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Advanced Protocols for Animal Transgenesis: An ISTT Manual (Springer Protocols Handbooks)
by Shirley Pease and Thomas L. SaundersThis laboratory manual, published in cooperation with the International Society for Transgenic Technology (ISTT), provides almost all current methods that can be applied to the creation and analysis of genetically modified animals. The chapters have been contributed by leading scientists who are actively using the technology in their laboratories. Based on their first-hand experience the authors also provide helpful notes and troubleshooting sections. Topics range from standard techniques, such as pronuclear microinjection of DNA, to more sophisticated and modern methods, such as the derivation and establishment of embryonic stem (ES) cell lines, with defined inhibitors in cell culture medium. In addition, related topics with relevance to the field are addressed, including global web-based resources, legal issues, colony management, shipment of mice and embryos, and the three R’s: refinement, reduction and replacement.
Das Projektmanagement-Office: Einführung und Nutzen
by Gerhard Ortner Betina SturIn projektorientierten Unternehmen spielen Projektmanagement-Offices (PMO) eine immer wichtigere, manchmal sogar zentrale Rolle, wenn es darum geht, die Projektmanagementaktivitäten des Unternehmens zielgerichtet und effizient auszurichten. Dabei entstehen unternehmensspezifisch Organisationen mit teilweise recht unterschiedlichen Aufgaben, Funktionen und organisatorischen Rahmenbedingungen. Das Buch soll einen kompakten Überblick über die Möglichkeiten, die ein PMO bietet und die Ausprägungen, wie es implementiert werden kann, geben.
Suchmaschinen
by Sonja Monika QuirmbachDie Optimierung der Usability und User Experience einer Suchmaschine ist Basis für die erfolgreiche Entwicklung von Websites. In dem Buch wird gezeigt, welche Methoden eingesetzt werden, um den Suchprozess zu optimieren, wo typische Probleme auftreten und wie sich diese auf die User Experience auswirken. Das Buch leistet Hilfestellung bei Live-Tests mit verschiedenen Versionen, bei der wirtschaftlichen Betrachtung und der Erstellung von Reports mit Web Analytics. Best-Practice-Beispiele helfen sowohl Einsteigern als auch Experten bei der Umsetzung.
Is this Cell a Human Being?
by Antoine Suarez Joachim HuarteThe central question of this book is whether or not particular cell entities of human origin ought to be considered human beings. The answer is crucial for making moral decisions for or against research and experimentation. Experts in the field discuss the production of embryonic-like pluripotent stem cells by altered nuclear transfer, parthenogenesis and reprogramming of adult somatic cells. They thoroughly analyse the biological and moral status of different cell entities, such as human stem cells, embryos and human-animal hybrid embryos, and make a decisive step towards establishing final criteria for what constitutes a human being. The topic is challenging in nature and of broad interest to all those concerned with current bioethical thought on embryonic human life and its implications for society.
Small Supernumerary Marker Chromosomes (sSMC)
by Thomas Liehr UniqueHuman beings normally have a total of 46 chromosomes, with each chromosome present twice, apart from the X and Y chromosomes in males. Some three million people worldwide, however, have 47 chromosomes: they have a small supernumerary marker chromosome (sSMC) in addition to the 46 normal ones. This sSMC can originate from any one of the 24 human chromosomes and can have different shapes. Approximately one third of sSMC carriers show clinical symptoms, while the remaining two thirds manifest no phenotypic effects. This guide represents the first book ever published on this topic. It presents the latest research results on sSMC and current knowledge about the genotype-phenotype correlation. The focus is on genetic diagnostics as well as on prenatal and fertility-related genetic counseling. A unique feature is that research meets practice: numerous patient reports complement the clinical aspects and depict the experiences of families living with a family member with an sSMC.
Evolutionary Biology – Concepts, Biodiversity, Macroevolution and Genome Evolution
by Pierre PontarottiThe annual Evolutionary Biology Meetings in Marseilles serve to gather leading scientists, promote the exchange of ideas and encourage the formation of international collaborations. This book contains the most essential contributions presented at the 14th Evolutionary Biology Meeting, which took place in September 2010. It comprises 19 chapters organized according to the following categories: · Evolutionary Biology Concepts · Biodiversity and Evolution · Macroevolution · Genome Evolution Offering an up-to-date overview of recent results in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
Layered Global Player
by Henri De WaeleLayered Global Player offers a concise but thorough overview of the principles of EU external relations law. By closely examining the role of the European Union on the global scene, it aims to provide a systematic overview of the relevant rules and competences, reflecting the legal developments in their historical and political context. The book contains up-to-date analyses of topics such as the Common Foreign and Security Policy, the Common Security and Defence Policy and the Common Commercial Policy. Moreover, it devotes specific attention to the EU's external powers with regard to the environment, fundamental human rights and development cooperation. It also includes a dedicated chapter exploring the relations with neighbouring countries, as well as one that elucidates the complex interplay between rules of domestic, European and international provenance. Overall, this book couples an innovative design with comprehensive coverage and an engaging style of writing. Its compactness and accessibility enable readers to master the main features of this dynamic field of law with ease, making it an indispensible resource for scholars and practitioners alike.
Navier-Stokes-Fourier Equations
by Radyadour Kh. ZeytounianThis research monograph deals with a modeling theory of the system of Navier-Stokes-Fourier equations for a Newtonian fluid governing a compressible viscous and heat conducting flows. The main objective is threefold. First , to 'deconstruct' this Navier-Stokes-Fourier system in order to unify the puzzle of the various partial simplified approximate models used in Newtonian Classical Fluid Dynamics and this, first facet, have obviously a challenging approach and a very important pedagogic impact on the university education. The second facet of the main objective is to outline a rational consistent asymptotic/mathematical theory of the of fluid flows modeling on the basis of a typical Navier-Stokes-Fourier initial and boundary value problem. The third facet is devoted to an illustration of our rational asymptotic/mathematical modeling theory for various technological and geophysical stiff problems from: aerodynamics, thermal and thermocapillary convections and also meteofluid dynamics.
Manuelle Medizin bei Säuglingen und Kindern
by Wilfrid CoenenDas Buch bietet einen systematischen Überblick über die Manualmedizin bei Säuglingen und Kindern. Die neurophysiologischen und entwicklungsneurologischen Grundlagen von peripheren und zentralen Bewegungsstörungen, muskuloskelettalen Schmerzen und Wirbelsäulendeformitäten werden klar und anschaulich erklärt. Der Band leitet zum Erlernen der diagnostischen und therapeutischen Techniken an und bietet ein Therapiekonzept für das Tonusasymmetriesyndrom (TAS). Mit 300 Fotos und Zeichnungen sowie Befund-Dokumentationsbögen zum Download im Internet.
Bifunctional Molecular Catalysis (Topics in Organometallic Chemistry #37)
by Masakatsu Shibasaki Takao IkariyaMasakatsu Shibasaki, Motomu Kanai, Shigeki Matsunaga, and Naoya Kumagai: Multimetallic Multifunctional Catalysts for Asymmetric Reactions.- Takao Ikariya: Bifunctional transition metal-based molecular catalysts for asymmetric syntheses.- Chidambaram Gunanathan and David Milstein: Bond Activation by Metal-Ligand Cooperation: Design of "Green" Catalytic Reactions Based on Aromatization-Dearomatization of Pincer Complexes.- Madeleine C. Warner, Charles P. Casey, and Jan-E. Bäckvall: Shvo's Catalyst in Hydrogen Transfer Reactions.- Noritaka Mizuno, Keigo Kamata, and Kazuya Yamaguchi: Liquid-Phase Selective Oxidation by Multimetallic Active Sites of Polyoxometalate-Based Molecular Catalysts.- Pingfan Li and Hisashi Yamamoto: Bifunctional Acid Catalysts for Organic Synthesis.- Jun-ichi Ito, Hisao Nishiyama: Bifunctional Phebox Complexes for Asymmetric Catalysis.
FBL Klein-Vogelbach Functional Kinetics praktisch angewandt: Brustkorb, Arme und Kopf untersuchen und behandeln
by Barbara Suppé Matthias BongartzIn der Buchreihe wird detailliert dargestellt, wie die Übungen und Behandlungstechniken der FBL/Functional Kinetics an und mit den Patienten angewandt werden können. Diese "Gebrauchsanleitung" für die Arbeit mit dem FBL-Instrumentarium gliedert sich jeweils in Untersuchung und problemorientierte Behandlung. Jeder der drei Bände thematisiert die Körperabschnitte, die als funktionelle Einheiten betrachtet und therapiert werden, bzw. therapierelevante Bewegungsabläufe: Becken und Beine (1); Brustkorb, Arme, Kopf (2); Gehen, Sitzen, Bücken (3).
