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Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development
by R. Scott Obach Jae S. Lee Michael B. FisherCritical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.
Image-Guided Radiotherapy of Lung Cancer
by Ramjee PrasadLung cancer is the leading cause of cancer death in the United States, but IGRT (image guided radiation therapy) offers the possibility of more aggressive and enhanced treatments. The only available source on the subject that emphasizes new imaging techniques, and provides step-by-step treatment guidelines for lung cancer, this source helps clinici
Organic, Physical, and Materials Photochemistry
by Kirk S. SchanzeThis text examines organic, physical and materials photochemistry. It reports the first example of a TiO2 sensitization with a fullerene-based donor-acceptor dyad, and covers halophenols, diflusinal photochemistry, hydroxystyrenes, acetylenes, and other related compounds. The volume also investigates whether c,d-alkenes influence the efficiency and
Introduction to Thermodynamics of Mechanical Fatigue
by Michael M. Khonsari Mehdi AmiriFatigue is probabilistic in nature and involves a complex spectrum of loading history with variable amplitudes and frequencies. Yet most available fatigue failure prediction methods are empirical and concentrate on very specific types of loading. Taking a different approach, Introduction to Thermodynamics of Mechanical Fatigue examines the treatmen
VC++ MFC Extensions by Example
by John SwankeExtend and modify MFC code to meet your needs! Author John Swanke delivers studied examples to give you a jump-start on creating more sophisticated and powerful applications. Each example is fully annotated and ready to insert into the your application --
Verification of Computer Codes in Computational Science and Engineering (Discrete Mathematics and Its Applications)
by Patrick Knupp Kambiz SalariHow can one be assured that computer codes that solve differential equations are correct? Standard practice using benchmark testing no longer provides full coverage because today's production codes solve more complex equations using more powerful algorithms. By verifying the order-of-accuracy of the numerical algorithm implemented in the code, one can detect most any coding mistake that would prevent correct solutions from being computed.Verification of Computer Codes in Computational Science and Engineering sets forth a powerful alternative called OVMSP: Order-Verification via the Manufactured Solution Procedure. This procedure has two primary components: using the Method of Manufactured Exact Solutions to create analytic solutions to the fully-general differential equations solved by the code and using grid convergence studies to confirm the order-of-accuracy. The authors present a step-by-step procedural guide to OVMSP implementation and demonstrate its effectiveness.Properly implemented, OVMSP offers an exciting opportunity to identify virtually all coding 'bugs' that prevent correct solution of the governing partial differential equations. Verification of Computer Codes in Computational Science and Engineering shows you how this can be done. The treatment is clear, concise, and suitable both for developers of production quality simulation software and as a reference for computational science and engineering professionals.
Handbook of Mouse Auditory Research: From Behavior to Molecular Biology
by James F. WillottThis unique compilation of chapters reviews a broad range of topics at the cutting edge of hearing research. The authors include many of the top auditory scientists in the world as well as some of the brightest rising stars. Although the book obviously focuses on the exciting, revolutionary work being done with mice, the authors have made a strong
Drilling Wastes
by John R. Wilson Sarah SharplesProceedings of the 1988 International Conference on Drilling Wastes, Calgary, Alberta, Canada, 5-8 April 1988.
Handbook of Multiple Sclerosis (Neurological Disease and Therapy)
by Stuart D. CookFilled with an abundance of reader-friendly and quick-reference tables and figures, this Fourth Edition spans the etiology, epidemiology, clinical features, diagnosis, pathology, and treatment of multiple sclerosis (MS). Surpassing other texts on the topic, this reference provides recommendations and research updates from renowned authorities in th
Stem Cells and Revascularization Therapies
by Lawrence B. Schook Hyunjoon Kong Andrew J. PutnamIn the last few decades, significant advancements in the biology and engineering of stem cells have enabled progress in their clinical application to revascularization therapies. Some strategies involve the mobilization of endogenous stem cell populations, and others employ cell transplantation. However, both techniques have benefited from multidis
Santaland: A Miller & Rhoads Christmas (Landmarks)
by Donna Strother DeekensWhen Santa and his helpers the Snow Queen and the Mischievous Little Elf are blown topsy-turvy in a Virginia blizzard, they land on the roof of Richmond's Miller & Rhoads. Surprised to discover such a grand store with no decorations for Christmas, the friends try to solve the mystery. Join Santa and his team as they search the Tea Room, a fantastic toy department and the Virginia Pantry for signs of the Christmas spirit. Santa soon finds that at Miller & Rhoads, friendship and a little magic bring Santaland to life if only you believe.
