed and selected from 29 submissions. The papers are organized in the following topical sections: Permission models and cloud, privacy, proactive security measures, and cyber physical systems.
Media and the Cold War in the 1980s: Between Star Wars and Glasnost (Palgrave Studies in the History of the Media)
by Martin Klimke Rolf Werenskjold Henrik G. BastiansenThe Cold War was a media phenomenon. It was a daily cultural political struggle for the hearts and minds of ordinary people—and for government leaders, a struggle to undermine their enemies’ ability to control the domestic public sphere. This collection examines how this struggle played out on screen, radio, and in print from the late 1970s through the early 1990s, a time when breaking news stories such as Ronald Reagan’s “Star Wars” program and Mikhail Gorbachev’s policy of glasnost captured the world’s attention. Ranging from the United States to the Soviet Union and China, these essays cover photojournalism on both sides of the Iron Curtain, Polish punk, Norwegian film, Soviet magazines, and more, concluding with a contribution from Stuart Franklin, one of the creators of the iconic “Tank Man” image during the Tiananmen Square protests. By investigating an array of media actors and networks, as well as narrative and visual frames on a local and transnational level, this volume lays the groundwork for writing media into the history of the late Cold War.
Provenance and Annotation of Data and Processes: 7th International Provenance and Annotation Workshop, IPAW 2018, London, UK, July 9-10, 2018, Proceedings (Lecture Notes in Computer Science #11017)
by Khalid Belhajjame Ashish Gehani Pinar AlperThis book constitutes the refereed proceedings of the 7th International Provenance and Annotation Workshop, IPAW 2018, held in London, UK, in July 2018.The 12 revised full papers, 19 poster papers, and 2 demonstration papers presented were carefully reviewed and selected from 50 submissions. The papers feature a variety of provenance-related topics ranging from the capture and inference of provenance to its use and application.They are organized in topical sections on reproducibility; modeling, simulating and capturing provenance; PROV extensions; scientific workflows; applications; and system demonstrations.
Traveller Vulnerability in the Context of Travel and Tourism Contracts: A Comparison Of Brazilian And Eu Law
by Maria Goretti Sanches LimaThe book highlights the link between consumers and travellers, identifying the meaning of vulnerability in Brazil and the EU. It also covers different types of contracts for tourism and travel services, including online booking processes. Only after 2015, as a result of the directive on package travel and linked travel arrangements, did the EU begin viewing travellers as consumers in the sense of Union Consumer Law; conversely, in Brazil, the traveller has no legal status whatsoever and is considered solely a consumer. As the traveller is implicitly a consumer he/she is subject to vulnerability. However, the definition of vulnerability differs considerably between Brazil and the EU: while in Brazil it is a principle stemming from the Consumer Defence Code, covering all consumers, in the EU vulnerability is not an established principle. In the EU, although the average consumer is assumed to be reasonably well informed, observant and circumspect, they are also recognised as the weaker party in the contract. That recognition does not fit with the notion of "confident consumer". Vulnerable consumers in the EU are those whose individual characteristics, such as their age, physical or mental infirmity, or credulity, make them particularly susceptible to unfair commercial practices. Conversely, in Brazil these consumers are seen as being hyper-vulnerable, rather than solely vulnerable. In this context, travellers are in a weaker position than regular consumers buying goods or services, because they are outside of their domicile or jurisdiction for a brief or extended period of time. This book examines two types of traveller vulnerability that make travellers, particularly international ones, a special type of consumers: 1. External and 2. Legal (jurisdiction). Travellers’ vulnerability mainly stems from consumers travelling to different markets and different cultures. As such, they are subject to different laws that require special global attention. While both the EU and Brazilian system have their respective advantages and disadvantages, the goal of both must be to further increase protection for travellers, including business travellers. In consumer societies, the traveller is indeed a consumer by logical causation and hence a “special consumer”.
Autopsy in the 21st Century: Best Practices and Future Directions
by Jody E. Hooper Alex K. WilliamsonAutopsy as a field is enjoying an unexpected renaissance as new and improved uses are found for postmortem examination in quality improvement, education, and research. Increased interest in the autopsy is evident in the popular press as well as in national and international physician meetings.This text will provide an overview of topics the authors consider crucial to competent and effective autopsy practice in the 21st century. Each chapter will combine relevant theoretical background with current and practical experience-based guidance so that pathologists and clinicians can better utilize the autopsy to provide optimal value to families, patients, hospitals, and health systems. Distinguished contributors will provide a review of the rich history of autopsy practice, including assessments of how the past both informs autopsy practice and impedes its progress. The autopsy will be placed in the context of larger healthcare systems with chapters on the use of autopsy in quality improvement and evaluating the value of autopsy as a professional activity, as well as new technology that affects practice models. Better and more reproducible methods for reporting autopsy findings will be explored to exploit the full potential of autopsy data for cross-institutional research. Two chapters will also provide the first book-level review of the growing field of autopsies performed on an urgent basis to sample both diseased and normal control tissue for research. These “rapid research autopsies” are especially crucial to cancer research and the growth of personalized medicine, and the book will explain the science behind utilization of autopsy tissue and offer a full template for designing and delivering a successful rapid autopsy program. Additionally, pathologist and clinician contributors will highlight current recommendations for special techniques and ancillary testing in postmortem examinations to serve the needs of today’s patient populations. As resident education is re-examined by pathology and education authorities, new competency-based training models will almost certainly come to the fore. A chapter will examine approaches to the future training of medical students, residents, and fellows in an environment of changing autopsy exposure. A final chapter will summarize the vision for the autopsy as a clinical outcome measure, and valuable scientific resource. This book will be a new type of volume in the field of autopsy pathology. It differs from the presently available review references and atlases in that it provides guidance for readers to embrace transformations that are already taking place in the field. There currently is no resource that offers comprehensive guidance for modern autopsy practice and looks forward to what the field might become in the future.
Applied Computing and Information Technology (Studies in Computational Intelligence #788)
by Roger LeeThis book presents the scientific outcomes of the 6th International Conference on Applied Computing and Information Technology (ACIT 2018), which was held in Kunming, China on June 13–15, 2018. The aim of this conference was to bring together researchers and scientists, businessmen and entrepreneurs, teachers, engineers, computer users, and students to discuss the numerous fields of computer science and to share their experiences and exchange new ideas and information in a meaningful way. The book includes research findings on all aspects (theory, applications and tools) of computer and information science and discusses the practical challenges encountered and the solutions adopted to address them.The book features 13 of the conference’s most promising papers.
Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (Studies in Computational Intelligence #149)
by Roger LeeThis edited book presents the scientific outcomes of the 19th IEEE/ACIS International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD 2018), which was held in Busan, Korea on June 27–29, 2018. The aim of this conference was to bring together researchers and scientists, businessmen and entrepreneurs, teachers, engineers, computer users and students to discuss the numerous fields of computer science and to share their experiences and exchange new ideas and information in a meaningful way. The book includes research findings on all aspects (theory, applications and tools) of computer and information science and discusses the practical challenges encountered along the way and the solutions adopted to respond to them. The book includes 13 of the conference’s most promising papers.
Report on the State of the European Union: Volume 5: The Euro at 20 and the Futures of Europe (Report On The State Of The European Union Ser.)
by Jérôme Creel Éloi Laurent Jacques Le CacheuxThis volume, the fifth instalment of the classic Report on the European Union series, offers at once an economic and intellectual historical perspective on the creation of the euro and its 20 first years, a comprehensive review of the current and future challenges of the euro area, including a critical look at the different options for the reform of its governance and institutional architecture and finally a close look at the “new euros”, i.e. the ambitious projects that could instil a new life into the stalled European project. It covers a wide range of key economic and social topics such as monetary and fiscal policy, tax competition, the EU budget, structural policy, inequality, gender equality, post carbon economy, well-being advancement and democracy. Weakened by a decade of economic crisis and shaken by the awakening of populism, the European project faces three disintegrations: democratic disaffection, monetary and financial fragmentation and territorial dislocation. If EU member states want to escape those looming risks, they must, as they always have in the last five decades, reinvent Europe in order to save it.
Foreign Investment Under the Comprehensive Economic and Trade Agreement (Studies in European Economic Law and Regulation #15)
by Makane Moïse Mbengue Stefanie SchachererThis book analyzes the investment chapter of a new type of trade agreement between Canada and the European Union to help readers gain a better understanding of this mega-regional deal, which includes foreign investment protection. It first provides background information on the Comprehensive Economic and Trade Agreement (CETA), particularly focusing on the chapter on foreign investment, including the rules on the entry of investments, their protection and the stringent dispute settlement mechanism. It goes on to explore whether these provisions are a further step toward reforming the current international investment law regime. It also examines the highly innovative part of the agreement: the inclusion of crosscutting issues, such as sustainable development. In addition, it examines the CETA investment chapter from the perspective of non-contracting parties, including Africa, Asia and Latin America. The book is of interest to academics and students in the field of international investment law. It is also an essential resource for government legal advisers, policymakers, business practitioners, and others dealing with international investment law.
Integration of Low Carbon Technologies in Smart Grids (Springer Theses)
by Donato ZarrilliThe thesis provides different opportunities and ideas to face some current challenges in the electricity systems. It focuses on the effective and efficient integration of distributed low carbon technologies in the grid of the future. Planning and operation problems for different clean solutions, such as market bidding strategies for intermittent energy producers, demand side management algorithms for smart buildings, and electrical storage options for network operators, are studied for facilitating the integration of renewable energy sources in the power system chain.
Adventures Between Lower Bounds and Higher Altitudes: Essays Dedicated to Juraj Hromkovič on the Occasion of His 60th Birthday (Lecture Notes in Computer Science #11011)
by Hans-Joachim Böckenhauer Dennis Komm Walter UngerThis Festschrift volume is published in honor of Juraj Hromkovič on the occasion of his 60th birthday. Juraj Hromkovič is a leading expert in the areas of automata and complexity theory, algorithms for hard problems, and computer science education.The contributions in this volume reflect the breadth and impact of his work. The volume contains 35 full papers related to Juraj Hromkovič’s research. They deal with various aspects of the complexity of finite automata, the information content of online problems, stability of approximation algorithms, reoptimization algorithms, computer science education, and many other topics within the fields of algorithmics and complexity theory. Moreover, the volume contains a prologue and an epilogue of laudatios from several collaborators, colleagues, and friends.