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Activity-Based Protein Profiling (Topics in Current Chemistry #324)
by Stephan A. SieberABPP Methodology: Introduction and Overview, by Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for Natural Product Target Discovery, by Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis, by William P. Heal und Edward W. Tate Functional Analysis of Protein Targets by Metabolomic Approaches, by Yun-Gon Kim und Alan Saghatelian
Laser-Assisted Fabrication of Materials
by Indranil Manna Jyotsna Dutta MajumdarLaser assisted fabrication involves shaping of materials using laser as a source of heat. It can be achieved by removal of materials (laser assisted cutting, drilling, etc.), deformation (bending, extrusion), joining (welding, soldering) and addition of materials (surface cladding or direct laser cladding). This book on ´Laser assisted Fabrication' is aimed at developing in-depth engineering concepts on various laser assisted macro and micro-fabrication techniques with the focus on application and a review of the engineering background of different micro/macro-fabrication techniques, thermal history of the treated zone and microstructural development and evolution of properties of the treated zone.
Whiplash Injury
by Andreas OtteIn the past two decades much has been published on whiplash injury, yet both the confusion regarding the condition and the medicolegal discussion surrounding it have increased. In this scenario, a guide to recent and current international research in the field is more necessary than ever. Especially functional imaging methods - such as single-photon emission tomography, positron emission tomography, functional MRI, and hybrid techniques - have demonstrated a variety of significant brain alterations. This book accordingly offers a critical approach to the challenging interpretation of the new research data obtained using functional neuroimaging in whiplash injury. It covers all aspects, including the imaging tools themselves and the different methods of image analysis. Whiplash Injury: New Methods of Functional Neuroimaging will hopefully help patients, their relatives and friends, physicians, and others to understand this condition as a disease.
Foundations of Micropolar Mechanics
by Leonid P. Lebedev Holm Altenbach Victor A. EremeyevThe book presents foundations of the micropolar continuum mechanics including a short but comprehensive introduction of stress and strain measures, derivation of motion equations and discussion of the difference between Cosserat and classical (Cauchy) continua, and the discussion of more specific problems related to the constitutive modeling, i.e. constitutive inequalities, symmetry groups, acceleration waves, etc.
Genomics and Systems Biology of Mammalian Cell Culture
by Wei Shou Hu An-Ping ZengTranscriptome Analysis, by Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam Lübbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome Data Analysis for Cell Culture Processes, by Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, by Ziomara P. Gerdtzen Metabolic Flux Analysis in Systems Biology of Mammalian Cells, by Jens Niklas und Elmar Heinzle Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data, by Jochen Schaub, Christoph Clemens, Hitto Kaufmann und Torsten W. Schulz Protein Glycosylation and Its Impact on Biotechnology, by Markus Berger, Matthias Kaup und Véronique Blanchard Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects, by Patrick Hossler Modeling of Intracellular Transport and Compartmentation, by Uwe Jandt und An-Ping Zeng Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, by L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser und D. Wirth.