The Ghostly Tales of the Long Beach Peninsula (Spooky America)
by Sydney StevensGhost stories from the Long Beach Peninsula have never been so creepy, fun, and full of mystery!The haunted history of Pacific County comes to life--even when the main players are dead. Learn about Oysterville Church and the wandering spirits who still call it home. Or discover the history of the Shelburne Hotel, but be careful or you'll end up trapped for eternity, too. Dive into this spooky chapter book for suspenseful tales of bumps in the night, paranormal investigations, and the unexplained; just be sure to keep the light on.
The Ghostly Tales of the Pacific Northwest (Spooky America)
by Deborah CuyleGhost stories from the Graveyard of the Pacific have never been so creepy, fun, and full of mystery!The haunted history of the Pacific Northwest's coast comes to life--even when the main players are dead. Keep your eye out for the spirits of long-lost sailors along the Columbia Bar. Or visit the White Eagle Saloon and Hotel to catch a glimpse of the spirits who checked in but never checked out. Dive into this spooky chapter book for suspenseful tales of bumps in the night, paranormal investigations, and the unexplained; just be sure to keep the light on.
When Corporations Rule the World
by David C. KortenOur Choice: Democracy or Corporate Rule A handful of corporations and financial institutions command an ever-greater concentration of economic and political power in an assault against markets, democracy, and life. It's a “suicide economy,” says David Korten, that destroys the very foundations of its own existence. The bestselling 1995 edition of When Corporations Rule the World helped launch a global resistance against corporate domination. In this twentieth-anniversary edition, Korten shares insights from his personal experience as a participant in the growing movement for a New Economy. A new introduction documents the further concentration of wealth and corporate power since 1995 and explores why our institutions resolutely resist even modest reform. A new conclusion chapter outlines high-leverage opportunities for breakthrough change.
Sacred Havens of Brooklyn: Spiritual Places and Peaceful Grounds (Landmarks)
by Terri CookDuring the nineteenth century, Brooklyn earned the nickname "Borough of Churches" as thousands settled here and brought their beliefs with them. Spirituality has always been a major part of life for Brooklynites. Peter Stuyvesant established the Flatbush Dutch Church in 1654, and freed slaves worshipped in their sanctuaries since 1766. Fatih Mosque calls Moslems to prayer five times a day, Dorje Ling Buddhist temple fills visitors with peace, and more than 150 temples minister to many branches of Judaism. Spirituality is also visible in historic sites and monuments, from Fort Greene Park's Revolutionary War memorial to a Japanese shrine in Botanic Gardens. Discover some of the more than two thousand havens that have overflowed with people who were determined to prevail in faith and hope in New York's most populous borough.
Lexington, Virginia and the Civil War (Civil War Series)
by G. Williams Jr.Jubilant at the outbreak of the Civil War and destitute in its aftermath, Lexington, Virginia, ultimately rose from the ashes to rebuild in the shadow of the conflict's legacy. It is the final resting place of two famous Confederate generals, Robert E. Lee and Stonewall Jackson, and the home of two of the South's most important war-era colleges, Washington College and the Virginia Military Institute. Author Richard G. Williams presents the trials and triumphs of Lexington during the war, including harrowing narratives of Union general Hunter's raid through the town, Lee's struggle between Union and state allegiances and Jackson's rise from professor to feared battlefield tactician.
The Essence of Invention: Medicine and the Joy of Creativity
by Kieran MurphyMeet the brilliant mavericks who invented the future of medicine and saved the lives of millions.The Essence of Invention tells the story of medical inventors who have laid the foundation for modern patient care, from the development of anaesthesia and safe surgery to the advent of vaccines against smallpox, polio, and Covid-19, and how, through creativity and persistence, they have changed the world. The same kind of energy that drove Van Gogh or the Beatles can manifest itself in medicine as inventiveness and the creation of new medical devices. The field may feel very different from what is traditionally considered a creative industry, but the fundamental motivation and aspiration to create and the conviction and resilience needed to do so are the same. Dr. Murphy celebrates the creative energy of courageous men and women, honours their unique gifts, and explains how a culture of creativity and collaboration can and must be established around them to allow their talents to take flight.
