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Biomechanics in Oncology (Advances in Experimental Medicine and Biology #1092)
by Cheng Dong Nastaran Zahir Konstantinos KonstantopoulosThis book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology.This book also:Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic processProvides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopyIncludes insight into NCIs’ role in supporting biomechanics in oncology researchDetails how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
The Philosophical Thought of Wang Chong
by Alexus McLeodThis book is a study of the methodological, metaphysical, and epistemological work of the Eastern Han Dynasty period scholar Wang Chong. It presents Wang’s philosophical thought as a unique and syncretic culmination of a number of ideas developed in earlier Han and Warring States philosophy. Wang’s philosophical methodology and his theories of truth, knowledge, and will and determinism offer solutions to a number of problems in the early Chinese tradition. His views also have much to offer contemporary philosophy, suggesting new ways of thinking about familiar problems. While Wang is best known as a critic and skeptic, Alexus McLeod argues that these aspects of his thought form only a part of a larger positive project, aimed at discerning truth in a variety of senses.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175 (Reviews of Physiology, Biochemistry and Pharmacology #175)
by Roland Lill Reinhard Jahn Thomas Gudermann Pieter De Tombe Bernd NiliusLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
New Methods in Fixed Income Modeling: Fixed Income Modeling (Contributions to Management Science)
by Mehdi Mili Reyes Samaniego Medina Filippo Di PietroThis book presents new approaches to fixed income modeling and portfolio management techniques. Taking into account the latest mathematical and econometric developments in finance, it analyzes the hedging securities and structured instruments that are offered by banks, since recent research in the field of fixed incomes and financial markets has raised awareness for changes in market risk management strategies. The book offers a valuable resource for all researchers and practitioners interested in the theory behind fixed income instruments, and in their applications in financial portfolio management.
Augmented Reality, Virtual Reality, and Computer Graphics: 5th International Conference, AVR 2018, Otranto, Italy, June 24–27, 2018, Proceedings, Part II (Lecture Notes in Computer Science #10851)
by Lucio Tommaso De Paolis Patrick BourdotThe 2-volume set LNCS 10850 and 10851 constitutes the refereed proceedings of the 5th International Conference on Augmented Reality, Virtual Reality, and Computer Graphics, AVR 2018, held in Otranto, Italy, in June 2018. The 67 full papers and 26 short papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in the following topical sections: virtual reality; augmented and mixed reality; computer graphics; human-computer interaction; applications of VR/AR in medicine; and applications of VR/AR in cultural heritage; and applications of VR/AR in industry.
Lung Stem Cell Behavior
by Ahmed El-HashashThis book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.
Trust Management XII: 12th IFIP WG 11.11 International Conference, IFIPTM 2018, Toronto, ON, Canada, July 10–13, 2018, Proceedings (IFIP Advances in Information and Communication Technology #528)
by Nurit Gal-Oz Peter R. LewisThis book constitutes the refereed proceedings of the 12th IFIP WG 11.11 International Conference on Trust Management, IFIPTM 2018, held in Toronto, ON, Canada, in July 2018.The 7 revised full papers and 3 short papers presented were carefully reviewed and selected from 22 submissions. The papers feature both theoretical research and real-world case studies and cover the following topical areas: trust in information technology; socio-technical, economic, and sociological trust; trust and reputation management systems; identity management and trust; secure, trustworthy and privacy-aware systems; trust building in large scale systems; and trustworthyness of adaptive systems. Also included is the 2018 William Winsborough commemorative address.
Digitalization Cases: How Organizations Rethink Their Business for the Digital Age (Management for Professionals)
by Nils Urbach Maximilian RöglingerThis book presents a rich compilation of real-world cases on digitalization, the goal being to share first-hand insights from respected organizations and to make digitalization more tangible. As virtually every economic and societal sector is now being challenged by emerging technologies, the digital economy is a highly volatile, uncertain, complex and ambiguous place – and one that holds substantial challenges and opportunities for established organizations. Against this backdrop, this book reports on best practices and lessons learned from organizations that have succeeded in overcoming the challenges and seizing the opportunities of the digital economy. It illustrates how twenty-one organizations have leveraged their capabilities to create disruptive innovations, to develop digital business models, and to digitally transform themselves. These cases stem from various industries (e.g. automotive, insurance, consulting, and public services) and countries, reflecting the many facets of digitalization. As all case descriptions follow a uniform schema, they are easily accessible, and provide insightful examples for practitioners as well as interesting cases for researchers, teachers and students.Digitalization is reshaping business on a global scale, and it is evident that organizations must transform to thrive in the digital economy. Digitalization Cases provides first-hand insights into the efforts of renowned companies. The presented actions, results, and lessons learned are a great inspiration for managers, students, and academics.Anna Kopp, Head of IT Germany, MicrosoftUnderstanding digitalization in all its facets requires knowledge about its opportunities and challenges in different contexts. Providing 21 cases from different companies all around the world, Digitalization Cases makes an important contribution toward the comprehensibility of digitalization – from a practical and a scientific point of view.Dorothy Leidner, Ferguson Professor of Information Systems, Baylor UniversityThis book is a great source of inspiration and insight on how to drive digitalization. It shows easy to understand good practice examples which illustrate opportunities, and at the same time helps to learn what needs to be done to realize them. I consider this book a must-read for every practitioner who cares about digitalization.Martin Petry, Chief Information Officer and Head of Business Excellence, Hilti
Augmented Reality, Virtual Reality, and Computer Graphics: 5th International Conference, AVR 2018, Otranto, Italy, June 24–27, 2018, Proceedings, Part I (Lecture Notes in Computer Science #10850)
by Lucio Tommaso De Paolis Patrick BourdotThe 2-volume set LNCS 10850 and 10851 constitutes the refereed proceedings of the 5th International Conference on Augmented Reality, Virtual Reality, and Computer Graphics, AVR 2018, held in Otranto, Italy, in June 2018. The 67 full papers and 26 short papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in the following topical sections: virtual reality; augmented and mixed reality; computer graphics; human-computer interaction; applications of VR/AR in medicine; and applications of VR/AR in cultural heritage; and applications of VR/AR in industry.
Forests of Southeast Europe Under a Changing Climate: Conservation of Genetic Resources (Advances in Global Change Research #65)
by Mirjana Šijačić-Nikolić Jelena Milovanović Marina NonićThis book integrates the different prospective, scientific and practical experience of researchers as well as beneficiaries and stakeholders in the field of forest conservation in Southeast Europe. The book stresses the importance of improving the adaptability of these ecosystems to the impacts of climate change. Gathered around a common idea, the book presents the latest results in forest genetic resources conservation at national and regional level. The chapters are written by experts from: Bosnia and Herzegovina, Bulgaria, Croatia, FYR Macedonia, Greece, Montenegro, Romania, Serbia and Slovenia. The book presents the current state, legal and institutional framework for conservation and management of forest genetic resources, case studies and best practices in the application of different conservation methods and techniques (in situ and ex situ) as well as climate change aspects in this area. This book will be of particular interest to scientists and experts in the field of forestry, environmental protection and rural development, bachelor, master and doctoral students, as well as for anyone interested in the conservation issues fuelled by ethical and economic motives.
Variational Source Conditions, Quadratic Inverse Problems, Sparsity Promoting Regularization: New Results In Modern Theory Of Inverse Problems And An Application In Laser Optics (Frontiers In Mathematics Ser.)
by Jens FlemmingThe book collects and contributes new results on the theory and practice of ill-posed inverse problems. Different notions of ill-posedness in Banach spaces for linear and nonlinear inverse problems are discussed not only in standard settings but also in situations up to now not covered by the literature. Especially, ill-posedness of linear operators with uncomplemented null spaces is examined.Tools for convergence rate analysis of regularization methods are extended to a wider field of applicability. It is shown that the tool known as variational source condition always yields convergence rate results. A theory for nonlinear inverse problems with quadratic structure is developed as well as corresponding regularization methods. The new methods are applied to a difficult inverse problem from laser optics.Sparsity promoting regularization is examined in detail from a Banach space point of view. Extensive convergence analysis reveals new insights into the behavior of Tikhonov-type regularization with sparsity enforcing penalty.
Drones and the Creative Industry: Innovative Strategies for European SMEs
by Marival Segarra-Oña Virginia Santamarina-CamposThis open access, interdisciplinary book presents innovative strategies in the use of civil drones in the cultural and creative industry. Specially aimed at small and medium-sized enterprises (SMEs), the book offers valuable insights from the fields of marketing, engineering, arts and management. With contributions from experts representing varied interests throughout the creative industry, including academic researchers, software developers and engineers, it analyzes the needs of the creative industry when using civil drones both outdoors and indoors. The book also provides timely recommendations to the industry, as well as guidance for academics and policymakers.
The Rational Shakespeare: Peter Ramus, Edward de Vere, and the Question of Authorship
by Michael WainwrightThe Rational Shakespeare: Peter Ramus, Edward de Vere, and the Question of Authorship examines William Shakespeare’s rationality from a Ramist perspective, linking that examination to the leading intellectuals of late humanism, and extending those links to the life of Edward de Vere, Seventeenth Earl of Oxford. The application to Shakespeare’s plays and sonnets of a game-theoretic hermeneutic, an interpretive approach that Ramism suggests but ultimately evades, strengthens these connections in further supporting the Oxfordian answer to the question of Shakespearean authorship.
Poetry and British Nationalisms in the Bardic Eighteenth Century: Imagined Antiquities (Palgrave Studies In The Enlightenment, Romanticism And Cultures Of Print Ser.)
by Jeff StraboneThis book offers a radical new theory of the role of poetry in the rise of cultural nationalism. With equal attention to England, Scotland, and Wales, the book takes an Archipelagic approach to the study of poetics, print media, and medievalism in the rise of British Romanticism. It tells the story of how poets and antiquarian editors in the British nations rediscovered forgotten archaic poetic texts and repurposed them as the foundation of a new concept of the nation, now imagined as a primarily cultural formation. It also draws on legal and ecclesiastical history in drawing a sharp contrast between early modern and Romantic antiquarianisms. Equally a work of literary criticism and history, the book offers provocative new theorizations of nationalism and Romanticism and new readings of major British poets, including Allan Ramsay, Thomas Gray, and Samuel Taylor Coleridge.
Photons: The History and Mental Models of Light Quanta
by Klaus Hentschel Ann M. HentschelThis book focuses on the gradual formation of the concept of ‘light quanta’ or ‘photons’, as they have usually been called in English since 1926. The great number of synonyms that have been used by physicists to denote this concept indicates that there are many different mental models of what ‘light quanta’ are: simply finite, ‘quantized packages of energy’ or ‘bullets of light’? ‘Atoms of light’ or ‘molecules of light’? ‘Light corpuscles’ or ‘quantized waves’? Singularities of the field or spatially extended structures able to interfere? ‘Photons’ in G.N. Lewis’s sense, or as defined by QED, i.e. virtual exchange particles transmitting the electromagnetic force?The term ‘light quantum’ made its first appearance in Albert Einstein’s 1905 paper on a “heuristic point of view” to cope with the photoelectric effect and other forms of interaction of light and matter, but the mental model associated with it has a rich history both before and after 1905. Some of its semantic layers go as far back as Newton and Kepler, some are only fully expressed several decades later, while others initially increased in importance then diminished and finally vanished. In conjunction with these various terms, several mental models of light quanta were developed—six of them are explored more closely in this book. It discusses two historiographic approaches to the problem of concept formation: (a) the author’s own model of conceptual development as a series of semantic accretions and (b) Mark Turner’s model of ‘conceptual blending’. Both of these models are shown to be useful and should be explored further.This is the first historiographically sophisticated history of the fully fledged concept and all of its twelve semantic layers. It systematically combines the history of science with the history of terms and a philosophically inspired history of ideas in conjunction with insights from cognitive science.
Powerful Pulsed Plasma Generators: Research and Application (Springer Series on Atomic, Optical, and Plasma Physics #101)
by Victor Kolikov Alexander Bogomaz Alexander BudinThis book presents experimental and theoretical results on extremely powerful plasma generators. It addresses pulsed electrical mega-ampere arcs and the mechanisms of energy transfer from the arc into hydrogen, helium and air under pressures up to 250 MPa and currents up to 2 MA. Extreme plasma parameters and increased energy density in the arc were achieved. It was found experimentally that increasing the initial gas pressure to hundreds of MPa leads to improved arc stability, high efficiency of energy transfer from arc to gas, and plasma enthalpy growth. The data obtained data provides the basis for the development of electrophysical devices with high energy density, e.g. high intensity sources for visible, UV and X-ray irradiation for laser pumping, generators of high enthalpy plasma jets, and plasma chemical reactors.
Principles of Modeling: Essays Dedicated to Edward A. Lee on the Occasion of His 60th Birthday (Lecture Notes in Computer Science #10760)
by Marten Lohstroh Patricia Derler Marjan SirjaniThis Festschrift is published in honor of Edward A. Lee, Robert S. Pepper Distinguished Professor Emeritus and Professor in the Graduate School in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley, USA, on the occasion of his 60th birthday.The title of this Festschrift is “Principles of Modeling" because Edward A. Lee has long been devoted to research that centers on the role of models in science and engineering. He has been examining the use and limitations of models, their formal properties, their role in cognition and interplay with creativity, and their ability to represent reality and physics. The Festschrift contains 29 papers that feature the broad range of Edward A. Lee’s research topics; such as embedded systems; real-time computing; computer architecture; modeling and simulation, and systems design.
Ordinary Differential Equations for Engineers: Problems with MATLAB Solutions
by Ali Ümit KeskinThis monograph presents teaching material in the field of differential equations while addressing applications and topics in electrical and biomedical engineering primarily. The book contains problems with varying levels of difficulty, including Matlab simulations. The target audience comprises advanced undergraduate and graduate students as well as lecturers, but the book may also be beneficial for practicing engineers alike.
Human Security and Cross-Border Cooperation in East Asia (Security, Development and Human Rights in East Asia)
by Carolina G. Hernandez Eun Mee Kim Yoichi Mine Ren XiaoThis book takes up a wide variety of human security challenges beyond the dimension of human conflict, and looks at both natural and human disasters that the East Asian region faces or is attempting to resolve. While discussing various human security issues, the case studies offer practical lessons to address serious human security challenges in the framework of the ASEAN Plus Three and beyond. Against the backdrop of multifaceted globalization and parochial reactions thereto, this book is a powerful contribution to universal human security.
Islamophobia and Radicalization: Breeding Intolerance and Violence
by John L. Esposito Derya InerWhile the themes of radicalization and Islamophobia have been broadly addressed by academia, to date there has been little investigation of the crosspollination between the two. Is Islamophobia a significant catalyst or influence on radicalization and recruitment? How do radicalization and Islamophobia interact, operate, feed one another, and ultimately pull societies toward polar extremes in domestic and foreign policy? The wide-ranging and global contributions collected here explore these questions through perspectives grounded in sociology, political theory, psychology, and religion. The volume provides an urgently needed and timely examination of the root causes of both radicalization and Islamophobia; the cultural construction and consumption of radical and Islamophobic discourses; the local and global contexts that fertilize these extreme stances; and, finally, the everyday Muslim in the shadow of these opposing but equally vociferous forces.
Diffuse Gastric Cancer
by Rodrigo Santa Cruz Guindalini Tiago Biachi de CastriaWe live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
Relative Aspects in Representation Theory, Langlands Functoriality and Automorphic Forms: CIRM Jean-Morlet Chair, Spring 2016 (Lecture Notes in Mathematics #2221)
by Volker Heiermann Dipendra PrasadThis volume presents a panorama of the diverse activities organized by V. Heiermann and D. Prasad in Marseille at the CIRM for the Chaire Morlet event during the first semester of 2016. It assembles together expository articles on topics which previously could only be found in research papers. Starting with a very detailed article by P. Baumann and S. Riche on the geometric Satake correspondence, the book continues with three introductory articles on distinguished representations due to P. Broussous, F. Murnaghan, and O. Offen; an expository article of I. Badulescu on the Jacquet–Langlands correspondence; a paper of J. Arthur on functoriality and the trace formula in the context of "Beyond Endoscopy", taken from the Simons Proceedings; an article of W-W. Li attempting to generalize Godement–Jacquet theory; and a research paper of C. Moeglin and D. Renard, applying the trace formula to the local Langlands classification for classical groups. The book should be of interest to students as well as professional researchers working in the broad area of number theory and representation theory.
Predictive Biomarkers in Oncology: Applications in Precision Medicine
by Sunil Badve George Louis Kumar“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.
An Introduction to Hamiltonian Mechanics (Birkhäuser Advanced Texts Basler Lehrbücher)
by Gerardo F. Torres del CastilloThis textbook examines the Hamiltonian formulation in classical mechanics with the basic mathematical tools of multivariate calculus. It explores topics like variational symmetries, canonoid transformations, and geometrical optics that are usually omitted from an introductory classical mechanics course. For students with only a basic knowledge of mathematics and physics, this book makes those results accessible through worked-out examples and well-chosen exercises.For readers not familiar with Lagrange equations, the first chapters are devoted to the Lagrangian formalism and its applications. Later sections discuss canonical transformations, the Hamilton–Jacobi equation, and the Liouville Theorem on solutions of the Hamilton–Jacobi equation. Graduate and advanced undergraduate students in physics or mathematics who are interested in mechanics and applied math will benefit from this treatment of analytical mechanics. The text assumes the basics of classical mechanics, as well as linear algebra, differential calculus, elementary differential equations and analytic geometry. Designed for self-study, this book includes detailed examples and exercises with complete solutions, although it can also serve as a class text.
Theatre Music and Sound at the RSC: Macbeth To Matilda (Palgrave Studies In British Musical Theatre Ser.)
by Millie TaylorThis book discusses an exciting laboratory that has been developing the practice of theatre music composition and sound design since 1961: the Royal Shakespeare Company. Musical practices have evolved as composers and musical directors inherited from the past and innovated with new technology; different interpretations of single plays in multiple iterations have provided a picture of developing styles, genres, working practices, technologies and contexts; actor musicianship has been practiced quietly and without fuss; and the role of the sound designer has appeared and transformed the theatrical soundscape. This book moves to musical theatre to evidence a continuum between its rich interdisciplinary textures and the musicodramatic world of Shakespeare’s plays, positioning the RSC as an innovative company that continually expands the creative and collaborative possibilities of the theatre.