EPR Spectroscopy
by Gunnar Jeschke Malte DrescherEPR Spectroscopy in Catalysis, by Sabine Van Doorslaer und Damien M. Murphy Radicals in Flavoproteins, by Erik Schleicher und Stefan Weber EPR Spectroscopy in Polymer Science, by Dariush Hinderberger EPR in Protein Science, by Intrinsically Disordered Proteins, by Malte Drescher Site-Directed Spin Labeling of Membrane Proteins, by Enrica Bordignon Structure and Dynamics of Nucleic Acids, by Ivan Krstić, Burkhard Endeward, Dominik Margraf, Andriy Marko und Thomas F Prisner New Directions in Electron Paramagnetic Resonance Spectroscopy on Molecular Nanomagnets, by J. van Slageren
Constitutional Dynamic Chemistry (Topics in Current Chemistry #322)
by Mihail BarboiuConstitutional Dynamic Chemistry: Bridge from Supramolecular Chemistry to Adaptive Chemistry, by Jean-Marie Lehn Multistate and Phase Change Selection in Constitutional Multivalent Systems, by Mihail Barboiu Dynamic Systemic Resolution, by Morakot Sakulsombat, Yan Zhang and Olof Ramström Dynamic Combinatorial Self-Replicating Systems, by Emilie Moulin and Nicolas Giuseppone DCC in the Development of Nucleic Acid Targeted and Nucleic Acid Inspired Structures, by Benjamin L. Miller Dynamic Nanoplatforms in Biosensor and Membrane Constitutional Systems, by Eugene Mahon, Teodor Aastrup und Mihail Barboiu Dynamic Assembly of Block-Copolymers, by D. Quémener, A. Deratani und S. Lecommandoux Dynamic Chemistry of Anion Recognition, by Radu Custelcean Supramolecular Naphthalenediimide Nanotubes, by Nandhini Ponnuswamy, Artur R. Stefankiewicz, Jeremy K. M. Sanders und G. Dan Pantoş Synthetic Molecular Machines and Polymer/Monomer Size Switches that Operate Through Dynamic and Non-Dynamic Covalent Changes, by Adrian-Mihail Stadler und Juan Ramírez Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity, by Kamel Meguellati und Sylvain Ladame.
Beauty in Chemistry: Artistry in the Creation of New Molecules (Topics in Current Chemistry #323)
by Luigi FabbrizziThe Beauty of Chemistry in the Words of Writers and in the Hands of Scientists, by Margherita Venturi, Enrico Marchi und Vincenzo Balzani Living in a Cage Is a Restricted Privilege, by Luigi Fabbrizzi Inner and Outer Beauty, by Kenneth N. Raymond und Casey J. Brown The Mechanical Bond: A Work of Art, by Carson J. Bruns und J. Fraser Stoddart The Beauty of Knots at the Molecular Level, by Jean-Pierre Sauvage und David B. Amabilino
Alice in the Land of Plants: Biology of Plants and Their Importance for Planet Earth
by Yiannis ManetasWhy is it that plants do not need to move? How does a nonmotile organism have sex or defend itself? Why are some plants virtually immortal? What is the mechanism that allows plants to exploit a practically inexhaustible extraterrestrial energy source? How do plants regulate the composition of our planet's atmosphere? Why have there not been mass extinctions among plants as there have been among animals? How do plants communicate with one another? In the end, are plants intelligent organisms? These are some of the questions the author discusses to demonstrate that plants are wrongly considered to be simple organisms lacking specific behaviour and intelligence. This book promises to be as pleasant a surprise as Alice's experience in the white rabbit's warren, in which she encountered a world very different from ours. The author explains the biology of plants following Einstein's maxim that everything should be made as simple as possible, but not simpler.
Ecology of Faunal Communities on the Andaman and Nicobar Islands
by C. Sivaperuman K. Venkataraman C. RaghunathanThe Andaman and Nicobar Islands, India, consist of 572 islands with a land area of 8,249 km2. Their topography is hilly and undulating, with elevations up to 732 m on the Andaman and up to 568 m on the Nicobar Islands. They are known for their rich biodiversity and a very high degree of endemicity in all taxa, especially in plants, reptiles, fishes and corals. Their habitats include bays, mangroves, moist deciduous forests and evergreen forests. Comprising 20 chapters each written by an expert or professional in his/her particular field this book offers new insights into the fascinating faunal communities of these islands and provides the fundamentals for their conservation and environmental management.
The Geometry of Special Relativity - a Concise Course
by Norbert DragonIn this concise primer it is shown that, with simple diagrams, the phenomena of time dilatation, length contraction and Lorentz transformations can be deduced from the fact that in a vacuum one cannot distinguish physically straight and uniform motion from rest, and that the speed of light does not depend on the speed of either the source or the observer. The text proceeds to derive the important results of relativistic physics and to resolve its apparent paradoxes. A short introduction into the covariant formulation of electrodynamics is also given. This publication addresses, in particular, students of physics and mathematics in their final undergraduate year.
Tax Progression in OECD Countries: An Integrative Analysis of Tax Schedules and Income Distributions
by Christian Seidl Kirill Pogorelskiy Stefan TraubThis is the first book that performs international and intertemporal comparisons of uniform tax progression with empirical data. While conventional measures of tax progression suffer from serious disadvantages for empirical analyses, this book extends uniform measures to progression comparisons of countries with different income distributions. Tax progression is analyzed in terms of Lorenz curve and Suits curve equivalents of net incomes and taxes. The authors derive six distinct definitions of the relation "is more progressive than", which are then utilized for an empirical analysis of 13 countries included in the Luxembourg Income Study (LIS). In two thirds of all international comparisons of tax progression, the authors report a clear ranking of the respective countries in terms of progression dominance. Tax based definitions of greater progressivity perform best. These observations are yet reinforced by statistical tests. The book also provides an account of the institutional background of the involved countries in order to facilitate the interpretation of the data. Moreover, the authors conduct intertemporal comparisons of tax progression for selected countries and perform a sensitivity analysis with respect to the parameterization of the equivalence scale.
Therapeutic Kinase Inhibitors
by Charles L. Sawyers Ingo K. MellinghoffCancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as "chemotherapy" and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates. This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editors invited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authors hope these lessons will be instructive for the novice as well as the expert.
Organometallics and Renewables
by Bert M. Weckhuysen Michael A.R. Meier Pieter C. BruijnincxLucas Montero de Espinosa and Michael A. R. Meier: Olefin Metathesis of Renewable Platform Chemicals.- Pieter C. A. Bruijnincx, Robin Jastrzebski, Peter J. C. Hausoul, Robertus J. M. Klein Gebbink, and Bert M. Weckhuysen: Pd-Catalysed Telomerisation of 1,3-Dienes with Multifunctional Renewable Substrates - Versatile Routes for the Valorisation of Biomass-Derived Platform Molecules.- A Behr, A. J. Vorholt: Hydroformylation and related reactions of renewable resources.- Ties J. Korstanje, Robertus J.M. Klein Gebbink: Catalytic oxidation and deoxygenation of renewables with rhenium complexes.- Antoine Buchard, Clare M. Bakewell, Jonathan Weiner and Charlotte K. Williams: Recent Developments In Catalytic Activation Of Renewable Resources For Polymer Synthesis.
Degenerate Nonlinear Diffusion Equations
by Angelo Favini Gabriela MarinoschiThe aim of these notes is to include in a uniform presentation style several topics related to the theory of degenerate nonlinear diffusion equations, treated in the mathematical framework of evolution equations with multivalued m-accretive operators in Hilbert spaces. The problems concern nonlinear parabolic equations involving two cases of degeneracy. More precisely, one case is due to the vanishing of the time derivative coefficient and the other is provided by the vanishing of the diffusion coefficient on subsets of positive measure of the domain. From the mathematical point of view the results presented in these notes can be considered as general results in the theory of degenerate nonlinear diffusion equations. However, this work does not seek to present an exhaustive study of degenerate diffusion equations, but rather to emphasize some rigorous and efficient techniques for approaching various problems involving degenerate nonlinear diffusion equations, such as well-posedness, periodic solutions, asymptotic behaviour, discretization schemes, coefficient identification, and to introduce relevant solving methods for each of them.
Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
by Ralf Pörtner Cornelia Kasper Frank WitteThe Cell-Surface Interaction, by J. S. Hayes, E. M. Czekanska and R. G. Richards. Studying Cell-Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques, by Stefanie Michaelis, Rudolf Robelek and Joachim Wegener. Harnessing Cell-Biomaterial Interactions for Osteochondral Tissue Regeneration, by Kyobum Kim, Diana M. Yoon, Antonios G. Mikos and F. Kurtis Kasper. Interaction of Cells with Decellularized Biological Materials, by Mathias Wilhelmi, Bettina Giere and Michael Harder. Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations, by Arie Bruinink and Reto Luginbuehl. Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues, by Margit Schulze and Edda Tobiasch. Bioactive Glass-Based Scaffolds for Bone Tissue Engineering, by Julia Will, Lutz-Christian Gerhardt and Aldo R. Boccaccini. Microenvironment Design for Stem Cell Fate Determination, by Tali Re'em and Smadar Cohen. Stem Cell Differentiation Depending on Different Surfaces, by Sonja Kress, Anne Neumann, Birgit Weyand and Cornelia Kasper. Designing the Biocompatibility of Biohybrids, by Frank Witte, Ivonne Bartsch and Elmar Willbold. Interaction of Cartilage and Ceramic Matrix, by K. Wiegandt, C. Goepfert, R. Pörtner and R. Janssen. Bioresorption and Degradation of Biomaterials, by Debarun Das, Ziyang Zhang, Thomas Winkler, Meenakshi Mour, Christina I. Günter, Michael M. Morlock, Hans-Günther Machens and Arndt F. Schilling.
Turbulent Impinging Jets into Porous Materials
by Marcelo J.S. de LemosThis short book deals with the mathematical modeling of jets impinging porous media. It starts with a short introduction to models describing turbulences in porous media as well as turbulent heat transfer. In its main part, the book presents the heat transfer of impinging jets using a local and a non-local thermal equilibrium approach.
Einführung in das betriebliche Rechnungswesen
by Mirja MummDas Lehr- und Arbeitsbuch bietet eine umfassende Einführung in die Finanzbuchhaltung von Industrie- und Handelsunternehmen. Grundlegende Begriffe und die Buchungstechnik werden erläutert, praxisrelevante Geschäftsvorfälle sowie die periodengerechte Erfolgsabgrenzung anhand vieler Beispiele ausführlich behandelt. Die 2., grundlegend überarbeitete Auflage wurde u. a. hinsichtlich Buchführungsvorschriften und Abschreibungsregeln aktualisiert. Übungsaufgaben mit Lösungshinweisen helfen Lesern, das erworbene Wissen anzuwenden und zu vertiefen.
Entrepreneurship and Taiwan's Economic Dynamics
by Fu-Lai Tony YuTaiwan's economic success is well known and considered to be one of the "East Asian Miracles" by the World Bank. This book examines the contributions of dynamic entrepreneurs to the economic development of Taiwan. It adopts Austrian theories of entrepreneurship and market process as a major analytical framework. Specifically, it focuses on knowledge and coordination problems. It examines how entrepreneurs identify and pursue profit opportunities, and how their efforts have enhanced Taiwan's economic dynamics. This book sheds new light on the economic development of Taiwan.
Sustainable Rural and Urban Ecosystems: Design, Implementation and Operation
by Detlef Glücklich Gunther GellerThese days human beings have a profound influence on aspects of the planetary ecosystem, e.g. on climate change and biodiversity, to name only two. This manual is intended to help practitioners, who are dealing with human-based rural and urban settlement-ecosystems, in the key steps towards their realization (design, implementation, and operation) and helpful for all, who are concerned about ensuring their practical sustainability. The ecosystem-approach is holistic and integrative, encompassing various disciplines like architecture, landscape architecture, environmental engineering, social sciences, life sciences, ecology, and management. It also considers issues such as energy-savings, ecological cycles, reuse, natural resources, socio-cultural background, real participation, and holistic quality management. Thus it not only explains the general concept, the steps of realization and the respective involved stakeholders, but also gives hints and tools for practitioners. The information, recommendations and tools are directed to the following target groups, among others: * Local planning authorities (giving hints for the procedure and the involved stakeholders) * Designers (holistic approach, procedures, tools) * Regulatory bodies, licensing and financing authorities (requirements for approach and procedures) * Construction and implementing firms and institutions (recommendations, tools) * Operating bodies (hints for operation, tools) The experiences are based on a joint German-Ghanaian program at Valley View University, the biggest private university in Ghana, intended to help realize the vision of a truly holistic ecological university. It was financed originally by the German Ministry of Education and Research and recently by the German Ministry for the Environment in the frame of the Climate Change Initiative of the Federal Government of Germany.