A Richard Rohmer Omnibus
by Richard RohmerThis volume combines three of Richard Rohmer’s best-selling novels in one book. Ultimatum, Exxoneration, and Periscope Red are all fast-paced, incisive novels in which Rohmer makes fiction read like fact. They are chilling visions of a world of military conflict, legal and political entanglements, and Canada’s role in domestic and international spheres. The issues inside are just as important to Canada today as they were when the books were written. In all of these works, Rohmer demonstrates his insider’s knowledge of the energy industry and the military, and his master storyteller’s ability to bring it alive.
Biotechnological Interventions to Aid Commercial Seaweed Farming
by Mangal S. Rathore Vaibhav A. MantriThis edited book focuses on various research topics and constraints over the seaweed sector’s sustainable development. Seaweed potentially contributes to multiple Sustainable Development Goals and thus there is a growing interest in seaweeds sectors for various industrial and ecosystem services. This book particularly focuses on the biological and biotechnological processes to aid the large-scale commercial seaweed farming. Developing quality material, disease resistance and heritable improvements in the existing germplasm sourced from wild populations, protoplast and callus-based technologies, and germplasm preservation are the major focus areas of the book. The information and knowledge provided by this book would facilitate evidence-based policymaking and sector management in seaweed development at the national and global levels. The seaweed sector has already been established or identified as sunrise sector in Asian, American, European and African countries. In these nations, this volume will act as valuable reference material for marine-sector professionals and government representatives as well.
The Combined Power of Research, Education, and Dissemination: Essays Dedicated to Tiziana Margaria on the Occasion of Her 60th Birthday (Lecture Notes in Computer Science #15240)
by Mike Hinchey Bernhard SteffenStarting with a Laurea in Ingegneria Elettronica and a PhD in Computer and Systems Engineering at the Politecnico di Torino, Tiziana has stayed faithful to her love of organized management of composable functionalities in software and systems, with building blocks and MDD, and she strives for coherence and alignment in complex systems through verification, model checking and workflow synthesis. Her quest for simplicity spans technologies (low-code/no-code; ITSy project), business (Business Model Canvas; tools for innovative business models) and disciplines with her concept of the Digital Thread, a metaphor for IT-mediated interoperation of reusable and ideally verified tools and systems in new platforms where reuse, repurposing and evolution are supported by design. Her most recent initiative, R@ISE, aims at opening the world of IT production and adaptation to a wider range of users and professions. Tiziana is a cofounder and managing editor of the International Journal on Software Tools for Technology Transfer, she cofounded the ISoLA conference, and cofounded METAFrame Technologies serving as CEO. She is a Fellow of the Society for Design and Process Science and a Fellow and President of the Irish Computer Society. Throughout her career Tiziana’s successes have been motivated by how best to advance science and engineering through the implementation of techniques in challenging applications, and the contributions in this volume by leading researchers are representative of a community that shares this drive.
Pediatric Cochlear Implantation: Learning and the Brain
by Karen Iler Kirk Nancy M. YoungThis second edition text will provide updated information to professionals and students in fields relevant to cochlear implantation. The main objective of this book is to provide the latest information about pediatric candidacy evaluation, medical and vestibular evaluation, surgery, language and literacy outcomes, habilitation, spatial hearing, influence of family dynamics and educational needs. This text also expands upon newer indications including unilateral and asymmetric hearing loss, management of children with residual hearing, and management of children from families whose primary language is Spanish. Additional important new topics discussed include the role of interprofessional training to better serve children, the Australian hearing health care model to achieve early implantation and addressing global barriers to pediatric implantation. Pediatric Cochlear Implantation is ideal for both trainees and practicing otolaryngologists, otologists/neurotologists, audiologists, speech language pathologists, psychologists and educators who work with deaf and head of hearing children.