Molecular Virology
by Dietrich Falke Hermann Schätzl Susanne Modrow Uwe TruyenThe book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
Introduction to Hydro Energy Systems: Basics, Technology and Operation
by Hermann-Josef Wagner Jyotirmay MathurThe authors have tried to strike a balance between a short book chapter and a very detailed book for subject experts. There are three prime reasons behind for doing so: first, the field is quite interdisciplinary and requires simplified presentation for a person from non-parent discipline. The second reason for this short-version of a full book is that both the authors have seen students and technically oriented people, who were searching for this type of book on hydro energy. The third reason and motivation was considering engineers who are starting their career in hydro energy sector. This book is targeted to present a good starting background and basic understanding for such professionals.
Interventional Magnetic Resonance Imaging
by Harald Busse Thomas KahnThe idea of using the enormous potential of magnetic resonance imaging (MRI) not only for diagnostic but also for interventional purposes may seem obvious, but it took major efforts by engineers, physicists, and clinicians to come up with dedicated interventional techniques and scanners, and improvements are still ongoing. Since the inception of interventional MRI in the mid-1990s, the numbers of settings, techniques, and clinical applications have increased dramatically. This state of the art book covers all aspects of interventional MRI. The more technical contributions offer an overview of the fundamental ideas and concepts and present the available instrumentation. The richly illustrated clinical contributions, ranging from MRI-guided biopsies to completely MRI-controlled therapies in various body regions, provide detailed information on established and emerging applications and identify future trends and challenges.
Imaging Endocrine Diseases in Children
by Fred AvniThis book is a unique resource that will help pediatric radiologists, pediatricians, and pediatric endocrinologists to optimize the work-up and treatment of pediatric patients with endocrine disorders. Acclaimed experts in the field present and discuss the imaging findings obtained in disorders of the various endocrine systems, including the hypothalamo-pituitary axis, the thyroid and parathyroids, the adrenals, and the pancreas. Detailed advice is also provided on the assessment of bone growth and on imaging of the fetal glands, ambiguous genitalia, and the female pelvis in the context of precocious puberty. Throughout, care is taken to highlight characteristic findings and diagnostic clues. All of the currently used imaging techniques are covered, with clear explanation of their benefits and limitations. The informative text is supported by a wealth of high-quality illustrations, the large majority of them in color.
Selenium and Tellurium Chemistry
by J. Derek Woollins Risto LaitinenOur knowledge of the chemistry of selenium and tellurium has seen significant progress in the last few decades. This monograph comprises contributions from leading scientists on the latest research into the synthesis, structure and bonding of novel selenium and tellurium compounds. It provides insight into mechanistic studies of these compounds and describes coordination chemistry involving selenium and tellurium containing ligands. Contributions also describe the theoretical and spectroscopic studies of selenium and tellurium compounds. Additionally, this monograph outlines the applications of selenium and tellurium in biological systems, materials science and as reagents in organic synthesis and shows how these applications have been a fundamental driving force behind the research into the inorganic and organic chemistry these fascinating elements.
Integrative Produktionstechnik für Hochlohnländer
by Christian BrecherAuch wenn die industrielle Fertigung von Produkten in Hochlohnländern wie Deutschland gefährdet ist, gibt es viele Beispiele für Unternehmen, denen es gelingt, durch ihre Produktion den Wettbewerb zu dominieren - u. a. indem sie Verschwendung durch synchronisierende Integrativität minimieren und sich höchst adaptiv verhalten. In dem Buch werden die wissenschaftlichen Ergebnisse des Aachener Exzellenzclusters "Integrative Produktionstechnik für Hochlohnländer" dargestellt und deren erfolgreiche Umsetzung in die industrielle Praxis beschrieben.
Die Notfallmedizin
by Burkhard DirksGroßes Grundlagenwerk der Notfallmedizin, das allen angehenden oder bereits tätigen Notfallmedizinern die wesentlichen Aspekte der Notfallmedizin fundiert und praxisnah vermittelt.Zahlreiche Experten präsentieren Informationen zu allen Teilaspekten der Notfallmedizin: Grundlagen, Notfälle nach Leitsymptomen, Notfälle nach Fachgebieten, Organisation der Notfallmedizin, Orientiert an den Weiterbildungsinhalten für die Zusatz-Weiterbildung "Notfallmedizin"Praxis: Typische Fallbeispiele, Hinweise auf Gefahrensituationen und Fallstricke, Notarztboxen mit konkreten Handlungsanleitungen für den Ernstfall und Zahlreiche Abbildungen aus der PraxisDie 2. Auflage erscheint aktualisiert und um das Thema "Geriatrische Notfälle" erweitert. Alle Inhalte orientieren sich an den aktuellen Reanimationsleitlinen des ERC.Die übersichtliche Didaktik und die optische Aufbereitung der Inhalte ermöglichen schnelles und effektives Lernen und Handeln!Die ideale Kombination aus Hintergrundwissen und praxisrelevantem "Know how"!
Die Zukunft der Dienstleistungsökonomie
by Nora S. StampflAuch wenn ihre Märkte nach wie vor rasant wachsen, die Dienstleistungsökonomie der modernen Wissensgesellschaft befindet sich im Umbruch. In dem Band wird die gesamte Dienstleistungslandschaft in den Blick genommen: Aus einem Verständnis der gegenwärtigen Situation heraus werden Entwicklungslinien in die Zukunft gezeichnet, Triebkräfte der Entwicklung beschrieben und die Grundzüge einer neuen Dienstleistungswelt dargestellt. Entwicklungstendenzen und Hintergründe des Wandels werden nachvollziehbar beschrieben und mit Beispielen illustriert.
Ambulantes Operieren: Rahmenbedingungen - Organisation - Patientenversorgung (Erfolgskonzepte Praxis- And Krankenhaus-management Ser.)
by Christoph Lussi Thomas StandlUm Kosten zu sparen, werden Operationen häufig ambulant durchgeführt. In dem Band erläutert ein erfahrenes Herausgeber- und Autoren-Team, wie ambulantes Operieren effektiv und ökonomisch umgesetzt werden kann. Mit dem Schwerpunkt auf strukturellen, organisatorischen, forensischen und ökonomischen Aspekten bietet der Band das notwendige Wissen, um ambulante OP-Einrichtungen aufzubauen und zu überprüfen. Mit Beispielen aus verschiedenen chirurgischen Fachgebieten. Die 2. Auflage wurde komplett überarbeitet und auf den neuesten Stand gebracht.
Encyclopedia of Colloid and Interface Science
by Tharwat TadrosAn authoritative and comprehensive reference relevant to all scientists and engineers in the field. This encyclopedia not only helps chemistry, materials science and physics researchers to understand the principles, but also provides practicing engineers with the necessary information for implementing practical applications, such as Food and agrochemicals Polymers and ceramics Cosmetics and detergents Paints and coatings Pharmaceuticals and drug delivery In addition, the encyclopedia is an important reference for industrial chemists and chemical engineers faced with a multitude of industrial systems of a colloidal nature. As wide as the range of applications that colloid and interface science has is the range of scientific disciplines that contribute to research and development in this field. These encompass chemistry, physics, biology and mathematics as well as nanoscience and nanotechnology. The encyclopedia provides easy-to-digest information for meeting these interdisciplinary challenges. While providing numerous concise definitions of key terms, the encyclopedia also features more than forty in-depth essays on topics ranging from Agrochemical Formulations to Zeta Potential. All entries are cross-referenced and include selected references to original literature as well as synonyms.
Forensic Histopathology
by Reinhard B. DettmeyerThis book, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.
Einführung in die Quanteninformatik
by Gilbert BrandsAusgehend von der Theorie und den Protokollen der Quantenkryptografie werden in dem Band die Servicequalitäten vorgestellt, die angesichts der aktuellen technischen Möglichkeiten erreichbar sind. Unter Berücksichtigung wenig beachteter Gesichtspunkte der Kryptoanalyse diskutiert der Autor die erreichbare Sicherheit und untersucht die Möglichkeiten des Quantencomputing. Anhand praxisnaher Aufgaben können Leser ihr Wissen vertiefen und lernen, die Techniken kritisch zu bewerten. Mit Programmieranleitung für Simulationsversuche auf dem eigenen Rechner.
Basic Techniques in Pediatric Surgery: An Operative Manual
by Robert Carachi Sandeep Agarwala Tim J. BradnockThis unique manual is a "surgical cookbook" designed to provide clear and concise guidance for trainees in pediatric surgery. With the aid of simple line drawings depicting each operative step, more than one hundred frequently performed procedures are explained and demonstrated. The reader will learn how to perform each procedure effectively and safely, avoiding potential complications. The full range of surgery is covered, including basic surgical skills, day surgery procedures, emergency surgery procedures and minimally invasive surgery. The book will be of value not only to trainees in pediatric surgery but also to trainees in general surgery, theatre nurses, parents and carers.
Raman Spectroscopy for Nanomaterials Characterization
by Challa S.S.R. KumarFirst volume of a 40-volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Raman spectroscopy for the characterization of nanomaterials. Modern applications and state-of-the-art techniques are covered and make this volume essential reading for research scientists in academia and industry.