The Fundamental Concept of a Crime in International Criminal Law: A Comparative Law Analysis
by Iryna MarchukThis book examines the rapid development of the fundamental concept of a crime in international criminal law from a comparative law perspective. In this context, particular thought has been given to the catalyzing impact of the criminal law theory that has developed in major world legal systems upon the crystallization of the substantive part of international criminal law. This study offers a critical overview of international and domestic jurisprudence with regard to the construal of the concept of a crime (actus reus, mens rea, defences, modes of liability) and exposes roots of confusion in international criminal law through a comprehensive comparative analysis of substantive criminal laws in selected legal jurisdictions.
Erfolgreich selbständig
by Werner Gross Andreas Goshöfer-NeubertDieses erste "Service"-Fachbuch für Psychologen liefert einen Leitfaden für die Existenzgründung in den verschiedenen Berufsfeldern der Psychologie. Der Autor, niedergelassener Psychotherapeut und Experte für Existenzgründung, beantwortet alle wesentlichen Fragen: von der Eignung für das selbständige Arbeiten über Finanzierungsmöglichkeiten, den Gründungsprozess bis zu Detailfragen wie Honorargestaltung. Außerdem werden die verschiedenen Tätigkeitsfelder für Psychologen - diplomiert oder mit Bachelor/ Master-Abschluss - vorgestellt.
The Quintessence of Intercultural Business Communication
by Melanie MollSuccessful business communication is more than simply speaking your client's language. At the heart of all effective communication lies a fundamental understanding of human behavior. The natural result of globalization is a level of behaviors that we all share and expect. However, underneath this level are many other influencing factors. We tend to view the situation around us according to our own expectations which are often shaped by our cultural backgrounds. What happens, though, when our cultures are so different that the expectations collide? This book combines theory and practice in a way that helps you as a busy intercultural manager understand what others are communicating to you and those around you. We take apart real examples of intercultural business interaction and show you how deeply embedded cultural norms are found within a simple conversation. Then we offer you important tools and principles that you can use to improve your own intercultural business communication. After reading this book, you should have a good understanding of the basic culture types, and be able to identify most cultures based on the principles described here. Additionally, you will know which social issues, attitudes, and values appear even in the most rational business negotiation. Most importantly, your cultural awareness will help you build successful and lasting relationships with your clients across regional and global boundaries.
Niere und Ableitende Harnwege
by Katja Segerer Christoph Wannerjan Steffel Thomas LuescherDer Band aus der Reihe ,,Module Innere Medizin" ermöglicht Lernenden den Blick aufs Ganze. Systematisch stellen die Autoren das gesamte Organsystem Niere und ableitende Harnwege dar: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Wegen seiner Praxisnähe eignet sich der Band nicht nur für Studierende, sondern auch für Ärzte in der nephrologischen Aus- und Weiterbildung.
Psychiatrie 2020 plus
by Peter Falkai Frank SchneiderUnter den medizinischen Disziplinen hat die Psychiatrie und Psychotherapie die größte Zukunft: In den letzten Jahrzehnten hat das Fach in Forschung und Versorgung Quantensprünge durchlaufen. Diese Entwicklung setzt sich fort. Herausforderungen sind die weitere Erforschung und der zunehmende Behandlungsbedarf im Bereich psychischer Erkrankungen. In dem Buch "Psychiatrie 2020" skizziert die Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN) neben einer Übersicht über die Entwicklung des Faches eine Vision für das Jahr 2020. Psychiatrie 2020 plus, ist nun die erweiterte und aktualisierte Auflage der Bestandsaufnahme und Vision für das Jahr 2020.