Political Economy of Emerging Urban and Peri-urban Spaces in India: A Roadmap Towards Environmental and Social Sustainability (New Frontiers in Regional Science: Asian Perspectives #81)
by Anjan Chakrabarti Vishwa Raj Sharma Mukunda MishraThis book addresses the “urban” and “peri-urban” spaces in India within a single frame. The reasoning is that while the former is studied for its transformation towards more value addition in terms of power and neoliberal economic viabilities, the latter is the land of visible transformation of the built environment. It acquaints readers with how the processes of circulation of migrant labour, the shift in occupations of landowning groups, and the residential cohabitation of diverse social groups contribute to re-scripting social relations, green spaces, and the forging of new subjectivities. The chapters of the book speak of the need to create sustainable cities for uncertain futures, with a quest to reverse global climate change and make an effort to halt urbanization at the cost of the natural ecosystem, all of which have become more urgent in the post-pandemic years. The book addresses different aspects of the evolutionary urban and peri-urban spaces in India amidst the conflict of the environmental and social sustainability agendas with the neo-liberal ascendancy. The integration of urban and peri-urban areas with emerging political and economic equations and the involvement of multiple disciplines to work in tandem for a deep insight into the complex phenomena incorporating diverse actors validate the need for such a volume. This edited volume seeks to record how all these stakeholders—state agencies, political leaders, businessmen, workers, investors, households, builders, real estate intermediaries, business owners, migrants, and many more with their varying capacities to influence outcomes on the ground—interact with one another. It also shows how multiple power relationships are calibrated and recalibrated to produce urban and peri-urban spaces in diverse ways in many parts of India.
EU Energy Geopolitics: Strategic Premiums, Challenges, and Dilemmas in the Global Energy Transition Era (Environmental Politics and Theory)
by Filippos ProedrouThe global energy transition will be a game-changer for global politics. The field of energy geopolitics hence is changing fast, providing challenges, opportunities and variable outcomes for states across the world. The academic scholarship on the geopolitics of renewables has expanded exponentially over the last decade focusing on winners vs losers, conflict vs cooperation and establishing initial expectations and general propositions regarding the outcomes of the global energy transition. Cases studies, however, have been far and few, and appear in book chapters or, more rarely, journal articles. Overall, there is a dearth of academic monographs examining in depth how specific actors in the global system approach new energy geopolitics, how they are impacted by the global energy transition, and how this links with their grand strategy. This short monograph aims to fill this gap by offering an up-to-date case study of EU energy geopolitics. Grounded upon the sub-field of energy geopolitics, it produces a conceptual framework linking the global energy transition with EU grand strategy to assess how it impacts EU’s position in the global system, as well as the strategic gains, trade-offs and risks implicated. The book takes as its starting point and reviews systematically the main assumptions of the geopolitics of the global energy transition literature and the EU energy and climate policy that drives and shapes the EU energy transition. It subsequently focuses its attention on the impact of the EU energy transition on EU energy security, economic competitiveness and foreign policy/ power position and the potential it generates for more conflict or cooperation. The discussion is anchored in the different forms of power the EU operationalizes and showcases the strengths, limits and antinomies of the EU power toolbox in EU energy geopolitics. The originality, significance and contribution of this monograph lies in the cross-fertilization of fossil divestment and clean energy geopolitics, energy and climate policy, energy transition and EU as a power scholarship, with an eye to provide a comprehensive, up-to-date account of new EU energy geopolitics. In all, this monograph dissects the prospects and geopolitical implications of the new energy geopolitics, and the foreign policy ramifications engendered by the global energy transition. This book is aimed at academics and students in the areas of International Relations, International Political Economy, European Studies, Geopolitics, and Energy Politics. It aspires, moreover, to become a reference point for the scholarship in the field of energy (geo)politics. Moreover, it will be of value to think-tanks and policy-makers working in the fields of foreign, energy and climate policy.
Handbook of Solubility Data for Pharmaceuticals
by Abolghasem JouybanAqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Chronic Obstructive Pulmonary Disease Exacerbations (Lung Biology in Health and Disease)
by Jadwiga A. Wedzicha Fernando J. MartinezChronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat